{"id":4553,"date":"2020-11-25T11:48:32","date_gmt":"2020-11-25T11:48:32","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4553"},"modified":"2021-08-26T08:07:06","modified_gmt":"2021-08-26T08:07:06","slug":"accupro-comp","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/accupro-comp\/","title":{"rendered":"Accupro Comp &#8211; Kinapril \/ Hydrochlorothiazide uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg \/ 12.5 mg and 20 mg \/ 12.5 mg&nbsp;film-coated tablets<br>kinapril \/&nbsp;hydrochlorothiazide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Accupro comp is and what it is used for<\/h2>\n\n\n\n<p>Accupro comp includes two active substances: quinapril and&nbsp;hydrochlorothiazide.&nbsp;April causes the body to produce smaller amounts of certain blood pressure-raising substances, which have an astringent effect on blood vessels and which retain salt and water in the body.&nbsp;The blood pressure-lowering effect of quinapril usually occurs within an hour is greatest after 2-4 hours and lasts about a day.<\/p>\n\n\n\n<p>Hydrochlorothiazide&nbsp;has a&nbsp;diuretic&nbsp;and antihypertensive effect.&nbsp;The decrease in blood pressure is partly due to the&nbsp;diuretic&nbsp;effect, but probably also due to the dilation of certain blood vessels.&nbsp;The increased urinary excretion due to&nbsp;hydrochlorothiazidebegins about 2 hours after taking a&nbsp;dose, is greatest after about 4 hours and lasts about 12 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Accupro comp<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Accupro comp<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to quinapril hydrochloride or other&nbsp;ACE inhibitors,&nbsp;hydrochlorothiazide&nbsp;or other sulphonamide derivatives, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>during the last 6 months of pregnancy.&nbsp;(Even earlier in pregnancy, it is good to avoid Accupro comp, see Pregnancy and breast-feeding.)<\/li><li>if you have previously had swelling (&nbsp;angioedema&nbsp;) of i.a.&nbsp;face, lips, tongue, and\/or throat in connection with treatment with&nbsp;ACE inhibitors&nbsp;or for some other unknown reason, or if someone in your family has had&nbsp;angioedema&nbsp;(the condition may be hereditary).<\/li><li>if you have severe renal impairment.<\/li><li>if you have an obstruction in the outflow from the heart<\/li><li>if you have&nbsp;diabetes&nbsp;or renal impairment and are being treated with a blood pressure-lowering medicine containing aliskiren.<\/li><li>if you are taking a&nbsp;heart failure&nbsp;medicine&nbsp;containing sacubitril\/valsartan.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Accupro comp:<\/p>\n\n\n\n<p>&#8211; if you have had skin cancer or if you get an unforeseen skin change during treatment.&nbsp;Treatment with&nbsp;hydrochlorothiazide, especially long-term use with high&nbsp;doses, may increase the risk of certain types of skin and lip cancer (non&#8211;melanoma skin cancer).&nbsp;Protect your skin from exposure to sunlight and UV rays while taking Accupro-comp.<\/p>\n\n\n\n<p>&#8211; if you have narrowing of the large carotid artery.<\/p>\n\n\n\n<p>&#8211; if you have or have had any form of&nbsp;asthma.<\/p>\n\n\n\n<p>&#8211; if you have prolonged diarrhea or vomiting.<\/p>\n\n\n\n<p>&#8211; if you are taking potassium supplements, potassium-sparing medicines, other medicines that are known to increase the levels of&nbsp;potassium&nbsp;in the blood, potassium-containing salt replacement, or if you have been prescribed a low-salt diet.<\/p>\n\n\n\n<p>&#8211; if you are using&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;).&nbsp;Your doctor may decide to stop your diuretic treatment and correct your fluid and salt balance before starting treatment with Accupro comp.<\/p>\n\n\n\n<p>&#8211; if you have a weak heart (&nbsp;heart failure&nbsp;) or any heart disease (eg some heart defects or thickening of the heart muscle).&nbsp;Your doctor may need to check you and change the dose of the medicine.<\/p>\n\n\n\n<p>&#8211; if you have liver disease, impaired kidney function, or if you have had a kidney transplant.&nbsp;Your doctor may need to check you and change the dose of the medicine.<\/p>\n\n\n\n<p>&#8211; if you have&nbsp;diabetes.&nbsp;You may need to check your blood sugar more often during the first month of treatment as Accupro comp may cause low blood sugar.&nbsp;Your doctor may in some cases recommend that you take potassium supplements.<\/p>\n\n\n\n<p>&#8211; severe allergic reactions may occur if Accupro comp is used in the treatment of hypersensitivity to bee or wasp venom (&nbsp;hyposensitization&nbsp;).&nbsp;Tell your doctor if you are going to undergo such treatment.<\/p>\n\n\n\n<p>&#8211;&nbsp;ACE inhibitors&nbsp;can cause dry cough which, however, disappears when you stop taking the medicine.<\/p>\n\n\n\n<p>&#8211; if you are receiving&nbsp;hemodialysis.&nbsp;Tell your doctor so that a technique can be chosen that does not give you a&nbsp;hypersensitivity reaction.<\/p>\n\n\n\n<p>&#8211; if you are undergoing a procedure to remove bad&nbsp;cholesterol&nbsp;from your blood (so-called&nbsp;LDL&nbsp;apheresis), you should not use Accupro comp.&nbsp;This is to avoid&nbsp;hypersensitivity reactions.<\/p>\n\n\n\n<p>&#8211; if you have had a drug reaction in the skin and mucous membranes (&nbsp;Stevens-Johnson syndrome&nbsp;).<\/p>\n\n\n\n<p>&#8211; if you have&nbsp;SLE&nbsp;(systemic lupus erythematosus, an&nbsp;autoimmune&nbsp;disease).<\/p>\n\n\n\n<p>&#8211; if you are being treated with medicines that affect the immune system, allopurinol (medicines for&nbsp;gout&nbsp;) or&nbsp;procainamide.<\/p>\n\n\n\n<p>&#8211; if you are taking any of the following medicines used to treat high blood pressure:<\/p>\n\n\n\n<p>&#8211; an&nbsp;angiotensin II receptor&nbsp;blocker (ARB) (also known as sartans &#8211; eg valsartan, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tolura\/\">telmisartan<\/a>, irbesartan), especially if you have diabetes-related kidney problems<\/p>\n\n\n\n<p>&#8211; aliskiren.<\/p>\n\n\n\n<p>Your doctor may need to check your kidney function,&nbsp;blood pressure,&nbsp;and the number of&nbsp;electrolytes&nbsp;(eg&nbsp;potassium&nbsp;) in&nbsp;your&nbsp;blood at regular intervals.&nbsp;See also the information under the heading &#8220;Do not take Accupro comp&#8221;.<\/p>\n\n\n\n<p>Before surgery and anesthesia (also applies to the dentist), the doctor\/dentist should know that you are being treated with Accupro comp, as there is a risk that the&nbsp;blood pressure will&nbsp;drop sharply during anesthesia.<\/p>\n\n\n\n<p>If you are going to have a test for your parathyroid function, your doctor should know that you are being treated with Accupro comp.<\/p>\n\n\n\n<p>Ethnic differences: Like other&nbsp;ACE inhibitors, April may be less effective in blacks than in non-black<\/p>\n\n\n\n<p>Contact a doctor immediately if you experience symptoms such as sudden&nbsp;visual acuity&nbsp;or eye pain.&nbsp;The symptoms usually occur within hours to weeks after the start of Accuretic and may indicate excess fluid in the eye (between choroid and sclera) or&nbsp;acute&nbsp;transient myopia and a form of&nbsp;acute&nbsp;glaucoma&nbsp;(&nbsp;angle-closure glaucoma&nbsp;).&nbsp;This can lead to permanent loss of vision if left untreated.&nbsp;If you have had a&nbsp;hypersensitivity reaction&nbsp;to&nbsp;penicillin&nbsp;or sulfonamide, you may be at greater risk of developing this.<\/p>\n\n\n\n<p>If you think you may be pregnant or become pregnant during treatment, consult your doctor.&nbsp;Accupro comp is not recommended during pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects, see Pregnancy and breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Accupro comp<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>It is especially important for your doctor to know if you are already being treated with any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antibiotics&nbsp;of the type&nbsp;tetracycline&nbsp;s because the effect of&nbsp;tetracycline&nbsp;s may decrease.<\/li><li>other&nbsp;antihypertensive&nbsp;drugs&nbsp;such as nitrates (used to treat coronary heart disease) and other antihypertensive drugs.&nbsp;Drugs used in connection with anesthesia can also have this blood pressure-lowering effect.<\/li><li>potassium-sparing&nbsp;diuretics&nbsp;(eg&nbsp;spironolactone, triamterene, or amiloride) and potassium supplements as potassium levels in the blood may be too high.&nbsp;Trimethoprim (an&nbsp;antibiotic&nbsp;for eg urinary tract infection) can also increase the level of potassium in the blood.<\/li><li>diuretics&nbsp;(&nbsp;diuretics, such as&nbsp;thiazides&nbsp;or loop diuretics) as the antihypertensive effect of Accupro comp may be increased.<\/li><li>lithium (used for manic depressive disorders).<\/li><li>analgesics (&nbsp;NSAIDs&nbsp;) such as&nbsp;acetylsalicylic acid,&nbsp;ibuprofen,&nbsp;or&nbsp;ketoprofen.<\/li><li>adrenaline&nbsp;can reduce the effect of Accupro comp.<\/li><li>diabetes&nbsp;drugs&nbsp;(both&nbsp;insulin&nbsp;and oral drugs).<\/li><li>neutralizing stomach medicine (antacids) may reduce the effect of Accupro comp.<\/li><li>medicines for&nbsp;gout&nbsp;(eg allopurinol).<\/li><li>procainamide&nbsp;(used to&nbsp;treat heart arrhythmias&nbsp;), anticancer medicines, or medicines that inhibit the body&#8217;s immune system (immunosuppressive).<\/li><li>carbenoxolone (medicine for oesophagitis),&nbsp;corticosteroids&nbsp;(medicines that reduce&nbsp;inflammation&nbsp;),&nbsp;corticotropin&nbsp;(ACTH, a&nbsp;hormone&nbsp;), or certain&nbsp;laxatives&nbsp;as potassium levels in the blood may decrease.<\/li><li>digoxin&nbsp;(heart medicine) as it is especially important to keep&nbsp;potassium&nbsp;and magnesium levels at a normal level if you are taking these medicines.<\/li><li>drugs that can affect the heart rhythm (&nbsp;Torsades de pointes&nbsp;).<\/li><li>resins against elevated&nbsp;cholesterol&nbsp;such as cholestyramine and colestipol.<\/li><\/ul>\n\n\n\n<p>Your doctor may need to change your&nbsp;dose&nbsp;and\/or take other precautions if you are taking&nbsp;angiotensin II receptor blockers&nbsp;(ARBs) or aliskiren (see also the information under the headings \u201cDo not take Accupro comp\u201d and \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Accupro comp with food, drink, and alcohol<\/h2>\n\n\n\n<p>Accupro comp can be taken regardless of the meal.&nbsp;Alcohol can lower&nbsp;blood pressure and make you feel tired or dizzy.&nbsp;Tell your doctor if you have been on a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>If you think you may be pregnant or become pregnant during treatment, consult your doctor.&nbsp;Usually, your doctor will suggest that you stop taking Accupro comp before pregnancy or as soon as you know you are pregnant and instead recommend another medicine for you.<\/p>\n\n\n\n<p>Accupro comp should not be used in early pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding or planning to start breast-feeding.&nbsp;Accupro comp is not recommended for breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Accupro comp may impair the ability to react.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;driving or precision work.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Accupro comp contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Accupro Comp<\/h2>\n\n\n\n<p>Always take Accupro comp exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;for adults is between one 10 mg \/ 12.5 mg tablet and one 20 mg \/ 12.5 mg tablet daily.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Accupro comp<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Stop taking Accupro comp and contact&nbsp;your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you get any of the following less common&nbsp;side effects&nbsp;(&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing.<\/li><\/ul>\n\n\n\n<p>It has been reported that Accupro comp can affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.<\/p>\n\n\n\n<p>The following other&nbsp;side effects&nbsp;have been reported:<\/p>\n\n\n\n<p><em>Common (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n<p>Elevated potassium levels in the blood, increased levels of urea in the blood, increased levels of&nbsp;serum creatinine, insomnia, fatigue, weakness, dizziness, headache, extreme drowsiness, dilation of blood vessels,&nbsp;inflammation&nbsp;of the trachea (&nbsp;bronchitis&nbsp;), cough,&nbsp;pharyngitis,&nbsp;rhinitis&nbsp;),&nbsp;infection&nbsp;of the upper respiratory tract, increased levels of&nbsp;uric acid&nbsp;in the blood,&nbsp;gout, chest pain, chest pain (&nbsp;angina pectoris&nbsp;), palpitations, stomach pain, diarrhea, gastritis (&nbsp;dyspepsia&nbsp;), nausea, vomiting, back pain, muscle pain.<\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100):<\/em><\/p>\n\n\n\n<p>Confusion, depression, anxiety, &#8220;ant crawls&#8221; (&nbsp;paresthesias&nbsp;),&nbsp;TIA&nbsp;(transient ischemic attacks), visual disturbance (amblyopia),&nbsp;tinnitus,&nbsp;vertigo, heart attack, low&nbsp;blood pressure, fainting, shortness of breath, sinusitis, flatulence, mouth or throat, altered taste, hair loss, photosensitivity reaction,&nbsp;itching, rash, increased&nbsp;transpiration, joint pain (&nbsp;arthralgia&nbsp;), renal impairment,&nbsp;protein&nbsp;&#8220;egg white&#8221; in the urine, urinary tract infection,&nbsp;impotence, fever, general or localized body swelling, viral infection, impaired glucose tolerance.<\/p>\n\n\n\n<p><em>Rare (affects less than 1 user in 1,000):<\/em><\/p>\n\n\n\n<p>Balance disorder, allergic&nbsp;pneumonia&nbsp;(&nbsp;eosinophilic&nbsp;pneumonitis&nbsp;), constipation, heartburn, skin changes in combination with fever, muscle aches, and joint pain,&nbsp;vasculitis&nbsp;(&nbsp;vasculitis&nbsp;), psoriasis-like skin inflammation.<\/p>\n\n\n\n<p><em>Very rare (affects less than 1 user in 10,000):<\/em><\/p>\n\n\n\n<p>Blurred vision,&nbsp;ileus,&nbsp;allergic reaction&nbsp;in the small intestine (intestinal&nbsp;angioedema&nbsp;) which can cause symptoms such as abdominal pain, nausea, and vomiting,&nbsp;hives,&nbsp;or hives (&nbsp;urticaria&nbsp;).<\/p>\n\n\n\n<p><em>No known frequency (cannot be calculated from the available data):<\/em><\/p>\n\n\n\n<p>Pronounced increase in the number of&nbsp;white blood cells&nbsp;in the blood, decreased number of&nbsp;platelets&nbsp;in the blood,&nbsp;acute&nbsp;and severe&nbsp;allergic reaction&nbsp;(anaphylactic), cerebral haemorrhage, impaired vision or pain in the eyes due to high pressure (possible signs of fluid accumulation in the eye (between the choroid and retina) , sudden myopia or&nbsp;glaucoma&nbsp;), irregular heartbeat (&nbsp;arrhythmia&nbsp;), sudden drop in blood pressure when getting up, respiratory cramps,&nbsp;inflammation&nbsp;of the pancreas,&nbsp;inflammation&nbsp;of the liver (&nbsp;hepatitis), obstruction of the bile duct (cholestatic jaundice), severe widespread skin damage (skin detachment), skin and mucosal changes (sometimes severe), skin and lip cancer (non-&nbsp;melanoma&nbsp;skin cancer), circular raised rash (erythema multiforme), blistering of the skin and mucous membranes (&nbsp;pemphigus&nbsp;),&nbsp;bluish-purple&nbsp;spots similar to bruises (purpura), systemic lupus erythematosus (&nbsp;SLE&nbsp;, an&nbsp;autoimmune&nbsp;disease), increased levels of&nbsp;cholesteroland&nbsp;triglycerides&nbsp;, decreased levels of&nbsp;hematocrit&nbsp;and increased&nbsp;levels&nbsp;of liver enzymes and blood bilirubin, increased levels of antinuclear, antinuclear increased rate of&nbsp;red blood cell&nbsp;sedimentation, in patients with&nbsp;congenital&nbsp;G-6 PDH deficiency, isolated cases of&nbsp;haemolytic anemia&nbsp;(&nbsp;anemia&nbsp;) have been reported.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Accupro comp<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>&#8211; The active substances are quinapril&nbsp;hydrochloride&nbsp;and&nbsp;hydrochlorothiazide.<\/p>\n\n\n\n<p>Accupro comp 10 mg \/ 12.5 mg contains quinapril hydrochloride equivalent to 10 mg quinapril and 12.5 mg&nbsp;hydrochlorothiazide&nbsp;.<\/p>\n\n\n\n<p>Accupro comp 20 mg \/ 12.5 mg contains quinapril hydrochloride equivalent to 20 mg quinapril and 12.5 mg&nbsp;hydrochlorothiazide&nbsp;.<br><\/p>\n\n\n\n<p>The other ingredients are&nbsp;lactose monohydrate, magnesium&nbsp;subcarbonate&nbsp;(heavy), magnesium stearate, crospovidone, povidone, hypromellose, hydroxypropyl cellulose, macrogol 400, candelilla wax, titanium dioxide (E 171), red and yellow iron oxide (E 172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Appearance:<\/p>\n\n\n\n<p>10 mg \/ 12.5 mg tablets are pink, elliptical, and scored.<\/p>\n\n\n\n<p>20 mg \/ 12.5 mg tablets are pink, triangular, and scored.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p><em>Tablets 10 mg \/ 12.5 mg:<\/em>&nbsp;Blister pack of 30 resp.&nbsp;100 tablets.<\/p>\n\n\n\n<p><em>Tablets 20 mg \/ 12.5 mg:<\/em>&nbsp;Blister pack of 100 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Accupro comp includes two active substances: quinapril and hydrochlorothiazide. April causes the body to produce smaller amounts of certain blood pressure-raising substances, which have an astringent effect on blood vessels and which retain salt and water in the body. The blood pressure-lowering effect of quinapril usually occurs within an hour is greatest after 2-4 hours and lasts about a day.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[11987,11990,3664,3666,4301,11992,11995,11991,11996,11989,7947,11988,4300,11993,11994],"class_list":["post-4553","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-accupro-comp","tag-accupro-comp-tablet","tag-hydrochlorothiazide","tag-hydrochlorothiazide-side-effects","tag-hydrochlorothiazide-tablet","tag-kinapril","tag-kinapril-tablet","tag-side-effects-of-accupro-comp","tag-side-effects-of-kinapril","tag-what-accupro-comp-is-used-for","tag-what-hydrochlorothiazide-is-used-for","tag-what-is-accupro-comp","tag-what-is-hydrochlorothiazide","tag-what-is-kinapril","tag-what-kinapril-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4553"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4553\/revisions"}],"predecessor-version":[{"id":13239,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4553\/revisions\/13239"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}