{"id":38696,"date":"2022-12-06T09:08:06","date_gmt":"2022-12-06T09:08:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=38696"},"modified":"2022-12-07T07:33:57","modified_gmt":"2022-12-07T07:33:57","slug":"zyloric","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zyloric\/","title":{"rendered":"Zyloric &#8211; Allopurinol uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg and 300 mg&nbsp;tablets<br>allopurinol<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zyloric is and what it is used for<\/h2>\n\n\n\n<p>Zyloric contains the active substance allopurinol.&nbsp;It works by slowing down various chemical reactions in the body to lower the level of&nbsp;uric acid&nbsp;in the blood and urine and prevents the formation of uric acid crystals.<\/p>\n\n\n\n<p>Zyloric is used for\u00a0gout\u00a0and other conditions associated with an excess of\u00a0uric acid\u00a0in the body, for example,\u00a0kidney stones, and certain kidney diseases.\u00a0It is also used as a preventive treatment against elevated uric acid levels as a result of the treatment of tumor diseases.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Zyloric<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zyloric<\/h2>\n\n\n\n<p>&#8211; if you are allergic to allopurinol or any other ingredient in this medicine (listed in section 6).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Zyloric:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have impaired liver or kidney function.<\/li><li>if you have an ongoing gout attack.<\/li><li>if you are of Han Chinese, Thai or Korean descent.<\/li><li>if you have thyroid problems.<\/li><\/ul>\n\n\n\n<p>During treatment with Zyloric:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Serious skin rashes (hypersensitivity syndrome,\u00a0Stevens-Johnson syndrome,\u00a0toxic epidermal necrolysis\u00a0) have been reported when using Zyloric.\u00a0Often the rash can include sores in the mouth, throat, nose, and genitals, and conjunctivitis (red and swollen eyes).\u00a0These severe skin rashes are often preceded by\u00a0flu-like symptoms such\u00a0as fever, headache, and body aches.\u00a0The rash can develop into extensive blistering and scaling of the skin.\u00a0These serious skin reactions may be more common in people of Han Chinese, Thai or Korean descent.\u00a0Chronic\u00a0kidney disease may further increase the risk in these patients.\u00a0If you develop a rash or these skin symptoms, stop taking Zyloric and see a doctor immediately.<\/li><li>If you have cancer or Lesch-Nyhan syndrome, xanthine, a precursor to\u00a0uric acid, can accumulate in the body.\u00a0To avoid xanthine precipitation in the urinary tract, it is therefore important to drink enough.<\/li><li>If you have\u00a0kidney stones, the\u00a0kidney\u00a0stones can become smaller and enter the urinary tract, which can cause problems.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zyloric<\/h2>\n\n\n\n<p>The effect of the treatment can be affected if Zyloric is taken at the same time as other medicines.\u00a0Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>azathioprine (used to suppress the immune system)<\/li><li>cytostatics\u00a0(used to treat cancer): When Zyloric and\u00a0cytostatics\u00a0are used together (eg cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkyl halides)\u00a0blood dyscrasias\u00a0occur more often than when these active substances are used separately.\u00a0The blood values \u200b\u200bshould therefore be checked regularly.<\/li><li>mercaptopurine (used to treat blood cancer (\u00a0leukemia\u00a0)<\/li><li>cyclosporine (used to suppress the immune system, for example after organ transplantation and in rheumatism)<\/li><li>didanosine (used to\u00a0treat\u00a0HIV\u00a0infection\u00a0)<\/li><li>theophylline (used to treat\u00a0asthma\u00a0)<\/li><li>vidarabine (used to treat viral infections)<\/li><li>phenytoin\u00a0(used in\u00a0epilepsy\u00a0)<\/li><li>blood thinners such as\u00a0warfarin<\/li><li>probenecid (used to treat\u00a0gout\u00a0)<\/li><li>chlorpropamide (used to treat\u00a0diabetes\u00a0)<\/li><li>diuretics,\u00a0ACE inhibitors\u00a0(medicines to treat heart problems or high\u00a0blood pressure\u00a0)<\/li><li>salicylates in high\u00a0doses\u00a0(used for pain relief, to reduce swelling, and to lower body temperature)<\/li><li>ampicillin or amoxicillin (medicines used to treat\u00a0infections\u00a0).\u00a0The risk of allergic rashes may increase with simultaneous treatment with Zyloric.<\/li><\/ul>\n\n\n\n<p>If aluminum hydroxide (used to neutralize stomach acid) is taken at the same time, the effect of Zyloric may be reduced.\u00a0There should be at least 3 hours between taking these two medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<p>Limited experience of use during pregnancy.<\/p>\n\n\n\n<p>Zyloric is excreted in breast milk.&nbsp;Zyloric is not recommended during breastfeeding.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Drowsiness, dizziness, and inability to coordinate movements have occurred during treatment with Zyloric.\u00a0This should be taken into account when increased attention is required, e.g.\u00a0when driving and handling machinery.\u00a0You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zyloric contains excipients<\/h2>\n\n\n\n<p>Zyloric contains&nbsp;lactose<\/p>\n\n\n\n<p>If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Zyloric<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>The dose&nbsp;is determined by the doctor who adjusts it individually for you.&nbsp;Dosage&nbsp;one should be adjusted by the doctor during treatment after measuring the level of uric acid salts and&nbsp;uric acid&nbsp;in blood and urine.<\/p>\n\n\n\n<p>The doctor usually starts with a low\u00a0dose of\u00a0allopurinol (eg 100 mg\/day) to reduce the risk of possible\u00a0side effects.\u00a0Your\u00a0dose\u00a0will be increased as needed.<\/p>\n\n\n\n<p>Adults<\/p>\n\n\n\n<p>You usually start with a low\u00a0dose, for example, 100 mg daily.\u00a0If necessary, the\u00a0dose\u00a0can be gradually increased to 900 mg daily.\u00a0Doses\u00a0above 300 mg should be divided over the day.<\/p>\n\n\n\n<p>To avoid possible nausea and vomiting, you should take the tablets after a meal with a glass of water.<\/p>\n\n\n\n<p>The break score is not for dividing the tablet into equal\u00a0doses, but only to facilitate swallowing.<\/p>\n\n\n\n<p>Older<\/p>\n\n\n\n<p>You will receive the lowest&nbsp;dose&nbsp;of Zyloric that is effective enough for you.<\/p>\n\n\n\n<p>Impaired kidney or liver function<\/p>\n\n\n\n<p>The doctor can lower the&nbsp;dose&nbsp;or decide that a longer time should pass between&nbsp;doses&nbsp;if you have impaired liver or kidney function.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Zyloric is rarely used in children, except in certain types of cancer (especially&nbsp;leukemia&nbsp;) and certain enzyme disorders such as Lesch-Nyhan syndrome.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children 6\u201310 years old is 100 mg 3 times daily.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Zyloric&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Signs of overdose may include nausea, vomiting, diarrhea, and dizziness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Zyloric<\/h2>\n\n\n\n<p>If you forget to take a tablet, take one as soon as you remember.\u00a0However, skip the missed\u00a0dose\u00a0if it is almost time to take the next tablet.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Zyloric<\/h2>\n\n\n\n<p>Do not stop taking the tablets without talking to your doctor first.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Stop taking Zyloric and contact your doctor or hospital immediately if you experience any of the following symptoms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions (\u00a0hypersensitivity reaction\u00a0).\u00a0Symptoms of an\u00a0allergic reaction\u00a0may include swelling of the eyelids, face, or lips, low\u00a0blood pressure, palpitations, sudden itchy rash (hives), sudden wheezing, chest tightness, shortness of breath, and dizziness.\u00a0(Uncommon\u00a0side effects\u00a0&#8211; may affect up to 1 in 100 users).<\/li><li>Severe\u00a0allergic reaction\u00a0causing swelling of the face, tongue, or throat;\u00a0difficulty swallowing;\u00a0hives\u00a0and difficulty breathing.\u00a0May be a sign of\u00a0angioedema\u00a0(A very rare\u00a0side effect\u00a0&#8211; that may affect up to 1 in 10,000 users).<\/li><li>Sometimes Zyloric can affect the blood, which can show up in the way that you bruise more easily than usual or that you get an\u00a0infection\u00a0with symptoms such as fever with a greatly worsened general condition or fever with local symptoms of infection such as sore throat\/pharynx\/mouth or severe to pee\u00a0These effects usually occur in people with liver or kidney problems.\u00a0Tell the doctor as soon as possible so that a blood test can rule out a lack of certain\u00a0blood cells\u00a0(\u00a0thrombocytopenia,\u00a0agranulocytosis,\u00a0or\u00a0aplastic anemia\u00a0).\u00a0It is important that you then information about your medication.\u00a0(Very rare\u00a0side effects\u00a0&#8211; may affect up to 1 in 10,000 users).<\/li><li>Skin changes or an extremely strong\u00a0allergic reaction\u00a0with skin rashes usually in the form of blisters or sores in the mouth and eyes as well as other mucous membranes such as the genitals.\u00a0Or a serious widespread skin injury (skin peeling of the epidermis and superficial mucous membranes).\u00a0Maybe a sign of erythema multiforme,\u00a0Stevens-Johnson syndrome,\u00a0or Lyell&#8217;s syndrome (\u00a0toxic epidermal necrolysis\u00a0) (Rare\u00a0side effects\u00a0&#8211; may occur in up to 1 in 1000 users).<\/li><li>Serious, potentially life-threatening\u00a0allergic reaction\u00a0(Very rare\u00a0side effects\u00a0&#8211; may affect up to 1 in 10,000 users).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>increased level of thyroid-stimulating hormone\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting, and diarrhea<\/li><li>impact on liver function.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation of the liver (\u00a0hepatitis\u00a0)<\/li><li>changes in the skin or mucous membranes, such as red or bumpy rash, widespread blistering or peeling,\u00a0itching,\u00a0redness, sores in the mouth, throat, nose, genitals, or\u00a0conjunctivitis\u00a0(red and swollen eyes).<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood in the urine<\/li><li>vomiting blood (hematemesis)<\/li><li>elevated cholesterol levels in the blood<\/li><li>a general feeling of sickness or weakness<\/li><li>drowsiness, headache, taste changes<\/li><li>dizziness<\/li><li>unconsciousness, difficulty moving (paralysis)<\/li><li>seizures (\u00a0spasms, attacks)<\/li><li>muscle pain<\/li><li>pressure on the chest, slow heart rate, increased\u00a0blood pressure, blood vessel inflammation<\/li><li>swelling of the mouth and lips (\u00a0stomatitis\u00a0)<\/li><li>swelling, usually in the legs, feet, or hands (\u00a0edema\u00a0)<\/li><li>thirst, fatigue, and weight loss (these may be symptoms of\u00a0diabetes\u00a0);\u00a0your doctor may want to measure your blood sugar level if this occurs<\/li><li>kidney inflammation<\/li><li>kidney failure<\/li><li>impact on the lymph nodes<\/li><li>male\u00a0infertility\u00a0or\u00a0erectile dysfunction\u00a0(\u00a0impotence\u00a0)<\/li><li>tenderness and swelling of the breasts, in both men and women<\/li><li>changed bowel movements\/bowel habits<\/li><li>visual disturbances<\/li><li>hair loss, discolored hair<\/li><li>Depression<\/li><li>disturbances in muscle coordination<\/li><li>tingling and burning sensation and numbness in the skin (\u00a0paresthesia\u00a0)<\/li><li>stones in the urinary tract<\/li><li>boils (\u00a0furunculosis\u00a0).<\/li><li>fat in the stool (\u00a0steatorrhoea\u00a0)<\/li><li>increase in\u00a0urea\u00a0and\u00a0creatinine\u00a0in the blood (azotemia)<\/li><li>joint pains<\/li><li>increased body temperature (fever).<\/li><\/ul>\n\n\n\n<p><strong>Not known<\/strong>\u00a0(frequency cannot be estimated from the available data): Aseptic\u00a0meningitis\u00a0(\u00a0inflammation\u00a0of the\u00a0membrane\u00a0that surrounds the brain and spinal cord): symptoms include neck stiffness, headache, nausea, fever, or impaired consciousness.\u00a0Seek medical attention immediately if this occurs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zyloric<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is allopurinol.\u00a0One tablet contains 100 mg and 300 mg of allopurinol respectively.<\/li><li>Other ingredients:\u00a0lactose monohydrate, magnesium stearate, povidone, and corn starch.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The 100 mg tablet is white to yellowish-white, round with a score line, and marked Z1.<\/p>\n\n\n\n<p>The 300 mg tablet is white to yellowish-white, round with a score line, and marked Z3.<\/p>\n\n\n\n<p>The break score is not for dividing the tablet into equal\u00a0doses, but only to facilitate swallowing.<\/p>\n\n\n\n<p>Pressed packaging with 100 tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive<\/p>\n\n\n\n<p>Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p>Phone: +46 856 642 572<\/p>\n\n\n\n<p>Manufacturer<\/p>\n\n\n\n<p>Aspen Bad Oldesloe GmbH,<\/p>\n\n\n\n<p>Industriestrasse 32-36,<\/p>\n\n\n\n<p>23843 Bad Oldesloe, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zyloric contains the active substance allopurinol.\u00a0It works by slowing down various chemical reactions in the body to lower the level of\u00a0uric acid\u00a0in the blood and urine and prevents the formation of uric acid crystals.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[10882,28707,10885,10884,10883,28709,28710,28708,28711,28712],"class_list":["post-38696","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-allopurinol","tag-allopurinol-side-effects","tag-allopurinol-tablet","tag-what-allopurinol-is-used-for","tag-what-is-allopurinol","tag-what-is-zyloric","tag-what-zyloric-is-used-for","tag-zyloric","tag-zyloric-side-effects","tag-zyloric-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=38696"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38696\/revisions"}],"predecessor-version":[{"id":38841,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38696\/revisions\/38841"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=38696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=38696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=38696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}