{"id":38689,"date":"2022-12-06T09:01:36","date_gmt":"2022-12-06T09:01:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=38689"},"modified":"2023-10-28T18:19:39","modified_gmt":"2023-10-28T18:19:39","slug":"zyban","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zyban\/","title":{"rendered":"Zyban &#8211; Bupropion hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>150 mg&nbsp;prolonged-release tablet&nbsp;er<br>bupropion hydrochloride<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zyban is and what it is used for<\/h2>\n\n\n\n<p>Zyban is a medicine prescribed for you to help you stop smoking, along with motivational support such as participation in a smoking cessation program.<\/p>\n\n\n\n<p><strong>Treatment with Zyban is most effective if you are completely convinced to stop smoking.&nbsp;<\/strong>Ask your doctor or pharmacist about treatments and other support to help you quit.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Zyban<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zyban<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to bupropion or any of the other ingredients of this medicine (listed in section 6)<\/li><li><strong>if you are taking any other medicines containing bupropion<\/strong>&nbsp;(such as Voxra, for the treatment of&nbsp;<strong>depression<\/strong>&nbsp;)<\/li><li><strong>if you have a condition that causes seizures<\/strong>, such as&nbsp;epilepsy, or if you have previously had seizures<\/li><li>if you have&nbsp;or have had an eating disorder (for example&nbsp;bulimia&nbsp;or&nbsp;anorexia nervosa&nbsp;)<\/li><li>if you have serious liver problems, such as&nbsp;cirrhosis<\/li><li>if you have a brain tumor<\/li><li>if you usually drink a lot of alcohol&nbsp;and have just stopped drinking alcohol or if you will stop while using Zyban<\/li><li>if you have recently stopped using tranquilizers or medicines to treat anxiety&nbsp;(especially benzodiazepines or similar medicines) or if you will stop taking them while you are using Zyban<\/li><li>if you have manic-depressive (bipolar) disorder (extreme mood swings).&nbsp;Zyban can induce an episode of this disorder.<\/li><li>if you are using medicines for depression&nbsp;or&nbsp;Parkinson&#8217;s disease&nbsp;called&nbsp;monoamine oxidase inhibitors&nbsp;(&nbsp;MAOIs&nbsp;)&nbsp;or if you have taken such medicines within the last 14 days.&nbsp;The time may be shorter for some types of&nbsp;MAO inhibitors, ask your doctor.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If any of these apply to you, talk to your doctor immediately and stop using Zyban.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Zyban, as some conditions make you more likely to have&nbsp;side effects&nbsp;(&nbsp;<em>see also section 4)<\/em>.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Zyban is not recommended for people under 18 years of age.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p><strong>Seizures<\/strong><\/p>\n\n\n\n<p>Zyban can cause seizures in about 1 in 1,000 people&nbsp;<em>(For more information, see also &#8220;Other medicines and Zyban&#8221; later in this section and section 4, &#8220;Possible side effects&#8221;)<\/em>. Seizures are more likely:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you regularly drink a lot of alcohol<\/strong><\/li><li><strong>if you have&nbsp;diabetes&nbsp;<\/strong>that you treat with&nbsp;insulin&nbsp;or tablets<\/li><li><strong>if you have ever had a serious head injury.<\/strong><\/li><\/ul>\n\n\n\n<p>Do not use Zyban if any of these apply to you without first agreeing with your doctor that there are good reasons.<\/p>\n\n\n\n<p>If you have a seizure during treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Stop using Zyban and do not take any more tablets.&nbsp;Contact your doctor.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>You may be at greater risk of side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have kidney or liver problems<\/strong><\/li><li><strong>if you are older than 65 years.<\/strong><\/li><\/ul>\n\n\n\n<p>You will need to take a lower&nbsp;dose&nbsp;(&nbsp;<em>see section 3<\/em>&nbsp;) and be closely monitored while taking Zyban.<\/p>\n\n\n\n<p><strong>If you have had any mental health problems<\/strong><\/p>\n\n\n\n<p>Some people using Zyban have experienced hallucinations or delusions (seeing, hearing, or believing things that aren&#8217;t there), thought disorders, or extreme mood swings.&nbsp;These effects are more likely in people with a history of mental health problems.<\/p>\n\n\n\n<p><strong>If you feel depressed or have suicidal thoughts<\/strong><\/p>\n\n\n\n<p>Some people may become depressed when trying to quit smoking and in very rare cases these people have had suicidal thoughts or attempted suicide.&nbsp;Such symptoms have occurred in people taking Zyban, and have been most common during the very first weeks of treatment.<\/p>\n\n\n\n<p>If you feel depressed and have suicidal thoughts.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor or see a hospital as soon as possible.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>If you are taking medication for depression<\/strong><\/p>\n\n\n\n<p>These medicines together with Zyban can lead to serotonin syndrome, which is a potentially life-threatening condition (see \u201cOther medicines and Zyban\u201d in this section).<\/p>\n\n\n\n<p><strong>High&nbsp;blood pressure&nbsp;and Zyban<\/strong><\/p>\n\n\n\n<p>Some people using Zyban have developed high&nbsp;blood pressure&nbsp;that requires treatment.&nbsp;If you already have high&nbsp;blood pressure, it can get worse.&nbsp;This is more likely if you also use&nbsp;<strong>nicotine patches<\/strong>&nbsp;to help you quit smoking.<\/p>\n\n\n\n<p><strong>Your blood pressure will be checked<\/strong>&nbsp;before you start Zyban and while you are taking it, especially if you already have high&nbsp;blood pressure.&nbsp;If you use nicotine patches at the same time, your&nbsp;blood pressure&nbsp;needs to be checked every week.&nbsp;If your&nbsp;blood pressure&nbsp;increases, you may need to stop using Zyban.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zyban<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p><strong>There may be an increased risk of seizures if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines to treat&nbsp;<strong>depression<\/strong>&nbsp;or&nbsp;<strong>other mental health problems<\/strong>&nbsp;(&nbsp;<em>see also \u201cDo not use Zyban\u201d at the beginning of section 2<\/em>&nbsp;)<\/li><li><strong>theophylline<\/strong>&nbsp;for the treatment of&nbsp;<strong>asthma<\/strong>&nbsp;or another lung disease<\/li><li>tramadol, a strong pain-relieving drug<\/li><li>drugs against&nbsp;malaria<\/li><li>stimulants&nbsp;or other medicines to control your&nbsp;weight&nbsp;or appetite<\/li><li>steroids&nbsp;(except ointments,&nbsp;creams,&nbsp;and&nbsp;lotions for eye and skin problems)<\/li><li>antibiotics&nbsp;called&nbsp;quinolones&nbsp;_<\/li><li>certain types of&nbsp;antihistamines&nbsp;that are&nbsp;mainly used to treat&nbsp;allergies&nbsp;and that can cause tiredness<\/li><li>drugs for the treatment of&nbsp;diabetes.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are using any medicine from this list, talk to your doctor immediately<\/strong>&nbsp;before you start using Zyban (&nbsp;<em>see section 3 under &#8220;Some people need to take a lower dose&#8221;<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Some medicines can affect how Zyban works or make you more likely to get&nbsp;side effects, such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines to treat&nbsp;<strong>depression<\/strong>&nbsp;(such as desipramine, imipramine,&nbsp;paroxetine,&nbsp;citalopram, escitalopram, and&nbsp;venlafaxine&nbsp;) or&nbsp;other mental health problems&nbsp;(such as&nbsp;risperidone&nbsp;and thioridazine).&nbsp;Zyban can affect or be affected by some medicines used to treat depression, and you may experience changes in mental status (eg agitation, hallucinations,&nbsp;coma&nbsp;), and other&nbsp;side effects&nbsp;such as body temperature above 38\u00b0C, increased heart rate, unsteady&nbsp;blood pressure, and overactive reflexes, muscle stiffness, lack of coordination, and\/or gastrointestinal symptoms (eg, nausea, vomiting, diarrhea).<\/li><li>medicines to treat&nbsp;Parkinson&#8217;s disease&nbsp;(such as&nbsp;levodopa, amantadine, or orphenadrine)<\/li><li>carbamazepine,&nbsp;phenytoin,&nbsp;or&nbsp;valproate&nbsp;to treat&nbsp;epilepsy&nbsp;or certain&nbsp;mental health problems<\/li><li>certain medicines to treat&nbsp;cancer&nbsp;(such as cyclophosphamide and ifosfamide)<\/li><li>ticlopidine&nbsp;or&nbsp;clopidogrel&nbsp;which is mainly used to treat&nbsp;heart disease&nbsp;or&nbsp;stroke<\/li><li>certain&nbsp;beta blockers&nbsp;(such as&nbsp;metoprolol&nbsp;) which are mainly used to treat high&nbsp;blood pressure<\/li><li>certain medicines to treat&nbsp;irregular heart rhythms&nbsp;(such as&nbsp;propafenone&nbsp;and&nbsp;flecainide&nbsp;)<\/li><li>ritonavir or efavirenz, for the treatment of HIV infection.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor if you are using any medicine from this list.&nbsp;<\/strong>Your doctor will weigh the benefits against the risks for you of using Zyban and the doctor may need to adjust the&nbsp;doses&nbsp;of the other medicines you are taking.<\/li><\/ul>\n\n\n\n<p><strong>Zyban can reduce the effect of other medicines<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are using tamoxifen to treat breast <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>. <\/strong>If this applies to you,&nbsp;talk to your doctor.&nbsp;It may be necessary to switch to another treatment for your smoking cessation.<\/li><li>if you use&nbsp;digoxin&nbsp;for the heart. If this applies to you,&nbsp;talk to your doctor.&nbsp;The doctor may consider changing the&nbsp;dose&nbsp;of&nbsp;digoxin.<\/li><\/ul>\n\n\n\n<p><strong>The dose&nbsp;of some medicines may need to be reduced while you stop smoking<\/strong><\/p>\n\n\n\n<p>When you smoke, the chemicals absorbed by your body can make certain medicines less effective.&nbsp;When you stop smoking, the&nbsp;doses&nbsp;of these medicines may need to be reduced, otherwise, you may experience&nbsp;side effects.<\/p>\n\n\n\n<p>If you are taking any other medicines, contact your doctor if you notice any new symptoms that you think may be&nbsp;side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zyban with alcohol<\/h2>\n\n\n\n<p>Some people may find that they are more sensitive to alcohol while taking Zyban.&nbsp;Your doctor may advise you not to drink alcohol or to drink as little as possible while using Zyban.&nbsp;If you drink a lot, do not stop suddenly, as there may be a risk of you having a seizure.<\/p>\n\n\n\n<p><strong>Effect on urine tests<\/strong><\/p>\n\n\n\n<p>Zyban may interfere with certain urine tests used to detect other drugs.&nbsp;If you need a urine test, tell your doctor or hospital that you are taking Zyban.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Zyban if you are pregnant, think you may be pregnant, or are planning to have a baby.&nbsp;Consult a doctor or pharmacist before taking this medicine.&nbsp;Some studies, but not all, have reported an increased risk of malformations, especially heart defects, in children whose mothers took Zyban.&nbsp;It is not known if this is due to the use of Zyban.<\/p>\n\n\n\n<p>The ingredients in Zyban pass into breast milk.&nbsp;Consult a doctor or pharmacist before taking this medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Some&nbsp;side effects&nbsp;of Zyban such as feeling dizzy or faint can affect your ability to concentrate and judge.<\/p>\n\n\n\n<p><strong>If you have these symptoms, you should not drive or operate machinery.<\/strong><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;A description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Discuss with your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Zyban<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>When to start and how much to take start<\/strong> taking Zyban while you are still smoking set<strong> a date for smoking cessation which should be during the second week of treatment.<\/strong><\/td><\/tr><tr><td><strong>Week 1<\/strong><strong>Continue to smoke while taking&nbsp;<\/strong><strong>Zyban<\/strong><\/td><td><strong>Day 1 to 6<\/strong><\/td><td>Take&nbsp;<strong>one tablet<\/strong>&nbsp;(150 mg)&nbsp;<strong>once daily.<\/strong><\/td><\/tr><tr><td><strong>Day 7<\/strong><\/td><td>Increase your&nbsp;dose&nbsp;to&nbsp;<strong>one tablet twice daily.&nbsp;<\/strong>There should be at least 8 hours between&nbsp;doses&nbsp;and avoid&nbsp;doses&nbsp;close to&nbsp;<strong>bedtime.<\/strong><\/td><\/tr><tr><td><strong>Week 2<\/strong><\/td><td>Continue to take&nbsp;<strong>one tablet twice daily.<\/strong><br>Quit smoking this week on&nbsp;<strong>the day you set for smoking cessation.<\/strong><\/td><\/tr><tr><td><strong>Weeks 3 to 9<\/strong><\/td><td>Continue to take&nbsp;<strong>one tablet twice daily for up to 9 weeks.<\/strong><br>If you have not been able to stop smoking after&nbsp;<strong>7 weeks<\/strong>, your doctor will advise you to stop using Zyban.<br>You may be advised to gradually stop using Zyban after 7-9 weeks.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong><br>Some people need to take a lower&nbsp;dose<\/strong>&nbsp;because they are more likely to have side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are older than 65 years<\/li><li>if you have liver or kidney disease<\/li><li>if you have a higher risk of seizures (&nbsp;<em>see \u201cWarnings and precautions\u201d and \u201cOther medicines and Zyban\u201d in section 2<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p>The recommended maximum&nbsp;dose&nbsp;in these cases is&nbsp;<strong>one 150 mg tablet once daily.<\/strong><\/p>\n\n\n\n<p><strong>How to take your tablets<\/strong><\/p>\n\n\n\n<p><strong>Take your Zyban tablets at least 8 hours apart.&nbsp;Do not take Zyban close to bedtime<\/strong>&nbsp;&#8211; it may lead to difficulty sleeping.<\/p>\n\n\n\n<p>You can take Zyban with or without food.<\/p>\n\n\n\n<p><strong>Swallow the Zyban tablets whole.&nbsp;<\/strong>The tablets should not be crushed, chewed, or split &#8211; if you do, there is a risk of overdose, as the medicine will leave your body too quickly.&nbsp;It can lead to an increased risk of&nbsp;side effects, including seizures.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20000519000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/GlaxoSmithKline\/Media\/Zyban20tablett.jpg\" alt=\"Zyban tablet\" title=\"Zyban tablet\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Zyban<\/h2>\n\n\n\n<p>If you take too many tablets, you are more likely to have a seizure or other&nbsp;side effects.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Without delay<\/strong>, contact a doctor or hospital for an assessment of the risk and advice.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Zyban<\/h2>\n\n\n\n<p>If you have forgotten a&nbsp;dose, wait and take the next tablet as usual.<\/p>\n\n\n\n<p><strong>Do not take a double&nbsp;dose&nbsp;to make up<\/strong>&nbsp;for a missed&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Zyban<\/h2>\n\n\n\n<p>You may need to take Zyban for up to 7 weeks to get the full effect.<\/p>\n\n\n\n<p><strong>Do not stop taking Zyban without first talking to your doctor.&nbsp;<\/strong>You may need to reduce your&nbsp;dose&nbsp;gradually.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong><em>Seizures<\/em><\/strong><\/p>\n\n\n\n<p>About 1 in 1,000 people who use Zyban are at risk of having a seizure.<\/p>\n\n\n\n<p><strong>Symptoms of seizures<\/strong>&nbsp;include convulsions and usually unconsciousness.&nbsp;A person who has had a seizure may be confused afterward and may not be able to remember what happened.<\/p>\n\n\n\n<p>The likelihood of having a seizure is greater if you take too many tablets, if you take other medicines or if you have a higher than usual risk of having a seizure (&nbsp;<em>see section 2<\/em>&nbsp;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you have a seizure<\/strong>, tell your doctor when you are better.&nbsp;<strong>Do not use any more Zyban.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>In rare cases (up to 1 in 1,000) people may have serious allergic reactions to Zyban.&nbsp;Signs of allergic reactions are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin rash (including itchy and pitted rash).&nbsp;Some skin rashes may require hospital care, especially if you also have a sore mouth\/throat or sore eyes.<\/li><li>unusual wheezing or trouble breathing<\/li><li>swelling of the eyelids, lips, or tongue<\/li><li>muscle or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a><\/li><li>collapse, or temporary and sudden memory loss.<\/li><li>If you have any signs of an&nbsp;allergic reaction, contact your doctor immediately,<strong> and do not take any more tablets.<\/strong><\/li><\/ul>\n\n\n\n<p><strong><em>Lupus skin rash or worsening lupus symptoms<\/em><\/strong><\/p>\n\n\n\n<p>Frequency not known &#8211; cannot be estimated from available data in people taking Zyban.&nbsp;Lupus is a disease of the immune system that affects the skin and other organs.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you experience lupus flares<\/strong>,&nbsp;skin rashes,<strong> or&nbsp;lesions&nbsp;(especially on areas exposed to sunlight) while taking Zyban, contact your doctor immediately, as it may be necessary to stop treatment.<\/strong><\/li><\/ul>\n\n\n\n<p><strong><em>Acute&nbsp;generalized exanthematous&nbsp;pustulosis&nbsp;(AGEP)<\/em><\/strong><\/p>\n\n\n\n<p>Frequency not known &#8211; cannot be estimated from available data in people taking Zyban.&nbsp;Symptoms of AGEP include a rash with blisters\/blisters.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you get a rash with filled pimples\/blisters, you should immediately contact a doctor as it may be necessary to stop the treatment.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Occurs in&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty sleeping (do not take Zyban near bedtime).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Occurs in&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling depressed (&nbsp;<em>see also \u201cWarnings and precautions\u201d in section 2<\/em>&nbsp;)<\/li><li>feeling anxious or upset<\/li><li>concentration difficulties<\/li><li>tremors&nbsp;_&nbsp;_<\/li><li>headache<\/li><li>nausea and vomiting<\/li><li>stomach ache or other disturbances (such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a>), taste changes, and&nbsp;dry mouth<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, dizziness, sweating, rash (sometimes due to an&nbsp;allergic reaction&nbsp;), and&nbsp;itching.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Occurs in&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tinnitus and vision changes<\/li><li>increased&nbsp;blood pressure&nbsp;(sometimes severe) and convulsions<\/li><li>loss of appetite (&nbsp;<em>anorexia<\/em>&nbsp;)<\/li><li>feeling of weakness<\/li><li>pain in the chest<\/li><li>confusion<\/li><li>rapid heartbeat.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Occurs in&nbsp;<strong>up to 1 in 1,000<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>seizures (see the beginning of this section)<\/li><li>twitching, muscle stiffness, uncontrolled movements, trouble walking, or problems with coordination (&nbsp;ataxia&nbsp;)<\/li><li>palpitation<\/li><li>fainting and feeling faint when you stand up quickly because your&nbsp;blood pressure&nbsp;drops<\/li><li>feeling irritated or hostile, unusual dreams (including nightmares)<\/li><li>memory loss<\/li><li>tingling or numbness<\/li><li>severe allergic reactions and rashes in connection with joint and muscle pain (&nbsp;see the beginning of this section)<\/li><li>urinating (throwing water) more or less than usual<\/li><li>severe skin rashes in the mouth and other parts of the body, which can be life-threatening<\/li><li>worsening&nbsp;psoriasis&nbsp;(thickened patches of red skin)<\/li><li>yellowing of your skin or the whites of your eyes (jaundice), increased liver enzyme levels, and&nbsp;hepatitis<\/li><li>changes in <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a><\/li><li>unreal or strange feelings (&nbsp;<em>depersonalization<\/em>&nbsp;), hearing and seeing things that are not there (&nbsp;<em>hallucinations<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>Occurs in&nbsp;<strong>up to 1 in 10,000<\/strong>&nbsp;users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the feeling of restlessness, aggressiveness<\/li><li>sensing or believing things that are not true (&nbsp;delusions&nbsp;), and severe suspiciousness (&nbsp;<em>paranoia<\/em>&nbsp;).<\/li><li>urinary incontinence (involuntary emptying of the bladder, urine leakage)<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;have occurred in a few users, but the exact frequency is not known:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>thoughts of harming yourself or of suicide while using Zyban or soon after stopping treatment (see section 2,&nbsp;<em>What you need to know before you use Zyban<\/em>&nbsp;).&nbsp;If you have similar thoughts, you should immediately contact a doctor or go to a hospital.<\/li><li>loss of contact with reality and inability to think or judge clearly (&nbsp;psychosis&nbsp;);&nbsp;other symptoms may include hallucinations and\/or delusions.<\/li><li>stuttering<\/li><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;), decreased number of&nbsp;white blood cells&nbsp;(&nbsp;leukopenia&nbsp;), and decreased number of&nbsp;platelets&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>decreased sodium levels in the blood (&nbsp;hyponatremia&nbsp;) changes in mental status (eg agitation, hallucinations,&nbsp;coma&nbsp;), and other&nbsp;side effects&nbsp;such as body temperature above 38 \u00b0C, increased heart rate, unstable&nbsp;blood pressure,&nbsp;overactive reflexes, muscle stiffness, lack of coordination and\/ or gastrointestinal symptoms (eg nausea, vomiting, diarrhea), may occur if you take Zyban with medicines used to treat depression (eg&nbsp;paroxetine,&nbsp;citalopram, escitalopram,&nbsp;fluoxetine,&nbsp;and&nbsp;venlafaxine&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Reactions to quitting smoking<\/strong><\/p>\n\n\n\n<p>People who stop smoking often experience withdrawal symptoms from nicotine.&nbsp;This can also affect people using Zyban.&nbsp;Signs of nicotine withdrawal symptoms are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty sleeping<\/li><li>tremors and sweating<\/li><li>anxiety, agitation, and depression, sometimes with suicidal thoughts.<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor<\/strong>&nbsp;if you have any concerns about how you are feeling.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zyban<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the packaging.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00baC.<\/p>\n\n\n\n<p>Store in the original packaging.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>Each tablet contains 150 mg of the active substance bupropion hydrochloride.<\/p>\n\n\n\n<p>Other ingredients are Tablet core: microcrystalline cellulose, hypromellose, cysteine \u200b\u200bhydrochloride monohydrate, and magnesium stearate.&nbsp;Film coating: hypromellose, macrogol 400, titanium dioxide (E171), carnauba wax.&nbsp;Printing ink: hypromellose, black iron oxide (dye E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zyban 150 mg tablets are white, film-coated, biconvex, and round and marked with \u201cGX CH7\u201d on one side.&nbsp;They are available in cartons containing child-resistant blisters of 30, 40, 50, 60, or 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>GlaxoSmithKline AB, Box 516, 169 29 Solna<\/p>\n\n\n\n<p>Phone: 08-638 93 00<\/p>\n\n\n\n<p>Email: info.produkt@gsk.com<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Glaxo Wellcome SA, Avenida de Extremadura, 3, 09400 Aranda de Duero, Burgos, Spain.<\/p>\n\n\n\n<p><strong>This medicine is approved within the European Economic Area<\/strong><\/p>\n\n\n\n<p><strong>and Great Britain (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<p><strong>Zyban:<\/strong>&nbsp;Belgium, Denmark, Finland, France, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, United Kingdom (Northern Ireland), Sweden, and Germany<\/p>\n\n\n\n<p><strong>Zyntabac:<\/strong>&nbsp;The Netherlands and Spain<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zyban is a medicine prescribed for you to help you stop smoking, along with motivational support such as participation in a smoking cessation program.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[8169,8173,8171,8172,8170,28740,28741,28739,28743,28742],"class_list":["post-38689","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-bupropion-hydrochloride","tag-bupropion-hydrochloride-side-effects","tag-bupropion-hydrochloride-tablet","tag-what-bupropion-hydrochloride-is-used-for","tag-what-is-bupropion-hydrochloride","tag-what-is-zyban","tag-what-zyban-is-used-for","tag-zyban","tag-zyban-side-effects","tag-zyban-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=38689"}],"version-history":[{"count":7,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38689\/revisions"}],"predecessor-version":[{"id":54109,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38689\/revisions\/54109"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=38689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=38689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=38689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}