{"id":4682,"date":"2020-11-28T10:10:46","date_gmt":"2020-11-28T10:10:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4682"},"modified":"2021-08-24T07:21:24","modified_gmt":"2021-08-24T07:21:24","slug":"aclasta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/aclasta\/","title":{"rendered":"Aclasta &#8211; Zoledronic acid uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg\u00a0solution for infusion\u00a0,\u00a0zoledronic acid\u00a0solution<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Aclasta is and what it is used for<\/h2>\n\n\n\n<p>Aclasta contains the active substance zoledronic acid.&nbsp;Aclasta belongs to a group of medicines called bisphosphonates and is used to treat&nbsp;osteoporosis&nbsp;in postmenopausal women and in adult men with&nbsp;osteoporosis&nbsp;or&nbsp;osteoporosis&nbsp;caused by treatment with&nbsp;corticosteroids&nbsp;used to treat&nbsp;inflammation&nbsp;and&nbsp;Paget&#8217;s disease&nbsp;in adults.<\/p>\n\n\n\n<p><strong>Osteoporosis<\/strong><\/p>\n\n\n\n<p>Osteoporosis&nbsp;is a disease that consists of thinning and weakening of the bone tissue and is common in women after menopause, but can also occur in men.&nbsp;In menopause woman&#8217;s ovaries stop producing the female&nbsp;hormone&nbsp;et&nbsp;estrogen, which helps to keep bones healthy.&nbsp;After menopause, there is a loss of bone tissue, which means that the skeleton is weakened and broken more easily.&nbsp;Osteoporosis&nbsp;can also occur in men and women due to long-term use of&nbsp;corticosteroids, which can affect the strength of the skeleton.&nbsp;Many patients with&nbsp;osteoporosis&nbsp;have no symptoms, but they are still at risk of skeletal fractures, due to&nbsp;osteoporosis made the skeleton weaker.&nbsp;Decreased circulating levels of sex hormones, mainly&nbsp;estrogen&nbsp;converted from&nbsp;androgens, also play a role in the more gradual bone loss observed in men.&nbsp;In both women and men, Aclasta strengthens the skeleton and therefore there is less risk of it breaking.&nbsp;Aclasta is also used for patients who have recently broken their hip in a minor accident such as a fall and therefore have a national for subsequent bone fractures.<\/p>\n\n\n\n<p><strong>Paget&#8217;s disease<\/strong><\/p>\n\n\n\n<p>Normally, old bone tissue is replaced with new.&nbsp;This process is called remodeling.&nbsp;In&nbsp;Paget&#8217;s disease, this remodeling is too fast and new bone tissue is formed in a disordered manner, making it weaker than normal.&nbsp;If the disease is not treated, the bones can deform and cause pain and possibly break.&nbsp;Aclasta works by restoring the bone remodeling process to normal, ensuring the formation of normal bone tissue and thus rebuilding the strength of the bone tissue.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you receive Aclasta<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Aclasta<\/h2>\n\n\n\n<p>Carefully follow all instructions given to you by your doctor, pharmacist, or nurse before receiving Aclasta.<\/p>\n\n\n\n<p><strong>Aclasta should not be used:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to zoledronic acid, other bisphosphonates, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have&nbsp;hypocalcemia&nbsp;(your blood calcium level is too low).<\/li><li>if you have severe kidney disease.<\/li><li>if you are pregnant.<\/li><li>if you are breast-feeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before receiving Aclasta:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are being treated with a medicine containing zoledronic acid, which is also the active substance in Aclasta (zoledronic acid is used in adult patients with certain cancers to prevent bone complications or to reduce the amount of&nbsp;calcium).<\/li><li>if you have or have had any kidney disease.<\/li><li>if you can not take daily calcium supplements.<\/li><li>if you have had surgery to remove any or all of the parathyroid glands in your throat.<\/li><li>if you have removed parts of your small intestine.<\/li><\/ul>\n\n\n\n<p>Following the marketing authorization, a side effect called&nbsp;osteonecrosis&nbsp;of the jaw (ONJ) \u200b\u200b(bone damage in the jaw) has been reported in patients treated with Aclasta (zoledronic acid) for osteoporosis.&nbsp;ONJ can also occur after the end of treatment.<\/p>\n\n\n\n<p>It is important to try to prevent ONJ from developing as it is a painful condition that can be difficult to treat.&nbsp;To reduce the risk of developing&nbsp;osteonecrosis&nbsp;of the jaw, there are certain precautions you should take.<\/p>\n\n\n\n<p>Before receiving Aclasta treatment, talk to your doctor, pharmacist, or nurse<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have any problems with your mouth or teeth such as poor dental health, gum problems, or a planned tooth extraction;<\/li><li>you do not receive regular dental care or have not had a dental examination for a long time;<\/li><li>you are a smoker (because it can increase the risk of dental problems);<\/li><li>you have previously been treated with a bisphosphonate (used to treat or prevent bone diseases);<\/li><li>you are taking medicines called&nbsp;corticosteroids&nbsp;(such as&nbsp;prednisolone&nbsp;or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a>);<\/li><li>you have cancer.<\/li><\/ul>\n\n\n\n<p>Your doctor may ask you to have a dental examination before starting treatment with Aclasta.<\/p>\n\n\n\n<p>While you are being treated with Aclasta, you should maintain good oral hygiene (including regular toothbrushing) and have regular dental check-ups.&nbsp;If you wear dentures, you should make sure that they fit snugly.&nbsp;If you are having dental treatment or are about to undergo dental surgery (eg extracting a tooth), inform your doctor about your dental care and tell your dentist that you are being treated with Aclasta.&nbsp;Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, pain or swelling, or wounds that do not heal or fluid, as these may be signs of&nbsp;osteonecrosis&nbsp;of the jaw.<\/p>\n\n\n\n<p><strong>Monitoring of renal function<\/strong><\/p>\n\n\n\n<p>Your doctor should take a blood test to check your kidney function (creatinine levels) before each&nbsp;dose&nbsp;of Aclasta.&nbsp;It is important that you drink at least 2 glasses of liquid (such as water), a few hours before you receive Aclasta, as directed by your healthcare professional.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Aclasta is not recommended for people under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Aclasta<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It is important that your doctor knows all the medicines you are taking, especially if you are taking any medicines that may be harmful to&nbsp;your&nbsp;kidneys (eg&nbsp;aminoglycosides&nbsp;) or&nbsp;diuretics&nbsp;(&#8221;&nbsp;diuretics&nbsp;&#8220;) which may cause dehydration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Aclasta should not be given to you if you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby.<\/p>\n\n\n\n<p>Ask your doctor, pharmacist, or nurse for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel dizzy while being treated with Aclasta, do not drive or use machines until you feel better.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aclasta contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per 100 ml&nbsp;vial&nbsp;of Aclasta, ie essentially &#8216;sodium-free&#8217;.&nbsp;essentially &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Aclasta<\/h2>\n\n\n\n<p>Carefully follow all instructions given to you by your doctor or nurse.&nbsp;If you are not sure, talk to your doctor or nurse.<\/p>\n\n\n\n<p><strong>Osteoporosis<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 5 mg given as an&nbsp;infusion&nbsp;into a vein at one time per year by your doctor or nurse.&nbsp;Infusion&nbsp;one takes at least 15 minutes.<\/p>\n\n\n\n<p>In case you have recently broken your hip, it is recommended that Aclasta be given two or more weeks after your hip surgery.<\/p>\n\n\n\n<p>It is important to take&nbsp;calcium&nbsp;and&nbsp;vitamin&nbsp;D&nbsp;supplements&nbsp;(eg in tablet form) according to the instructions given to you by your doctor.<\/p>\n\n\n\n<p>In&nbsp;osteoporosis, Aclasta works for one year.&nbsp;Your doctor will tell you when to return for your next&nbsp;dose.<\/p>\n\n\n\n<p><strong>Paget&#8217;s disease<\/strong><\/p>\n\n\n\n<p>For the treatment of Paget&#8217;s disease: Aclasta should only be prescribed by doctors who have experience in the treatment of&nbsp;Paget&#8217;s disease.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 5 mg, which is given as a first&nbsp;infusion&nbsp;into a vein by your doctor or nurse.&nbsp;Infusion&nbsp;one takes at least 15 minutes.&nbsp;Aclasta may last for more than a year and your doctor will tell you if you need to be treated again.<\/p>\n\n\n\n<p>Your doctor may recommend that you take&nbsp;calcium&nbsp;and&nbsp;vitamin&nbsp;D&nbsp;supplements&nbsp;(eg tablets) for at least the first ten days after receiving Aclasta.&nbsp;It is important that you follow this advice carefully so that the level of&nbsp;calcium&nbsp;in the blood does not become too low during the period after&nbsp;infusion&nbsp;one.&nbsp;Your doctor will inform you about the symptoms associated with&nbsp;hypocalcemia.<\/p>\n\n\n\n<p><strong>Aclasta with food and drink<\/strong><\/p>\n\n\n\n<p>Make sure you drink enough fluids (at least one or two glasses) before and after treatment with Aclasta as directed by your doctor.&nbsp;This helps prevent dehydration.&nbsp;You can eat normally on the day you are treated with Aclasta.&nbsp;This is especially important in patients taking&nbsp;diuretics&nbsp;(&#8221;&nbsp;diuretics&nbsp;&#8220;) and in elderly patients (65 years or older).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss a dose of Aclasta<\/h2>\n\n\n\n<p>Contact your doctor or hospital as soon as possible to book a new appointment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Aclasta<\/h2>\n\n\n\n<p>If you are considering stopping treatment with Aclasta, go to your next scheduled visit and discuss this with your doctor.&nbsp;Your doctor will advise you and decide how long you should be treated with Aclasta.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;associated with the first&nbsp;infusion&nbsp;are very common (occurring in 30% of patients), but are less common with subsequent&nbsp;infusions.&nbsp;Most of the&nbsp;side effects, such as fever and chills, muscle and joint pain, and headaches appear within the first three days after a&nbsp;dose&nbsp;of Aclasta.&nbsp;The symptoms are usually mild to moderate and disappear within three days.&nbsp;Your doctor may recommend a mild painkiller such as&nbsp;ibuprofen&nbsp;or&nbsp;paracetamol&nbsp;to reduce the&nbsp;side effects.&nbsp;The likelihood of experiencing these&nbsp;side effects&nbsp;decreases with continued treatment with Aclasta.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious<\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<p>Irregular heart rhythm (&nbsp;atrial fibrillation&nbsp;) has been noted in patients treated with Aclasta for&nbsp;postmenopausal&nbsp;osteoporosis.&nbsp;It is currently unclear if Aclasta causes the irregular heartbeat, but you should report to your doctor if you experience such symptoms after being treated with Aclasta.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<p>Swelling,&nbsp;redness, pain, and&nbsp;itching&nbsp;in the eyes or photosensitivity.<\/p>\n\n\n\n<p><em>Very rare&nbsp;<\/em><em>(may affect up to 1 in 10,000 people)<\/em><\/p>\n\n\n\n<p>Talk to a doctor if you have ear pain, discharge from the ear, and\/or an ear infection.&nbsp;This may be a sign of a bone injury in the ear.<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<p>Pain in the mouth and\/or jaw, swelling or sores that do not heal in the mouth or jaw, warts, numbness or a feeling of heaviness in the jaw, or tooth loss;&nbsp;this may be a sign of bone damage in the jaw (&nbsp;osteonecrosis&nbsp;).&nbsp;Tell your doctor and dentist immediately if you experience such symptoms while you are being treated with Aclasta or after stopping treatment.<\/p>\n\n\n\n<p>Renal impairment (eg decreased urine output) may occur.&nbsp;Your doctor should take a blood test to check your kidney function (creatinine levels) before each&nbsp;dose&nbsp;of Aclasta.&nbsp;It is important that you drink at least 2 glasses of liquid (such as water), a few hours before you receive Aclasta, as directed by your healthcare professional.<\/p>\n\n\n\n<p>If you experience any of the above&nbsp;side effects&nbsp;then you should contact your doctor immediately.<\/p>\n\n\n\n<p><strong>Aclasta can cause other&nbsp;side effects&nbsp;that are<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n<p>Fever<br><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<p>Headache, dizziness, nausea, vomiting, diarrhea, muscle aches, pain in the bones and\/or joints, back, arm, or leg pain, flu-like symptoms (eg fatigue, chills, joint and muscle pain), chills, feeling tired, and disinterest, weakness, pain, malaise, swelling and\/or pain at the infusion site.<\/p>\n\n\n\n<p>In patients with&nbsp;Paget&#8217;s disease, symptoms due to low&nbsp;levels&nbsp;of&nbsp;calcium&nbsp;in the blood, such as muscle spasms or numbness or a stinging sensation, especially around the mouth, have been reported.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<p>Influenza, upper respiratory infections, decreased&nbsp;red blood cells, loss of appetite, insomnia, drowsiness, which can include reduced alertness and attention, needle sticks or numbness, extreme fatigue, tremor, temporary loss of consciousness,&nbsp;an eye infection&nbsp;or irritation or&nbsp;inflammation&nbsp;with pain and&nbsp;redness, vertigo, increase in&nbsp;blood pressure&nbsp;et,&nbsp;flushing, coughing, shortness of breath, indigestion, abdominal pain, constipation,&nbsp;dry mouth, heartburn, rash, sweating,&nbsp;itching, red skin, neck pain, stiffness in muscles, skeleton and\/or joints, joint swelling, muscle spasms, shoulder pain, chest and chest pain, joint inflammation, muscle weakness, abnormal laboratory results regarding kidney function, frequent urination, swelling and swelling of the hands, swelling of the hands, , thirst, toothache, taste disorders.<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<p>Unusual femoral fractures, especially in patients receiving long-term treatment for osteoporosis, may occur in rare cases.<\/p>\n\n\n\n<p>Contact your doctor if you experience pain, weakness, or discomfort in the thigh, hip, or groin as this may be an early sign of a possible femoral fracture.&nbsp;Low levels of phosphate in the blood.<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<p>Severe allergic reactions including dizziness and difficulty breathing, swelling mainly in the face and throat, decreased&nbsp;blood pressure, dehydration secondary to acute phase reactions (symptoms such as fever, vomiting, and diarrhea which occurred after&nbsp;dosing&nbsp;).<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;Postal address<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Aclasta<\/h2>\n\n\n\n<p>Your doctor, pharmacist, or nurse knows how to store Aclasta correctly.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and bottle after EXP.<\/li><li>The unopened vial does not require any special storage instructions.<\/li><li>After opening, the solution should be used immediately to prevent bacteria from coming into contact with the solution.&nbsp;If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user.&nbsp;Normally this time should not exceed 24 hours at 2 \u00b0 C &#8211; 8 \u00b0 C.&nbsp;Allow the cooled solution to reach room temperature before&nbsp;administration.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is zoledronic acid.&nbsp;Each&nbsp;vial&nbsp;of 100 ml contains 5 mg of zoledronic acid (as monohydrate). One ml of solution contains 0.05 mg of anhydrous zoledronic acid (as monohydrate).<\/li><li>The other ingredients are mannitol, sodium citrate, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Aclasta is a clear and colorless solution.&nbsp;It is supplied in a 100 ml plastic bottle as a reconstituted infusion solution.&nbsp;Aclasta is supplied in packs, one&nbsp;vial&nbsp;or multiple packs consisting of five packs, one&nbsp;vial&nbsp;each.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstra\u00dfe 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lithuanian branches.Tel: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel: +359 2 489 98 28<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis sroTel: +420 225 775 111<\/td><td><strong>Hungary<\/strong>Novartis Hungary Kft.Tel .: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Sandoz A \/ STel: +45 63 95 10 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Tel: +356 2122 2872<\/td><\/tr><tr><td><strong>Germany<\/strong>Novartis Pharma GmbHTel: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVTel: +31 88 04 52 111<\/td><\/tr><tr><td><strong>Eesti<\/strong>SIA Novartis Baltics Eesti subsidiaryTel: +372 66 30 810<\/td><td><strong>Norway<\/strong>Sandoz A \/ STel: +45 63 95 10 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Hellas) AEBE:\u0397\u03bb: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHTel: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>BEXAL PHARMACEUTICALS, SATel: +34 900 456 856<\/td><td><strong>Poland<\/strong>Novartis Poland Sp.&nbsp;z ooTel .: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>SandozTel: +33 800 45 57 99<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Pharmaceutical Products, SATel: +351 21 000 8600<\/td><\/tr><tr><td><strong>Croatia<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Sandoz SRLTel: +40 21 40751 60<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedTel: +353 1 260 12 55<\/td><td><strong>Slovenia<\/strong>Novartis Pharma Services Inc.Tel: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Novartis Slovakia sroTel: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Farma SpATel: +39 02 96 54 1<\/td><td><strong>Finland \/ Finland<\/strong>Novartis Finland OyPuh \/ Tel: +358 (0) 10 6133 200<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Novartis Pharma Services Inc.:\u0397\u03bb: +357 22 690 690<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsTel: +371 67 887 070<\/td><td><strong>United Kingdom<\/strong>Novartis Pharmaceuticals UK Ltd.Tel: +44 1276 698370<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>This leaflet was last modified in:<\/strong><\/p>\n\n\n\n<p>2020-03-26<\/p>\n\n\n\n<p><strong>Other sources of information<\/strong><\/p>\n\n\n\n<p>Further information on this medicine is available on the European Medicines Agency web site: http:\/\/www.ema.europa.eu<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">INFORMATION FOR NURSING STAFF<\/h2>\n\n\n\n<p>The following information is intended for healthcare professionals only (see section 3):<br><\/p>\n\n\n\n<p><strong>Preparation&nbsp;and&nbsp;administration&nbsp;of Aclasta<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Aclasta 5 mg infusion solution is reconstituted.<\/li><\/ul>\n\n\n\n<p>For single use only.&nbsp;Any unused solution should be discarded.&nbsp;Only clear solutions without particles and discoloration should be used.&nbsp;Aclasta must not be mixed or administered&nbsp;intravenously&nbsp;with any other medicinal product and must be administered via a separate ventilated infusion channel at a constant infusion rate.&nbsp;The infusion time must not be less than 15 minutes.&nbsp;Aclasta must not come into contact with&nbsp;calcium-containing solutions.&nbsp;If the solution is cooled, it should be allowed to warm to room temperature before&nbsp;administration.&nbsp;Preparation of&nbsp;infusion&nbsp;should be performed under aseptic conditions.&nbsp;Infusion&nbsp;one should be administered according to current medical&nbsp;practice.<\/p>\n\n\n\n<p><strong>Storage of Aclasta<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and bottle after EXP.<\/li><li>The unopened vial does not require any special storage instructions.<\/li><li>After opening, the solution should be used immediately to avoid&nbsp;microbiological contamination.<\/li><li>If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 \u00b0 C &#8211; 8 \u00b0 C.&nbsp;Allow the cooled solution to reach room temperature before&nbsp;administration<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Aclasta contains the active substance zoledronic acid. Aclasta belongs to a group of medicines called bisphosphonates and is used to treat osteoporosis in postmenopausal women and in adult men with osteoporosis or osteoporosis caused by treatment with corticosteroids used to treat inflammation and Paget&#8217;s disease in adults.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[11836,11840,11834,11839,11835,11838,11837,11832,11833,11831],"class_list":["post-4682","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-aclasta","tag-benefits-of-aclasta","tag-benefits-of-zoledronic-acid","tag-side-effects-of-aclasta","tag-side-effects-of-zoledronic-acid","tag-what-aclasta-is-used-for","tag-what-is-aclasta","tag-what-is-zoledronic-acid","tag-what-zoledronic-acid-is-used-for","tag-zoledronic-acid"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4682"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4682\/revisions"}],"predecessor-version":[{"id":13176,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4682\/revisions\/13176"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}