{"id":4422,"date":"2020-11-21T14:50:32","date_gmt":"2020-11-21T14:50:32","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4422"},"modified":"2021-08-28T08:13:13","modified_gmt":"2021-08-28T08:13:13","slug":"abacavir-lamivudine-teva","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/abacavir-lamivudine-teva\/","title":{"rendered":"Abacavir \/ Lamivudine Teva &#8211; Lamivudine uses, dose and side effects"},"content":{"rendered":"\n<p> 600 mg \/ 300 mg&nbsp;film-coated tablets&nbsp;<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">abacavir<\/a> \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Abacavir \/ Lamivudine Teva is and what it is used for<\/h2>\n\n\n\n<p><strong>Abacavir \/ Lamivudine Teva used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;infection&nbsp;with human immunodeficiency virus) in adults, adolescents, and children weighing at least 25 kg.<\/strong><\/p>\n\n\n\n<p>Abacavir \/ Lamivudine Teva contains two active substances that are used to treat&nbsp;HIV infection: abacavir and lamivudine.&nbsp;These substances belong to a group of antiretroviral drugs called&nbsp;nucleoside&nbsp;reverse transcriptase inhibitors (NRTIs).<\/p>\n\n\n\n<p>Abacavir \/ Lamivudine Teva does not cure&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;completely.&nbsp;It reduces the number of&nbsp;viruses&nbsp;in the body and keeps it at a low level.&nbsp;It also increases the number of CD4 cells in the blood.&nbsp;CD4 cells are a type of&nbsp;white blood cell&nbsp;that is important for the body to fight&nbsp;infections.<\/p>\n\n\n\n<p>Not all patients respond to Abacavir \/ Lamivudine Teva in the same way.&nbsp;Your doctor will check the treatment effect you are getting.<\/p>\n\n\n\n<p>Abacavir and lamivudine contained in Abacavir \/ Lamivudine Teva may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Abacavir \/ Lamivudine Teva:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to abacavir (or to any other medicine containing abacavir) or lamivudine or any of the other ingredients of this medicine (listed in section 6). <strong>Be sure to read all the information about&nbsp;hypersensitivity reactions&nbsp;in Section 4.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Check with your doctor<\/strong>&nbsp;if you think this applies to you.&nbsp;<strong>Do not take Abacavir \/ Lamivudine Teva.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Some patients taking Abacavir \/ Lamivudine Teva or other combination therapies for&nbsp;HIV are&nbsp;at greater risk for serious&nbsp;side effects.&nbsp;You need to be aware of the extra risks:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;<strong>moderate or severe liver disease<\/strong><\/li><li>if you have a&nbsp;history of liver disease, including&nbsp;hepatitis&nbsp;B or&nbsp;hepatitis&nbsp;C (if you have&nbsp;hepatitis&nbsp;B&nbsp;infection, do not stop taking Abacavir \/ Lamivudine Teva without consulting your doctor as your&nbsp;hepatitis&nbsp;may return)<\/li><li>if you are severely&nbsp;<strong>overweight<\/strong>&nbsp;(especially if you are a woman)<\/li><li>if you have&nbsp;<strong>any kidney disease<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor before taking Abacavir \/ Lamivudine Teva if any of these apply to you.&nbsp;<\/strong>You may need extra checks, including blood tests, while you are taking medication.&nbsp;<strong>See section 4 for more information.<\/strong><\/p>\n\n\n\n<p><strong>Hypersensitivity reaction&nbsp;to abacavir<\/strong><\/p>\n\n\n\n<p>Even patients who do not have the HLA-B * 5701 gene may develop a&nbsp;<strong>hypersensitivity reaction<\/strong>&nbsp;(severe&nbsp;allergic reaction&nbsp;).<\/p>\n\n\n\n<p><strong>Be sure to read all the information about&nbsp;hypersensitivity reactions&nbsp;in section 4 of this leaflet.<\/strong><\/p>\n\n\n\n<p><strong>Risk of heart attack<\/strong><\/p>\n\n\n\n<p>It cannot be ruled out that abacavir may increase the risk of myocardial infarction.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you have heart problems, if you smoke or if you have other diseases that may increase the risk of heart diseases such as high&nbsp;blood pressure&nbsp;or&nbsp;diabetes.&nbsp;Do not stop taking Abacavir \/ Lamivudine Teva unless your doctor tells you to.<\/p>\n\n\n\n<p><strong>Pay attention to important symptoms<\/strong><\/p>\n\n\n\n<p>Some patients who use drugs against&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;develop other conditions, which can be serious.&nbsp;You need to know important signs and symptoms to notice while taking Abacavir \/ Lamivudine Teva.<\/p>\n\n\n\n<p><strong>Read the information \u201cOther possible&nbsp;side effects&nbsp;of combination therapy for HIV\u201d in section 4 of this leaflet.<\/strong><\/p>\n\n\n\n<p><strong>Protect other people<\/strong><\/p>\n\n\n\n<p>HIV&nbsp;&#8211;&nbsp;infection&nbsp;is spread by sexual contact with someone with&nbsp;infection&nbsp;one or by infected blood (eg. Ex. By sharing needles).&nbsp;You can still transmit&nbsp;HIV&nbsp;infection when you take this medicine, even though the risk of effective&nbsp;antiviral&nbsp;therapy is&nbsp;reduced.&nbsp;Discuss with your doctor the necessary steps to avoid infecting others.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking, have recently taken,<\/strong> or might take any other medicines, including&nbsp;medicines obtained&nbsp;without a prescription, herbal medicines, herbal medicines, or other natural products.<\/p>\n\n\n\n<p>Remember to tell your doctor or pharmacist if you start taking a new medicine while taking Abacavir \/ Lamivudine Teva<\/p>\n\n\n\n<p><strong>These medicines should not be taken with Abacavir \/ Lamivudine Teva:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>emtricitabine, to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection<\/li><li>other drugs containing lamivudine, for treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;or&nbsp;hepatitis B&nbsp;infection<\/li><li>high&nbsp;doses&nbsp;of&nbsp;trimethoprim\/sulfamethoxazole, an&nbsp;antibiotic<\/li><li>cladribine, which is used to treat&nbsp;hairy cell leukemia.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are being treated with any of these medicines.<\/p>\n\n\n\n<p><strong>Some medicines affect or are affected by Abacavir \/ Lamivudine Teva<\/strong><\/p>\n\n\n\n<p>These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>phenytoin<\/strong>, for the treatment of&nbsp;epilepsy. <strong>Tell your doctor<\/strong>&nbsp;if you are taking&nbsp;phenytoin.&nbsp;Your doctor may need to check you while you are taking Abacavir \/ Lamivudine Teva.<\/li><li><strong>methadone<\/strong>&nbsp;is used as a&nbsp;heroin substitute.&nbsp;Abacavir increases the rate at which&nbsp;methadone is&nbsp;eliminated from the body.&nbsp;If you are taking&nbsp;methadone, you will be checked for withdrawal symptoms.&nbsp;Your methadone dose may need to be changed. Tell your doctor&nbsp;if you are taking&nbsp;methadone.<\/li><li>medicines (usual liquids) containing&nbsp;sorbitol and other sugar alcohols&nbsp;(such as xylitol, mannitol, lactitol, and maltitol), if taken regularly. <strong>Tell your doctor or pharmacist<\/strong>&nbsp;if you are being treated with any of these medicines.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p><strong>Abacavir \/ Lamivudine Teva&nbsp;is not recommended for use during pregnancy.&nbsp;<\/strong>&nbsp;Abacavir \/ Lamivudine Teva and similar medicines can cause&nbsp;side effects&nbsp;in the unborn baby.&nbsp;If you have taken Abacavir \/ Lamivudine Teva during your pregnancy, your doctor may ask you to have regular blood tests and other diagnostic tests to check your baby&#8217;s development.&nbsp;For children with a&nbsp;mother&nbsp;who has taken NRTIs during pregnancy, the benefit of&nbsp;HIV&nbsp;protection outweighs the&nbsp;risk of&nbsp;side effects.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p><strong>Women who are&nbsp;HIV-&nbsp;positive should not breast-feed<\/strong>&nbsp;because&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;can be transmitted to the baby through breast milk.&nbsp;A small amount of the ingredients in Abacavir \/ Lamivudine Teva may also pass into breast milk.<\/p>\n\n\n\n<p>If you are breast-feeding or considering breastfeeding:<\/p>\n\n\n\n<p><strong>Talk to your doctor immediately.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Abacavir \/ Lamuvidin Teva may cause&nbsp;side effects&nbsp;that may affect your ability to drive or use machines.&nbsp;<strong>Talk to your doctor<\/strong>&nbsp;about your ability to drive or use machines while taking Abacavir \/ Lamivudine Teva.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abacavir \/ Lamivudine Teva contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie&nbsp;essentially&nbsp;&#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<p><strong>Always take this medicine exactly as your doctor has told you.&nbsp;<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;of Abacavir \/ Lamivudine Teva for adults, adolescents, and children weighing at least 25 kg is one tablet once a day.<\/strong><\/p>\n\n\n\n<p>Swallow the tablets whole with a little water.&nbsp;Abacavir \/ Lamivudine Teva can be taken with or without food.<\/p>\n\n\n\n<p><strong>Keep in regular contact with your doctor<\/strong><\/p>\n\n\n\n<p>Abacavir \/ Lamivudine Teva helps keep your disease under control.&nbsp;You must take it every day to prevent the disease from getting worse.&nbsp;You may still develop other&nbsp;infections&nbsp;you or illnesses associated with&nbsp;HIV&nbsp;&#8211;&nbsp;infection.<\/p>\n\n\n\n<p><strong>Keep in touch with your doctor and do not stop taking Abacavir \/ Lamivudine Teva<\/strong>&nbsp;without&nbsp;your doctor&#8217;s advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose, take it as soon as you remember.&nbsp;Then continue with the treatment as before.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<p>It is important that you take Abacavir \/ Lamivudine Teva regularly, as irregular intake may increase the risk of&nbsp;hypersensitivity reactions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have stopped taking Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<p>If for any reason you have stopped taking Abacavir \/ Lamivudine Teva &#8211; then you think you may have had&nbsp;side effects&nbsp;or due to another illness:<\/p>\n\n\n\n<p><strong>Talk to your doctor before taking the medicine again<\/strong>.&nbsp;Your doctor will check if your symptoms were related to a&nbsp;hypersensitivity reaction.&nbsp;If your doctor thinks there is a connection,&nbsp;&nbsp;you will be asked never to take Abacavir \/ Lamivudine Teva or other medicines containing abacavir again.&nbsp;It is important that you follow this advice.<\/p>\n\n\n\n<p>If your doctor advises you to start taking Abacavir \/ Lamivudine Teva again, you may be asked to take the first&nbsp;dose&nbsp;in a place where you have access to medical care if needed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;Your doctor will perform tests to find such changes<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>In the treatment of an&nbsp;HIV&nbsp;&#8211;&nbsp;infection, it is not always possible to tell whether a symptom of drug side effects caused by Abacavir \/ Lamivudine Teva or by other medicines taken at the same time.&nbsp;<strong>For this reason, it is very important that you talk to your doctor about any changes in your state of health.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Hypersensitivity&nbsp;s<\/strong><strong>Abacavir \/ Lamivudine Teva<\/strong>&nbsp;contains&nbsp;<strong>abacavir<\/strong>&nbsp;.&nbsp;Abacavir can cause a severe&nbsp;allergic reaction&nbsp;, a so-called&nbsp;hypersensitivity reaction&nbsp;.&nbsp;These&nbsp;hypersensitivity reactions&nbsp;have been seen more frequently in people taking abacavir-containing medicines.<br><strong>Who can get these reactions?<\/strong>Anyone taking Abacavir \/ Lamivudine Teva may develop a&nbsp;hypersensitivity reaction&nbsp;to abacavir, which may be life-threatening if they continue to take Abacavir \/ Lamivudine Teva.<br>You are more likely to develop this reaction if you have a gene called&nbsp;<strong>HLA-B * 5701<\/strong>&nbsp;(but you can get a reaction even if you do not have this gene).&nbsp;You should have been tested for this gene before you were prescribed Abacavir \/ Lamivudine Teva.&nbsp;<strong>If you know that you carry this gene, talk to your doctor before taking Abacavir \/ Lamivudine Teva.<\/strong><br>About 3-4 out of every 100 patients&nbsp;treated with abacavir&nbsp;in a&nbsp;clinical study&nbsp;who did not carry the HLA-B * 5701 gene developed a&nbsp;hypersensitivity reaction&nbsp;.<br><strong>What are the symptoms?<\/strong>The most common symptoms are:<strong>fever<\/strong>&nbsp;(high temperature) and&nbsp;<strong>rash<\/strong>&nbsp;.<strong>Other<\/strong>&nbsp;common symptoms are:<strong>nausea<\/strong>&nbsp;, vomiting, diarrhea, abdominal pain, pronounced fatigue.Other symptoms are:Joint or muscle pain, swollen throat, shortness of breath, sore throat, cough, temporary headache, eye inflammation (&nbsp;conjunctivitis&nbsp;), cold sores, low&nbsp;blood pressure&nbsp;, tingling or numbness in the hands or feet.<br><strong>When do these symptoms occur?<\/strong>Hypersensitivity reactions&nbsp;may occur at any time during treatment with Abacavir \/ Lamivudine Teva, but more likely during the first six weeks of treatment.<br><strong>Contact your doctor immediately:<\/strong><strong>1. if you get a rash, OR<\/strong><strong>2. if you get symptoms from at least 2 of the following groups:<\/strong>fevershortness of breath, sore throat or coughnausea or vomiting, diarrhea or abdominal painpronounced fatigue or pain or general malaise.<strong>Your doctor may advise you to stop taking Abacavir \/ Lamivudine Teva<\/strong>&nbsp;.<br><strong>If you have stopped taking Abacavir \/ Lamivudine Teva<\/strong>If you have stopped taking Abacavir \/ Lamivudine Teva due to a&nbsp;hypersensitivity reaction&nbsp;,&nbsp;<strong>you should NEVER take Abacavir \/ Lamivudine Teva, or any other medicine containing abacavir, again<\/strong>&nbsp;.&nbsp;If you do, you could get a dangerous drop in blood pressure within a few hours, which could result in death.<br>If you have stopped taking Abacavir \/ Lamivudine Teva for any reason &#8211; especially when you think you may have had&nbsp;side effects&nbsp;or due to another illness:<strong>Talk to your doctor before taking the medicine again<\/strong>&nbsp;.&nbsp;Your doctor will check if your symptoms were related to a&nbsp;hypersensitivity reaction&nbsp;.&nbsp;If your doctor thinks there is a connection,&nbsp;<strong>you will be asked never to take Abacavir \/ Lamivudine Teva or other medicines containing abacavir again<\/strong>&nbsp;.&nbsp;It is important that you follow this advice.<br>Occasionally,&nbsp;hypersensitivity reactions&nbsp;have developed in patients who start taking abacavir again and who had only one of the symptoms listed on the warning card before stopping taking the medicine.<br>In very rare cases,&nbsp;hypersensitivity reactions&nbsp;have developed in patients who start taking abacavir again but have no symptoms before stopping the medicine.<br>If your doctor advises you to start taking Abacavir \/ Lamivudine Teva again, you may be asked to take the first&nbsp;dose&nbsp;in a place where you have access to medical care if needed.<strong>If you are hypersensitive to Abacavir \/ Lamivudine Teva, return all unused Abacavir \/ Lamivudine Teva tablets for safe destruction.&nbsp;<\/strong>Consult your doctor or pharmacist.<br>Packages with Abacavir \/ Lamivudine Teva contains a&nbsp;<strong>warning cards<\/strong>&nbsp;&nbsp;to remind you and medical staff about&nbsp;hypersensitivity reaction&nbsp;you&nbsp;<strong>.&nbsp;<\/strong><strong>Remove the card from the packaging and always carry it with you.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypersensitivity reaction<\/li><li>headache<\/li><li>vomiting<\/li><li>nausea<\/li><li>diarrhea<\/li><li>abdominal pain<\/li><li>loss of appetite<\/li><li>fatigue, weakness<\/li><li>fever (high temperature)<\/li><li>the general (general) feeling of illness<\/li><li>difficulty sleeping (&nbsp;<em>insomnia<\/em>&nbsp;)<\/li><li>muscle pain and discomfort<\/li><li>joint pain<\/li><li>cough<\/li><li>irritated or runny nose<\/li><li>rash<\/li><li>hair loss.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;users and they can be detected in blood tests:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;red blood cell count&nbsp;(&nbsp;<em>anemia<\/em>&nbsp;) or low&nbsp;white blood cell count&nbsp;(&nbsp;<em>neutropenia<\/em>&nbsp;)<\/li><li>increase in liver enzyme levels<\/li><li>reduction in the number of blood cells involved in blood coagulation (&nbsp;<em>thrombocytopenia<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 1,000<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, lips, tongue or throat, difficulty breathing and\/or swallowing,&nbsp;hives&nbsp;(&nbsp;angioedema&nbsp;)<\/li><li>liver diseases, such as jaundice, enlarged liver or&nbsp;fatty liver,&nbsp;inflammation&nbsp;(&nbsp;<em>hepatitis<\/em>&nbsp;)<\/li><li>inflammation&nbsp;of the pancreas (&nbsp;<em>pancreatitis<\/em>&nbsp;)<\/li><li>degradation of muscle tissue.<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;that can be detected in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increase in an&nbsp;enzyme&nbsp;called&nbsp;<em>amylase.<\/em><\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effect&nbsp;s<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10,000<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>numbness and tingling in the skin<\/li><li>the feeling of weakness in arms and legs<\/li><li>skin rash, which can become blisters and look like small targets (dark spot in the middle surrounded by a lighter field and a dark ring along the edge) (&nbsp;erythema multiforme&nbsp;)<\/li><li>scattered skin rashes with blisters and flaking skin occur especially around the mouth, nose, eyes, and genitals (&nbsp;<em>Stevens-Johnson syndrome<\/em>&nbsp;), and a more severe form that causes skin flaking on more than 30% of the body surface (&nbsp;<em>toxic epidermal necrolysis<\/em>&nbsp;).<\/li><li>lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood)<\/li><\/ul>\n\n\n\n<p><strong>If you notice any of these symptoms, contact a doctor immediately<\/strong>.<\/p>\n\n\n\n<p>Very rare&nbsp;side effects&nbsp;that can be detected in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>failure of the bone marrow&#8217;s ability to form new&nbsp;red blood cells&nbsp;(&nbsp;<em>erythroblastopenia<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>If you get&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor or pharmacist<\/strong>&nbsp;if any of these&nbsp;side effects&nbsp;gets serious or bothersome, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet.<br><\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are with combination therapy for&nbsp;HIV<\/strong><\/p>\n\n\n\n<p>Combination therapy such as Abacavir \/ Lamivudine Teva may cause other conditions to develop during&nbsp;HIV&nbsp;treatment.<\/p>\n\n\n\n<p><strong>Symptoms of&nbsp;infection&nbsp;and&nbsp;inflammation<\/strong><\/p>\n\n\n\n<p><strong>Old&nbsp;infection&nbsp;can flare up<\/strong><\/p>\n\n\n\n<p>Patients with advanced&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) have weak immune systems and are more likely to develop a serious&nbsp;infection&nbsp;(&nbsp;opportunistic&nbsp;infection&nbsp;s&nbsp;).&nbsp;Such&nbsp;infections&nbsp;may have been &#8220;silent&#8221; and not detected by the weak immune system before starting treatment.&nbsp;When treatment is started, the immune system becomes stronger and can fight the&nbsp;infections, which can cause symptoms of infection or inflammation.&nbsp;Symptoms usually&nbsp;<strong>include fever<\/strong>&nbsp;and any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>gripe<\/li><li>breathing difficulties<\/li><\/ul>\n\n\n\n<p>In rare cases, when the immune system becomes stronger, it can also attack healthy body tissue (&nbsp;autoimmune diseases&nbsp;).&nbsp;The symptoms of autoimmune diseases may develop several months after you start taking medicines for your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>palpitations (rapid or irregular heartbeat) or tremors<\/li><li>hyperactivity (excessive restlessness and excessive movement)<\/li><li>weakness that begins in the hands and feet and moves upwards towards the torso.<\/li><\/ul>\n\n\n\n<p><strong>If you get symptoms of an&nbsp;infection&nbsp;<\/strong>and&nbsp;inflammation&nbsp;or if you notice any of the symptoms mentioned above:<\/p>\n\n\n\n<p><strong>Talk to your doctor immediately.&nbsp;<\/strong>Do not take any other anti-infective&nbsp;medication&nbsp;without consulting your doctor.<\/p>\n\n\n\n<p><strong>You may have a skeletal problem<\/strong><\/p>\n\n\n\n<p>Some patients treated with combination therapy for&nbsp;HIV&nbsp;develop a condition called&nbsp;<em>osteonecrosis<\/em>.&nbsp;In this condition, parts of the bone tissue die due to reduced blood supply.&nbsp;Patients may be at greater risk of getting this condition:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if they have been treated with combination therapy for a long time<\/li><li>if they are also taking anti-inflammatory medicines called&nbsp;corticosteroids&nbsp;s<\/li><li>if they drink alcohol<\/li><li>if their immune system is very weak<\/li><li>if they are overweight.<\/li><\/ul>\n\n\n\n<p><strong>Characteristics of&nbsp;osteonecrosis&nbsp;include<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stiffness in the joints<\/li><li>aches and pains (especially in the hips, knees, or shoulders)<\/li><li>mobility impairment.<\/li><\/ul>\n\n\n\n<p>If you notice any of these symptoms:<\/p>\n\n\n\n<p><strong>Tell your doctor.<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Abacavir \/ Lamivudine Teva<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are abacavir and lamivudine.<\/li><li>One film-coated tablet contains 600 mg of abacavir and 300 mg of lamivudine.<\/li><li>Other ingredients are:<ul><li>Tablet core: microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate (type A), and magnesium stearate.<\/li><li>Film coating: hypromellose, macrogol 4000, titanium dioxide (E171), polysorbate 80, yellow iron oxide (E172), and red iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Abacavir \/ Lamivudine Teva 600 mg \/ 300 mg film-coated tablets are orange, rectangular, and biconvex tablets, imprinted with 600 on one side and 300 on the other side and approximately 20.5 mm x 9 mm in size.<\/p>\n\n\n\n<p>Abacavir \/ Lamivudine Teva 600 mg \/ 300 mg film-coated tablets are available in pack sizes of 10, 30 or 90 film-coated tablets in blisters or 10&#215;1, 30&#215;1 or 90&#215;1 film-coated tablets in perforated unit dose blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Box 1070<\/p>\n\n\n\n<p>251 10 Helsingborg<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>PLIVA Hrvatska doo (PLIVA Croatia Ltd.)<\/p>\n\n\n\n<p>Prilaz baruna Filipovica 25,<\/p>\n\n\n\n<p>Zagreb 1000<\/p>\n\n\n\n<p>Croatia<br><\/p>\n\n\n\n<p>Teva Pharma BV<\/p>\n\n\n\n<p>Swensveg 5,<\/p>\n\n\n\n<p>2031 GA Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Merckle GmbH<\/p>\n\n\n\n<p>Graf-Acro Page 3<\/p>\n\n\n\n<p>89079Ulm<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abacavir \/ Lamivudine Teva used to treat HIV &#8211; infection ( infection with human immunodeficiency virus) in adults, adolescents, and children weighing at least 25 kg.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[12082,12085,4015,4017,5225,12096,12100,12099,12095,12084,12083,4016,12097,12093,12098],"class_list":["post-4422","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-abacavir","tag-abacavir-tablet","tag-lamivudine","tag-lamivudine-side-effects","tag-lamivudine-tablet","tag-lamivudine-teva","tag-lamivudine-teva-side-effects","tag-lamivudine-teva-tablet","tag-side-effects-of-abacavir","tag-what-abacavir-is-used-for","tag-what-is-abacavir","tag-what-is-lamivudine","tag-what-is-lamivudine-teva","tag-what-lamivudine-is-used-for","tag-what-lamivudine-teva-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4422"}],"version-history":[{"count":7,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4422\/revisions"}],"predecessor-version":[{"id":13275,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4422\/revisions\/13275"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}