0.5 mg, 1 mg, 1.5 mg, 2 mg and 2.5 mg film-coated tablets
riociguat<\/p>\n\n\n\n
Adempas contains the active substance riociguat. Riociguat is a type of medicine called a guanylate cyclase (GC) stimulant. It works by dilating the pulmonary arteries (the blood vessels that connect the heart to the lungs), making it easier for the heart to pump blood through the lungs. Adempas can be used to treat adults with certain forms of pulmonary hypertension, a condition in which these blood vessels become narrow, making it harder for the heart to pump blood through them and leading to high blood pressure in the vessels. Because the heart has to work harder than normal, people with pulmonary hypertension feel tired, dizzy, and short of breath. By widening the repressed arteries lead to the use of Adempas to improve your ability to be physically active.<\/p>\n\n\n\n
Adempas is used for two types of pulmonary hypertension:
<\/p>\n\n\n\n
If any of these apply to you, do not take Adempas without talking to your doctor first.<\/strong><\/p>\n\n\n\n Talk to your doctor or pharmacist before taking Adempas if:<\/p>\n\n\n\n You will receive Adempas only for certain types of pulmonary arterial hypertension(PAH), see section 1. There is no experience with the use of Adempas in other forms of PAH. Therefore, the use of Adempas in other forms of PAH is not recommended. Your doctor will check if Adempas is suitable for you.<\/p>\n\n\n\n The use of Adempas in children and adolescents (under 18 years of age) should be avoided as efficacy and safety have not been established for this age group.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, especially medicines used for:<\/p>\n\n\n\n Smoking<\/strong><\/p>\n\n\n\n If you smoke, it is recommended that you quit because smoking may reduce the effectiveness of these tablets. Tell your doctor if you smoke or if you stop smoking during treatment.<\/p>\n\n\n\n Pregnancy<\/em><\/p>\n\n\n\n Do not take Adempas during pregnancy. If there is a possibility that you may become pregnant, use a reliable method of contraception while taking these tablets. You are also advised to take monthly pregnancy tests. If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n Breast-feeding<\/em><\/p>\n\n\n\n If you are breast-feeding or planning to breast-feed, ask your doctor or pharmacist for advice before taking this medicine as it may harm your baby. You should not breast-feed while taking this medicine. Your doctor will decide with you whether to stop breast-feeding or stop treatment with Adempas.<\/p>\n\n\n\n Adempas has a moderate effect on the ability to drive and use machines. It can cause side effects such as dizziness. You should be aware of the side effects of this medicine before driving or using machines (see section 4).<\/p>\n\n\n\n If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. Adempas contains sodium<\/strong><\/p>\n\n\n\n This medicine contains less than 1 mmol sodium (23 mg) per dose, ie essentially ‘sodium-free’. Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure. Treatment should only be started and followed up by a doctor who has experience in the treatment of CTEPH or PAH. During the first weeks of treatment, your doctor will need to measure your blood pressure at regular intervals. Adempas is available in different strengths and your doctor will make sure you get the right dose by checking your blood pressure regularly at the beginning of treatment. Crushed tablets:<\/em><\/p>\n\n\n\n Talk to your doctor about other ways to take Adempas if you have difficulty swallowing the entire tablet. The tablet can be crushed and mixed with water or soft food, e.g. apple puree, immediately before taking it. Dose<\/strong><\/p>\n\n\n\n The recommended starting dose is a 1 mg tablet taken 3 times a day for 2 weeks.<\/p>\n\n\n\n The tablets should be taken 3 times a day at approximately 6 to 8-hour intervals. They can be taken with or without food. However, if you have a tendency to have low blood pressure ( hypotension ), do not switch between taking Adempas with food and Adempas without food, as it may affect how you react to Adempas.<\/p>\n\n\n\n Your doctor will increase your dose every two weeks to a maximum of 2.5 mg 3 times a day (maximum daily dose of 7.5 mg) if you do not experience side effects or very low blood pressure. In this case, your doctor will prescribe Adempas at the highest dose that you feel good about. For some patients, a lower dose three times a day may be enough; Your doctor will choose the dose that is best for you.<\/p>\n\n\n\n Special considerations for patients with kidney or liver problems<\/em><\/p>\n\n\n\n You should tell your doctor if you have kidney or liver problems. Dose one may need to be adjusted.<\/p>\n\n\n\n If you have severe liver problems (Child-Pugh C), do not take Adempas.<\/p>\n\n\n\n 65 years or older<\/em><\/p>\n\n\n\n If you are 65 years of age or older, your doctor will adjust your dose of Adempas especially carefully, as you may have an increased risk of low blood pressure. Special considerations for patients who smoke<\/em><\/p>\n\n\n\n You should tell your doctor if you start or stop smoking during treatment with this medicine. Your dose may need to be adjusted.<\/p>\n\n\n\n If you take more tablets than you should and experience side effects (see section 4), contact your doctor. If your blood pressure drops (which can cause dizziness) you may need immediate medical attention.<\/p>\n\n\n\n Do not take a double dose to make up for a forgotten dose. If you miss a dose, continue with the next dose as planned.<\/p>\n\n\n\n Do not stop taking this medicine without first talking to your doctor as this medicine will prevent the further development of the disease. If you have to stop treatment for 3 days or more, tell your doctor before starting treatment again.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n If you switch between sildenafil or tadalafil and Adempas<\/strong><\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n The most serious <\/strong>side effects are:<\/p>\n\n\n\n If this happens, consult a doctor immediately<\/strong> as you may need urgent medical attention. The overall list of possible side effects:<\/strong><\/p>\n\n\n\n Very common:<\/strong> may affect more than 1 in 10 people<\/p>\n\n\n\n Common:<\/strong> may affect up to 1 in 10 people<\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. <\/p>\n\n\n\n Keep this medicine out of the sight and reach of children. No special storage instructions.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Adempas is a film-coated tablet:<\/p>\n\n\n\n Adempas <\/em>0.5 mg film-coated tablets<\/em><\/p>\n\n\n\n Adempas 1 <\/em>mg film-coated tablets<\/em><\/p>\n\n\n\n Adempas <\/em>1.5 mg film-coated tablets<\/em><\/p>\n\n\n\n Adempas <\/em>2 mg film-coated tablets<\/em><\/p>\n\n\n\n Adempas <\/em>2.5 mg film-coated tablets<\/em><\/p>\n\n\n\n They are available in packs of:<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Bayer AG<\/p>\n\n\n\n 51368 Leverkusen<\/p>\n\n\n\n Germany Manufacturer<\/strong><\/p>\n\n\n\n Bayer AG<\/p>\n\n\n\n Kaiser-Wilhelm-Allee<\/p>\n\n\n\n 51368 Leverkusen<\/p>\n\n\n\n Germany<\/p>\n\n\n\n Contact the representative of the marketing authorization holder to find out more about this medicine<\/p>\n\n\n\n Adempas contains the active substance riociguat. Riociguat is a type of medicine called a guanylate cyclase (GC) stimulant. It works by dilating the pulmonary arteries (the blood vessels that connect the heart to the lungs), making it easier for the heart to pump blood through the lungs. Adempas can be used to treat adults with certain forms of pulmonary hypertension, a condition in which these blood vessels become narrow, making it harder for the heart to pump blood through them and leading to high blood pressure in the vessels. Because the heart has to work harder than normal, people with pulmonary hypertension feel tired, dizzy, and short of breath. By widening the repressed arteries lead to the use of Adempas to improve your ability to be physically active.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[11594,11597,11599,11593,11588,11592,11591,11598,11596,11595,11589,11590],"class_list":["post-4797","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-adempas","tag-adempas-tablet","tag-benefits-of-adempas","tag-benefits-of-riociguat","tag-riociguat","tag-riociguat-side-effects","tag-riociguat-tablet","tag-side-effects-of-adempas","tag-what-adempas-is-used-for","tag-what-is-adempas","tag-what-is-riociguat","tag-what-riociguat-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4797"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4797\/revisions"}],"predecessor-version":[{"id":13092,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4797\/revisions\/13092"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Adempas<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Adempas contains lactose<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n3. How to take Adempas<\/h2>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\nIf you take more Adempas than you should<\/h2>\n\n\n\n
If you forget to take Adempas<\/h2>\n\n\n\n
If you stop taking Adempas<\/h2>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
<\/p>\n\n\n\n5. How to store Adempas<\/h2>\n\n\n\n
<\/p>\n\n\n\n6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
Each film-coated tablet contains 0.5 mg riociguat.Adempas 1 mg film-coated tablets<\/em>Each film-coated tablet contains 1 mg of riociguat.Adempas 1.5 mg film-coated tablets<\/em>Each film-coated tablet contains 1.5 mg of riociguat.Adempas 2 mg film-coated tablets<\/em>Each film-coated tablet contains 2 mg of riociguat.Adempas 2.5 mg film-coated tablets<\/em>Each film-coated tablet contains 2.5 mg of riociguat.
<\/li>
Tablet core:<\/em> microcrystalline cellulose, crospovidone (type B), hypromellose 5 cP, lactose monohydrate, magnesium stearate, and sodium lauryl sulfate (see the end of section 2 for more information on lactose ).
Film coating * hydroxypropyl cellulose, hypromellose 3 cP, propylene glycol (E 1520), and titanium dioxide (E 171).
Adempas * 1 mg, 1.5 mg tablets also contain: iron oxide yellow (E 172).
Adempas * 2 mg and 2.5 mg tablets also contain iron oxide yellow (E 172) and iron oxide red (E 172).<\/li><\/ul>\n\n\n\nWhat the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
<\/p>\n\n\n\nBelgium \/ Belgique \/ Belgien<\/strong>MSD Belgium BVBA \/ SPRLTel \/ Tel: +32 (0) 27766211
dpoc_belux@merck.com<\/td>Lithuania<\/strong>UAB Merck Sharp & DohmeTel: + 370 5 2780247
msd_lietuva@merck.com<\/td><\/tr>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel .: + 359 2 819 37 37
info-msdbg@merck.com<\/td>Luxembourg \/ Luxemburg<\/strong>MSD Belgium BVBA \/ SPRLTel \/ Tel: +32 (0) 27766211
dpoc_belux@merck.com<\/td><\/tr>Czech Republic<\/strong>Merck Sharp & Dohme sroTel .: +420 233 010 111
dpoc_czechslovak@merck.com<\/td>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: + 36 1 888-5300hungary_msd@merck.com<\/td><\/tr> Denmark<\/strong>MSD Danmark ApSTel: + 45 4482 4000
dkmail@merck.com<\/td>Malta<\/strong>Merck Sharp & Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)
malta _<\/strong> info@merck.com<\/td><\/tr>Germany<\/strong>MSD SHARP & DOHME GMBHTel: 0800 673 673 673 (+49 (0) 89 4561 2612)email@msd.de<\/td> The Netherlands<\/strong>Merck Sharp & Dohme BVTel: 0800 9999 000 (+ 31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr> Eesti<\/strong>Merck Sharp & Dohme O\u00dcTel: + 372 6144 200msdeesti@merck.com<\/td> Norway<\/strong>MSD (Norway) ASTel: + 47 32 20 73 00msdnorge@msd.no<\/td><\/tr> Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395:\u0397\u03bb: + 30 210 98 97 300dpoc_greece@merck.com<\/td> Austria<\/strong>Merck Sharp & Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr> Spain<\/strong>Merck Sharp & Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td> Poland<\/strong>MSD Polska Sp.z ooTel .: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr> France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40 <\/td> Portugal<\/strong>Merck Sharp & Dohme, LdaTel: + 351 214465700inform_pt@merck.com<\/td><\/tr> Croatia<\/strong>Merck Sharp & Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td> Romania<\/strong>Merck Sharp & Dohme Romania SRLTel: + 40 21 529 29 00msdromania@merck.com<\/td><\/tr> Ireland<\/strong>Merck Sharp & Dohme Ireland ( HumanHealth) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td> Slovenia<\/strong>Merck Sharp & Dohme, an innovative creative artistTel: + 386 1 5204201msd_slovenia@merck.com<\/td><\/tr> Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td> Slovak Republic<\/strong>Merck Sharp & Dohme, sroTel: + 421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr> Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td> Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: + 358 (0) 9 804650info@msd.fi<\/td><\/tr> \u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Merck Sharp & Dohme Cyprus Limited:\u0397\u03bb: 800 00 673 (+357 22866700)cyprus_info@merck.com<\/td> <\/td><\/tr> Latvia<\/strong>SIA Merck Sharp & Dohme LatvijaTel: + 371 67364224msd_lv@merck.com<\/td> United Kingdom<\/strong>Merck Sharp & Dohme LimitedTel: +44 (0) 1992 467272medicalinformationuk@merck.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"