![\"Accofil](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/Accofil-300x264.png\" "\\"Accofil")
<\/figure><\/div>\n\n\nWhat Accofil 30 is<\/strong><\/h3>\n\n\n\nAccofil contains the active substance Filgrastim. It is a protein produced in a bacterium called Escherichia coli<\/em> by recombinant DNA technology. It belongs to a group of proteins called cytokines and is very similar to granulocyte colony-stimulating factor ( G-CSF ) which is produced in the human body.<\/p>\n\n\n\n Filgastrim stimulates the bone marrow (the tissue where new blood cells are produced) so that it forms more white blood cells that help the body fight infection.<\/p>\n\n\n\n
Filgrastim Injection Uses<\/strong><\/h3>\n\n\n\nYour doctor has prescribed Accofil 30<\/strong> to help your body produce more white blood cells. Your doctor will tell you the benefits of filgrastim injection<\/strong>. Filgrastim injection uses<\/strong> are several in different conditions, namely:<\/p>\n\n\n\n- Chemotherapy<\/li>
- Bone marrow transplant<\/li>
- Severe chronic neutropenia (a small number of white blood cell types )<\/li>
- Neutropenia (low number of a type of white blood cells ) in patients with HIV – infection.<\/li>
- Mobilization of peripheral stem cells (to stimulate stem cells to enter the bloodstream where they can be collected and used in bone marrow transplantation).<\/li><\/ul>\n\n\n\n
What You Need To Know Before Using Filgrastim Injection<\/h2>\n\n\n\nDo Not Use<\/h2>\n\n\n\n- If you are allergic (hypersensitive<\/a>) to filgrastim or any of the other ingredients of this medicine.<\/li><\/ul>\n\n\n\n
Warnings And Cautions Of Filgrastim Injection Uses<\/h2>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking a filgrastim:<\/p>\n\n\n\n
Before treatment, tell your doctor if you:<\/p>\n\n\n\n
- If you have sickle cell anemia, filgrastim may cause a sickle cell crisis.<\/li>
- If you have osteoporosis (osteoporosis).<\/li><\/ul>\n\n\n\n
Tell your doctor immediately if you are taking Filgastrim during treatment:<\/p>\n\n\n\n
- Gets pain in the upper left part of the abdomen (abdomen), pain under the ribs on the left side or at the tip of the shoulder blade (this may be a symptom of an enlarged spleen ( splenomegaly ) or possibly a broken spleen ).<\/li>
- Detects unusual bleeding or bruising (this may be a symptom of decreased platelet count ( thrombocytopenia ), which reduces the blood’s ability to clot).<\/li>
- Suffer from sudden signs of allergy, such as rash, itching or hives, swelling of the face, lips, tongue, or other body parts, shortness of breath, wheezing, or difficulty breathing, as these may be signs of a severe allergy.<\/li>
- Get swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual ( glomerulonephritis ).<\/li><\/ul>\n\n\n\n
The needle cover of the pre-filled syringe contains dry natural rubber (latex), which may cause an allergic reaction.<\/p>\n\n\n\n
Inflammation of the aorta (the large carotid artery that carries blood from the heart to the body) has been reported as a rare side effect in cancer patients and healthy donors. Symptoms may include fever, abdominal pain, malaise, back pain<\/a>, and increased inflammatory markers. <\/p>\n\n\n\nTell your doctor if you experience these symptoms.<\/p>\n\n\n\n
Unsatisfactory treatment response to Filgrastim<\/h2>\n\n\n\n
If you respond less or stop responding to filgrastim treatment, your doctor will investigate what is causing this. Among other things, he or she will check if you have developed antibodies that neutralize the activity of filgrastim.<\/p>\n\n\n\n
Your doctor may want you to have frequent check-ups; see section 4 of the Package Leaflet.<\/p>\n\n\n\n
If you have severe chronic neutropenia, you may be at risk of developing blood cancer ( leukemia, myelodysplastic syndrome [MDS]). Talk to your doctor about the risk of developing blood cancer and what tests should be done. If you develop or are at high risk of developing blood cancer, do not use it unless your doctor tells you to.<\/p>\n\n\n\n
If you are a stem cell donor, you must be between 16 and 60 years old.<\/p>\n\n\n\n
Take Special Care With Other Products That Stimulate White Blood Cells <\/h2>\n\n\n\n
Filgrastim belongs to a group of medicines that stimulate the production of white blood cells. Healthcare professionals should always note the exact product they are using.<\/p>\n\n\n\n
Other Medicines And Filgrastim Injection<\/h2>\n\n\n\n
You should not receive it 24 hours before and 24 hours after chemotherapy.<\/p>\n\n\n\n
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n
Filgrastim Injection With Pregnancy And Breastfeeding<\/h2>\n\n\n\n
In<\/strong>j Filgrastim<\/strong> has not been tested in pregnant women.<\/p>\n\n\n\nYou must tell your doctor if you:<\/p>\n\n\n\n
- Is pregnant or breastfeeding<\/li>
- Think you may be pregnant or<\/li>
- Planning to have children.<\/li><\/ul>\n\n\n\n
It is unknown if filgrastim passes into breast milk. Therefore, your doctor may decide not to use this medicine if you are Breast Feeding.<\/p>\n\n\n\n
Driving And Using Machines With<\/h2>\n\n\n\nFilgrastim Injection<\/h2>\n\n\n\n
Filgrastim may have less effect on your ability to drive and use machines. This medicine may cause dizziness. You should wait and see how you feel after taking Accofil 30<\/i> before driving or using machines.<\/p>\n\n\n\nFilgrastim Injection Contains Sorbitol And Sodium<\/h2>\n\n\n\n
This medicine contains sorbitol.<\/p>\n\n\n\n
If your doctor has told you that you are intolerant to some sugars (fructose), contact your doctor before taking this medicine.<\/p>\n\n\n\n
This medicine also contains sodium.<\/p>\n\n\n\n
Contains less than 1 mmol sodium (0.035 mg) per filgrastim dose<\/strong>, ie essentially ‘sodium-free’.<\/p>\n\n\n\nHow To Give Filgrastim Injection: Instructions<\/h2>\n\n\n\n
Always use Accofil injection<\/strong> exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\nThe dose inj filgrastim<\/strong> of your requirement depends on your body’s condition and weight.<\/p>\n\n\n\nFilgrastim Dose<\/h2>\n\n\n\n
Filgrastim and neutropenia (a small number of white blood cell types ) associated with chemotherapy<\/em><\/p>\n\n\n\nThe usual dose of filgrastim injection<\/strong> is 0.5 million units (5 micrograms) per kg of body weight daily. For example, if you weigh 60 kilograms, your daily filgrastim injection dose is 30 million units (300 micrograms). Treatment with filgrastim usually lasts for about 14 da<\/p>\n\n\n\n<\/p>\n\n\n\n
ys. In some types of disease, however, longer treatment of up to about a month may be required.<\/p>\n\n\n\n
Filgrastim Injection And Bone Marrow Transplant<\/h2>\n\n\n\n
The usual starting dose is 1 million units (10 micrograms) per kg body weight each day is given as an infusion. For example, if you weigh 60 kg, your daily Filgastrim injection dose<\/strong> will be 60 million units (600 micrograms). <\/p>\n\n\n\nYou will usually receive your first dose of Accofil 30<\/strong> at least 24 hours after chemotherapy and at least 24 hours after receiving your bone marrow transplant. The doctor can then test the blood to see how well the treatment works and how long it should last.<\/p>\n\n\n\nAccophilic And Severe Chronic Neutropenia (A Small Number Of White Blood Cell Types )<\/h3>\n\n\n\n
The usual starting dose is between 0.5 million units (5 micrograms) and 1.2 million units (12 micrograms) per kg body weight daily as a single dose or divided into several doses. The doctor can then test your blood to see how well the treatment works and find the best dose for you. To reduce neutropenia, long-term treatment with filgrastim is required.<\/p>\n\n\n\n
Filgrastim Injection And Neutropenia (Low Number Of A Type Of White Blood Cells ) In Patients With HIV – Infection<\/h3>\n\n\n\n
The usual starting dose is between 0.1 million units (1 microgram) and 0.4 million units (4 micrograms) per kg of body weight daily. Your doctor may test your blood regularly to see how well the treatment works. When the number of white blood cells in the blood has returned to normal, it may be possible to reduce the dosing frequency to less than once a day. To maintain a normal white blood cell count, long-term treatment with filgrastim may be needed.<\/p>\n\n\n\n
Accumulation And Transplantation Of Peripheral Stem Cells ( Stem Cells Collected From The Blood For Use In A Bone Marrow Transplant)<\/h3>\n\n\n\n
If you donate stem cells to yourself, the usual dose is 0.5 million (5 micrograms) to 1.0 million units (10 micrograms) per kg body weight each day. Treatment with filgrastim lasts for up to 2 weeks. Your doctor will check your blood to determine the best time for stem cell collection. If you are a stem cell donor to another person, the usual filgrastim dose<\/strong> is 1 million units (10 micrograms) per kg body weight each day. Treatment with filgrastin lasts for 4 to 5 days. Your doctor will take regular blood tests to determine the best time for stem cell collection.<\/p>\n\n\n\nHow To Give Filgrastim Injection<\/h2>\n\n\n\n
This medicine is given as an injection, either by intravenous (iv) infusion (drip) or as a subcutaneous (SC) injection into the tissue just under the skin.<\/p>\n\n\n\n
If you are given this medicine as a subcutaneous injection, your doctor may suggest you learn to give yourself the injections. Your doctor or nurse will give instructions on how to do this (see information below for instructions for injection with filgrastim). Do not try to self-administer without this training. Some of the information you need is given at the end of this leaflet, but proper treatment of your illness requires close and constant cooperation with your doctor.<\/p>\n\n\n\n
Information On How To Give Yourself And Filgrastim Injection<\/h3>\n\n\n\n
This section contains information on how to give yourself an injection of filgrastim. You mustn’t try to give yourself an injection without first receiving special training from your doctor or nurse.<\/p>\n\n\n\n
If you are not sure how to give yourself an injection, or if you have any questions, contact your doctor or nurse for help.<\/p>\n\n\n\n
How Do I Give Myself A Filgrastim Injection?<\/h3>\n\n\n\n
You should inject one into the tissue just below the skin. This is called a subcutaneous injection. You should take the injections at about the same time each day.<\/p>\n\n\n\n
Equipment you need<\/strong><\/p>\n\n\n\nTo give yourself a subcutaneous injection, you need the following:<\/p>\n\n\n\n
- A pre-filled syringe with Accofil injection<\/em> solution<\/li>
- Injection dryer or similar<\/li><\/ul>\n\n\n\n
What Should I Do Before Giving Myself A Subcutaneous Filgrastim Injection?<\/strong><\/h3>\n\n\n\nLeave the needle cover on the syringe until you are ready to inject one<\/p>\n\n\n\n
- Take your pre-filled syringe of filgrastin out of the refrigerator.<\/li>
- Check the expiration date on the pre-filled syringe label (Exp. Date). Do not use it if the last day of the month indicated has passed, if it has been stored outside the refrigerator for more than 15 days, or is unusable for any other reason.<\/li>
- Check the appearance of Filgrastim. It must be a clear and colorless liquid. If it contains particles, do not use it.<\/li>
- Injection one feels more comfortable if you leave the pre-filled syringe for 30 minutes to reach room temperature or hold it gently in your hand for a few minutes. Do not heat Filgastrim in any other way (eg do not<\/em><\/strong> heat the syringe in the microwave or hot water).<\/li>
- Wash your hands thoroughly.<\/li>
- Find a comfortable and well-lit place and put everything you need within reach (the pre-filled syringe with filgastrim and injection dryer).<\/li><\/ol>\n\n\n\n
How do I Prepare My Injection With Filgrastim?<\/h3>\n\n\n\n
Before injecting filgrastim, you must do the following:<\/p>\n\n\n\n
- Hold the syringe and gently take the protection of the needle without twisting. Pull straight out as shown in Figure 1 and Figure 2. Do not touch the needle or push the syringe plunger.<\/li>
- You may notice a small air bubble in the pre-filled syringe. You do not need to remove the air bubble before injecting. It is safe to inject the solution with the air bubble left.<\/li>
- The syringe may contain more liquid than you need. Use the scale on the cylinder container as follows to set the correct dose of filgastrim prescribed by your doctor. Squeeze out unnecessary liquid by pushing the plunger to the number (ml) on the syringe that corresponds to the prescribed dose.<\/li>
- Check again to ensure that the syringe contains the correct dose of filgastrim.<\/li>
- You can now use the pre-filled syringe.<\/li><\/ol>\n\n\n\n
![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a1-1.jpg\" "\\"How")
1: <\/strong>How to give filgrastim injection – hold<\/figcaption><\/figure><\/div>\n\n\n![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a2.jpg\" "\\"How")
2: <\/strong>How to give filgrastim injection – open cap<\/figcaption><\/figure><\/div>\n\n\nFilgrastim Injection Site<\/h3>\n\n\n\n
The most suitable places to give yourself an injection are the following:<\/p>\n\n\n\n
- At the top of the thighs<\/li>
- Abdomen, except the area around the navel (see picture 3)<\/li><\/ul>\n\n\n\n
![\"Accofil](\"https:\/\/www.fass.se\/res\/RootMedia\/Accord20Healthcare\/Media\/Accofil\/Bild3.jpg\" "\\"Accofil")
<\/a>3: <\/strong>injection site on lower body<\/figcaption><\/figure><\/div>\n\n\nIf someone else gives you an injection, he or she can also use the back of your arms (see picture 4).
<\/p>\n\n\n
\n![\"Accofil](\"https:\/\/www.fass.se\/res\/RootMedia\/Accord20Healthcare\/Media\/Accofil\/Bild4.jpg\" "\\"Accofil")
<\/a>4: <\/strong> injection site on arm<\/figcaption><\/figure><\/div>\n\n\nIt is better to change the injection site every day to avoid the risk of soreness in one place.<\/p>\n\n\n\n
How Do I Give Myself An Accofil Filgrastim Injection?<\/h2>\n\n\n\n- Disinfect the injection site with an injection dryer and pinch the skin between the thumb and forefinger without squeezing (see picture 5).
Pre-filled syringe without needle cover<\/li> - Insert the needle completely through the skin, as shown by the nurse or doctor (see picture 6).<\/li>
- Pull the plunger up slightly to ensure you have not punctured a blood vessel. If you see blood in the syringe, pull the needle and insert it in another place.<\/li>
- Always hold the grip on the skin and simultaneously push the plunger down with a slow, constant pressure until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- Inject only the dose prescribed by your doctor.<\/li>
- After injecting the liquid, remove the needle while maintaining the pressure on the plunger and then release the skin.<\/li>
- Place the used syringe in the waste container. Each syringe should only be used for one injection.
Pre-filled syringe with the needle guard<\/em><\/li>- Insert the needle completely through the skin as instructed by the nurse or doctor (see Figure 7).<\/li>
- Pull the plunger up slightly to make sure you have not punctured a blood vessel. If you see blood in the syringe, pull out the needle and insert it in another place.<\/li>
- Only inject the dose prescribed by your doctor by following the instructions below.<\/li>
- Always hold the grip on the skin and push the plunger down with a slow, constant pressure while holding the flange, until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- After injecting the liquid, remove the needle while holding the syringe at the same angle and maintaining the pressure on the plunger, then release the skin. The protective cuff automatically covers the needle and an audible “click” confirms that the protection has been activated (see figure 8). The needle guard is not activated unless the full dose has been given.<\/li><\/ol>\n\n\n\n
![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a5.jpg\" "\\"How")
5: <\/strong>How to give injection – hold skin<\/figcaption><\/figure><\/div>\n\n\n![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a6.jpg\" "\\"How")
6: <\/strong>How to give injection – insert needle<\/figcaption><\/figure><\/div>\n\n\n![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a7.jpg\" "\\"How")
7: <\/strong>How to give accofil filgrastim injection<\/figcaption><\/figure><\/div>\n\n\n![\"How](\"https:\/\/zeepedia.com\/wp-content\/uploads\/2021\/05\/a8.jpg\" "\\"How")
8: <\/strong>How to give accofil filgrastim injection – Click<\/figcaption><\/figure><\/div>\n\n\nRemember<\/strong><\/p>\n\n\n\nIf you have problems, do not hesitate to ask your doctor or nurse for help and advice.<\/p>\n\n\n\n
Disposal of used syringes<\/strong><\/p>\n\n\n\nThe needle guard prevents stab injuries after use and therefore no special precautions are required for waste disposal. Dispose of the syringe according to the instructions of a doctor, nurse, or pharmacist.<\/em><\/p>\n\n\n\nOverdose Of Filgrastim Injection<\/h2>\n\n\n\n
If you use more Accofil than you should, contact your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n
Missed Dose Of Filgrastim Injection<\/h2>\n\n\n\n
Do not take a double dose to make up for a forgotten injection. Contact your doctor to discuss when you should inject the next dose.<\/p>\n\n\n\n
If You Stop Using Filgrastim Injection<\/h2>\n\n\n\n
Your doctor will tell you when to stop using filgrastim. It is perfectly normal to receive several treatments with filgastrim.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Possible Accofil Filgrastim Side Effects<\/h2>\n\n\n\n
Like all medicines, side effects of Inj Filgrastim<\/strong> can occur, although not everybody gets them.<\/p>\n\n\n\nTalk to your doctor immediately during treatment<\/strong><\/p>\n\n\n\n- After getting Filgrastin injection<\/strong> if you have an allergic reaction with weakness, drop in blood pressure, difficulty breathing, swelling of the face ( anaphylaxis ), skin rash, itchy rash ( urticaria ), swelling of the face, lips, mouth, tongue, or throat ( angioedema ) and shortness of breath ( dyspnoea ). Hypersensitivity is common in patients with cancer.<\/li>
- A cough<\/a>, fever<\/a>, and difficulty breathing ( dyspnoea ) may be a sign of acute respiratory distress syndrome (ARDS). ARDS is less common in patients with cancer.<\/li>
- If you experience pain in the left upper abdomen (abdomen), pain under the left rib arch or at the tip of the shoulder blade, this may be due to problems with the spleen (enlargement of the spleen [splenomegaly] or ruptured spleen ).<\/li>
- If you are being treated for severe chronic neutropenia and have blood in your urine ( haematuria ). Your doctor may test your urine regularly if you experience this side effect or if the protein is detected in your urine ( proteinuria ).<\/li>
- If you have any of the following or a combination of the following accofil side effects<\/strong>: swelling or bags, which may be associated with less frequent passing water, difficulty breathing, swollen abdomen and feeling of fullness, and a general feeling of tiredness. These symptoms usually appear quickly. These can be the symptoms of an unusual disease (which may occur in 1 in 100 people) called capillary leakage syndrome, which causes the blood to leak from the small blood vessels in the body and needs urgent medical attention.<\/li>
- If you have a combination of any of the following symptoms:
Fever or chills or if you feel very cold<\/a>, high heart rate, confusion or disorientation, shortness of breath, extreme pain or discomfort, and sticky or sweaty skin. These can be symptoms of a condition called “sepsis” (also called sepsis), a serious infection that involves the whole body responding to inflammation. This can be life-threatening and requires immediate emergency medical attention.<\/li>- if you get kidney damage ( glomerulonephritis ). Kidney damage has been seen in patients receiving filgrastim. Contact a doctor immediately if you experience swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual.<\/li><\/ul>\n\n\n\n
Common side effects of Accofil injection<\/strong> is muscle or skeletal pain (musculoskeletal pain), which can be relieved with common painkillers ( analgesics ). In patients undergoing stem cell or bone marrow transplantation, graft-versus-host disease (GvHD) may occur – this is a reaction of the donor cells to the patient receiving the graft; Signs and symptoms are rashes on the palms and soles of the feet and sores in the <\/p>\n\n\n\n- Mouth <\/li>
- Intestines<\/li>
- Liver<\/li>
- Skin or eyes<\/li>
- Lungs<\/li>
- Vagina<\/li>
- Joints<\/li><\/ul>\n\n\n\n
A side effect that is very common in healthy stem cell donors is increased white blood cell count ( leukocytosis ) and decreased number of platelets, which impairs the blood’s ability to coagulate ( thrombocytopenia ), your doctor will check this.<\/p>\n\n\n\n
Very common Side Effects of Filgrastim Injection Are (seen in more than 1 in 10 people taking Accofil):<\/h3>\n\n\n\n
Filgastrim stimulates the bone marrow (the tissue where new blood cells are produced) so that it forms more white blood cells that help the body fight infection.<\/p>\n\n\n\n
Filgrastim Injection Uses<\/strong><\/h3>\n\n\n\nYour doctor has prescribed Accofil 30<\/strong> to help your body produce more white blood cells. Your doctor will tell you the benefits of filgrastim injection<\/strong>. Filgrastim injection uses<\/strong> are several in different conditions, namely:<\/p>\n\n\n\n- Chemotherapy<\/li>
- Bone marrow transplant<\/li>
- Severe chronic neutropenia (a small number of white blood cell types )<\/li>
- Neutropenia (low number of a type of white blood cells ) in patients with HIV – infection.<\/li>
- Mobilization of peripheral stem cells (to stimulate stem cells to enter the bloodstream where they can be collected and used in bone marrow transplantation).<\/li><\/ul>\n\n\n\n
What You Need To Know Before Using Filgrastim Injection<\/h2>\n\n\n\nDo Not Use<\/h2>\n\n\n\n- If you are allergic (hypersensitive<\/a>) to filgrastim or any of the other ingredients of this medicine.<\/li><\/ul>\n\n\n\n
Warnings And Cautions Of Filgrastim Injection Uses<\/h2>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking a filgrastim:<\/p>\n\n\n\n
Before treatment, tell your doctor if you:<\/p>\n\n\n\n
- If you have sickle cell anemia, filgrastim may cause a sickle cell crisis.<\/li>
- If you have osteoporosis (osteoporosis).<\/li><\/ul>\n\n\n\n
Tell your doctor immediately if you are taking Filgastrim during treatment:<\/p>\n\n\n\n
- Gets pain in the upper left part of the abdomen (abdomen), pain under the ribs on the left side or at the tip of the shoulder blade (this may be a symptom of an enlarged spleen ( splenomegaly ) or possibly a broken spleen ).<\/li>
- Detects unusual bleeding or bruising (this may be a symptom of decreased platelet count ( thrombocytopenia ), which reduces the blood’s ability to clot).<\/li>
- Suffer from sudden signs of allergy, such as rash, itching or hives, swelling of the face, lips, tongue, or other body parts, shortness of breath, wheezing, or difficulty breathing, as these may be signs of a severe allergy.<\/li>
- Get swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual ( glomerulonephritis ).<\/li><\/ul>\n\n\n\n
The needle cover of the pre-filled syringe contains dry natural rubber (latex), which may cause an allergic reaction.<\/p>\n\n\n\n
Inflammation of the aorta (the large carotid artery that carries blood from the heart to the body) has been reported as a rare side effect in cancer patients and healthy donors. Symptoms may include fever, abdominal pain, malaise, back pain<\/a>, and increased inflammatory markers. <\/p>\n\n\n\nTell your doctor if you experience these symptoms.<\/p>\n\n\n\n
Unsatisfactory treatment response to Filgrastim<\/h2>\n\n\n\n
If you respond less or stop responding to filgrastim treatment, your doctor will investigate what is causing this. Among other things, he or she will check if you have developed antibodies that neutralize the activity of filgrastim.<\/p>\n\n\n\n
Your doctor may want you to have frequent check-ups; see section 4 of the Package Leaflet.<\/p>\n\n\n\n
If you have severe chronic neutropenia, you may be at risk of developing blood cancer ( leukemia, myelodysplastic syndrome [MDS]). Talk to your doctor about the risk of developing blood cancer and what tests should be done. If you develop or are at high risk of developing blood cancer, do not use it unless your doctor tells you to.<\/p>\n\n\n\n
If you are a stem cell donor, you must be between 16 and 60 years old.<\/p>\n\n\n\n
Take Special Care With Other Products That Stimulate White Blood Cells <\/h2>\n\n\n\n
Filgrastim belongs to a group of medicines that stimulate the production of white blood cells. Healthcare professionals should always note the exact product they are using.<\/p>\n\n\n\n
Other Medicines And Filgrastim Injection<\/h2>\n\n\n\n
You should not receive it 24 hours before and 24 hours after chemotherapy.<\/p>\n\n\n\n
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n
Filgrastim Injection With Pregnancy And Breastfeeding<\/h2>\n\n\n\n
In<\/strong>j Filgrastim<\/strong> has not been tested in pregnant women.<\/p>\n\n\n\nYou must tell your doctor if you:<\/p>\n\n\n\n
- Is pregnant or breastfeeding<\/li>
- Think you may be pregnant or<\/li>
- Planning to have children.<\/li><\/ul>\n\n\n\n
It is unknown if filgrastim passes into breast milk. Therefore, your doctor may decide not to use this medicine if you are Breast Feeding.<\/p>\n\n\n\n
Driving And Using Machines With<\/h2>\n\n\n\nFilgrastim Injection<\/h2>\n\n\n\n
Filgrastim may have less effect on your ability to drive and use machines. This medicine may cause dizziness. You should wait and see how you feel after taking Accofil 30<\/i> before driving or using machines.<\/p>\n\n\n\nFilgrastim Injection Contains Sorbitol And Sodium<\/h2>\n\n\n\n
This medicine contains sorbitol.<\/p>\n\n\n\n
If your doctor has told you that you are intolerant to some sugars (fructose), contact your doctor before taking this medicine.<\/p>\n\n\n\n
This medicine also contains sodium.<\/p>\n\n\n\n
Contains less than 1 mmol sodium (0.035 mg) per filgrastim dose<\/strong>, ie essentially ‘sodium-free’.<\/p>\n\n\n\nHow To Give Filgrastim Injection: Instructions<\/h2>\n\n\n\n
Always use Accofil injection<\/strong> exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\nThe dose inj filgrastim<\/strong> of your requirement depends on your body’s condition and weight.<\/p>\n\n\n\nFilgrastim Dose<\/h2>\n\n\n\n
Filgrastim and neutropenia (a small number of white blood cell types ) associated with chemotherapy<\/em><\/p>\n\n\n\nThe usual dose of filgrastim injection<\/strong> is 0.5 million units (5 micrograms) per kg of body weight daily. For example, if you weigh 60 kilograms, your daily filgrastim injection dose is 30 million units (300 micrograms). Treatment with filgrastim usually lasts for about 14 da<\/p>\n\n\n\n<\/p>\n\n\n\n
ys. In some types of disease, however, longer treatment of up to about a month may be required.<\/p>\n\n\n\n
Filgrastim Injection And Bone Marrow Transplant<\/h2>\n\n\n\n
The usual starting dose is 1 million units (10 micrograms) per kg body weight each day is given as an infusion. For example, if you weigh 60 kg, your daily Filgastrim injection dose<\/strong> will be 60 million units (600 micrograms). <\/p>\n\n\n\nYou will usually receive your first dose of Accofil 30<\/strong> at least 24 hours after chemotherapy and at least 24 hours after receiving your bone marrow transplant. The doctor can then test the blood to see how well the treatment works and how long it should last.<\/p>\n\n\n\nAccophilic And Severe Chronic Neutropenia (A Small Number Of White Blood Cell Types )<\/h3>\n\n\n\n
The usual starting dose is between 0.5 million units (5 micrograms) and 1.2 million units (12 micrograms) per kg body weight daily as a single dose or divided into several doses. The doctor can then test your blood to see how well the treatment works and find the best dose for you. To reduce neutropenia, long-term treatment with filgrastim is required.<\/p>\n\n\n\n
Filgrastim Injection And Neutropenia (Low Number Of A Type Of White Blood Cells ) In Patients With HIV – Infection<\/h3>\n\n\n\n
The usual starting dose is between 0.1 million units (1 microgram) and 0.4 million units (4 micrograms) per kg of body weight daily. Your doctor may test your blood regularly to see how well the treatment works. When the number of white blood cells in the blood has returned to normal, it may be possible to reduce the dosing frequency to less than once a day. To maintain a normal white blood cell count, long-term treatment with filgrastim may be needed.<\/p>\n\n\n\n
Accumulation And Transplantation Of Peripheral Stem Cells ( Stem Cells Collected From The Blood For Use In A Bone Marrow Transplant)<\/h3>\n\n\n\n
If you donate stem cells to yourself, the usual dose is 0.5 million (5 micrograms) to 1.0 million units (10 micrograms) per kg body weight each day. Treatment with filgrastim lasts for up to 2 weeks. Your doctor will check your blood to determine the best time for stem cell collection. If you are a stem cell donor to another person, the usual filgrastim dose<\/strong> is 1 million units (10 micrograms) per kg body weight each day. Treatment with filgrastin lasts for 4 to 5 days. Your doctor will take regular blood tests to determine the best time for stem cell collection.<\/p>\n\n\n\nHow To Give Filgrastim Injection<\/h2>\n\n\n\n
This medicine is given as an injection, either by intravenous (iv) infusion (drip) or as a subcutaneous (SC) injection into the tissue just under the skin.<\/p>\n\n\n\n
If you are given this medicine as a subcutaneous injection, your doctor may suggest you learn to give yourself the injections. Your doctor or nurse will give instructions on how to do this (see information below for instructions for injection with filgrastim). Do not try to self-administer without this training. Some of the information you need is given at the end of this leaflet, but proper treatment of your illness requires close and constant cooperation with your doctor.<\/p>\n\n\n\n
Information On How To Give Yourself And Filgrastim Injection<\/h3>\n\n\n\n
This section contains information on how to give yourself an injection of filgrastim. You mustn’t try to give yourself an injection without first receiving special training from your doctor or nurse.<\/p>\n\n\n\n
If you are not sure how to give yourself an injection, or if you have any questions, contact your doctor or nurse for help.<\/p>\n\n\n\n
How Do I Give Myself A Filgrastim Injection?<\/h3>\n\n\n\n
You should inject one into the tissue just below the skin. This is called a subcutaneous injection. You should take the injections at about the same time each day.<\/p>\n\n\n\n
Equipment you need<\/strong><\/p>\n\n\n\nTo give yourself a subcutaneous injection, you need the following:<\/p>\n\n\n\n
- A pre-filled syringe with Accofil injection<\/em> solution<\/li>
- Injection dryer or similar<\/li><\/ul>\n\n\n\n
What Should I Do Before Giving Myself A Subcutaneous Filgrastim Injection?<\/strong><\/h3>\n\n\n\nLeave the needle cover on the syringe until you are ready to inject one<\/p>\n\n\n\n
- Take your pre-filled syringe of filgrastin out of the refrigerator.<\/li>
- Check the expiration date on the pre-filled syringe label (Exp. Date). Do not use it if the last day of the month indicated has passed, if it has been stored outside the refrigerator for more than 15 days, or is unusable for any other reason.<\/li>
- Check the appearance of Filgrastim. It must be a clear and colorless liquid. If it contains particles, do not use it.<\/li>
- Injection one feels more comfortable if you leave the pre-filled syringe for 30 minutes to reach room temperature or hold it gently in your hand for a few minutes. Do not heat Filgastrim in any other way (eg do not<\/em><\/strong> heat the syringe in the microwave or hot water).<\/li>
- Wash your hands thoroughly.<\/li>
- Find a comfortable and well-lit place and put everything you need within reach (the pre-filled syringe with filgastrim and injection dryer).<\/li><\/ol>\n\n\n\n
How do I Prepare My Injection With Filgrastim?<\/h3>\n\n\n\n
Before injecting filgrastim, you must do the following:<\/p>\n\n\n\n
- Hold the syringe and gently take the protection of the needle without twisting. Pull straight out as shown in Figure 1 and Figure 2. Do not touch the needle or push the syringe plunger.<\/li>
- You may notice a small air bubble in the pre-filled syringe. You do not need to remove the air bubble before injecting. It is safe to inject the solution with the air bubble left.<\/li>
- The syringe may contain more liquid than you need. Use the scale on the cylinder container as follows to set the correct dose of filgastrim prescribed by your doctor. Squeeze out unnecessary liquid by pushing the plunger to the number (ml) on the syringe that corresponds to the prescribed dose.<\/li>
- Check again to ensure that the syringe contains the correct dose of filgastrim.<\/li>
- You can now use the pre-filled syringe.<\/li><\/ol>\n\n\n\n
1: <\/strong>How to give filgrastim injection – hold<\/figcaption><\/figure><\/div>\n\n\n2: <\/strong>How to give filgrastim injection – open cap<\/figcaption><\/figure><\/div>\n\n\nFilgrastim Injection Site<\/h3>\n\n\n\n
The most suitable places to give yourself an injection are the following:<\/p>\n\n\n\n
- At the top of the thighs<\/li>
- Abdomen, except the area around the navel (see picture 3)<\/li><\/ul>\n\n\n\n
<\/a>3: <\/strong>injection site on lower body<\/figcaption><\/figure><\/div>\n\n\nIf someone else gives you an injection, he or she can also use the back of your arms (see picture 4).
<\/p>\n\n\n
\n<\/a>4: <\/strong> injection site on arm<\/figcaption><\/figure><\/div>\n\n\nIt is better to change the injection site every day to avoid the risk of soreness in one place.<\/p>\n\n\n\n
How Do I Give Myself An Accofil Filgrastim Injection?<\/h2>\n\n\n\n- Disinfect the injection site with an injection dryer and pinch the skin between the thumb and forefinger without squeezing (see picture 5).
Pre-filled syringe without needle cover<\/li> - Insert the needle completely through the skin, as shown by the nurse or doctor (see picture 6).<\/li>
- Pull the plunger up slightly to ensure you have not punctured a blood vessel. If you see blood in the syringe, pull the needle and insert it in another place.<\/li>
- Always hold the grip on the skin and simultaneously push the plunger down with a slow, constant pressure until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- Inject only the dose prescribed by your doctor.<\/li>
- After injecting the liquid, remove the needle while maintaining the pressure on the plunger and then release the skin.<\/li>
- Place the used syringe in the waste container. Each syringe should only be used for one injection.
Pre-filled syringe with the needle guard<\/em><\/li>- Insert the needle completely through the skin as instructed by the nurse or doctor (see Figure 7).<\/li>
- Pull the plunger up slightly to make sure you have not punctured a blood vessel. If you see blood in the syringe, pull out the needle and insert it in another place.<\/li>
- Only inject the dose prescribed by your doctor by following the instructions below.<\/li>
- Always hold the grip on the skin and push the plunger down with a slow, constant pressure while holding the flange, until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- After injecting the liquid, remove the needle while holding the syringe at the same angle and maintaining the pressure on the plunger, then release the skin. The protective cuff automatically covers the needle and an audible “click” confirms that the protection has been activated (see figure 8). The needle guard is not activated unless the full dose has been given.<\/li><\/ol>\n\n\n\n
5: <\/strong>How to give injection – hold skin<\/figcaption><\/figure><\/div>\n\n\n6: <\/strong>How to give injection – insert needle<\/figcaption><\/figure><\/div>\n\n\n7: <\/strong>How to give accofil filgrastim injection<\/figcaption><\/figure><\/div>\n\n\n8: <\/strong>How to give accofil filgrastim injection – Click<\/figcaption><\/figure><\/div>\n\n\nRemember<\/strong><\/p>\n\n\n\nIf you have problems, do not hesitate to ask your doctor or nurse for help and advice.<\/p>\n\n\n\n
Disposal of used syringes<\/strong><\/p>\n\n\n\nThe needle guard prevents stab injuries after use and therefore no special precautions are required for waste disposal. Dispose of the syringe according to the instructions of a doctor, nurse, or pharmacist.<\/em><\/p>\n\n\n\nOverdose Of Filgrastim Injection<\/h2>\n\n\n\n
If you use more Accofil than you should, contact your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n
Missed Dose Of Filgrastim Injection<\/h2>\n\n\n\n
Do not take a double dose to make up for a forgotten injection. Contact your doctor to discuss when you should inject the next dose.<\/p>\n\n\n\n
If You Stop Using Filgrastim Injection<\/h2>\n\n\n\n
Your doctor will tell you when to stop using filgrastim. It is perfectly normal to receive several treatments with filgastrim.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Possible Accofil Filgrastim Side Effects<\/h2>\n\n\n\n
Like all medicines, side effects of Inj Filgrastim<\/strong> can occur, although not everybody gets them.<\/p>\n\n\n\nTalk to your doctor immediately during treatment<\/strong><\/p>\n\n\n\n- After getting Filgrastin injection<\/strong> if you have an allergic reaction with weakness, drop in blood pressure, difficulty breathing, swelling of the face ( anaphylaxis ), skin rash, itchy rash ( urticaria ), swelling of the face, lips, mouth, tongue, or throat ( angioedema ) and shortness of breath ( dyspnoea ). Hypersensitivity is common in patients with cancer.<\/li>
- A cough<\/a>, fever<\/a>, and difficulty breathing ( dyspnoea ) may be a sign of acute respiratory distress syndrome (ARDS). ARDS is less common in patients with cancer.<\/li>
- If you experience pain in the left upper abdomen (abdomen), pain under the left rib arch or at the tip of the shoulder blade, this may be due to problems with the spleen (enlargement of the spleen [splenomegaly] or ruptured spleen ).<\/li>
- If you are being treated for severe chronic neutropenia and have blood in your urine ( haematuria ). Your doctor may test your urine regularly if you experience this side effect or if the protein is detected in your urine ( proteinuria ).<\/li>
- If you have any of the following or a combination of the following accofil side effects<\/strong>: swelling or bags, which may be associated with less frequent passing water, difficulty breathing, swollen abdomen and feeling of fullness, and a general feeling of tiredness. These symptoms usually appear quickly. These can be the symptoms of an unusual disease (which may occur in 1 in 100 people) called capillary leakage syndrome, which causes the blood to leak from the small blood vessels in the body and needs urgent medical attention.<\/li>
- If you have a combination of any of the following symptoms:
Fever or chills or if you feel very cold<\/a>, high heart rate, confusion or disorientation, shortness of breath, extreme pain or discomfort, and sticky or sweaty skin. These can be symptoms of a condition called “sepsis” (also called sepsis), a serious infection that involves the whole body responding to inflammation. This can be life-threatening and requires immediate emergency medical attention.<\/li>- if you get kidney damage ( glomerulonephritis ). Kidney damage has been seen in patients receiving filgrastim. Contact a doctor immediately if you experience swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual.<\/li><\/ul>\n\n\n\n
Common side effects of Accofil injection<\/strong> is muscle or skeletal pain (musculoskeletal pain), which can be relieved with common painkillers ( analgesics ). In patients undergoing stem cell or bone marrow transplantation, graft-versus-host disease (GvHD) may occur – this is a reaction of the donor cells to the patient receiving the graft; Signs and symptoms are rashes on the palms and soles of the feet and sores in the <\/p>\n\n\n\n- Mouth <\/li>
- Intestines<\/li>
- Liver<\/li>
- Skin or eyes<\/li>
- Lungs<\/li>
- Vagina<\/li>
- Joints<\/li><\/ul>\n\n\n\n
A side effect that is very common in healthy stem cell donors is increased white blood cell count ( leukocytosis ) and decreased number of platelets, which impairs the blood’s ability to coagulate ( thrombocytopenia ), your doctor will check this.<\/p>\n\n\n\n
Very common Side Effects of Filgrastim Injection Are (seen in more than 1 in 10 people taking Accofil):<\/h3>\n\n\n\n
- Chemotherapy<\/li>
- Bone marrow transplant<\/li>
- Severe chronic neutropenia (a small number of white blood cell types )<\/li>
- Neutropenia (low number of a type of white blood cells ) in patients with HIV – infection.<\/li>
- Mobilization of peripheral stem cells (to stimulate stem cells to enter the bloodstream where they can be collected and used in bone marrow transplantation).<\/li><\/ul>\n\n\n\n
What You Need To Know Before Using Filgrastim Injection<\/h2>\n\n\n\n
Do Not Use<\/h2>\n\n\n\n
- If you are allergic (hypersensitive<\/a>) to filgrastim or any of the other ingredients of this medicine.<\/li><\/ul>\n\n\n\n
Warnings And Cautions Of Filgrastim Injection Uses<\/h2>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking a filgrastim:<\/p>\n\n\n\n
Before treatment, tell your doctor if you:<\/p>\n\n\n\n
- If you have sickle cell anemia, filgrastim may cause a sickle cell crisis.<\/li>
- If you have osteoporosis (osteoporosis).<\/li><\/ul>\n\n\n\n
Tell your doctor immediately if you are taking Filgastrim during treatment:<\/p>\n\n\n\n
- Gets pain in the upper left part of the abdomen (abdomen), pain under the ribs on the left side or at the tip of the shoulder blade (this may be a symptom of an enlarged spleen ( splenomegaly ) or possibly a broken spleen ).<\/li>
- Detects unusual bleeding or bruising (this may be a symptom of decreased platelet count ( thrombocytopenia ), which reduces the blood’s ability to clot).<\/li>
- Suffer from sudden signs of allergy, such as rash, itching or hives, swelling of the face, lips, tongue, or other body parts, shortness of breath, wheezing, or difficulty breathing, as these may be signs of a severe allergy.<\/li>
- Get swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual ( glomerulonephritis ).<\/li><\/ul>\n\n\n\n
The needle cover of the pre-filled syringe contains dry natural rubber (latex), which may cause an allergic reaction.<\/p>\n\n\n\n
Inflammation of the aorta (the large carotid artery that carries blood from the heart to the body) has been reported as a rare side effect in cancer patients and healthy donors. Symptoms may include fever, abdominal pain, malaise, back pain<\/a>, and increased inflammatory markers. <\/p>\n\n\n\n
Tell your doctor if you experience these symptoms.<\/p>\n\n\n\n
Unsatisfactory treatment response to Filgrastim<\/h2>\n\n\n\n
If you respond less or stop responding to filgrastim treatment, your doctor will investigate what is causing this. Among other things, he or she will check if you have developed antibodies that neutralize the activity of filgrastim.<\/p>\n\n\n\n
Your doctor may want you to have frequent check-ups; see section 4 of the Package Leaflet.<\/p>\n\n\n\n
If you have severe chronic neutropenia, you may be at risk of developing blood cancer ( leukemia, myelodysplastic syndrome [MDS]). Talk to your doctor about the risk of developing blood cancer and what tests should be done. If you develop or are at high risk of developing blood cancer, do not use it unless your doctor tells you to.<\/p>\n\n\n\n
If you are a stem cell donor, you must be between 16 and 60 years old.<\/p>\n\n\n\n
Take Special Care With Other Products That Stimulate White Blood Cells <\/h2>\n\n\n\n
Filgrastim belongs to a group of medicines that stimulate the production of white blood cells. Healthcare professionals should always note the exact product they are using.<\/p>\n\n\n\n
Other Medicines And Filgrastim Injection<\/h2>\n\n\n\n
You should not receive it 24 hours before and 24 hours after chemotherapy.<\/p>\n\n\n\n
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n
Filgrastim Injection With Pregnancy And Breastfeeding<\/h2>\n\n\n\n
In<\/strong>j Filgrastim<\/strong> has not been tested in pregnant women.<\/p>\n\n\n\n
You must tell your doctor if you:<\/p>\n\n\n\n
- Is pregnant or breastfeeding<\/li>
- Think you may be pregnant or<\/li>
- Planning to have children.<\/li><\/ul>\n\n\n\n
It is unknown if filgrastim passes into breast milk. Therefore, your doctor may decide not to use this medicine if you are Breast Feeding.<\/p>\n\n\n\n
Driving And Using Machines With<\/h2>\n\n\n\n
Filgrastim Injection<\/h2>\n\n\n\n
Filgrastim may have less effect on your ability to drive and use machines. This medicine may cause dizziness. You should wait and see how you feel after taking Accofil 30<\/i> before driving or using machines.<\/p>\n\n\n\n
Filgrastim Injection Contains Sorbitol And Sodium<\/h2>\n\n\n\n
This medicine contains sorbitol.<\/p>\n\n\n\n
If your doctor has told you that you are intolerant to some sugars (fructose), contact your doctor before taking this medicine.<\/p>\n\n\n\n
This medicine also contains sodium.<\/p>\n\n\n\n
Contains less than 1 mmol sodium (0.035 mg) per filgrastim dose<\/strong>, ie essentially ‘sodium-free’.<\/p>\n\n\n\n
How To Give Filgrastim Injection: Instructions<\/h2>\n\n\n\n
Always use Accofil injection<\/strong> exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
The dose inj filgrastim<\/strong> of your requirement depends on your body’s condition and weight.<\/p>\n\n\n\n
Filgrastim Dose<\/h2>\n\n\n\n
Filgrastim and neutropenia (a small number of white blood cell types ) associated with chemotherapy<\/em><\/p>\n\n\n\n
The usual dose of filgrastim injection<\/strong> is 0.5 million units (5 micrograms) per kg of body weight daily. For example, if you weigh 60 kilograms, your daily filgrastim injection dose is 30 million units (300 micrograms). Treatment with filgrastim usually lasts for about 14 da<\/p>\n\n\n\n
<\/p>\n\n\n\n
ys. In some types of disease, however, longer treatment of up to about a month may be required.<\/p>\n\n\n\n
Filgrastim Injection And Bone Marrow Transplant<\/h2>\n\n\n\n
The usual starting dose is 1 million units (10 micrograms) per kg body weight each day is given as an infusion. For example, if you weigh 60 kg, your daily Filgastrim injection dose<\/strong> will be 60 million units (600 micrograms). <\/p>\n\n\n\n
You will usually receive your first dose of Accofil 30<\/strong> at least 24 hours after chemotherapy and at least 24 hours after receiving your bone marrow transplant. The doctor can then test the blood to see how well the treatment works and how long it should last.<\/p>\n\n\n\n
Accophilic And Severe Chronic Neutropenia (A Small Number Of White Blood Cell Types )<\/h3>\n\n\n\n
The usual starting dose is between 0.5 million units (5 micrograms) and 1.2 million units (12 micrograms) per kg body weight daily as a single dose or divided into several doses. The doctor can then test your blood to see how well the treatment works and find the best dose for you. To reduce neutropenia, long-term treatment with filgrastim is required.<\/p>\n\n\n\n
Filgrastim Injection And Neutropenia (Low Number Of A Type Of White Blood Cells ) In Patients With HIV – Infection<\/h3>\n\n\n\n
The usual starting dose is between 0.1 million units (1 microgram) and 0.4 million units (4 micrograms) per kg of body weight daily. Your doctor may test your blood regularly to see how well the treatment works. When the number of white blood cells in the blood has returned to normal, it may be possible to reduce the dosing frequency to less than once a day. To maintain a normal white blood cell count, long-term treatment with filgrastim may be needed.<\/p>\n\n\n\n
Accumulation And Transplantation Of Peripheral Stem Cells ( Stem Cells Collected From The Blood For Use In A Bone Marrow Transplant)<\/h3>\n\n\n\n
If you donate stem cells to yourself, the usual dose is 0.5 million (5 micrograms) to 1.0 million units (10 micrograms) per kg body weight each day. Treatment with filgrastim lasts for up to 2 weeks. Your doctor will check your blood to determine the best time for stem cell collection. If you are a stem cell donor to another person, the usual filgrastim dose<\/strong> is 1 million units (10 micrograms) per kg body weight each day. Treatment with filgrastin lasts for 4 to 5 days. Your doctor will take regular blood tests to determine the best time for stem cell collection.<\/p>\n\n\n\n
How To Give Filgrastim Injection<\/h2>\n\n\n\n
This medicine is given as an injection, either by intravenous (iv) infusion (drip) or as a subcutaneous (SC) injection into the tissue just under the skin.<\/p>\n\n\n\n
If you are given this medicine as a subcutaneous injection, your doctor may suggest you learn to give yourself the injections. Your doctor or nurse will give instructions on how to do this (see information below for instructions for injection with filgrastim). Do not try to self-administer without this training. Some of the information you need is given at the end of this leaflet, but proper treatment of your illness requires close and constant cooperation with your doctor.<\/p>\n\n\n\n
Information On How To Give Yourself And Filgrastim Injection<\/h3>\n\n\n\n
This section contains information on how to give yourself an injection of filgrastim. You mustn’t try to give yourself an injection without first receiving special training from your doctor or nurse.<\/p>\n\n\n\n
If you are not sure how to give yourself an injection, or if you have any questions, contact your doctor or nurse for help.<\/p>\n\n\n\n
How Do I Give Myself A Filgrastim Injection?<\/h3>\n\n\n\n
You should inject one into the tissue just below the skin. This is called a subcutaneous injection. You should take the injections at about the same time each day.<\/p>\n\n\n\n
Equipment you need<\/strong><\/p>\n\n\n\n
To give yourself a subcutaneous injection, you need the following:<\/p>\n\n\n\n
- A pre-filled syringe with Accofil injection<\/em> solution<\/li>
- Injection dryer or similar<\/li><\/ul>\n\n\n\n
What Should I Do Before Giving Myself A Subcutaneous Filgrastim Injection?<\/strong><\/h3>\n\n\n\n
Leave the needle cover on the syringe until you are ready to inject one<\/p>\n\n\n\n
- Take your pre-filled syringe of filgrastin out of the refrigerator.<\/li>
- Check the expiration date on the pre-filled syringe label (Exp. Date). Do not use it if the last day of the month indicated has passed, if it has been stored outside the refrigerator for more than 15 days, or is unusable for any other reason.<\/li>
- Check the appearance of Filgrastim. It must be a clear and colorless liquid. If it contains particles, do not use it.<\/li>
- Injection one feels more comfortable if you leave the pre-filled syringe for 30 minutes to reach room temperature or hold it gently in your hand for a few minutes. Do not heat Filgastrim in any other way (eg do not<\/em><\/strong> heat the syringe in the microwave or hot water).<\/li>
- Wash your hands thoroughly.<\/li>
- Find a comfortable and well-lit place and put everything you need within reach (the pre-filled syringe with filgastrim and injection dryer).<\/li><\/ol>\n\n\n\n
How do I Prepare My Injection With Filgrastim?<\/h3>\n\n\n\n
Before injecting filgrastim, you must do the following:<\/p>\n\n\n\n
- Hold the syringe and gently take the protection of the needle without twisting. Pull straight out as shown in Figure 1 and Figure 2. Do not touch the needle or push the syringe plunger.<\/li>
- You may notice a small air bubble in the pre-filled syringe. You do not need to remove the air bubble before injecting. It is safe to inject the solution with the air bubble left.<\/li>
- The syringe may contain more liquid than you need. Use the scale on the cylinder container as follows to set the correct dose of filgastrim prescribed by your doctor. Squeeze out unnecessary liquid by pushing the plunger to the number (ml) on the syringe that corresponds to the prescribed dose.<\/li>
- Check again to ensure that the syringe contains the correct dose of filgastrim.<\/li>
- You can now use the pre-filled syringe.<\/li><\/ol>\n\n\n\n
1: <\/strong>How to give filgrastim injection – hold<\/figcaption><\/figure><\/div>\n\n \n2: <\/strong>How to give filgrastim injection – open cap<\/figcaption><\/figure><\/div>\n\n\n Filgrastim Injection Site<\/h3>\n\n\n\n
The most suitable places to give yourself an injection are the following:<\/p>\n\n\n\n
- At the top of the thighs<\/li>
- Abdomen, except the area around the navel (see picture 3)<\/li><\/ul>\n\n\n\n<\/a>
3: <\/strong>injection site on lower body<\/figcaption><\/figure><\/div>\n\n\n If someone else gives you an injection, he or she can also use the back of your arms (see picture 4).
<\/p>\n\n\n\n<\/a>4: <\/strong> injection site on arm<\/figcaption><\/figure><\/div>\n\n\n It is better to change the injection site every day to avoid the risk of soreness in one place.<\/p>\n\n\n\n
How Do I Give Myself An Accofil Filgrastim Injection?<\/h2>\n\n\n\n
- Disinfect the injection site with an injection dryer and pinch the skin between the thumb and forefinger without squeezing (see picture 5).
Pre-filled syringe without needle cover<\/li> - Insert the needle completely through the skin, as shown by the nurse or doctor (see picture 6).<\/li>
- Pull the plunger up slightly to ensure you have not punctured a blood vessel. If you see blood in the syringe, pull the needle and insert it in another place.<\/li>
- Always hold the grip on the skin and simultaneously push the plunger down with a slow, constant pressure until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- Inject only the dose prescribed by your doctor.<\/li>
- After injecting the liquid, remove the needle while maintaining the pressure on the plunger and then release the skin.<\/li>
- Place the used syringe in the waste container. Each syringe should only be used for one injection.
Pre-filled syringe with the needle guard<\/em><\/li>- Insert the needle completely through the skin as instructed by the nurse or doctor (see Figure 7).<\/li>
- Pull the plunger up slightly to make sure you have not punctured a blood vessel. If you see blood in the syringe, pull out the needle and insert it in another place.<\/li>
- Only inject the dose prescribed by your doctor by following the instructions below.<\/li>
- Always hold the grip on the skin and push the plunger down with a slow, constant pressure while holding the flange, until the entire dose has been injected and the plunger can no longer be pushed down. Do not release the pressure on the piston!<\/li>
- After injecting the liquid, remove the needle while holding the syringe at the same angle and maintaining the pressure on the plunger, then release the skin. The protective cuff automatically covers the needle and an audible “click” confirms that the protection has been activated (see figure 8). The needle guard is not activated unless the full dose has been given.<\/li><\/ol>\n\n\n
\n5: <\/strong>How to give injection – hold skin<\/figcaption><\/figure><\/div>\n\n \n6: <\/strong>How to give injection – insert needle<\/figcaption><\/figure><\/div>\n\n \n7: <\/strong>How to give accofil filgrastim injection<\/figcaption><\/figure><\/div>\n\n \n8: <\/strong>How to give accofil filgrastim injection – Click<\/figcaption><\/figure><\/div>\n\n\n Remember<\/strong><\/p>\n\n\n\n
If you have problems, do not hesitate to ask your doctor or nurse for help and advice.<\/p>\n\n\n\n
Disposal of used syringes<\/strong><\/p>\n\n\n\n
The needle guard prevents stab injuries after use and therefore no special precautions are required for waste disposal. Dispose of the syringe according to the instructions of a doctor, nurse, or pharmacist.<\/em><\/p>\n\n\n\n
Overdose Of Filgrastim Injection<\/h2>\n\n\n\n
If you use more Accofil than you should, contact your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n
Missed Dose Of Filgrastim Injection<\/h2>\n\n\n\n
Do not take a double dose to make up for a forgotten injection. Contact your doctor to discuss when you should inject the next dose.<\/p>\n\n\n\n
If You Stop Using Filgrastim Injection<\/h2>\n\n\n\n
Your doctor will tell you when to stop using filgrastim. It is perfectly normal to receive several treatments with filgastrim.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Possible Accofil Filgrastim Side Effects<\/h2>\n\n\n\n
Like all medicines, side effects of Inj Filgrastim<\/strong> can occur, although not everybody gets them.<\/p>\n\n\n\n
Talk to your doctor immediately during treatment<\/strong><\/p>\n\n\n\n
- After getting Filgrastin injection<\/strong> if you have an allergic reaction with weakness, drop in blood pressure, difficulty breathing, swelling of the face ( anaphylaxis ), skin rash, itchy rash ( urticaria ), swelling of the face, lips, mouth, tongue, or throat ( angioedema ) and shortness of breath ( dyspnoea ). Hypersensitivity is common in patients with cancer.<\/li>
- A cough<\/a>, fever<\/a>, and difficulty breathing ( dyspnoea ) may be a sign of acute respiratory distress syndrome (ARDS). ARDS is less common in patients with cancer.<\/li>
- If you experience pain in the left upper abdomen (abdomen), pain under the left rib arch or at the tip of the shoulder blade, this may be due to problems with the spleen (enlargement of the spleen [splenomegaly] or ruptured spleen ).<\/li>
- If you are being treated for severe chronic neutropenia and have blood in your urine ( haematuria ). Your doctor may test your urine regularly if you experience this side effect or if the protein is detected in your urine ( proteinuria ).<\/li>
- If you have any of the following or a combination of the following accofil side effects<\/strong>: swelling or bags, which may be associated with less frequent passing water, difficulty breathing, swollen abdomen and feeling of fullness, and a general feeling of tiredness. These symptoms usually appear quickly. These can be the symptoms of an unusual disease (which may occur in 1 in 100 people) called capillary leakage syndrome, which causes the blood to leak from the small blood vessels in the body and needs urgent medical attention.<\/li>
- If you have a combination of any of the following symptoms:
Fever or chills or if you feel very cold<\/a>, high heart rate, confusion or disorientation, shortness of breath, extreme pain or discomfort, and sticky or sweaty skin. These can be symptoms of a condition called “sepsis” (also called sepsis), a serious infection that involves the whole body responding to inflammation. This can be life-threatening and requires immediate emergency medical attention.<\/li>- if you get kidney damage ( glomerulonephritis ). Kidney damage has been seen in patients receiving filgrastim. Contact a doctor immediately if you experience swelling of the face or ankles, blood in the urine or brown urine, or if you notice that you urinate less than usual.<\/li><\/ul>\n\n\n\n
Common side effects of Accofil injection<\/strong> is muscle or skeletal pain (musculoskeletal pain), which can be relieved with common painkillers ( analgesics ). In patients undergoing stem cell or bone marrow transplantation, graft-versus-host disease (GvHD) may occur – this is a reaction of the donor cells to the patient receiving the graft; Signs and symptoms are rashes on the palms and soles of the feet and sores in the <\/p>\n\n\n\n
- Mouth <\/li>
- Intestines<\/li>
- Liver<\/li>
- Skin or eyes<\/li>
- Lungs<\/li>
- Vagina<\/li>
- Joints<\/li><\/ul>\n\n\n\n
A side effect that is very common in healthy stem cell donors is increased white blood cell count ( leukocytosis ) and decreased number of platelets, which impairs the blood’s ability to coagulate ( thrombocytopenia ), your doctor will check this.<\/p>\n\n\n\n
Very common Side Effects of Filgrastim Injection Are (seen in more than 1 in 10 people taking Accofil):<\/h3>\n\n\n\n
- A cough<\/a>, fever<\/a>, and difficulty breathing ( dyspnoea ) may be a sign of acute respiratory distress syndrome (ARDS). ARDS is less common in patients with cancer.<\/li>
- Disinfect the injection site with an injection dryer and pinch the skin between the thumb and forefinger without squeezing (see picture 5).
- Injection dryer or similar<\/li><\/ul>\n\n\n\n
- A pre-filled syringe with Accofil injection<\/em> solution<\/li>
- If you are allergic (hypersensitive<\/a>) to filgrastim or any of the other ingredients of this medicine.<\/li><\/ul>\n\n\n\n