{"id":39367,"date":"2022-12-09T10:17:54","date_gmt":"2022-12-09T10:17:54","guid":{"rendered":"https:\/\/zeepedia.com\/?p=39367"},"modified":"2022-12-10T07:37:53","modified_gmt":"2022-12-10T07:37:53","slug":"zyvoxide","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zyvoxide\/","title":{"rendered":"Zyvoxide &#8211; Linezolid"},"content":{"rendered":"\n<p>600 mg&nbsp;film-coated tablets<br>linezolid<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zyvoxid is and what it is used for<\/h2>\n\n\n\n<p>Zyvoxid is an\u00a0antibiotic\u00a0from the oxazolidinone class that prevents the growth of certain bacteria (\u00a0pathogens\u00a0) that cause\u00a0infection.\u00a0Zyvoxid is used to treat\u00a0pneumonia\u00a0and certain skin and soft tissue infections.\u00a0Your doctor will decide if Zyvoxid is a suitable treatment for your\u00a0infection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Zyvoxid<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zyvoxid<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to linezolid or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you use or if you have used in the last 2 weeks any\u00a0monoamine oxidase inhibitor\u00a0(MAO inhibitor: for example phenelzine, isocarboxazid,\u00a0selegiline, moclobemide).\u00a0These drugs can be used, among other things, to treat depression or\u00a0Parkinson&#8217;s disease.<\/li><li>if you are breastfeeding, as Zyvoxid passes into breast milk and may affect the baby.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Zyvoxid.<\/p>\n\n\n\n<p>Zyvoxid should possibly not be used if you answer yes to any of the questions below.&nbsp;If this is the case, inform your doctor who may need to review your general health including your&nbsp;blood pressure&nbsp;before and during treatment, and possibly decide that another treatment is more suitable for you.<\/p>\n\n\n\n<p>Discuss with your doctor if you are unsure if any of the questions below apply to you.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do you have high\u00a0blood pressure, regardless of whether you take any medicine for it?<\/li><li>Have you been diagnosed with an overactive\u00a0thyroid?<\/li><li>Do you have a\u00a0tumor\u00a0on the adrenal gland (\u00a0pheochromocytoma\u00a0) or carcinoid syndrome (caused by a\u00a0tumor\u00a0in the hormonal system with symptoms such as diarrhea,\u00a0flushing, and problems with wheezing when breathing)?<\/li><li>Do you suffer from manic depression, schizophrenia with mood swings, confusional states, or other mental problems?<\/li><li>Have you previously had\u00a0hyponatremia\u00a0(low sodium levels in the blood) or are you taking medicines that lower sodium levels in the blood, e.g.\u00a0certain\u00a0diuretics\u00a0(also known as diuretics) such as\u00a0hydrochlorothiazide?<\/li><li>Do you\u00a0use opioids?<\/li><\/ul>\n\n\n\n<p>The use of certain medicines, including antidepressants and\u00a0opioids, together with Zyvoxid can lead to serotonin syndrome, a potentially life-threatening condition (see section 2 \u201cOther medicines and Zyvoxid\u201d and section 4).<\/p>\n\n\n\n<p><strong>Be especially careful with Zyvoxid<\/strong><\/p>\n\n\n\n<p>Tell your doctor before starting treatment with this medicine if you<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is an elderly person<\/li><li>bruises easily and starts bleeding<\/li><li>have\u00a0anemia\u00a0(low number of\u00a0red blood cells\u00a0)<\/li><li>is susceptible\u00a0to\u00a0infection<\/li><li>previously had seizures<\/li><li>have liver or kidney problems and above all, if you are on\u00a0dialysis<\/li><li>have diarrhea.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if during ongoing treatment you experience the:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>vision problems, such as blurred vision, altered color vision, reduced\u00a0visual acuity,\u00a0or limitations in the field of\u00a0vision, etc.<\/li><li>loss of feeling in the arms or legs, or tingling or crawling in the arms or legs.<\/li><li>diarrhea.\u00a0You may develop diarrhea while taking or after taking\u00a0antibiotics, including Zyvoxid.\u00a0If diarrhea becomes severe or persistent, or if you find that your stool contains blood or mucus, stop taking Zyvoxid immediately and contact your doctor.\u00a0In this situation, you should not take any medicine that can stop or prolong bowel movements.<\/li><li>recurrent nausea or vomiting, abdominal pain, or faster breathing.<\/li><li>nausea and not feeling well with muscle weakness, headache, confusion, and forgetfulness.\u00a0It may indicate\u00a0hyponatremia\u00a0(low sodium levels in the blood).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zyvoxid<\/h2>\n\n\n\n<p>There is a risk that Zyvoxid sometimes interacts with certain other medicines and causes\u00a0side effects\u00a0such as changes in\u00a0blood pressure, body temperature, or heart rate.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n<p><strong>Tell your doctor if you are taking or in the last two weeks<\/strong>&nbsp;have taken any of the following medicines as Zyvoxid must&nbsp;<strong>not be<\/strong>&nbsp;used if you are already taking or have recently taken them (see also section 2 &#8220;Do not take Zyvoxid&#8221;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>monoamine oxidase inhibitors\u00a0(eg phenelzine, isocarboxazid,\u00a0selegiline, moclobemide).\u00a0These drugs can be used to treat depression or\u00a0Parkinson&#8217;s disease.<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor if you are taking any of the following medicines.\u00a0Your doctor may still decide to give you Zyvoxid but needs to check your general health and\u00a0blood pressure\u00a0before starting treatment and continuously during treatment.\u00a0Your doctor may also decide to give you another, more appropriate treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decongestants containing pseudoephedrine or phenylpropanolamine<\/li><li>certain medicines used to treat\u00a0asthma\u00a0such as\u00a0salbutamol,\u00a0terbutaline, fenoterol<\/li><li>certain antidepressants are known as tricyclics or\u00a0SSRIs\u00a0(selective serotonin reuptake inhibitors).\u00a0There are many such drugs such as amitriptyline,\u00a0citalopram, clomipramine, dosulepin, doxepin,\u00a0fluoxetine, fluvoxamine, imipramine, lofepramine,\u00a0paroxetine,\u00a0sertraline<\/li><li>medicines used to treat\u00a0migraines, such as sumatriptan and zolmitriptan<\/li><li>medicines used to treat sudden, severe allergic reactions, such as\u00a0adrenaline<\/li><li>medicines that raise your\u00a0blood pressure, such as\u00a0norepinephrine,\u00a0dopamine,\u00a0and\u00a0dobutamine<\/li><li>opioids\u00a0such as pethidine &#8211; used to treat moderate to severe pain conditions<\/li><li>medicines used to treat anxiety disorders such as buspirone<\/li><li>medicines that prevent the formation of blood clots, such as\u00a0warfarin.<\/li><li>an\u00a0antibiotic\u00a0called rifampicin<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Zyvoxid with food, drink, and alcohol<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>You can take Zyvoxid either before, during, or after a meal.<\/li><li>Avoid large amounts of aged cheese, yeast extract, or soybean extract (such as soy sauce), and avoid drinking alcohol (especially draft beer and wine).\u00a0This is because Zyvoxid can react with a substance, tyramine, which is found naturally in certain foods.\u00a0This\u00a0interaction\u00a0can increase\u00a0blood pressure\u00a0et.<\/li><li>Tell your doctor, pharmacist, or nurse immediately if you experience a pounding headache after eating or drinking.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>The effect of Zyvoxid on pregnant women is unknown.\u00a0Therefore, Zyvoxid should not be used during pregnancy unless specifically\u00a0prescribed\u00a0by a doctor.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>You should not breastfeed while using Zyvoxid as the medicine passes into breast milk and may affect the baby.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zyvoxid may make you feel dizzy or experience problems with your vision.&nbsp;If this happens, do not drive or use machines.&nbsp;Remember that if you are unwell, your ability to drive and use machines may be affected.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zyvoxid contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per 600 mg tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Zyvoxid<\/h2>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Always use this medicine according to what is written in this leaflet or according to the instructions of the doctor, pharmacist, or nurse.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.\u00a0The recommended\u00a0dose\u00a0is one tablet (600 mg linezolid) twice daily (every 12 hours).\u00a0Swallow the tablet whole with water.<\/p>\n\n\n\n<p>If you are undergoing kidney dialysis, Zyvoxid should be taken after the dialysis treatment.<\/p>\n\n\n\n<p>The usual duration of treatment is 10 to 14 days but can be up to 28 days.\u00a0The safety and effectiveness of this drug have not been established when used for more than 28 days.\u00a0Your doctor will decide how long you will be treated.<\/p>\n\n\n\n<p>While you are taking Zyvoxid, your doctor will carry out regular blood tests to check your blood count.<\/p>\n\n\n\n<p>Your doctor should check your vision if you receive Zyvoxid for more than 28 days.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Zyvoxid is not normally used for treatment in children and adolescents (under 18 years of age).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Zyvoxid&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,&nbsp;a child accidentally ingested the medicine<\/p>\n\n\n\n<p>immediately contact a doctor or hospital for an assessment of the risk and advice.\u00a0Alternatively, contact a pharmacist immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Zyvoxid<\/h2>\n\n\n\n<p>Take the forgotten tablet as soon as you remember.&nbsp;Take the next tablet 12 hours after this and then continue to take your tablets every 12 hours.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Zyvoxid<\/h2>\n\n\n\n<p>You must continue to take Zyvoxid unless your doctor tells you to stop treatment.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist immediately if you stop treatment and the return of your original symptoms.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor, nurse, or pharmacist immediately<\/strong>\u00a0if you experience any of the following\u00a0side effects\u00a0during treatment with Zyvoxid.<\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;(with frequency in brackets) during treatment with Zyvoxid are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe skin reactions (uncommon), swelling especially of the face and neck (uncommon), wheezing, and\/or difficulty breathing (rare).\u00a0This may be a sign of an\u00a0allergic reaction\u00a0and it may be necessary for you to stop treatment with Zyvoxid.\u00a0Skin reactions such as a raised, purple rash due to\u00a0inflammation\u00a0of the blood vessels (rare), tender\u00a0redness\u00a0and scaly skin (\u00a0dermatitis\u00a0) (uncommon), rash (common),\u00a0and itching\u00a0(common).<\/li><li>Problems with your vision (uncommon) such as blurred vision (uncommon), change in color vision (reported), difficulty seeing details (reported), or if you feel that your field of\u00a0vision\u00a0is becoming restricted (rare).<\/li><li>Severe diarrhea containing blood and\/or mucus (antibiotic-associated colitis\u00a0including pseudomembranous\u00a0colitis\u00a0), which may rarely develop into life-threatening complications (less common).<\/li><li>Recurrent nausea or vomiting, stomach pain, or faster breathing (rare).<\/li><li>Seizures (less common) have been reported with Zyvoxid.<\/li><li>Serotonergic syndrome (has been reported): You should contact your doctor immediately if you experience restlessness,\u00a0confusion, confusion, stiffness, tremors, difficulty coordinating your movements, seizures, faster\u00a0heart rate, severe breathing difficulties, and diarrhea (signs of serotonin syndrome) if you at the same time also taking antidepressants known as\u00a0SSRIs\u00a0or\u00a0opioids\u00a0(see section 2).<\/li><li>Unexplained bleeding or bruising may be due to changes in the number of certain\u00a0blood cells\u00a0may affect the ability of the blood to clot (coagulate) or lead to\u00a0anemia\u00a0(\u00a0common\u00a0).<\/li><li>Changes in the number of certain\u00a0blood cells\u00a0can affect your ability to fight\u00a0infection\u00a0(less common).\u00a0Signs of\u00a0infection\u00a0include fever (common), sore throat (less common), mouth sores (less common), and fatigue (less common).<\/li><li>Inflammation\u00a0of the pancreas (less common).<\/li><li>Cramps (less common).<\/li><li>Transient ischemic attacks (temporary disturbances in blood flow through the brain causing short, transient symptoms such as loss of vision, weakness in the legs and arms, slurred speech, and unconsciousness) (uncommon).<\/li><li>Tinnitus (\u00a0less\u00a0common).<\/li><\/ul>\n\n\n\n<p>Numbness, tingling, or blurred vision have been reported in patients treated with Zyvoxid for more than 28 days.\u00a0Contact your doctor immediately if you experience vision problems.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infections, especially in the vagina or oral cavity<\/li><li>headache<\/li><li>metallic taste in the mouth<\/li><li>diarrhea, nausea, or vomiting<\/li><li>change in certain blood test results, including those that measure protein levels, salts, or\u00a0enzymes, which show your kidney or liver function or blood sugar level<\/li><li>sleep difficulties<\/li><li>increased\u00a0blood pressure<\/li><li>anemia\u00a0(low number of\u00a0red blood cells\u00a0)<\/li><li>dizziness<\/li><li>localized or generalized abdominal pain<\/li><li>constipation<\/li><li>indigestion<\/li><li>localized pain<\/li><li>decreased number of\u00a0blood platelets.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the vagina or vagina in women<\/li><li>sensations such as numbness and tingling<\/li><li>swollen, tender, or discolored tongue<\/li><li>dry mouth<\/li><li>increased frequency of urination<\/li><li>overindulge<\/li><li>increased thirst<\/li><li>increased sweating<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>hyponatremia&nbsp;(low levels of&nbsp;sodium&nbsp;in the blood)<\/li><li>kidney failure<\/li><li>gas in the stomach<\/li><li>elevated&nbsp;creatinine<\/li><li>stomach ache<\/li><li>impact on heart rhythm (e.g. faster heart rate)<\/li><li>reduced number of&nbsp;blood&nbsp;cells<\/li><li>weakness and\/or sensory changes.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>superficial tooth discoloration, which can be removed manually with professional teeth cleaning.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hair loss.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Zyvoxid should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the package or blister pack.&nbsp;The expiration date is the last day of the specified month.&nbsp;This medicine has no special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is linezolid.\u00a0One tablet contains 600 mg of linezolid.<\/li><li>Other ingredients are corn starch (from corn), microcrystalline cellulose (E460), hydroxypropyl cellulose (E463), sodium starch glycolate type A (see section 2, &#8220;Zyvoxide contains sodium&#8221;), and magnesium stearate (E572).\u00a0The film coating\u00a0contains hypromellose (E464), titanium dioxide (E171), macrogol 400, and carnauba wax (E903).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zyvoxid 600 mg tablets are white, oval, and debossed with \u201cZYV\u201d on one side and \u201c600\u201d on the other side.<\/p>\n\n\n\n<p>Zyvoxid tablets are supplied in blister packs of 10 tablets packed in a carton.\u00a0Each box contains either 10, 20, 30, 50, 60, or 100 tablets.\u00a0The tablets are also supplied in a white HDPE jar with a polypropylene screw cap containing either 10, 14, 20, 24, 30, 50, 60, or 100 (hospital use only) tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Phone: 08\/550 520 00<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pfizer Service Company, BVBA, Hoge Wei 10, 1930 Zaventem, Belgium<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Pfizer Manufacturing Deutschland GmbH, Betriebsst\u00e4tte Freiburg, Mooswaldallee 1, D-79090 Freiburg,<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zyvoxid is an\u00a0antibiotic\u00a0from the oxazolidinone class that prevents the growth of certain bacteria (\u00a0pathogens\u00a0) that cause\u00a0infection\u00a0.\u00a0Zyvoxid is used to treat\u00a0pneumonia\u00a0and certain skin and soft tissue infections.\u00a0Your doctor will decide if Zyvoxid is a suitable treatment for your\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[16034,16038,16037,16035,28822,16036,28821,28820,28824,28823],"class_list":["post-39367","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-linezolid","tag-linezolid-side-effects","tag-linezolid-tablet","tag-what-is-linezolid","tag-what-is-zyvoxide","tag-what-linezolid-is-used-for","tag-what-zyvoxide-is-used-for","tag-zyvoxide","tag-zyvoxide-side-effects","tag-zyvoxide-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/39367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=39367"}],"version-history":[{"count":2,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/39367\/revisions"}],"predecessor-version":[{"id":39600,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/39367\/revisions\/39600"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=39367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=39367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=39367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}