{"id":38693,"date":"2022-12-06T09:04:29","date_gmt":"2022-12-06T09:04:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=38693"},"modified":"2022-12-07T07:34:24","modified_gmt":"2022-12-07T07:34:24","slug":"zydelig","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zydelig\/","title":{"rendered":"Zydelig &#8211; Idelalisib uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;film-coated tablets<br>idelalisib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zydelig is and what it is used for<\/h2>\n\n\n\n<p>Zydelig is a cancer medicine that contains the active substance idelalisib.\u00a0It works by blocking the effects of an\u00a0enzyme\u00a0involved in the proliferation and survival of certain\u00a0white blood cells\u00a0called\u00a0lymphocytes.\u00a0Because this\u00a0enzyme\u00a0is overactivated in some cancerous\u00a0white blood cells, Zydelig kills and reduces the number of cancer cells by blocking the\u00a0enzyme\u00a0et.<\/p>\n\n\n\n<p>Zydelig can be used to treat two different types of cancer in adults:<\/p>\n\n\n\n<p><strong>Chronic lymphocytic leukemia<\/strong><\/p>\n\n\n\n<p><em>Chronic lymphocytic leukemia\u00a0<\/em>(\u00a0CLL\u00a0) is a form of cancer in a type of\u00a0white blood cell\u00a0called B\u00a0lymphocyte.\u00a0In this disease, the\u00a0lymphocytes\u00a0multiply too quickly and live too long, so there are too many of them circulating in the blood.<\/p>\n\n\n\n<p>In\u00a0CLL, treatment with Zydelig is used in combination with another drug (rituximab) in patients who have certain high-risk factors or in patients whose cancer has returned after at least one previous treatment.<\/p>\n\n\n\n<p><strong>Follicular&nbsp;lymphoma<\/strong><\/p>\n\n\n\n<p><em>Follicular\u00a0lymphoma<\/em>\u00a0(FL) is a form of cancer in a type of\u00a0white blood cell\u00a0called B\u00a0lymphocyte. In follicular\u00a0lymphoma, B\u00a0lymphocytes\u00a0multiply too quickly and live too long, so there are too many of them in the lymph nodes.\u00a0In FL, Zydelig is used alone in patients whose cancer has not responded to treatment with two previous cancer treatments.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Zydelig<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Zydelig<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to idelalisib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Talk to your doctor<\/strong>&nbsp;if this applies to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Zydelig.&nbsp;Tell doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver problems<\/li><li>if you have any other medical conditions or illnesses (especially an&nbsp;infection&nbsp;or fever).<\/li><\/ul>\n\n\n\n<p>Serious and fatal\u00a0infections\u00a0have occurred in patients taking Zydelig.\u00a0You should take additional medicines that your doctor gives you while you are taking Zydelig to prevent a type of\u00a0infection.\u00a0The doctor will check you for signs of\u00a0infection.\u00a0Tell your doctor immediately if you become ill (especially if you develop a fever, cough, or difficulty breathing) while taking Zydelig.<\/p>\n\n\n\n<p>Tell your doctor immediately if you or anyone else notices the following in you: memory loss, difficulty thinking, difficulty walking, or loss of vision &#8211; this may be due to a very rare but serious brain infection that can be fatal (\u00a0progressive\u00a0multifocal\u00a0leukoencephalopathy or PML).<\/p>\n\n\n\n<p><strong>You will have regular blood tests<\/strong>\u00a0before and during treatment with Zydelig.\u00a0This is done to check that you do not have an\u00a0infection, that the liver is working as it should, and that you have a normal number of\u00a0blood cells.\u00a0If necessary, the doctor may decide to stop the treatment for some time before starting the treatment again with the same or a lower\u00a0dose.\u00a0The doctor may also decide to stop treatment with Zydelig permanently.<\/p>\n\n\n\n<p>Zydelig can cause severe diarrhea.&nbsp;Talk to a doctor immediately at the first sign of diarrhea.<\/p>\n\n\n\n<p>Zydelig can cause\u00a0pneumonia.\u00a0Tell a doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you develop a new or worsening cough<\/li><li>if you have shortness of breath or difficulty breathing.<\/li><\/ul>\n\n\n\n<p>Serious blistering skin conditions, such as\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis,\u00a0and drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS), have been reported in association with idelalisib treatment.\u00a0Stop using idelalisib and seek medical attention immediately if you experience any of the symptoms described in section 4.<\/p>\n\n\n\n<p>Tell a doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you get\u00a0redness\u00a0and blisters on the skin<\/li><li>if you get swelling and blisters in the mucous membrane of the mouth, throat, nose, genitals, and\/or eyes.<\/li><\/ul>\n\n\n\n<p>Laboratory tests may show an increase in\u00a0white blood cells\u00a0(called &#8220;lymphocytes&#8221;) in your blood during the first few weeks of treatment.\u00a0This is expected and may last for a few months.\u00a0It usually does not mean that your blood cancer is getting worse.\u00a0Your doctor will check the number of\u00a0blood cells\u00a0in your blood before or during treatment with Zydelig and in rare cases, another medicine may need to be given.\u00a0Talk to your doctor about what your test results mean.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age as it has not been studied in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zydelig<\/h2>\n\n\n\n<p><strong>Zydelig should not be used with any other medicine unless your doctor has told you it is safe to do so.<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor if you are taking, have recently taken, or might take any other medicines.\u00a0<\/strong>This is extremely important because the use of more than one drug at the same time can strengthen or weaken their effect.<\/p>\n\n\n\n<p>Taking Zydelig with certain other medicines can lead to the medicines not working as they should or to some&nbsp;side effects&nbsp;becoming worse.&nbsp;In particular, tell the doctor if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>alfuzosin<\/strong>, a medicine used to treat enlarged\u00a0prostate<\/li><li>dabigatran,\u00a0warfarin,\u00a0medicines used to thin the blood<\/li><li>amiodarone, bepridil,\u00a0disopyramide,\u00a0lidocaine,\u00a0quinidine,\u00a0medicines used to treat heart problems<\/li><li>dihydroergotamine,\u00a0ergotamine, a medicine used to treat migraine headaches<\/li><li>cisapride, a drug used to relieve certain stomach problems<\/li><li>pimozide,\u00a0a medicine used to treat abnormal thoughts or feelings<\/li><li>midazolam, triazolam,\u00a0when taken by mouth to help you sleep and\/or reduce anxiety<\/li><li>quetiapine,\u00a0a medicine used to treat schizophrenia,\u00a0bipolar disorder,\u00a0and major depression<\/li><li>amlodipine,\u00a0diltiazem, felodipine, nicardipine, nifedipine, medicines used to treat high\u00a0blood pressure\u00a0and heart problems<\/li><li>bosentan,\u00a0a medicine used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension<\/li><li>sildenafil, and tadalafil,\u00a0drugs used to treat\u00a0impotence\u00a0and\u00a0pulmonary\u00a0hypertension, a lung disease that makes breathing difficult<\/li><li>budesonide,\u00a0fluticasone,\u00a0drugs used to treat hay fever and\u00a0asthma, and\u00a0salmeterol,\u00a0used to treat\u00a0asthma<\/li><li>rifabutin,\u00a0a medicine used to treat bacterial\u00a0infections\u00a0such as\u00a0tuberculosis<\/li><li>itraconazole,\u00a0ketoconazole\u00a0, posaconazole, voriconazole,\u00a0medicines used to treat fungal infections<\/li><li>boceprevir, telaprevir,\u00a0medicines used to treat\u00a0hepatitis\u00a0C<\/li><li>carbamazepine, S-mephenytoin,\u00a0phenytoin,\u00a0medicines used to prevent seizures<\/li><li>rifampicin, a medicine used to prevent and treat\u00a0tuberculosis\u00a0and\u00a0other\u00a0infections<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0), a herbal medicine used for mild depression and mild anxiety<\/li><li>alfentanil,\u00a0fentanyl,\u00a0methadone, buprenorphine\/naloxone,\u00a0drugs used for pain relief<\/li><li>ciclosporin, sirolimus, tacrolimus,\u00a0medicines used to control the body&#8217;s\u00a0immune response\u00a0after transplantation<\/li><li>colchicine,\u00a0a medicine used to treat\u00a0gout<\/li><li>trazodone,\u00a0a medicine used to treat depression<\/li><li>buspirone, clorazepate,\u00a0diazepam\u00a0, estazolam, flurazepam, zolpidem,\u00a0medicines used to treat disorders of the nervous system<\/li><li>dasatinib, nilotinib, paclitaxel, vinblastine, vincristine,\u00a0medicines used to treat cancer<\/li><li>oral or implanted hormonal contraceptives\u00a0used to prevent pregnancy<\/li><li>clarithromycin, telithromycin,\u00a0medicines used to treat\u00a0bacterial\u00a0infections<\/li><li>atorvastatin, lovastatin,\u00a0and simvastatin\u00a0are drugs used to lower\u00a0cholesterol.<\/li><\/ul>\n\n\n\n<p>Zydelig can be prescribed in combination with other medicines for the treatment of\u00a0CLL.\u00a0It is very important that you also read the leaflets that come with these medicines.<\/p>\n\n\n\n<p>Contact your doctor if you have any questions about any of your medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Zydelig should not be used during pregnancy.\u00a0<\/strong>There is no information on the safety of this medicine in pregnant women.<\/li><li><strong>Use a safe method of contraception<\/strong>\u00a0to prevent pregnancy while being treated with Zydelig and for 1 month after the last treatment.<\/li><li><strong>Zydelig may mean that the\u00a0pill\u00a0and implanted hormonal contraceptives do not work as well<\/strong>.\u00a0You must use a barrier contraceptive such as\u00a0a condom or\u00a0IUD\u00a0while taking Zydelig and for 1 month after the last treatment.<\/li><li><strong>Tell your doctor immediately if you become pregnant.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>You should not breastfeed<\/strong> while taking Zydelig.\u00a0If you are currently breastfeeding, talk to your doctor before starting treatment with Zydelig.\u00a0It is unknown whether the active substance in Zydelig passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zydelig is unlikely to affect your ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zydelig contains para-orange (E110)<\/h2>\n\n\n\n<p>Tell the doctor if you are allergic to para-orange (E110).&nbsp;Zydelig contains para-orange (E110) which can cause allergic reactions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Zydelig<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended\u00a0dose<\/strong>\u00a0is 150 mg by mouth twice a day.\u00a0However, if you experience certain\u00a0side effects, the doctor may lower the\u00a0dose\u00a0to 100 mg twice a day.<\/p>\n\n\n\n<p>Zydelig can be taken with or without food.<\/p>\n\n\n\n<p><strong>Swallow the tablet whole.&nbsp;<\/strong>Do not chew or crush the tablet.&nbsp;Tell the doctor if you have problems swallowing tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Zydelig<\/h2>\n\n\n\n<p>If you accidentally take more than the recommended&nbsp;dose&nbsp;of Zydelig, you may be at greater risk of&nbsp;side effects&nbsp;from this medicine (see section 4&nbsp;<em>Possible&nbsp;side effects&nbsp;).<\/em><\/p>\n\n\n\n<p>Immediately contact a doctor or the nearest emergency department for advice.&nbsp;Take the can and this leaflet with you so you can easily tell what you have taken.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Zydelig<\/h2>\n\n\n\n<p>Be careful not to miss a&nbsp;dose&nbsp;of Zydelig.&nbsp;If you forget to take a&nbsp;dose&nbsp;by less than 6 hours, take the missed&nbsp;dose&nbsp;immediately.&nbsp;Then take the next&nbsp;dose&nbsp;as usual.&nbsp;If you miss a&nbsp;dose&nbsp;by more than 6 hours, wait and take the next&nbsp;dose&nbsp;at the usual time.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Zydelig<\/h2>\n\n\n\n<p>Do not stop taking this medicine unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious.<\/strong><\/p>\n\n\n\n<p><strong>STOP taking Zydelig and seek medical attention immediately if you experience any of the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reddish spots on the trunk;\u00a0small demarcated areas of discolored skin, often with blisters in the center;\u00a0skin peeling;\u00a0ulcers in the mouth, throat, nose, genitals, and eyes.\u00a0These severe skin rashes may be preceded by fever and\u00a0flu-like symptoms\u00a0(\u00a0Stevens-Johnson syndrome,\u00a0toxic epidermal necrolysis\u00a0).<\/li><li>widespread skin rash, high body temperature, and enlarged\u00a0lymph nodes\u00a0(DRESS syndrome).<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea\/inflammation of the colon<\/li><li>rash<\/li><li>changed the number of\u00a0white blood cells<\/li><li>infection\u00a0_<\/li><li>fever<\/li><\/ul>\n\n\n\n<p><em>Blood tests may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased blood levels of liver enzymes<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the lungs<\/li><li>liver damage<\/li><\/ul>\n\n\n\n<p><em>Blood tests may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated blood levels of fats<\/li><\/ul>\n\n\n\n<p>By reporting\u00a0side effects, you can contribute to increasing information about drug safety.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zydelig<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substance<\/strong>&nbsp;is idelalisib.&nbsp;Each film-coated tablet contains 100 mg of idelalisib.<\/p>\n\n\n\n<p><strong>Other ingredients are:<\/strong><\/p>\n\n\n\n<p><em>Tablet core:<\/em><\/p>\n\n\n\n<p>Microcrystalline cellulose, hydroxypropyl cellulose (E463), croscarmellose sodium, sodium starch glycolate, magnesium stearate.<\/p>\n\n\n\n<p><em>Film coating:<\/em><\/p>\n\n\n\n<p>Polyvinyl alcohol (E1203), macrogol 3350 (E1521), titanium dioxide (E171), talc (E553B), para-orange (E110) (see section 2,&nbsp;<em>What you need to know before you take Zydelig<\/em>&nbsp;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The film-coated tablets are orange, oval tablets, debossed with \u201cGSI\u201d on one side and \u201c100\u201d on the other side.<\/p>\n\n\n\n<p>The following pack size is available: outer carton containing 1 plastic bottle with 60 film-coated tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zydelig is a cancer medicine that contains the active substance idelalisib.\u00a0It works by blocking the effects of an\u00a0enzyme\u00a0involved in the proliferation and survival of certain\u00a0white blood cells\u00a0called\u00a0lymphocytes\u00a0.\u00a0Because this\u00a0enzyme\u00a0is overactivated in some cancerous\u00a0white blood cells\u00a0, Zydelig kills and reduces the number of cancer cells by blocking the\u00a0enzyme\u00a0et.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[28729,28725,28727,28726,28732,28724,28728,28723,28731,28730],"class_list":["post-38693","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-idelalisib","tag-idelalisib-side-effects","tag-idelalisib-tablet","tag-what-idelalisib-is-used-for","tag-what-is-idelalisib","tag-what-is-zydelig","tag-what-zydelig-is-used-for","tag-zydelig","tag-zydelig-side-effects","tag-zydelig-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=38693"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38693\/revisions"}],"predecessor-version":[{"id":38843,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38693\/revisions\/38843"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=38693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=38693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=38693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}