{"id":38852,"date":"2022-12-07T08:59:12","date_gmt":"2022-12-07T08:59:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=38852"},"modified":"2022-12-09T10:12:06","modified_gmt":"2022-12-09T10:12:06","slug":"zypadhera","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zypadhera\/","title":{"rendered":"ZYPADHERA &#8211; Olanzapine uses, dose and side effects"},"content":{"rendered":"\n<p>210 mg;\u00a0300 mg;\u00a0405 mg\u00a0powder and liquid for\u00a0injection, depot suspension<br>Olanzapine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">WHAT ZYPADHERA IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<p>ZYPADHERA contains the active substance olanzapine.\u00a0ZYPADHERA belongs to the\u00a0neuroleptic\u00a0drug group and is used to treat schizophrenia &#8211; a disorder with symptoms such as hearing, seeing or sensing something that is not there, delusions, unusual suspiciousness, and withdrawal.\u00a0People with this disorder may also feel depressed, anxious, or tense.<\/p>\n\n\n\n<p>ZYPADHERA should be administered to adult patients stabilized on&nbsp;oral&nbsp;olanzapine therapy.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">WHAT YOU NEED TO KNOW BEFORE YOU RECEIVE ZYPADHERA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not receive ZYPADHERA if you:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>are allergic (hypersensitive) to olanzapine or any of the other ingredients of this medicine (listed in section 6).\u00a0<strong>An\u00a0allergic reaction<\/strong>\u00a0can manifest itself as a skin rash,\u00a0itching, swollen face, swollen lips, or difficulty breathing.\u00a0If this has happened to you, contact your nurse or doctor.<\/li><li>previously had eye problems such as certain types of\u00a0glaucoma\u00a0(increased pressure in the eye)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and caution<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before you are given ZYPADHERA.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><em>A less common but serious reaction may occur after\u00a0injection<\/em><\/strong>.\u00a0ZYPADHERA can sometimes enter the bloodstream too quickly.\u00a0If this occurs, you may have the following symptoms after\u00a0injection.\u00a0In some cases, these symptoms can lead to unconsciousness.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>extreme sleepiness<\/td><td>dizziness<\/td><\/tr><tr><td>confusion<\/td><td>disorientation<\/td><\/tr><tr><td>irritability<\/td><td>anxiety<\/td><\/tr><tr><td>aggression<\/td><td>increased&nbsp;blood pressure<\/td><\/tr><tr><td>difficulty speaking<\/td><td>weakness<\/td><\/tr><tr><td>difficulty walking<\/td><td>muscle stiffness or tremors<\/td><\/tr><tr><td>cramps<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>These symptoms usually disappear within 24 to 72 hours after&nbsp;injection&nbsp;one.&nbsp;You will be observed for the appearance of the above symptoms in the medical ward for at least 3 hours.<\/p>\n\n\n\n<p>You are not likely to get such symptoms after more than 3 hours after\u00a0injection, but if they do, contact your doctor or nurse immediately.\u00a0Because of this risk, you should not drive or operate machinery for the remainder of the day after\u00a0injection\u00a0one.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor or nurse if you feel dizzy or faint after\u00a0injection\u00a0one.\u00a0You will probably need to lie down until you feel better.\u00a0Possibly, your doctor or nurse will measure\u00a0blood pressure\u00a0and\u00a0pulse.<\/li><li>The use of ZYPADHERA in\u00a0elderly patients with dementia\u00a0(confusion and memory loss) is not recommended as it may cause serious\u00a0side effects.<\/li><li>It is very rare, but sometimes this type of medicine can cause abnormal movements, especially of the face or tongue, or a combination of fever, shortness of breath, sweating, muscle stiffness, and drowsiness or sleepiness.\u00a0If this happens after receiving ZYPADHERA, contact your doctor or nurse immediately.<\/li><li>Weight gain has occurred in patients taking ZYPADHERA.\u00a0You and your doctor should check your weight regularly.\u00a0If necessary, consider a referral to a dietitian or help with a diet plan.<\/li><li>High blood sugar and high blood fat levels (\u00a0triglycerides\u00a0and\u00a0cholesterol\u00a0) have occurred in patients taking ZYPADHERA.\u00a0Your doctor should do blood tests for blood sugar and lipid levels before you start taking ZYPADHERA and then at regular intervals during treatment.<\/li><li>Tell your doctor if you or someone in your family has a history of blood clots, as medicines like these have been associated with blood clots.<\/li><\/ul>\n\n\n\n<p>You must tell your doctor as soon as possible if any of the following apply to you:<\/p>\n\n\n\n<p>&#8211; had a&nbsp;stroke&nbsp;(stroke) or a mild form of&nbsp;stroke&nbsp;(temporary symptoms of&nbsp;stroke&nbsp;)<\/p>\n\n\n\n<p>&#8211; has&nbsp;Parkinson&#8217;s disease<\/p>\n\n\n\n<p>&#8211; have prostate problems<\/p>\n\n\n\n<p>&#8211; has intestinal inflammation (paralytic&nbsp;ileus&nbsp;)<\/p>\n\n\n\n<p>&#8211; have liver or kidney disease<\/p>\n\n\n\n<p>&#8211; have any blood disease<\/p>\n\n\n\n<p>&#8211; recently had a heart attack, have heart disease, have sick sinus syndrome (abnormal heart rhythm),\u00a0unstable angina,\u00a0or have low\u00a0blood pressure<\/p>\n\n\n\n<p>&#8211; have&nbsp;diabetes<\/p>\n\n\n\n<p>&#8211; have seizures<\/p>\n\n\n\n<p>&#8211; if you know you may have a salt deficiency as a result of prolonged severe diarrhea and vomiting or use&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;)<\/p>\n\n\n\n<p>If you are\u00a0<strong>over 65 years old<\/strong>, as a precautionary measure, the doctor may need to regularly check\u00a0your blood pressure,\u00a0etc.<\/p>\n\n\n\n<p>It is not recommended to start ZYPADHERA if you are over 75 years of age.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p><strong>ZYPADHERA should not be used by patients under 18 years of age.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and ZYPADHERA<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You must tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs against\u00a0Parkinson&#8217;s disease.<\/li><li>carbamazepine (anti-epileptic\u00a0and mood stabilizer), fluvoxamine (a medicine for depression), or\u00a0ciprofloxacin\u00a0(an\u00a0antibiotic\u00a0) \u2013 it may be necessary to change your ZYPADHERADA\u00a0dose.<\/li><\/ul>\n\n\n\n<p>If you are already taking medicines for depression, medicines for anxiety, or sleeping pills, you may feel drowsy when you receive ZYPADHERA.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ZYPADHERA with alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol after receiving ZYPADHERA because ZYPADHERA together with alcohol can cause drowsiness.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving this medicine.\u00a0You should not receive this medicine if you are breastfeeding, as small amounts of olanzapine may pass into breast milk.<\/p>\n\n\n\n<p>In newborn babies whose mothers received ZYPADHERA during the last trimester (the last three months of pregnancy), the following symptoms may occur: tremors, stiff and\/or weak muscles, sleepiness, agitation, breathing problems, and difficulty eating.\u00a0If your child develops any of these symptoms, you may need to contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Do not drive or operate machinery for the remainder of the day you receive an\u00a0injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sodium<\/h2>\n\n\n\n<p>After\u00a0preparation, this medicine contains less than 1 mmol (23 mg)\u00a0of sodium\u00a0per\u00a0vial, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HOW ZYPADHERA IS GIVEN<\/h2>\n\n\n\n<p>Your doctor will decide how much ZYPADHERA you need and how often you need to have an\u00a0injection.\u00a0ZYPADHERA is given in\u00a0doses\u00a0of 150 and mg-300 mg every two weeks or 300 mg-405 mg every four weeks.<\/p>\n\n\n\n<p>ZYPADHERA is a powder.&nbsp;Your doctor or nurse prepares a&nbsp;suspension&nbsp;of the powder, which will then be injected into the muscle of your buttock<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have been given too much ZYPADHERA<\/h2>\n\n\n\n<p>This medicine will be given to you under medical supervision, so it is unlikely that you will get too much.<\/p>\n\n\n\n<p>Patients who have received too much olanzapine have experienced the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fast heart rate, agitation\/aggressiveness, difficulty speaking, involuntary movements (especially of the face or tongue), and decreased level of consciousness.<\/li><\/ul>\n\n\n\n<p>Other symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acute\u00a0confusion, seizures (\u00a0epilepsy\u00a0),\u00a0coma, a combination of fever, rapid breathing, sweating, muscle stiffness, drowsiness or sleepiness, slow breathing, breathing problems, high or low\u00a0blood pressure, and abnormal heart rhythm.<\/li><\/ul>\n\n\n\n<p>Contact your doctor or hospital immediately if you experience any of the above symptoms.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you skip an injection of ZYPADHERA<\/h2>\n\n\n\n<p>Do not stop treatment because you feel better.\u00a0You must continue to receive ZYPADHERA for as long as your doctor has prescribed.<\/p>\n\n\n\n<p>If you forget to get an\u00a0injection, you should contact your doctor to get the next\u00a0injection\u00a0as soon as possible.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Contact your doctor immediately if you get:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>extreme sleepiness, dizziness, confusion, disorientation, difficulty speaking, difficulty walking, muscle stiffness or tremors, weakness, irritability, aggression, anxiety, increased\u00a0blood pressure,\u00a0or seizures and may lead to unconsciousness.\u00a0These signs and symptoms can sometimes occur if ZYPADHERA enters the bloodstream too quickly (a common\u00a0side effect\u00a0that may affect up to 1 in 10 people);<\/li><li>involuntary movement disorders (a common\u00a0side effect\u00a0that may affect up to 1 in 10 users) especially in the face or tongue;<\/li><li>blood clots in the veins (an uncommon\u00a0side effect\u00a0that may affect up to 1 in 100 people) especially in the legs (symptoms are swelling, pain, and\u00a0redness\u00a0of the legs).\u00a0The blood clots can be transported to the lungs and cause chest pain and difficulty breathing.\u00a0If you experience any of these symptoms, seek medical attention immediately.<\/li><li>a combination of fever, faster breathing, sweating, muscle stiffness, and drowsiness or sleepiness (the frequency of this\u00a0side effect\u00a0cannot be estimated from the available data).<\/li><\/ul>\n\n\n\n<p>Other common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people) with ZYPADHERA include sleepiness and pain at the injection site.<\/p>\n\n\n\n<p>Rare\u00a0side effects\u00a0(may affect up to 1 in 1,000 people) of ZYPADHERA include injection site\u00a0infection.<\/p>\n\n\n\n<p>The side effects\u00a0below have been observed when olanzapine has been given orally (by mouth), but they can also occur after the ZYPADHERA\u00a0injection.<\/p>\n\n\n\n<p>Other very common\u00a0side effects\u00a0(which may affect more than 1 in 10 users) include weight gain;\u00a0and increased levels of\u00a0prolactin\u00a0in the blood.\u00a0At the beginning of treatment, some people may feel dizzy or faint (with a slow heart rate), especially when getting up from a lying or sitting position.\u00a0This often goes away on its own.\u00a0If not, contact your doctor.<\/p>\n\n\n\n<p>Other common\u00a0side effects\u00a0(may affect up to 1 in 10 users) include changes in levels of\u00a0blood cells, blood lipids and, at the start of treatment, temporarily increased liver enzymes;\u00a0increased sugar levels in the blood and urine;\u00a0increased level of\u00a0uric acid\u00a0and\u00a0creatinine\u00a0phosphokinase in the blood;\u00a0increased appetite;\u00a0dizziness;\u00a0restlessness;\u00a0tremors;\u00a0movement difficulties (\u00a0dyskinesia\u00a0);\u00a0constipation;\u00a0dry mouth;\u00a0rash;\u00a0impotence;\u00a0extreme fatigue;\u00a0fluid retention leading to swelling of the hands, ankles or feet;\u00a0fever;\u00a0joint pain;\u00a0sexual problems such as reduced sex drive in men and women or erectile problems in men.<\/p>\n\n\n\n<p>Other less common\u00a0side effects\u00a0(which may affect up to 1 in 100 users) include hypersensitivity (eg swelling of the mouth and throat,\u00a0itching, rash);\u00a0diabetes\u00a0or worsening of diabetes, sometimes associated with\u00a0ketoacidosis\u00a0(ketones in the blood and urine) or coma;\u00a0convulsions, generally in case of a known tendency to seizures (\u00a0epilepsy\u00a0);\u00a0muscle stiffness or\u00a0spasm (including eye movements);\u00a0crawling and feeling of restlessness in the legs when resting (restless legs);\u00a0speech difficulties;\u00a0stuttering;\u00a0slow heartbeat;\u00a0sun sensitivity;\u00a0nosebleed;\u00a0distended abdomen;\u00a0drooling;\u00a0memory loss or forgetfulness;\u00a0urinary incontinence;\u00a0difficulty urinating;\u00a0hair loss;\u00a0absent or shortened menstruation;\u00a0and breast changes in men and women such as abnormal production of breast milk or abnormal enlargement.<\/p>\n\n\n\n<p>Rare\u00a0side effects\u00a0(may affect up to 1 in 1,000 users) include lowering of the normal body temperature;\u00a0abnormal heart rhythm;\u00a0sudden, unexplained death;\u00a0inflammation\u00a0of the pancreas causing severe stomach pain, fever, and malaise;\u00a0liver disease manifesting as yellowing of the skin and whites of the eyes;\u00a0muscle disease manifesting as unexplained aches and pains;\u00a0and prolonged and\/or painful\u00a0erection.<\/p>\n\n\n\n<p>Very rare\u00a0side effects\u00a0include serious allergic reactions such as drug reactions with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS).\u00a0DRESS presents initially with\u00a0flu-like symptoms\u00a0with a rash on the face and then by more widespread rash, fever, enlarged\u00a0lymph nodes, elevated levels of liver enzymes seen in blood tests, and elevated levels of a type of\u00a0white blood cell\u00a0(\u00a0eosinophils\u00a0).<\/p>\n\n\n\n<p>When taking medication with olanzapine, elderly patients with dementia may experience\u00a0a stroke,\u00a0pneumonia, urinary incontinence, increased tendency to fall, extreme fatigue, visual hallucinations, increased body temperature, skin redness, and difficulty walking.\u00a0Some deaths have been reported in this specific patient group.<\/p>\n\n\n\n<p>For patients with\u00a0Parkinson&#8217;s disease, olanzapine given orally may worsen symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HOW TO STORE ZYPADHERA<\/h2>\n\n\n\n<p>Store out of sight and reach of children.<\/p>\n\n\n\n<p>Injection&nbsp;one must be used before the expiry date stated on the carton.<\/p>\n\n\n\n<p>Store protected from cold.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Chemical and physical in-use stability for 24 hours at 20-25 \u00b0C has been demonstrated for the\u00a0suspension\u00a0in the vial.\u00a0From a microbiological perspective, the drug should be used immediately.\u00a0If not used immediately, in-use storage times and conditions before use is the responsibility of the user and would normally not be longer than 24 hours at 20-25\u00b0C.\u00a0Do not use the medicine if you see discoloration or other visible signs that the medicine has deteriorated.<\/p>\n\n\n\n<p>If the medicine is not used at once, it should be shaken vigorously so that it forms a\u00a0suspension\u00a0again.\u00a0Once the\u00a0suspension has\u00a0been withdrawn from the vial into the syringe, it should be used immediately.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PACKAGING CONTENTS AND OTHER INFORMATION<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration for ZYPADHERA<\/h2>\n\n\n\n<p>The&nbsp;<strong>active substance<\/strong>&nbsp;is olanzapine.<\/p>\n\n\n\n<p>ZYPADHERA 210 mg: One&nbsp;vial&nbsp;contains olanzapine pamoate monohydrate equivalent to 210 mg olanzapine.<\/p>\n\n\n\n<p>ZYPADHERA 300 mg: One&nbsp;vial&nbsp;contains olanzapine pamoate monohydrate equivalent to 300 mg olanzapine.<\/p>\n\n\n\n<p>ZYPADHERA 405 mg: One&nbsp;vial&nbsp;contains olanzapine pamoate monohydrate equivalent to 405 mg olanzapine.<\/p>\n\n\n\n<p>After preparation: 1 ml&nbsp;suspension&nbsp;contains 150 mg\/ml olanzapine.<\/p>\n\n\n\n<p><strong>The diluent<\/strong>\u00a0contains carmellose sodium, mannitol, polysorbate 80, water for injections,\u00a0hydrochloric acid,\u00a0and sodium hydroxide.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>ZYPADHERA powder for\u00a0injection\u00a0for\u00a0preparation\u00a0of\u00a0the extended-release\u00a0suspension\u00a0is a yellow powder in a\u00a0clear glass\u00a0vial.\u00a0Your doctor or nurse makes a\u00a0suspension\u00a0of the powder using the diluent for ZYPADHERA, which is a clear, colorless pale yellow solution in a\u00a0clear glass\u00a0vial.<\/p>\n\n\n\n<p>ZYPADHERA consists of a powder and\u00a0diluent\u00a0for prolonged-release suspension for\u00a0injection.\u00a0The package contains one\u00a0vial\u00a0of powder for\u00a0injection\u00a0for\u00a0the preparation\u00a0of\u00a0extended-release\u00a0suspension, one\u00a0vial\u00a0of 3 ml\u00a0diluent, one\u00a0syringe\u00a0with attached safety needle, 19 gauge, 38 mm and three separate safety needles, one 19 gauge 38 mm needles and two 19 gauge 50, etc. cannulas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Eli Lilly Nederland BV, Papendorpseweg 83, 3528 BJ Utrecht, The Netherlands.<\/p>\n\n\n\n<p>Lilly SA, Avda.&nbsp;de la Industria 30, 28108 Alcobendas, Madrid, Spain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ZYPADHERA contains the active substance olanzapine.\u00a0ZYPADHERA belongs to the\u00a0neuroleptic\u00a0drug group and is used to treat schizophrenia &#8211; a disorder with symptoms such as hearing, seeing or sensing something that is not there, delusions, unusual suspiciousness and withdrawal.\u00a0People with this disorder may also feel depressed, anxious or tense.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[19678,28786,10033,19677,10034,28783,10035,28784,28782,28785],"class_list":["post-38852","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-olanzapine","tag-benefits-of-zypadhera","tag-olanzapine","tag-olanzapine-side-effects","tag-what-is-olanzapine","tag-what-is-zypadhera","tag-what-olanzapine-is-used-for","tag-what-zypadhera-is-used-for","tag-zypadhera","tag-zypadhera-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=38852"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38852\/revisions"}],"predecessor-version":[{"id":39364,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38852\/revisions\/39364"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=38852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=38852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=38852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}