{"id":4439,"date":"2020-11-21T17:13:56","date_gmt":"2020-11-21T17:13:56","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4439"},"modified":"2021-08-28T08:12:32","modified_gmt":"2021-08-28T08:12:32","slug":"abboticin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/abboticin\/","title":{"rendered":"Abboticin &#8211; Erythromycin uses, dose and side effects"},"content":{"rendered":"\n<p> 1 g&nbsp;powder for&nbsp;solution&nbsp;for&nbsp;infusion,&nbsp;<br>erythromycin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Abboticin is and what it is used for<\/h2>\n\n\n\n<p>Abboticin interferes with the bacteria&#8217;s production of&nbsp;proteins&nbsp;and thus prevents the bacteria from multiplying.<\/p>\n\n\n\n<p>Abboticin is mainly used in various bacterial infections of the respiratory tract such as&nbsp;pneumonia, pertussis, and&nbsp;diphtheria.&nbsp;Abboticin is also used in&nbsp;infections&nbsp;in the abdomen as well as in eye inflammation and&nbsp;pneumonia&nbsp;in newborns caused by a Chlamydia bacterium.<\/p>\n\n\n\n<p>Abboticin is also used in the treatment of community-acquired pneumonia, skin, and soft tissue infections in people who do not tolerate&nbsp;penicillin&nbsp;or where&nbsp;penicillin&nbsp;is inappropriate for other reasons.<\/p>\n\n\n\n<p>Erythromycin contained in Abboticin may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you should know before you receive Abboticin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You must not be given Abboticin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to erythromycin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have abnormally low levels of&nbsp;potassium&nbsp;or&nbsp;magnesium&nbsp;in your blood (hypomagnesemia&nbsp;or&nbsp;hypokalaemia&nbsp;)<\/li><li>if you or someone in your family has a history of cardiac arrhythmias (ventricular&nbsp;arrhythmia&nbsp;or&nbsp;torsades de pointes&nbsp;) or an abnormality in the electrocardiogram (electrical recording of the heart) called &#8220;long&nbsp;QT&nbsp;syndrome&#8221;.<\/li><li>if you are taking any of the following medicines:<ul><li>astemizole or terfenadine (medicines for&nbsp;allergies&nbsp;)<\/li><li>cisapride (medicine for gastrointestinal disorders)<\/li><li>dihydroergotamine (medicine for low&nbsp;blood pressure&nbsp;)<\/li><li>disopyramide&nbsp;(medicine for heart problems)<\/li><li>ergotamine&nbsp;(anti-migraine&nbsp;medication&nbsp;)<\/li><li>pimozide (medicine for mental illness)<\/li><li>drugs called statins, e.g.&nbsp;simvastatin, atorvastatin, and lovastatin (medicines to treat high blood fats).<\/li><li>domperidone (medicines for nausea and vomiting)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before receiving Abboticin<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have impaired liver function<\/li><li>if you are taking other medicines that are known to cause severe heart rhythm disorders<\/li><li>if you have heart problems.<\/li><li>if you suffer from&nbsp;Myasthenia gravis, as symptoms may worsen.<\/li><\/ul>\n\n\n\n<p>If your child gets Abboticin and starts vomiting or gets irritated during feeding, contact a doctor immediately.<\/p>\n\n\n\n<p>Bacteria can cause diarrhea during and after treatment with Abboticin.&nbsp;Contact your doctor if you have prolonged or severe diarrhea.<\/p>\n\n\n\n<p>Contact a doctor if you get a new&nbsp;infection&nbsp;while you are being treated with Abboticin.&nbsp;Your doctor will decide if you need to change treatment<\/p>\n\n\n\n<p>If you notice any visual impairment after treatment with this medicine, consult a doctor.<\/p>\n\n\n\n<p>If you are going to take a urine sample, tell your doctor that you are using erythromycin, as it may affect some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Abboticin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><strong>It is especially important to consult a doctor if you are taking any of the medicines mentioned&nbsp;in the section &#8221;&nbsp;You must&nbsp;not&nbsp;be given&nbsp;Abboticin&#8221;.<\/strong><\/p>\n\n\n\n<p>Ask your doctor for advice if you are taking the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluconazole,&nbsp;ketoconazole,&nbsp;and itraconazole (used to treat fungal infections)<\/li><li>protease inhibitors&nbsp;(used in&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;)<\/li><li>oral contraceptives (&nbsp;birth control pills&nbsp;)<\/li><li>clarithromycin, rifampicin (for bacterial infections)<\/li><li>digoxin,&nbsp;quinidine&nbsp;(used for heart problems)<\/li><li>cilostazol (used for&nbsp;window disease&nbsp;)<\/li><li>anticoagulants, e.g.&nbsp;warfarin, acenocoumarol, and rivaroxaban (used for blood thinning)<\/li><li>fexofenadine (used to&nbsp;treat allergies&nbsp;)<\/li><li>valproate, carbamazepine, phenobarbital, or&nbsp;phenytoin&nbsp;(for&nbsp;epilepsy&nbsp;)<\/li><li>theophylline (used for&nbsp;asthma&nbsp;and other respiratory problems)<\/li><li>ciclosporin, tacrolimus (used after organ transplantation)<\/li><li>bromocriptine (used to treat&nbsp;Parkinson&#8217;s disease&nbsp;)<\/li><li>zopiclone, triazolam, alprazolam, clozapine, midazolam, hexobarbitone (used for anxiety, worry, and sleep disorders)<\/li><li>alfentanil (for pain during surgery)<\/li><li>cimetidine, omeprazole (used to treat acid reflux and&nbsp;stomach ulcers&nbsp;)<\/li><li>colchicine (used for joint pain)<\/li><li>methylprednisolone (used to suppress the body&#8217;s immune system eg in case of&nbsp;allergies&nbsp;and&nbsp;inflammation&nbsp;)<\/li><li>St. John&#8217;s wort&nbsp;(a natural remedy)<\/li><li>verapamil (used to treat heart disease such as high&nbsp;blood pressure&nbsp;)<\/li><li>vinblastine (used to treat certain types of cancer)<\/li><li>sildenafil (used for erection problems)<\/li><\/ul>\n\n\n\n<p><em>Important!&nbsp;Do not&nbsp;change the dosage of&nbsp;one of these drugs on your own without first talking to your doctor.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Women who are planning to become pregnant or are pregnant should not use Abboticin.&nbsp;Treatment with Abboticin should be taken only if absolutely necessary and only after a doctor&#8217;s&nbsp;prescription.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Abboticin should be used with caution in breast-feeding mothers as erythromycin is excreted in human milk and may cause&nbsp;side effects&nbsp;in the baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p>No effects on the ability to drive and use machines have been observed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to get Abboticin<\/h2>\n\n\n\n<p>Abboticin is given to you by a doctor or nurse, as an&nbsp;infusion&nbsp;directly into the bloodstream.&nbsp;Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.&nbsp;The size of the dose depends on the type and severity of the infection.<\/p>\n\n\n\n<p><em>The recommended&nbsp;dose&nbsp;for adults<\/em>&nbsp;is 15-20 mg \/ kg \/ day.&nbsp;If necessary, the&nbsp;dose&nbsp;can be increased up to 4 grams per day.&nbsp;Abboticin can be given in divided&nbsp;doses&nbsp;every 6 or 8 hours or as a&nbsp;continuous&nbsp;intravenous&nbsp;infusion.<\/p>\n\n\n\n<p><em>The recommended&nbsp;dose&nbsp;for children<\/em>&nbsp;is 15-50 mg\/kg\/day in divided&nbsp;doses&nbsp;every 6 or 8 hours or as a&nbsp;continuous&nbsp;intravenous&nbsp;infusion.<\/p>\n\n\n\n<p>Even after a couple of days of treatment with Abboticin, you can feel better.&nbsp;<em>However, it is very important that the entire course is completed according to the doctor&#8217;s&nbsp;prescription.&nbsp;<\/em>If this does not happen, the bacteria are given the opportunity to recover and&nbsp;infection&nbsp;can flare up again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Contact&nbsp;<strong>a<\/strong>&nbsp;doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat, difficulty swallowing&nbsp;hives,&nbsp;and difficulty breathing.<\/li><\/ul>\n\n\n\n<p>These symptoms may be signs of&nbsp;<strong>angioedema<\/strong>&nbsp;or&nbsp;<strong>allergic reaction<\/strong>&nbsp;(&nbsp;anaphylaxis&nbsp;).&nbsp;Angioedema&nbsp;occurs in an unknown number of people (no known frequency) while allergic reactions can occur in up to 1 in 100 people (rare)<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported in an unknown number of users.&nbsp;Contact a doctor immediately if you get the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe skin reaction: red, scaly rash with lumps under the skin and blisters (exanthematous&nbsp;pustulosis&nbsp;).<\/li><li>skin and mucosal changes (sometimes severe) and severe skin damage (skin peeling).<\/li><li>abnormal heart rhythm (including palpitations, rapid heartbeat, life-threatening irregular heartbeat called&nbsp;torsades de pointes,&nbsp;or abnormal&nbsp;ECG&nbsp;heart tracking) or cardiac arrest.<\/li><li>inflammation&nbsp;of the kidneys (a condition called interstitial nephritis).<\/li><li>certain forms of hepatitis (cholestatic and hepatocellular&nbsp;hepatitis&nbsp;).<\/li><li>jaundice (causes yellowing of the skin and whites of the eyes).<\/li><li>hepatic impairment, liver enlargement, and liver failure.<\/li><li>prolonged or severe diarrhea<\/li><\/ul>\n\n\n\n<p>Other side effects:<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stomach upset (in the form of nausea, stomach cramps, and diarrhea).<\/li><li>rash.<\/li><li>swelling and pain at the infusion site.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives.<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1000 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>temporary hearing loss especially in patients with high&nbsp;doses&nbsp;or who have impaired renal function)<\/li><li>elevated liver values \u200b\u200b(seen with laboratory tests)<\/li><li>bile stasis (a condition caused by a blockage in the liver)<\/li><li>liver inflammation (&nbsp;hepatitis&nbsp;).<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users<\/em>&nbsp;)&nbsp;<em>:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling sick<\/li><li>abdominal pain<\/li><li>inflamed&nbsp;pancreas&nbsp;(&nbsp;pancreatitis&nbsp;)<\/li><li>vomiting<\/li><li>tinnitus (&nbsp;tinnitus&nbsp;)<\/li><li>deafness<\/li><li>chest pain<\/li><li>fever<\/li><li>loss of appetite<\/li><li>confusion<\/li><li>cramps<\/li><li>dizziness<\/li><li>impaired vision<\/li><li>hallucinations (seeing or hearing things that are not there),<\/li><li>low&nbsp;blood pressure<\/li><li>itching<\/li><li>increase in the number of&nbsp;white blood cells&nbsp;in the blood (&nbsp;eosinophilia&nbsp;)<\/li><\/ul>\n\n\n\n<p>Fungal overgrowth in the oral cavity and abdomen may occur.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Abboticin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is erythromycin.&nbsp;1&nbsp;vial&nbsp;contains erythromycin lactobionate equivalent to 1 g of erythromycin.<\/li><li>Other ingredients: none<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>White or almost white powder.<\/p>\n\n\n\n<p><em>Pack size:&nbsp;Vial<\/em>, 1g.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Amdipharm Limited&nbsp;<br>Temple Chambers&nbsp;<br>3 Burlington Road&nbsp;<br>Dublin 4&nbsp;<br>Ireland<\/p>\n\n\n\n<p>Tel.&nbsp;+44 1268 82 3049<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Delpharm Saint Remy<\/p>\n\n\n\n<p>Rue de l&#8217;Isle<\/p>\n\n\n\n<p>Saint Remy Sur Avre,<\/p>\n\n\n\n<p>28380, France<\/p>\n\n\n\n<p>This leaflet was last modified on 7 October 2020<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The following information is intended for healthcare professionals only:<\/h2>\n\n\n\n<p><strong>USED \u200b\u200bFOR IV&nbsp;INFUSION ONLY.<\/strong><\/p>\n\n\n\n<p><strong>MAY NOT BE GIVEN AS A BOLUS INJECTION.<\/strong><br><\/p>\n\n\n\n<p><strong><em>Preparation&nbsp;of 1 g powder for&nbsp;solution&nbsp;for&nbsp;infusion<\/em><\/strong><br><\/p>\n\n\n\n<p><strong>1:&nbsp;Preparation&nbsp;of stock solution:<\/strong><\/p>\n\n\n\n<p>A 5%&nbsp;stock solution&nbsp;(50 mg erythromycin\/ml) is prepared by dissolving the powder in the vial (1 g erythromycin) in 20 ml water for injections.&nbsp;The stock solution&nbsp;must be further diluted before&nbsp;administration.&nbsp;The stock solution&nbsp;should be used immediately after&nbsp;reconstitution&nbsp;and any residue discarded.&nbsp;For aseptic&nbsp;preparation,&nbsp;the stock solution&nbsp;can be&nbsp;stored for up to 24 hours in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<br><\/p>\n\n\n\n<p><strong>2: Dilution of&nbsp;stock solution<\/strong><\/p>\n\n\n\n<p>a)&nbsp;Infusion&nbsp;fluid for intermittent infusion:<\/p>\n\n\n\n<p>Further, dilute&nbsp;20 ml of&nbsp;the stock solution&nbsp;by adding 200-250 ml of suitable&nbsp;infusion solution&nbsp;(see below).<br><\/p>\n\n\n\n<p>b)&nbsp;infusion&nbsp;for&nbsp;continuous&nbsp;infusion:<\/p>\n\n\n\n<p>Further, dilute&nbsp;20 ml of&nbsp;the stock solution&nbsp;by adding 500 ml or 1000 ml of suitable&nbsp;infusion solution&nbsp;(see below).<\/p>\n\n\n\n<p>A reconstituted&nbsp;infusion solution&nbsp;should be used immediately after&nbsp;reconstitution.<\/p>\n\n\n\n<p><em>Infusion fluids suitable for diluting the stock solution:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Call&nbsp;isotonic&nbsp;saline solution, Sodium chloride 9 mg\/ml&nbsp;solution for infusion.<\/li><li>Glucose&nbsp;50 mg \/ ml and 100 mg \/ ml and Ringer&nbsp;glucose&nbsp;with sodium bicarbonate 14 mg \/ ml.<\/li><\/ul>\n\n\n\n<p>Solutions containing&nbsp;glucose&nbsp;must first be added to sodium bicarbonate as a&nbsp;buffer to ensure neutrality.<\/p>\n\n\n\n<p>Make sure that the finished infusion solution is free of particles before&nbsp;administration.<\/p>\n\n\n\n<p><strong><em>Method of administration<\/em><\/strong><\/p>\n\n\n\n<p>As rapid&nbsp;infusion is&nbsp;more commonly associated with&nbsp;arrhythmias&nbsp;or&nbsp;hypotension, it is recommended that Abboticin&nbsp;infusion fluid&nbsp;be given slowly.&nbsp;This should be especially considered for patients with risk factors or previous signs of&nbsp;arrhythmias.<\/p>\n\n\n\n<p>The low infusion rate is also recommended for heart disease and premature infants.<\/p>\n\n\n\n<p>a) Intermittent infusion:<\/p>\n\n\n\n<p>The reconstituted infusion solution is infused slowly&nbsp;intravenously&nbsp;(max. 5 ml\/min for 20-60 minutes) to avoid local irritation.<\/p>\n\n\n\n<p>b)&nbsp;Continuous&nbsp;infusion:<\/p>\n\n\n\n<p>The finished infusion solution is administered as a&nbsp;continuous&nbsp;infusion&nbsp;over up to 24 hours<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abboticin interferes with the bacteria&#8217;s production of proteins and thus prevents the bacteria from multiplying.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[12064,12067,3876,3879,12058,12068,12066,12057,12065,3880],"class_list":["post-4439","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-abboticin","tag-abboticin-tablet","tag-erythromycin","tag-erythromycin-side-effects","tag-erythromycin-tablet","tag-side-effects-of-abboticin","tag-what-abboticin-is-used-for","tag-what-erythromycin-is-used-for","tag-what-is-abboticin","tag-what-is-erythromycin"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4439"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4439\/revisions"}],"predecessor-version":[{"id":13271,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4439\/revisions\/13271"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}