{"id":4744,"date":"2020-11-30T10:03:08","date_gmt":"2020-11-30T10:03:08","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4744"},"modified":"2021-08-21T07:26:52","modified_gmt":"2021-08-21T07:26:52","slug":"adalat-oros","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/adalat-oros\/","title":{"rendered":"Adalat Oros &#8211; Nifedipine uses, dose and side effects"},"content":{"rendered":"\n<p>30 mg&nbsp;prolonged-release tablet&nbsp;is<br>nifedipine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Adalat Oros is and what it is used for<\/h2>\n\n\n\n<p>Adalat Oros is used for treating high&nbsp;blood pressure&nbsp;and stable angina in the heart.<\/p>\n\n\n\n<p>High&nbsp;blood pressure&nbsp;occurs i.a.&nbsp;a. when the resistance in the blood vessels is too high.&nbsp;Adalat Oros is a calcium channel blocker (a drug that inhibits the influx of&nbsp;calcium&nbsp;into certain cells).&nbsp;Treatment with Adalat Oros reduces the tension in the muscle cells of the blood vessels.&nbsp;As a result, more blood (and thus more oxygen) can emerge and the blood vessels dilate.&nbsp;<br>The most common type of angina occurs when the heart muscle receives too little oxygen.&nbsp;In the case of angina, Adalat Oros dilates the blood vessels, the heart does not have to work as hard to pump out the blood and thus less oxygen is needed.<\/p>\n\n\n\n<p>Adalat Oros is a new type of tablet (&nbsp;prolonged-release tablets&nbsp;) of nifedipine.&nbsp;The drug is released continuously and gives an even effect throughout the day with a tablet once a day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Adalat Oros<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Adalat Oros<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to nifedipine or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are before week 20 of pregnancy or if you are breast-feeding<\/li><li>if you have untreated&nbsp;heart failure&nbsp;or&nbsp;acute&nbsp;myocardial infarction.&nbsp;Adalat Oros should not be used for the first 8 days after a heart attack<\/li><li>if you have&nbsp;cardiovascular&nbsp;shock<\/li><li>if you are being treated with rifampicin at the same time<\/li><li>if you have a so-called Kocks bladder (&nbsp;ileostomy&nbsp;after a proctocolectomy).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Those with the following conditions should consult a physician before starting treatment with Adalat Oros:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>narrowing of the great carotid artery (aortic stenosis)<\/li><li>very low&nbsp;blood pressure<\/li><li>hepatic impairment<\/li><li>heart failure<\/li><li>narrowing of the gastrointestinal tract<\/li><li>chronic&nbsp;diarrhea (&nbsp;Crohn&#8217;s disease,&nbsp;ulcerative colitis&nbsp;)<\/li><\/ul>\n\n\n\n<p>During X-ray examinations with contrast media, doctors should be informed about the use of Adalat Oros as the tablets may cause filling defects in the contrast which may be misinterpreted as&nbsp;polyps.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Adalat Oros is not recommended for use in children and adolescents below 18 years of age due to limited safety and efficacy data in this patient group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Adalat Oros<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;Also over-the-counter medicines, herbal remedies, or other natural products.<\/p>\n\n\n\n<p>Adalat Oros is broken down via an&nbsp;enzyme&nbsp;system called&nbsp;cytochrome P450&nbsp;3A4.&nbsp;Concomitant use of Adalat Oros and other medicines that affect this&nbsp;enzyme&nbsp;system may&nbsp;affect the&nbsp;effectiveness of the treatment.<\/p>\n\n\n\n<p>Adalat Oros may affect or be affected by certain medicines containing the following active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifampicin (for&nbsp;tuberculosis&nbsp;)<\/li><li>cimetidine (for&nbsp;stomach ulcers&nbsp;)<\/li><li>phenytoin, carbamazepine, phenobarbital,&nbsp;valproic acid&nbsp;(for&nbsp;epilepsy&nbsp;)<\/li><li>macrolide antibiotics (eg erythromycin, clarithromycin, telithromycin) (against&nbsp;infections&nbsp;)<\/li><li>azole antifungals (eg&nbsp;ketoconazole, itraconazole, voriconazole, posaconazole,&nbsp;fluconazole&nbsp;) (&nbsp;antifungal&nbsp;)<\/li><li>HIV&nbsp;&#8211;&nbsp;protease inhibitors&nbsp;(e.g., ritonavir, indinavir, saquinavir, atazanavir, nelfinavir) (to treat&nbsp;HIV&nbsp;)<\/li><li>cisapride (an intestinal stimulant)<\/li><li>fluoxetine, nefazodone,&nbsp;St. John&#8217;s wort&nbsp;(for depression)<\/li><li>quinupristin\/dalfopristin (against&nbsp;infection&nbsp;)<\/li><li>verapamil,&nbsp;diltiazem&nbsp;(for high&nbsp;blood pressure, angina)<\/li><li>digoxin&nbsp;(affects heart and blood vessels)<\/li><li>quinidine&nbsp;(for irregular heartbeat)<\/li><li>tacrolimus (usually given after organ transplantation)<\/li><li>aprepitant (for nausea associated with&nbsp;chemotherapy&nbsp;)<\/li><\/ul>\n\n\n\n<p>Concomitant treatment with beta-receptor blockers or other&nbsp;antihypertensive&nbsp;drugs&nbsp;may lead to worsening of&nbsp;heart failure&nbsp;and potentiating the effect of lowering blood pressure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Adalat Oros with food and drink<\/h2>\n\n\n\n<p>Do not drink grapefruit juice while taking Adalat Oros.&nbsp;It may affect the effectiveness of the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Pregnant women should not use Adalat Oros during the first 20 weeks of pregnancy.&nbsp;Taking Adalat Oros should be avoided by women who are planning to become pregnant or are pregnant.&nbsp;Treatment during any part of the pregnancy should only be done after a doctor&#8217;s&nbsp;prescription.<\/p>\n\n\n\n<p>Adalat passes into breast milk.&nbsp;Therefore, do not use Adalat Oros during breast-feeding unless specifically&nbsp;prescribed&nbsp;by a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Reactions to the drug can affect the ability to drive or perform precision work, especially at the beginning of treatment, when changing drugs and in combination with alcohol.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Adalat Oros contains sodium<\/h2>\n\n\n\n<p>This medicine contains&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) in the following amounts: 8.3 mg (20 mg tablet), 9.4 mg (30 mg tablet), and 18.8 mg<\/p>\n\n\n\n<p>(60 mg tablet).&nbsp;Increasing the daily dose to 120 mg nifedipine results in an intake of up to 37.6 mg&nbsp;sodium.&nbsp;This corresponds to 1.88% of the WHO&#8217;s highest recommended daily intake (2 grams of&nbsp;sodium&nbsp;for adults).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Adalat Oros<\/h2>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you<\/p>\n\n\n\n<p><em>In the <\/em>case of angina: The&nbsp;appropriate starting dose is 1 tablet 30 mg once daily.&nbsp;Doseone may sometimes need to be increased to 60-90 mg daily.&nbsp;<br>In the <em>case of high blood pressure: The<\/em>&nbsp;appropriate starting dose is 20 mg once daily.&nbsp;The usual maintenance dose is 20-30 mg once daily.&nbsp;Dose&nbsp;one can be increased to 60 mg once daily if needed.<\/p>\n\n\n\n<p>The tablets must be swallowed whole with liquid and must not be crushed, chewed, or divided.&nbsp;<br>The tablets can be taken regardless of the meal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>Stop taking Adalat Oros and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing<\/li><\/ul>\n\n\n\n<p>Angioedema&nbsp;is classified as a less common side effect, which means that less than 1 person in 100 is affected.<\/p>\n\n\n\n<p>Adalat Oros can in rare cases affect the white&nbsp;blood cells&nbsp;so that the defense of infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.&nbsp;The frequency of&nbsp;agranulocytosis&nbsp;is unknown.<br><\/p>\n\n\n\n<p>Most&nbsp;side effects&nbsp;of Adalat Oros are related to the vasodilating effect.&nbsp;They usually appear at the beginning of treatment and often disappear on their own.<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><em>Common: (more than 1 person in 100 affected)<\/em><\/td><td>Swelling, headache, flushing with a feeling of heat, constipation, general malaise.<\/td><\/tr><tr><td><em>Uncommon:<\/em><em>(less than 1 person in 100 affected)<\/em><\/td><td>Allergic reaction, anxiety&nbsp;reactions, sleep disturbances, dizziness,&nbsp;migraine, tremors, visual disturbances, increased&nbsp;heart rate, palpitations, low&nbsp;blood pressure, fainting spells, nosebleeds, nasal congestion, abdominal pain, nausea, indigestion, flatulence,&nbsp;dry mouth,&nbsp;dry mouth, rash increased need for urination, urination problems, erectile dysfunction, non-specific pain, chills.<\/td><\/tr><tr><td><em>Rare:&nbsp;<\/em><em>(less than 1 person in 1000 affected)<\/em><\/td><td>Itching&nbsp;, runny nose, rash, sensory disturbances \/ hallucinations, gum growth (gingival&nbsp;hyperplasia&nbsp;).<\/td><\/tr><tr><td><em>No known frequency (cannot be calculated from the available data)<\/em><\/td><td>Rapid onset of severe&nbsp;hypersensitivity reaction, elevated blood sugar, numbness, sleepiness, eye pain, chest pain (&nbsp;angina pectoris&nbsp;), shortness of breath, bezoars (lumps the nondegradable tablet shells in the stomach), swallowing, intestine, intestinal ulcer, vomiting,&nbsp;gastroesophageal&nbsp;sfinkterinsufficiens causing leakage of stomach acid via the upper stomach mouth this can cause heartburn, jaundice, severe widespread skin damage (skin detachment),&nbsp;allergic reaction&nbsp;with photosensitivity, reddish skin changes (purpura), joint and muscle pain.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Adalat Oros<\/h2>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.&nbsp;<br>Do not use this medicine after the expiry date which is stated on the carton.<br><\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is Nifedipine.&nbsp;One tablet contains 20 mg, 30 mg, and 60 mg nifedipine respectively.&nbsp;<br>The other ingredients are Iron oxide, magnesium stearate, sodium chloride, hypromellose, cellulose acetate, polyethylene glycol, polyethylene oxide, hydroxypropyl cellulose, titanium dioxide, and propylene glycol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Round, convex, pink&nbsp;prolonged-release tablets&nbsp;with laser holes on one side, marked with &#8216;Adalat 20&#8217;, &#8216;Adalat 30&#8217;, and &#8216;Adalat 60&#8217; respectively.&nbsp;<br>All strengths have blister packs of 28 pcs and 98 pcs and a single-dose pack of 49 pcs (49&#215;1).<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bayer AB<\/p>\n\n\n\n<p>Box 606&nbsp;<\/p>\n\n\n\n<p>SE-169 26 Solna&nbsp;<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Bayer AG<\/p>\n\n\n\n<p>51368 Leverkusen<\/p>\n\n\n\n<p>Germany<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adalat Oros is used for treating high blood pressure and stable angina in the heart.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[11702,11706,11705,11707,11700,11696,11699,11701,11704,11703,11697,11698],"class_list":["post-4744","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-adalat-oros","tag-adalat-oros-side-effects","tag-adalat-oros-tablet","tag-benefits-of-adalat-oros","tag-benefits-of-nifedipine","tag-nifedipine","tag-nifedipine-tablet","tag-side-effects-of-nifedipine","tag-what-adalat-oros-is-used-for","tag-what-is-adalat-oros","tag-what-is-nifedipine","tag-what-nifedipine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4744"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4744\/revisions"}],"predecessor-version":[{"id":13126,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4744\/revisions\/13126"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}