{"id":4502,"date":"2020-11-24T07:33:12","date_gmt":"2020-11-24T07:33:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4502"},"modified":"2022-12-07T14:28:28","modified_gmt":"2022-12-07T14:28:28","slug":"absenor","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/absenor\/","title":{"rendered":"Absenor &#8211; Valproic Acid Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Absenor&nbsp;Enterotablett&nbsp;er 100 mg, 300 mg and 500 mg<br>Absenor Depot&nbsp;Tablet&nbsp;er 300 mg and 500 mg<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Absenor Is And What Absenor Used For<\/h2>\n\n\n\n<p>Absenor is a drug used to treat\u00a0epilepsy\u00a0and mania.<\/p>\n\n\n\n<p><strong>Absenor medicine<\/strong> is used in various types of\u00a0epilepsy, in the treatment of manic episodes, as well as a maintenance treatment or preventive treatment of manic-depressive illness in patients who do not improve with or do not tolerate lithium.<\/p>\n\n\n\n<p>Mania means <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A state of strong arousal<\/li><li>Elation<\/li><li>EAgitation<\/li><li>Enthusiasm<\/li><li>Hyperactivity<\/li><\/ul>\n\n\n\n<p>Mania occurs in a disease called\u00a0bipolar disorder.\u00a0Absenor can be used when you can not take lithium.<\/p>\n\n\n\n<p>Sodium valproate contained in Absenor may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<p><strong>How does the drug work?<\/strong><\/p>\n\n\n\n<p>Absenor&#8217;s mode of action is not fully understood.&nbsp;One theory is that Absenor prevents or dampens impulses in the brain so that epileptic seizures and manic episodes are counteracted.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before Taking Absenor<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Take Absenor<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to sodium valproate or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you are allergic to peanuts or soy, do not take Absenor\u00a0Depot<\/li><li>If you have liver disease or impaired liver function<\/li><li>In\u00a0porphyria\u00a0(increased accumulation of certain blood dyes)<\/li><li>If you have a hereditary problem that causes a disturbance in the cells&#8217; energy supply (eg Alpers-Huttenlocher syndrome).<\/li><li>If you have a known metabolic disease, ie.\u00a0disturbance in urea turnover.<\/li><\/ul>\n\n\n\n<p>Bipolar disease<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For\u00a0bipolar disorder, do not use <em>Absenor medicine<\/em> if you are pregnant.<\/li><li>For\u00a0bipolar disorder, if you are a woman who may have children, do not take Absenor unless you are using an effective contraceptive throughout treatment with Absenor.\u00a0Do not stop taking Absenor or your contraceptive until you have discussed it with your doctor.\u00a0Your doctor will give you further advice (see below under &#8220;Pregnancy, breast-feeding and\u00a0fertility\u00a0&#8211; Important advice for women&#8221;).<\/li><\/ul>\n\n\n\n<p>Epilepsy<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;epilepsy, do not use Absenor if you are pregnant, unless otherwise indicated for you.<\/li><li>For&nbsp;epilepsy, if you are a woman who may have children, do not take Absenor unless you are using an effective contraceptive throughout treatment with Absenor.&nbsp;Do not stop taking Absenor or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice (see below under &#8220;Pregnancy, breast-feeding and&nbsp;fertility&nbsp;&#8211; Important advice for women&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Absenor.<\/p>\n\n\n\n<p>Treatment with <em>Absenor medicine<\/em> requires close monitoring with a call to blood tests for liver and pancreatic\u00a0functions\u00a0and\u00a0platelets.\u00a0It is important that you go for these checks.\u00a0This is especially true at the beginning of treatment, as well as during surgeries.<\/p>\n\n\n\n<p>The use of&nbsp;acetylsalicylic acid&nbsp;(for pain, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>) in children under 3 years of age should be avoided due to the risk of liver damage.<\/p>\n\n\n\n<p>In case of<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood disease<\/li><li>Certain skin diseases (\u00a0SLE\u00a0)<\/li><li>Impaired kidney function<\/li><li>Metabolic disease (especially hereditary enzyme deficiency diseases)<\/li><li>If you easily get bruises or bleeding, the doctor should be informed about this.\u00a0<\/li><\/ul>\n\n\n\n<p>Always follow the doctor&#8217;s prescription carefully!\u00a0Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>There is a risk of weight gain when taking Absenor.\u00a0Contact a doctor if you need help checking your weight.<\/p>\n\n\n\n<p>A small number of people who are treated with antiepileptic\u00a0drugs\u00a0such as\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Valproate also had thoughts of harming themselves or committing suicide.<\/li><\/ul>\n\n\n\n<p><strong>Note:<\/strong> \u00a0If you ever get these thoughts, contact your doctor immediately.<\/p>\n\n\n\n<p><em>Always consult a doctor if the following symptoms occur: <\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Nausea<\/li><li>Drowsiness<\/li><li>Fatigue, which sometimes occur with repeated vomiting or abdominal pain<\/li><li>Jaundice<\/li><li>Swelling in the legs or feet, and in case of sudden impaired seizure control.<\/li><\/ul>\n\n\n\n<p>This can be a sign of a serious effect on the liver or pancreas.\u00a0This is especially true in infants and children under 3 years of age with severe forms of\u00a0epilepsy\u00a0(especially children with brain damage, developmental disorders, genetic and\/or metabolic diseases) and in combination therapy with other\u00a0antiepileptic drugs.\u00a0See also section 4 Possible\u00a0side effects.<\/p>\n\n\n\n<p>Talk to your doctor if you know that there is a hereditary problem in your family that is causing a disruption in the cells&#8217; energy supply.<\/p>\n\n\n\n<p>As with other antiepileptic medicines,&nbsp;seizures&nbsp;may worsen or occur more often when you take this medicine.&nbsp;Contact a doctor immediately if this happens.<\/p>\n\n\n\n<p>You should not stop the medication abruptly, as the risk of seizures may increase.&nbsp;Never change the&nbsp;prescribed&nbsp;dose&nbsp;yourself&nbsp;without consulting a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p><em>Absenor medicine<\/em> should not be used in children and adolescents under 18 years of age when treating mania.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Absenor<\/h2>\n\n\n\n<p>Absenor can affect or be affected by other drugs such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Painkillers (\u00a0acetylsalicylic acid\u00a0)<\/li><li>Agent against\u00a0gastric ulcers\u00a0(cimetidine)<\/li><li>Drugs against cardiovascular disease (nimodipine)<\/li><li>Agents against\u00a0epilepsy\u00a0<ul><li>Ethosuximide<\/li><li>Felbamate<\/li><li>Phenobarbital<\/li><li>Phenytoin<\/li><li>Carbamazepine<\/li><li>Lamotrigine<\/li><li>Primidone<\/li><li>Rufinamide<\/li><li>Topiramate<\/li><\/ul><\/li><li>Anti-anxiety drugs <ul><li>Lorazepam<\/li><\/ul><\/li><li>Anti-malarial\u00a0drugs<ul><li>Mefloquine<\/li><\/ul><\/li><li>Anesthetic <ul><li>Propofol<\/li><\/ul><\/li><li>Agents for viral infections <ul><li>Zidovudine<\/li><\/ul><\/li><li>Remedies for\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/psychosis\/\">psychosis<\/a>\u00a0and certain other mental illnesses<\/li><li>Antidepressants and sleeping pills<\/li><li>Certain blood thinners (\u00a0warfarin\u00a0)<\/li><li>Certain\u00a0antibiotics\u00a0(<ul><li>Erythromycin<\/li><li>Rifampicin<\/li><li>Carbapenems such as <ul><li>Ertapenem<\/li><li>Imipenem<\/li><li>Meropenem<\/li><li>Panipenem<\/li><\/ul><\/li><\/ul><\/li><li>Certain lipid-lowering drugs <ul><li>Cholestyramine<\/li><\/ul><\/li><li>Certain anti-glaucoma\u00a0drugs\u00a0<ul><li>Acetazolamide<\/li><\/ul><\/li><li>Treatment with\u00a0antibiotics\u00a0containing pivalic acid <ul><li>Pivampicillin<\/li><li>Pivmecillinam should be avoided<\/li><\/ul><\/li><li>Estrogen-containing agents\u00a0(including some\u00a0birth control pills).<\/li><\/ul>\n\n\n\n<p>You, therefore, need to tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It is unlikely that Absenor will affect the effect of&nbsp;birth control pills.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Absence With Food, Drink, And Alcohol<\/h2>\n\n\n\n<p>Absenor is taken with a meal.&nbsp;Alcohol should not be consumed during treatment, as Absenor increases the effect of alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p><em>Pregnancy and\u00a0fertility<\/em><\/p>\n\n\n\n<p><strong>Important advice for women<\/strong><\/p>\n\n\n\n<p>Bipolar disease<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;bipolar disorder, do not use Absenor if you are pregnant.<\/li><li>For&nbsp;bipolar disorder, if you are a woman who may have children, do not take Absenor unless you are using an effective contraceptive throughout treatment with Absenor.&nbsp;Do not stop taking Absenor or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice.<\/li><\/ul>\n\n\n\n<p>Epilepsy<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For&nbsp;epilepsy, do not use Absenor if you are pregnant, unless otherwise indicated for you.<\/li><li>For&nbsp;epilepsy, if you are a woman who may have children, do not take Absenor unless you are using an effective contraceptive throughout treatment with Absenor.&nbsp;Do not stop taking Absenor or your contraceptive until you have discussed it with your doctor.&nbsp;Your doctor will give you further advice.<\/li><\/ul>\n\n\n\n<p><em>The risks of&nbsp;valproate&nbsp;when taken during pregnancy (regardless of the disease for which&nbsp;valproate&nbsp;is used):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you are planning to become pregnant or are pregnant.<\/li><li>Valproate\u00a0is a risk if taken during pregnancy.\u00a0The higher the\u00a0dose, the greater the risk, but all\u00a0doses\u00a0involve a risk.<\/li><li>It can cause serious birth defects and affect how the baby develops as it grows.\u00a0Fetal injuries that have been reported include\u00a0<em>spina bifida<\/em>\u00a0(where the bones of the spine are not properly developed).\u00a0malformations of the face and skull;\u00a0heart, kidney, urinary tract and malformations of the genitals as well as malformations of the\u00a0extremities\u00a0er.\u00a0Hearing problems or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a> have been reported in children who have been exposed to\u00a0valproate\u00a0during pregnancy.<\/li><li>If you take\u00a0valproate\u00a0during pregnancy, you have a higher risk than other women of having a child with birth defects that require medical treatment.\u00a0Because\u00a0valproate\u00a0has been used for many years, we know that in women taking\u00a0valproate, about 10 children out of 100 will have birth defects.\u00a0This compares with 2 to 3 in 100 born to women who do not have\u00a0epilepsy.<\/li><li>It is estimated that up to 30-40% of preschool children, whose mothers took\u00a0valproate\u00a0during pregnancy, may have problems with early childhood development.\u00a0Affected children may be late to walk and talk, have a lower intellectual ability than other children, and have difficulty with language and memory.<\/li><li>Autism spectrum disorders are more commonly diagnosed in children exposed to\u00a0valproate\u00a0and there is some support that children may be more likely to develop symptoms of\u00a0ADHD\u00a0(Attention Deficit Hyperactivity Disorder).<\/li><li>Before you are prescribed this medicine, your doctor will have explained what can happen to your baby if you become pregnant while taking\u00a0valproate.\u00a0If you later decide to have a child, do not stop taking your medicine or contraceptive until you have discussed it with your doctor.<\/li><li>If you are the parent or caregiver of a girl treated with\u00a0valproate, consult your doctor when your child using\u00a0valproate\u00a0gets his first period.<\/li><li>Some\u00a0birth control pills\u00a0(estrogen-containing birth control pills) can lower the valproate levels in your blood.\u00a0Make sure you talk to your doctor about which contraceptive (birth control) is most suitable for you.<\/li><li>Talk to your doctor about taking\u00a0folic acid\u00a0when trying to conceive.\u00a0Folic acid\u00a0can lower the overall risk of\u00a0<em>spina bifida<\/em>\u00a0and early miscarriage that occurs with all pregnancies.\u00a0However, it is unlikely that it will reduce the risk of birth defects in connection with valproate use.<\/li><\/ul>\n\n\n\n<p><strong>Please select and read the situations that apply to you from the situations described below:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>I BEGIN TREATMENT WITH ABSENOR<\/li><li>I TAKE ABSENOR BUT I DON&#8217;T PLAN TO HAVE CHILDREN<\/li><li>I TAKE ABSENOR AND PLAN TO HAVE CHILDREN<\/li><li>I AM PREGNANT AND I TAKE ABSENES<\/li><\/ul>\n\n\n\n<p><strong>I BEGIN TREATMENT WITH ABSENOR<\/strong><\/p>\n\n\n\n<p>If this is your first time taking Absenor, your doctor will explain the risks to an unborn baby if you become pregnant.\u00a0If you can have children, you must ensure that you use an effective method of contraception without interruption during your treatment with Absenor.\u00a0Talk to your doctor or midwife if you need contraceptive advice.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pregnancy must be ruled out as a result of a pregnancy test, which has been confirmed by your doctor before starting treatment with Absenor.<\/li><li>You must use an effective contraceptive throughout the treatment with Absenor.<\/li><li>You must discuss appropriate methods of birth control (contraception) with your doctor.&nbsp;Your doctor will give you information on how to prevent pregnancy and can refer you to a specialist doctor for advice on birth control.<\/li><li>You must have regular (at least annual) appointments with a specialist doctor who has experience in treating&nbsp;bipolar disorder&nbsp;or&nbsp;epilepsy.&nbsp;During this visit, your doctor should make sure that you are well aware of and have understood all the risks and advice related to the use of&nbsp;valproate&nbsp;during pregnancy.<\/li><li>Tell your doctor if you want to get pregnant.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I TAKE ABSENOR BUT I DON&#8217;T PLAN TO HAVE CHILDREN<\/strong><\/p>\n\n\n\n<p>If you continue treatment with Absenor but do not plan to have children, make sure that you use an effective contraceptive without interruption throughout the treatment with Absenor.\u00a0Talk to your doctor or midwife if you need contraceptive advice.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You must use an effective contraceptive throughout the treatment with Absenor.<\/li><li>You must discuss contraception (birth control) with your doctor.&nbsp;Your doctor will give you information on how to prevent pregnancy and may refer you to a specialist for birth control advice.<\/li><li>You must have regular (at least annual) appointments with a specialist doctor who has experience in treating&nbsp;bipolar disorder&nbsp;or&nbsp;epilepsy.&nbsp;During this visit, your doctor should make sure that you are well aware of and have understood all the risks and advice related to the use of&nbsp;valproate&nbsp;during pregnancy.<\/li><li>Tell your doctor if you want to get pregnant.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I TAKE ABSENOR AND PLAN TO HAVE CHILDREN<\/strong><\/p>\n\n\n\n<p>If you are planning to have a baby, make an appointment with your doctor.<\/p>\n\n\n\n<p>Do not stop taking Absenor or your contraceptive until you have discussed it with your doctor.\u00a0Your doctor will give you further advice.<\/p>\n\n\n\n<p>Children born to mothers who have taken\u00a0valproate\u00a0have a serious risk of birth defects and developmental disorders that can be severely impaired.\u00a0Your doctor will refer you to a specialist who has experience in treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy\u00a0so that other treatment options can be evaluated early.\u00a0Your specialist doctor can take several measures so that your pregnancy goes as smoothly as possible and any risks to you and your unborn child are reduced as much as possible.<\/p>\n\n\n\n<p>Your specialist doctor may decide to change the\u00a0dose of\u00a0one of Absenor or switch to another medicine, or stop treatment with Absenor, in good time before you become pregnant &#8211; to ensure that your disease is stable.<\/p>\n\n\n\n<p>Consult your doctor about taking&nbsp;folic acid&nbsp;when planning to have children.&nbsp;Folic acid can lower the overall risk of spina bifida and early miscarriage that occurs with all pregnancies.&nbsp;However, it is unlikely that it will reduce the risk of birth defects associated with valproate use.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop taking Absenor unless your doctor tells you to.<\/li><li>Do not stop using your contraceptive until you have talked to your doctor and worked out a plan together to ensure that your condition is stable and that the risks to your child are reduced.<\/li><li>Book an appointment with your doctor.&nbsp;During this visit, your doctor should make sure that you are well aware of and have understood all the risks and advice related to the use of&nbsp;valproate&nbsp;during pregnancy.<\/li><li>Your doctor will try to switch to another medicine or stop taking Absenor well in advance of your pregnancy.<\/li><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<p><strong>I AM PREGNANT AND I TAKE ABSENES<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop taking Absenor unless your doctor tells you that your condition may be getting worse.\u00a0Tell your doctor immediately if you are pregnant or think you may be pregnant.\u00a0Your doctor will give you further advice.<\/li><li>Children born to mothers who have taken\u00a0valproate\u00a0have a serious risk of birth defects and developmental disorders that can be severely impaired.<\/li><li>You will be referred to a specialist who has experience in treating\u00a0bipolar disorder\u00a0or\u00a0epilepsy\u00a0so that other treatment options can be evaluated.<\/li><li>In the exceptional circumstances when Absenor is the only available treatment option during pregnancy, you will be examined very carefully both in terms of your medical condition and to check how your unborn baby is developing.\u00a0You and your partner can get advice and support regarding pregnancy that is exposed to\u00a0valproate.<\/li><\/ul>\n\n\n\n<p>Ask your doctor for&nbsp;folic acid.&nbsp;Folic acid&nbsp;can lower the overall risk of spina bifida and early miscarriage that occurs with all pregnancies.&nbsp;However, it is unlikely that it will reduce the risk of birth defects associated with valproate use.<\/p>\n\n\n\n<p><strong>Main message:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you are pregnant or think you may be pregnant.<\/li><li>Do not stop taking Absenor unless your doctor tells you to.<\/li><li>Make sure you are referred to a specialist with experience in the treatment of&nbsp;epilepsy&nbsp;or&nbsp;bipolar disorder&nbsp;to evaluate the need for alternative treatment options.<\/li><li>You must receive careful advice on the risks of Absenor during pregnancy, including the risk of birth defects and developmental disorders in children.<\/li><li>Make sure you are referred to as a &#8220;prenatal monitoring&#8221; specialist to detect possible birth defects in the unborn baby.<\/li><\/ul>\n\n\n\n<p><strong>Make sure you read the patient information brochure&nbsp;that you will receive from your doctor.&nbsp;Your doctor will discuss the annual risk confirmation form and will ask you to sign and keep it.&nbsp;You will also receive a patient card from your doctor to remind you of the risks of&nbsp;valproate&nbsp;during pregnancy.<\/strong><\/p>\n\n\n\n<p>Extremely rare cases of blood coagulation problems have been reported in neonates whose mothers were treated with&nbsp;valproate&nbsp;during pregnancy.&nbsp;Although&nbsp;hypoglycemia&nbsp;(low blood glucose) and&nbsp;hypothyroidism&nbsp;(malfunction of the thyroid gland, which can cause tiredness and weight increase) may occur in the newborn.<\/p>\n\n\n\n<p>Withdrawal symptoms may occur in newborns whose mothers have taken Absenor during the last third of pregnancy<\/p>\n\n\n\n<p><em><strong>Breast-feeding<\/strong><\/em><\/p>\n\n\n\n<p>Valproate\u00a0passes into breast milk.\u00a0Talk to your doctor before using Absenor during breast-feeding.<\/p>\n\n\n\n<p><em><strong>Fertility<\/strong><\/em><\/p>\n\n\n\n<p>Absence may reduce&nbsp;fertility&nbsp;in both men and women.&nbsp;However, available information indicates that&nbsp;fertility&nbsp;returns to normal when treatment with Absenor is stopped.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Absence can impair the ability to react, which should be kept in mind at times when sharper attention is required, e.g.\u00a0while driving and precision work.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0<\/p>\n\n\n\n<p>Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Absenor Contains<\/h2>\n\n\n\n<p><strong>Absenor contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>Absenor contains\u00a0sodium\u00a0(the main ingredient in table salt\/table salt):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Enterotablett<\/em><ul><li><em>100 mg<\/em>\u00a0&#8211; contains 14 mg of\u00a0sodium\u00a0per tablet.\u00a0This corresponds to 0.7% of the highest recommended daily intake of\u00a0sodium\u00a0for adults.<\/li><li><em>300 mg<\/em>\u00a0&#8211; contains 42 mg of\u00a0sodium\u00a0per tablet.\u00a0This corresponds to 2.1% of the highest recommended daily intake of\u00a0sodium\u00a0for adults.<\/li><li><em>500 mg<\/em>\u00a0&#8211; contains 70 mg of\u00a0sodium\u00a0per tablet.\u00a0This corresponds to 3.5% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<\/li><\/ul><\/li><li><em>Prolonged-release tablet<\/em><ul><li><em>300 mg<\/em>\u00a0&#8211; contains 42 mg of\u00a0sodium\u00a0per tablet.\u00a0This corresponds to 2.1% of the highest recommended daily intake of\u00a0sodium\u00a0for adults.<\/li><li><em>500 mg<\/em>\u00a0&#8211; contains 69 mg of\u00a0sodium\u00a0per tablet.\u00a0This corresponds to 3.5% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Talk to your doctor or pharmacist if your need for Absenor is 2800 mg per day or more for an extended period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Absenor\u00a0Depot\u00a0prolonged-release tablets\u00a0contain soy lecithin<\/strong><\/li><\/ul>\n\n\n\n<p>If you are allergic to peanuts or soy, do not use this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Take Absenor<\/h2>\n\n\n\n<p>Please note that your doctor may have prescribed Absenor for other uses and in a different\u00a0dose\u00a0than indicated in this leaflet.\u00a0Always follow your doctor&#8217;s\u00a0prescription the instructions on the medicine pack.\u00a0Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Treatment with Absenor must be initiated and supervised by a physician who specializes in the treatment of\u00a0epilepsy\u00a0or\u00a0bipolar disorder.<\/li><li>Dose\u00a0one should be determined by a doctor who adapts it individually for you.<\/li><li>The daily dose can vary greatly depending on age, body weight, and the severity of the disease.<\/li><li>Absenor is taken with a meal.<\/li><li><em>The prolonged-release tablets\u00a0are<\/em>\u00a0swallowed whole with water or juice.<\/li><li><em>Gastro\u00a0engines<\/em>\u00a0have a protective casing for tablets that are not dissolved until in the intestine, leading to fewer gastrointestinal side effects.\u00a0In order for this casing to remain intact, the\u00a0enteric tablets\u00a0must be swallowed whole.<\/li><\/ul>\n\n\n\n<p><strong>Epilepsy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Prolonged-release tablets:<\/em><ul><li><em>The usual maintenance dose<\/em>\u00a0is 20-30 mg\/kg body weight daily.\u00a0This usually corresponds to 4-10 tablets (300 mg) or 2-6 tablets (500 mg) divided into 1-2 dosing times.<\/li><li>The prolonged-release tablets\u00a0can also be used for children where appropriate.\u00a0<em>The usual\u00a0dose\u00a0for children<\/em>\u00a0is around 30 mg\/kg body weight daily.<\/li><\/ul><\/li><li><em>Entero-tablets:<\/em><ul><li><em>The usual\u00a0dose\u00a0for adults in epilepsy:<\/em>\u00a0at the beginning of treatment 300 mg 3 times a day,\u00a0dose\u00a0one is then gradually increased until the seizures are under control.<\/li><li><em>The usual\u00a0dose\u00a0for children with\u00a0epilepsy: at the beginning of treatment 20-40 mg\/kg body weight divided into 2-3\u00a0doses\u00a0is\u00a0given<\/em>.\u00a0Dose\u00a0one is then gradually increased until the seizures are under control.<\/li><\/ul><\/li><li>Do not stop treatment without consulting your doctor.\u00a0Otherwise, the disease may worsen.<\/li><li>Absenor can be combined with other medicines to treat\u00a0epilepsy.\u00a0Then pay extra attention if the following symptoms occur: fatigue, nausea, headache, altered eye, and muscle movements and consult a doctor as the\u00a0dose\u00a0may need to be adjusted.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Mania:<\/strong><ul><li>The daily\u00a0dose\u00a0should be determined and monitored individually by your doctor.<\/li><\/ul><\/li><li><em><strong>Starting dose<\/strong>:<\/em><ul><li>The recommended daily starting dose is 750 mg.<\/li><\/ul><\/li><li><strong><em>Average daily dose:<\/em>\u00a0<\/strong><ul><li>The recommended daily\u00a0dose\u00a0is usually between 1000 mg and 2000 mg.<\/li><\/ul><\/li><li>Signs of\u00a0acute\u00a0massive overdose are usually\u00a0<ul><li>Coma, with decreased muscle tension<\/li><li>Weak reflexes<\/li><li>Reduced\u00a0pupils<\/li><li>Impaired breathing<\/li><li>Metabolic\u00a0acidosis<\/li><li>Low\u00a0blood pressure<\/li><li>Collapse of blood circulation<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Absenor<\/h2>\n\n\n\n<p>If you forget to take your medicine, take a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Absenor Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects,\u00a0although not everybody gets them.<\/p>\n\n\n\n<p><strong>Angioedema&nbsp;<\/strong><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;<\/p>\n\n\n\n<p>Stop taking Absenor and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, tongue, or throat<\/li><li>Difficulty swallowing<\/li><li>Hives\u00a0and difficulty breathing<\/li><\/ul>\n\n\n\n<p><strong>Severe effects on the liver or pancreas&nbsp;<\/strong>&nbsp;<em>Uncommon (may&nbsp;<\/em><strong>affect&nbsp;<\/strong><em>up to 1 in 100 people):<\/em>&nbsp;<\/p>\n\n\n\n<p>Contact a doctor immediately if the following symptoms occur: <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Nausea<\/li><li>Drowsiness, and fatigue Which sometimes occur with repeated <ul><li>Vomiting or abdominal pain<\/li><li>Jaundice<\/li><li>Swelling in the legs or feet, and in case of sudden impaired seizure control.\u00a0<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>This can be a sign of a serious effect on the liver or pancreas (sometimes fatal).\u00a0This has usually affected children under the age of 3 with several disabilities, children who have received high\u00a0doses\u00a0in combination with other antiepileptic drugs, and more rare children who only take Absenor.<\/p>\n\n\n\n<p><strong>Agranulocytosis&nbsp;<\/strong><em>Rare (may affect up to 1 in 1,000 people):<\/em>&nbsp;<\/p>\n\n\n\n<p>Absence can in rare cases affect the white\u00a0blood cells\u00a0so that the defense of infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever with severe general deterioration<\/li><li>Fever with local infection symptoms such as <ul><li>Sore throat\/throat\/mouth<\/li><li>Difficulty urinating<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>You should see a doctor as soon as possible so that blood tests can rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0It is important that you then information about your medication.<\/p>\n\n\n\n<p><strong>Rhabdomyolysis<\/strong><em>&nbsp;Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>Stop taking Absenor and contact a doctor as soon as possible if you experience unexplained muscle pain, muscle cramps, or muscle weakness.\u00a0(There is an increased risk of\u00a0rhabdomyolysis\u00a0in people with a special enzyme deficiency, CPT type II.)<\/p>\n\n\n\n<p><strong>Lyell&#8217;s syndrome&nbsp;(&nbsp;toxic epidermal necrolysis&nbsp;)&nbsp;<\/strong><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>Contact a doctor immediately if you getserious widespread skin damage (skin peeling of the epidermis and superficial mucous membranes).<\/p>\n\n\n\n<p><strong>Stevens-Johnson syndrome<\/strong><em>&nbsp;Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<p>An extremely severe&nbsp;allergic reaction&nbsp;with skin rash usually in the form of blisters or sores in the oral cavity and eyes as well as other mucous membranes, such as genitals.<\/p>\n\n\n\n<p>Contact a doctor immediately if you get such a reaction.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur<\/strong><\/p>\n\n\n\n<p><em>Very common (may&nbsp;<\/em><em>affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tremors<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><em>Common (may&nbsp;<\/em><em>affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach upset in the form of pain, vomiting, and diarrhea<\/li><li>Gum problems,\u00a0inflammation\u00a0of the oral mucosa<\/li><li>Transient and\/or dose-dependent hair loss<\/li><li>Problems with nails and\u00a0nail bed<\/li><li>Allergic skin reactions<\/li><li>Increased appetite<\/li><li>Abnormal weight gain<\/li><li>Loss of appetite,<\/li><li>Weight loss<\/li><li>Confusion<\/li><li>Hallucinations<\/li><li>Aggression<\/li><li>Agitation<\/li><li>Problems with attention<\/li><li>Dizziness<\/li><li>Extrapyramidal symptoms<ul><li>Stiffness<\/li><li>Drowsiness<\/li><li>Cramps<\/li><li>Impaired memory<\/li><li>Headache<\/li><li>Rapid<\/li><li>Uncontrolled eye movements<\/li><\/ul><\/li><li>Increased tendency to bleed due to decreased\u00a0platelet count\u00a0(\u00a0thrombocytopenia) or prolonged bleeding time, bleeding<\/li><li>Anemia<\/li><li>Painful menstruation<\/li><li>Deafness<\/li><li>Liver damage, the effect on liver function with a change in liver function values<\/li><li>Reduced amount of\u00a0sodium\u00a0in the blood, which i.a.\u00a0can lead to confusion<\/li><li>Urinary incontinence (accidental urination).<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may&nbsp;<\/em><em>affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty sleeping<\/li><li>An ant crawling and tingling, disorders of coordination (ability to coordinate), transient&nbsp;parkinsonism&nbsp;(shaking, stiffness), unsteady gait, decreased level of consciousness,&nbsp;coma, effects on the brain, aggravated seizures that may occur more often<\/li><li>Reduction in the number of&nbsp;white blood cells&nbsp;(&nbsp;leukopenia&nbsp;), shortage of all types of&nbsp;blood cell&nbsp;s<\/li><li>More frequent urination, impaired renal function<\/li><li>Swelling of the legs or feet (&nbsp;edema&nbsp;), water in the lung sac, increased amount of fluid in the body<\/li><li>Lowered body temperature<\/li><li>Fatigue<\/li><li>Hair problems (change in hair color, hair structure, hair growth)<\/li><li>Irregular or missed periods, too high levels of male sex hormones<\/li><li>Inflammation&nbsp;of the pancreas<\/li><li>Inflammation&nbsp;of a vessel wall (&nbsp;vasculitis&nbsp;)<\/li><li>Skeletal diseases, e.g.&nbsp;reduced bone density, osteoporosis, and bone fractures.&nbsp;Contact a doctor or pharmacist if you are being treated with epilepsy medication for a long time, if you know you have osteoporosis or if you are on medication with&nbsp;steroids.<\/li><\/ul>\n\n\n\n<p><em>Rare (may&nbsp;<\/em><em>affect up to 1 in 1,000 people)<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Prolonged bleeding time, abnormal coagulation tests, increased\u00a0white blood cell count, impaired bone marrow function which includes very severe\u00a0anemia\u00a0(pure red cell aplasia), conditions where normal blood formation is disturbed,\u00a0anemia with enlarged\u00a0red blood cells<\/li><li>SLE\u00a0(a severe\u00a0autoimmune\u00a0disease)<\/li><li>Psychosis<ul><li>Behavioral disorders<\/li><li>Hyperactivity<\/li><li>Learning disabilities<\/li><li>Memory impairment<\/li><li>Transient dementia<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">Double vision<\/a><\/li><\/ul><\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">Constipation<\/a><\/li><li>Severe liver effects in older children<\/li><li>Elevated levels of ammonium ions in the blood<\/li><li>Bedwetting,\u00a0inflammation\u00a0of the kidneys, transient renal impairment (Fanconi syndrome)<\/li><li>Impaired thyroid function<\/li><li>Infertility\u00a0in men, polycystic ovaries (ovaries produce more vesicles than normal)<\/li><li>Biotin deficiency (b-vitamin component)<\/li><li>Obesity<\/li><li>In very rare cases, severe brain effects have been reported, especially with concomitant treatment with topiramate or phenobarbital, or with a sudden increase in the sodium valproate dose.\u00a0A condition with drug-induced skin rash, enlarged\u00a0lymph nodes,\u00a0and the possible deterioration of other organs has been reported.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Absenor<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Store in the original package.\u00a0Close the package tightly.\u00a0Moisture sensitive.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton.\u00a0The expiration date is the last day of the specified month.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Absenor\u00a0gastro\u00a0s<\/em>\u00a0<ul><li>The active substance is sodium valproate 100 mg, 300 mg, and 500 mg.\u00a0<\/li><li>The other ingredients are povidone, calcium silicate, talc, magnesium stearate, partially hydrolyzed polyvinyl alcohol, titanium dioxide, macrogol, polyvinyl acetate phthalate, sodium bicarbonate, triethyl citrate, stearic acid, sodium alginate, anhydrous\u00a0colloidal\u00a0silicon dioxide.<\/li><\/ul><\/li><li><em>Absenor\u00a0Depot\u00a0release tablet\u00a0s<\/em>\u00a0<ul><li>The active substance is sodium valproate 300 mg and 500 mg.\u00a0<\/li><li>The other ingredients are crospovidone, hypromellose, anhydrous\u00a0colloidal\u00a0silica, magnesium stearate, polyvinyl alcohol, titanium dioxide (dye E 171), talc, lecithin (soy) (E322), xanthan gum.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance Of The Drug<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Absenor 100 mg\u00a0enteric tablets\u00a0are white, round, cupped, diameter 7.4 mm\u00a0<\/li><li>Absenor 300 mg\u00a0enteric tablets\u00a0are white, round, cupped, diameter 10.4 mm\u00a0<\/li><li>Absenor 500 mg\u00a0enteric tablets\u00a0are white, round, cupped, diameter 12.4 mm.<\/li><li><strong>Absenor\u00a0Depot\u00a0300 mg<\/strong>\u00a0prolonged-release tablets\u00a0are white, round, film-coated, convex, diameter 12.5 mm.\u00a0<\/li><li><strong>Absenor\u00a0Depot\u00a0500 mg<\/strong>\u00a0prolonged-release tablets\u00a0are white, capsule-shaped, film-coated, size 9.9 x 20.8 mm.\u00a0<\/li><li>The Absenor\u00a0Depot\u00a0package contains a desiccant capsule.<\/li><li><strong>Pack sizes:<\/strong><ul><li>Gastro\u00a0s 100 mg: 100 and 300\u00a0gastro\u00a0s<\/li><li>Gastro\u00a0s 300 mg: 100 and 300\u00a0gastro\u00a0s<\/li><li>Gastro\u00a0s 500 mg: 100 and 200\u00a0gastro\u00a0s<\/li><li>Absenor\u00a0XR\u00a0300 mg and 500 mg: 100\u00a0release tablet\u00a0s<\/li><\/ul><\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Orion Corporation\u00a0<br>Orionintie 1\u00a0<br>FI-02200 Espoo\u00a0<br>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;<br>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Joensuunkatu 7<\/p>\n\n\n\n<p>FI-24100 Salo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Absenor is approved for the subsequent indications: \u2022 Remedy of epilepsy. Medicine of manic attacks in bipolar sickness. The continuation of treatment after a manic episode could consider in patients who have responded to valproate for acute mania.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[12024,12027,12029,12023,12028,12012,12022,12026,12025,12013,12014],"class_list":["post-4502","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-absenor","tag-absenor-tablet","tag-benefits-of-absenor","tag-benefits-of-valproic-acid","tag-side-effects-of-absenor","tag-valproic-acid","tag-valproic-acid-side-effects","tag-what-absenor-is-used-for","tag-what-is-absenor","tag-what-is-valproic-acid","tag-what-valproic-acid-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4502"}],"version-history":[{"count":107,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4502\/revisions"}],"predecessor-version":[{"id":39058,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4502\/revisions\/39058"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}