{"id":38685,"date":"2022-12-06T08:57:02","date_gmt":"2022-12-06T08:57:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=38685"},"modified":"2022-12-07T07:34:46","modified_gmt":"2022-12-07T07:34:46","slug":"zubsolv","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zubsolv\/","title":{"rendered":"Zubsolv &#8211; Buprenorphine\/naloxone uses, dose and side effects"},"content":{"rendered":"\n<p>0.7 mg\/0.18 mg, 1.4 mg\/0.36 mg, 2.9 mg\/0.71 mg, 5.7 mg\/1.4 mg, 8.6 mg\/2.1 mg and 11.4 mg\/2.9 mg&nbsp;sublingual resorbable tablets<br>buprenorphine\/naloxone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zubsolv is and what it is used for<\/h2>\n\n\n\n<p>Zubsolv contains the active substances buprenorphine and naloxone.\u00a0Zubsolv is used to treat drug addicts who are dependent on opioid drugs (narcotics), such as heroin or morphine, who have consented to treatment for their addiction.\u00a0Treatment with Zubsolv is intended for adults and adolescents over 15 years of age, who also receive medical, social, and psychological support.<\/p>\n\n\n\n<p><strong>How Zubsolv works<\/strong><\/p>\n\n\n\n<p>The resoriblet contains buprenorphine which provides the therapeutic effect of&nbsp;opioid&nbsp;(narcotic) addiction.&nbsp;It also contains naloxone, which is used to prevent&nbsp;intravenous&nbsp;abuse of the product.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Zubsolv<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Zubsolv if you:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>are allergic to buprenorphine, naloxone, or any of the other ingredients of this medicine (listed in section 6)<\/li><li>have\u00a0serious breathing problems<\/li><li>have\u00a0serious liver problems<\/li><li>is intoxicated by alcohol or has tremors, sweating, anxiety, confusion, or hallucinations caused by alcohol<\/li><li>taking naltrexone or nalmefene to treat alcohol or opioid dependence.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Abuse and misuse<\/strong><\/li><\/ul>\n\n\n\n<p>If Zubsolv is used incorrectly, e.g.&nbsp;by&nbsp;injection&nbsp;into a vein (&nbsp;intravenous&nbsp;use), serious cases of&nbsp;infection&nbsp;with a potentially fatal outcome can occur.<\/p>\n\n\n\n<p>This drug may be desirable for people who abuse prescription drugs and should be kept in a safe place to protect it from theft.\u00a0Do not give this medicine to anyone else.\u00a0It can cause death or otherwise injure them.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Breathing problems<\/strong>&nbsp;(see also \u201cDo not take Zubsolv\u201d above)<\/li><\/ul>\n\n\n\n<p>Some people have died from\u00a0respiratory depression\u00a0(severe difficulty breathing) due to misuse of this drug or taking it in combination with other agents that cause\u00a0central nervous system depression, such as alcohol,\u00a0benzodiazepines\u00a0(tranquilizers), or other\u00a0opioids.<\/p>\n\n\n\n<p>This medicine should be used with caution in patients who have breathing problems.<\/p>\n\n\n\n<p>This medicine can cause serious, possibly life-threatening, respiratory paralysis (impaired ability to breathe) in children and people who do not have an opioid addiction.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Drowsiness<\/strong><\/li><\/ul>\n\n\n\n<p>This medicine may cause drowsiness, especially when taken with alcohol or other medicines that cause depression of the&nbsp;central nervous system&nbsp;(such as sedatives, or sleeping pills).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Dependent<\/strong><\/li><\/ul>\n\n\n\n<p>This medicine can be addictive.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Liver damage<\/strong><\/li><\/ul>\n\n\n\n<p>Liver damage has been reported in connection with the use of buprenorphine\/naloxone, especially when the drug has been used incorrectly.\u00a0These liver damages can also be due to viral infections (\u00a0chronic\u00a0hepatitis\u00a0C), alcohol abuse,\u00a0anorexia,\u00a0or the use of other drugs that can damage the liver.\u00a0Regular blood tests may be performed by your doctor to monitor your liver condition.\u00a0<strong>Tell your doctor if you have any liver problems before starting treatment with Zubsolv.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Withdrawal symptoms<\/strong><\/li><\/ul>\n\n\n\n<p>This medicine may cause withdrawal symptoms if you take it sooner than six hours after using a short-acting\u00a0opioid\u00a0(eg, morphine, or heroin) or sooner than 24 hours after using a long-acting\u00a0opioid\u00a0such as\u00a0methadone.<\/p>\n\n\n\n<p>Zubsolv can also cause withdrawal symptoms if you suddenly stop taking it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Blood pressure<\/strong><\/li><\/ul>\n\n\n\n<p>This medicine can cause your&nbsp;blood pressure&nbsp;to drop suddenly, causing you to feel dizzy if you get up quickly from a sitting or lying position.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Sleep-related breathing problems<\/strong><\/li><\/ul>\n\n\n\n<p>Zubsolv can cause sleep-related breathing problems such as\u00a0sleep apnea\u00a0(pauses in breathing during sleep) and sleep-related\u00a0hypoxia\u00a0(low oxygen levels in the blood).\u00a0Symptoms may include breathing pauses during sleep, waking up at night due to shortness of breath, difficulty staying asleep, or excessive fatigue during the day.\u00a0Contact your doctor if you or anyone else observes these symptoms.\u00a0Your doctor may consider reducing the\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Children and young people<\/strong><\/li><\/ul>\n\n\n\n<p>The doctor may monitor you more closely if you are under 18 years of age.&nbsp;This medicine must not be taken by people under 15 years of age.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Diagnosis of unrelated medical conditions<\/strong><\/li><\/ul>\n\n\n\n<p>This medicine can mask pain symptoms that are signs of certain diseases.&nbsp;Remember to inform the doctor that you are taking this medicine.<\/p>\n\n\n\n<p><strong>Talk to your doctor before taking Zubsolv<\/strong>&nbsp;if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have depression or other conditions treated with antidepressants.\u00a0If these medicines are used together with Zubsolv, this can lead to serotonin syndrome, a condition that can be life-threatening (see &#8220;Other medicines and Zubsolv&#8221;).<\/li><li>have kidney problems<\/li><li>have recently suffered a head injury or brain disease<\/li><li>have low\u00a0blood pressure, an enlarged prostate gland, or difficulty urinating due to a narrowing of the urethra<\/li><li>have an underactive\u00a0thyroid\u00a0which can cause fatigue or weight gain<\/li><li>have impaired adrenal function (e.g.\u00a0Addison&#8217;s disease\u00a0)<\/li><li>have problems with the bile ducts (e.g. gallbladder, bile duct)<\/li><li>are older<\/li><li>have a physical or mental weakness.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zubsolv<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Certain medicines can increase the&nbsp;side effects&nbsp;of Zubsolv and in some cases can cause very serious reactions.&nbsp;Do not take other medicines while taking Zubsolv without first talking to your doctor, especially:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antidepressants such as\u00a0<strong>moclobemide, tranylcypromine,\u00a0citalopram<\/strong>, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline, duloxetine,\u00a0venlafaxine, amitriptyline, doxepin, or trimipramine.\u00a0These medicines can affect or be affected by Zubsolv and you may have symptoms such as involuntary rhythmic muscle twitching, including in the muscles that control eye movements, agitation, hallucinations,\u00a0coma, profuse sweating, tremors, increased reflexes, tense muscles and body temperature above 38\u00b0C.\u00a0Contact the doctor if you experience such symptoms.<\/li><li>Naltrexone and nalmefene\u00a0(drugs for the treatment of addiction), as may counteract the therapeutic effects of Zubsolv.\u00a0They must not be taken together with Zubsolv treatment as you may experience a sudden onset of prolonged and intense withdrawal symptoms.<\/li><li>Benzodiazepines\u00a0(used to treat anxiety or sleep disorders) such as\u00a0diazepam, temazepam, and alprazolam.\u00a0If you use Zubsolv at the same time as sedatives such as\u00a0benzodiazepines\u00a0or similar medicines, it can increase the risk of drowsiness, difficulty breathing (\u00a0respiratory depression\u00a0), and\u00a0coma, and it can be life-threatening.\u00a0Concurrent treatment should therefore only be considered if there are no other treatment options.\u00a0However, if the doctor prescribes Zubsolv together with sedative drugs, the doctor must limit the\u00a0dose of\u00a0one and the duration of treatment of the other drug.\u00a0Inform the doctor about all sedatives you are taking and follow the doctor&#8217;s\u00a0prescription very carefully.\u00a0It may be helpful to inform family and friends that they should be aware of the signs and symptoms described above.\u00a0Contact the doctor if you experience any such symptoms.<\/li><li>Other medicines that can make you feel sleepy\u00a0are used to treat conditions such as anxiety, insomnia, seizures\/fits, pain, and other mental health conditions.\u00a0These types of drugs reduce your level of alertness, which can make driving and operating machinery risky.\u00a0They can also cause impairment of the\u00a0central nervous system, which is very serious.\u00a0Below is a list of examples of these types of drugs:<ul><li>other medicines that contain\u00a0opioids, such as\u00a0methadone, some painkillers, or cough suppressants<\/li><li>certain antidepressants (used to treat depression) such as isocarboxazid, phenelzine,\u00a0selegiline, tranylcypromine,\u00a0valproate\u00a0and\u00a0monoamine oxidase inhibitors\u00a0(\u00a0MAOIs\u00a0) may increase the effect of this medicine<\/li><li>sedative\u00a0HI\u00a0receptor\u00a0antagonists (used to treat allergic reactions) such as diphenhydramine and chlorphenamine<\/li><li>barbiturates\u00a0(used to induce sleep or provide a sedative effect) such as phenobarbital and secobarbital<\/li><li>sedative medicines (used to induce sleep or have a sedative effect) such as chloral hydrate<\/li><li>clonidine\u00a0(used to treat high\u00a0blood pressure\u00a0) and related medicines may prolong the effects of this medicine<\/li><\/ul><\/li><li>antiretroviral medicines (used to treat\u00a0HIV\u00a0) such as ritonavir, nelfinavir, and indinavir, may prolong the effect of this medicine<\/li><li>certain antifungal medicines (used to treat fungal infections) such as\u00a0ketoconazole, itraconazole and some\u00a0antibiotics\u00a0may prolong the effects of this medicine<\/li><li>some medicines can reduce the effect of Zubsolv.\u00a0These include drugs for the treatment of\u00a0epilepsy\u00a0(e.g. carbamazepine and\u00a0phenytoin\u00a0), and drugs for the treatment of\u00a0tuberculosis\u00a0(rifampicin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Zubsolv with food, drink, and alcohol<\/h2>\n\n\n\n<p>Alcohol can increase drowsiness and increase the risk of\u00a0respiratory depression\u00a0if used together with Zubsolv.\u00a0<strong>Do not take Zubsolv with alcohol.\u00a0<\/strong>Do not swallow or consume food or drink of any kind until the resorbable has completely dissolved.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>The risks for pregnant women using Zubsolv are not known.\u00a0Inform the doctor if you are pregnant or plan to become pregnant.\u00a0The doctor will decide if your treatment should be continued with another medicine.<\/p>\n\n\n\n<p>If medicines such as Zubsolv are taken during pregnancy, especially during advanced pregnancy, they can cause withdrawal symptoms and also breathing problems in the newborn baby.&nbsp;These problems can occur several days after birth.<\/p>\n\n\n\n<p>Do not breastfeed while taking this medicine, as Zubsolv passes into breast milk.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zubsolv may cause drowsiness.\u00a0It may happen more often in the first few weeks of treatment when your\u00a0dose\u00a0is changed, but it can also happen if you drink alcohol or take other sedatives while taking Zubsolv.\u00a0Do not drive, use tools or machines, or do dangerous activities until you know how this medicine affects you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zubsolv contains Sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Zubsolv<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your treatment is prescribed and supervised by doctors experienced in drug addiction treatment.<\/p>\n\n\n\n<p>The doctor will decide which&nbsp;dose&nbsp;is best for you.&nbsp;During your treatment, the doctor may adjust the&nbsp;dose&nbsp;depending on how you react.<\/p>\n\n\n\n<p><strong>Initial treatment<\/strong><\/p>\n\n\n\n<p>The recommended starting dose for adults and adolescents over 15 years of age is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one recordable tablet of Zubsolv 1.4 mg\/0.36 mg every day or<\/li><li>one recordable tablet of Zubsolv 2.9 mg\/0.71 mg every day.<\/li><\/ul>\n\n\n\n<p>An additional resotriplet of Zubsolv 1.4 mg\/0.36 mg or 2.9 mg\/0.71 mg may be given on day 1, depending on your need.<\/p>\n\n\n\n<p>There are other strengths available for use.&nbsp;The doctor will decide which treatment is best for you.&nbsp;This may mean that you may take a combination of different strengths, but your daily&nbsp;dose&nbsp;should not exceed 17.2 mg of buprenorphine.<\/p>\n\n\n\n<p>Clear signs of&nbsp;withdrawal&nbsp;should be evident before taking the first&nbsp;dose&nbsp;of Zubsolv.&nbsp;The doctor&#8217;s assessment of how ready you are for treatment determines when you should receive the first&nbsp;dose&nbsp;of Zubsolv.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Initial treatment with Zubsolv during heroin addiction:<br>If you are addicted to heroin or a short-acting\u00a0opioid, your first\u00a0dose\u00a0of Zubsolv should be taken when signs of\u00a0withdrawal\u00a0appear, but no earlier than 6 hours after you last used the\u00a0opioid.<\/li><li>Initial treatment with Zubsolv during methadone dependence:<br>If you have taken\u00a0methadone\u00a0or a long-acting\u00a0opioid, the\u00a0dose\u00a0of\u00a0methadone\u00a0should preferably be reduced to below 30 mg\/day before starting treatment with Zubsolv.\u00a0The first\u00a0dose\u00a0of Zubsolv is taken when signs of\u00a0withdrawal\u00a0appear, but no earlier than 24 hours after you last used\u00a0methadone.<\/li><\/ul>\n\n\n\n<p><strong>How to take Zubsolv<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take one\u00a0dose\u00a0once a day or as recommended by your doctor.<\/li><li>Remove the travel tickets from the blister as described below.\u00a0Only open the blister just before you are about to take\u00a0dose\u00a0one.\u00a0Never open the blister in advance because the resorbable is sensitive to moisture.<\/li><li>Place the resoriblets under the tongue.<\/li><li>Keep the recordable tablets in place under the tongue until they are completely dissolved.<\/li><li>You must not chew or swallow the travel tickets.\u00a0The medicine will then not work, and this can lead to withdrawal symptoms.<\/li><li>You may not eat or drink anything until the resoriblets have completely dissolved.\u00a0Although you may notice that most of the resorbable tablet dissolves within 40 seconds, it may take 5 to 10 minutes for the entire resorbable tablet to disappear from your mouth.<\/li><\/ul>\n\n\n\n<p><strong>Do this to remove the travel ticket from the blister card<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><td>1. Do not push the recordable label through the foil.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><td>2. Remove a box from the blister card by dragging along the perforated line.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><td>3. Fold the map along the dotted line.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><td>4. Pull off the foil in the direction of the arrow.\u00a0If the blister card is damaged, discard the recordable label.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Dose adjustment and maintenance treatment<\/strong><\/p>\n\n\n\n<p>The doctor may increase the&nbsp;dose&nbsp;of Zubsolv according to your needs.&nbsp;Talk to the doctor or pharmacist if you think the effect of Zubsolv is too strong or too weak.&nbsp;The maximum daily&nbsp;dose&nbsp;is 17.2 mg.<\/p>\n\n\n\n<p>After a period of successful treatment, you can agree with the doctor to gradually reduce the\u00a0dose\u00a0to a lower maintenance dose.<\/p>\n\n\n\n<p><strong>End of treatment<\/strong><\/p>\n\n\n\n<p>Do not change the treatment in any way, and do not stop the treatment without the consent of the doctor treating you.<\/p>\n\n\n\n<p>Beroende p\u00e5 ditt tillst\u00e5nd, kan man forts\u00e4tta att minska&nbsp;dosen av Zubsolv under noggrann medicinsk \u00f6vervakning, tills den eventuellt kan avslutas helt.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Om du har tagit f\u00f6r stor m\u00e4ngd av Zubsolv<\/h2>\n\n\n\n<p>Om du eller n\u00e5gon annan tar f\u00f6r stor m\u00e4ngd av detta l\u00e4kemedel, m\u00e5ste du omedelbart ta dig till eller tas till en akutmottagning eller sjukhus f\u00f6r behandling, eftersom \u00f6verdosering med Zubsolv kan orsaka allvarliga och livshotande andningsproblem.<\/p>\n\n\n\n<p>Symptom p\u00e5 \u00f6verdosering kan inkludera l\u00e5ngsammare och svagare andning \u00e4n normalt, att du k\u00e4nner dig mer s\u00f6mnig \u00e4n normalt, minskning av pupillernas storlek, l\u00e5gt&nbsp;blodtryck, sjukdomsk\u00e4nsla, kr\u00e4kningar och\/eller sluddrigt tal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Om du har gl\u00f6mt att ta Zubsolv<\/h2>\n\n\n\n<p>Ber\u00e4tta f\u00f6r l\u00e4karen s\u00e5 snart som m\u00f6jligt om du missar en&nbsp;dos.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Om du slutar att ta Zubsolv<\/h2>\n\n\n\n<p>\u00c4ndra inte behandlingen p\u00e5 n\u00e5got s\u00e4tt och avbryt inte behandlingen utan samtycke fr\u00e5n den l\u00e4kare som behandlar dig.&nbsp;<strong>Pl\u00f6tsligt avbrytande av behandlingen kan leda till abstinenssymptom.<\/strong><\/p>\n\n\n\n<p>Om du har ytterligare fr\u00e5gor om detta l\u00e4kemedel, kontakta l\u00e4kare eller apotekspersonal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Eventuella biverkningar<\/h2>\n\n\n\n<p>Liksom alla l\u00e4kemedel kan detta l\u00e4kemedel orsaka&nbsp;biverkningar, men alla anv\u00e4ndare beh\u00f6ver inte f\u00e5 dem.<\/p>\n\n\n\n<p><strong>Meddela genast l\u00e4kare eller s\u00f6k akutv\u00e5rd<\/strong>&nbsp;om du upplever&nbsp;biverkningar s\u00e5som:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>uppsv\u00e4llt ansikte, l\u00e4ppar, tunga eller hals, som kan g\u00f6ra det sv\u00e5rt att sv\u00e4lja eller andas, allvarliga utslag\/n\u00e4sselutslag. Dessa kan vara tecken p\u00e5 en livshotande&nbsp;allergisk reaktion<\/li><li>k\u00e4nsla av s\u00f6mnighet och klumpighet, dimsyn, sluddrigt tal, sv\u00e5righeter att t\u00e4nka klart eller att andningen blir mycket l\u00e5ngsammare \u00e4n vad som \u00e4r normalt f\u00f6r dig<\/li><li>sv\u00e5r tr\u00f6tthet,&nbsp;kl\u00e5da&nbsp;med gulf\u00e4rgning av hud eller \u00f6gon. Dessa kan vara symptom p\u00e5 leverskada.<\/li><li>att man ser eller h\u00f6r saker som inte finns (hallucinationer).<\/li><\/ul>\n\n\n\n<p><strong>Andra&nbsp;biverkningar<\/strong><\/p>\n\n\n\n<p><strong>Mycket vanliga<\/strong>&nbsp;(kan f\u00f6rekomma hos fler \u00e4n 1 av 10 anv\u00e4ndare):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>s\u00f6mnl\u00f6shet (of\u00f6rm\u00e5ga att sova)<\/li><li>huvudv\u00e4rk<\/li><li>f\u00f6rstoppning, illam\u00e5ende<\/li><li>kraftig svettning<\/li><li>drogabstinenssyndrom.<\/li><\/ul>\n\n\n\n<p><strong>Vanliga<\/strong>&nbsp;(kan f\u00f6rekomma hos upp till 1 av 10 anv\u00e4ndare):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>influensaliknande symptom,&nbsp;infektion, halsont och ont att sv\u00e4lja, rinnande n\u00e4sa<\/li><li>\u00e5ngest, depression, minskad sexlust, nervositet, onormala tankar<\/li><li>migr\u00e4n, yrsel, svimning, \u00f6kade muskelsp\u00e4nningar, stickande k\u00e4nsla i huden, d\u00e5sighet<\/li><li>\u00f6kat t\u00e5rfl\u00f6de (rinnande \u00f6gon) eller annan rubbning i t\u00e5rfl\u00f6det, dimsyn<\/li><li>f\u00f6rh\u00f6jt&nbsp;blodtryck, v\u00e4rmevallningar<\/li><li>\u00f6kad hosta<\/li><li>magsm\u00e4rta, orolig mage eller andra magbesv\u00e4r, diarr\u00e9, gaser, kr\u00e4kningar.<\/li><li>utslag,&nbsp;kl\u00e5da,&nbsp;n\u00e4sselutslag<\/li><li>ryggv\u00e4rk, ledv\u00e4rk, muskelsm\u00e4rta, benkramper (muskelspasmer)<\/li><li>urinbesv\u00e4r<\/li><li>sv\u00e5righeter att f\u00e5 eller beh\u00e5lla en&nbsp;erektion<\/li><li>svaghet, br\u00f6stsm\u00e4rta, frossa, feber, k\u00e4nsla av allm\u00e4nt obehag, sm\u00e4rta, svullnad (h\u00e4nder och f\u00f6tter)<\/li><li>onormal leverfunktion, viktminskning<\/li><li>skada vid olycksfall p\u00e5 grund av s\u00e4nkt medvetandegrad eller koordination.<\/li><\/ul>\n\n\n\n<p><strong>Mindre vanliga<\/strong>&nbsp;(kan f\u00f6rekomma hos upp till 1 av 100 anv\u00e4ndare):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>avvikande blodprover, svullna&nbsp;k\u00f6rtlar&nbsp;(lymfknutor)<\/li><li>onormala dr\u00f6mmar, uppr\u00f6rdhet (agitation), ointresse, personlighetsf\u00f6r\u00e4ndring (inte k\u00e4nna sig som sig sj\u00e4lv), l\u00e4kemedelsberoende, \u00f6verdriven k\u00e4nsla av v\u00e4lbefinnande, k\u00e4nslor av fientlighet<\/li><li>minnesf\u00f6rlust(minnesst\u00f6rning), krampanfall, talsv\u00e5righeter, darrningar<\/li><li>\u00f6goninflammation eller&nbsp;\u00f6goninfektion, liten pupillstorlek<\/li><li>fast or slow heartbeats, myocardial infarction (heart attack), palpitations, tightness in the chest<\/li><li>low&nbsp;blood pressure<\/li><li>asthma&nbsp;, shortness of breath, yawning<\/li><li>pain and sores in the mouth, discoloration of the tongue<\/li><li>acne&nbsp;, hair loss, dry or scaly skin, skin lump<\/li><li>arthritis<\/li><li>protein&nbsp;in the urine, urinary tract infection, difficulty urinating, pain when you urinate, blood in the urine,&nbsp;kidney stones<\/li><li>menstrual or vaginal problems, abnormal ejaculation (semen depletion)<\/li><li>sensitivity to heat or cold<\/li><li>heatstroke.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>deterioration of brain function, which is a serious complication of liver disease<\/li><li>feeling that everything is spinning<\/li><li>drop in blood pressure when changing position from sitting or lying to standing<\/li><li>sudden withdrawal syndrome caused by taking the medicine too soon after using illicit\u00a0opioids, and drug withdrawal syndrome in newborns.<\/li><\/ul>\n\n\n\n<p>Misuse of this medicine by\u00a0injection\u00a0can cause withdrawal symptoms,\u00a0infection, other skin reactions, and potentially serious liver problems (see section 2, Warnings and precautions).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zubsolv<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25\u00b0C.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Zubsolv can be demanding for people who abuse prescription drugs.&nbsp;Keep this medicine in a safe place to protect it from theft.<\/p>\n\n\n\n<p>Keep the blister safe.<\/p>\n\n\n\n<p>Never open the blister beforehand.<\/p>\n\n\n\n<p>Do not take this medicine in front of children.<\/p>\n\n\n\n<p>In case of accidental ingestion or suspected ingestion, an emergency department must be contacted immediately.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substances are buprenorphine and naloxone.<\/p>\n\n\n\n<p>One 0.7 mg\/0.18 mg&nbsp;sublingual&nbsp;resorbable tablet contains 0.7 mg buprenorphine (as hydrochloride) and 0.18 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>One 1.4 mg\/0.36 mg&nbsp;sublingual&nbsp;resorbable tablet contains 1.4 mg buprenorphine (as hydrochloride) and 0.36 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>One 2.9 mg\/0.71 mg&nbsp;sublingual&nbsp;resorbable tablet contains 2.9 mg buprenorphine (as hydrochloride) and 0.71 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>One 5.7 mg\/1.4 mg&nbsp;sublingual&nbsp;resorbable tablet contains 5.7 mg buprenorphine (as hydrochloride) and 1.4 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>One 8.6 mg\/2.1 mg&nbsp;sublingual&nbsp;resorbable tablet contains 8.6 mg buprenorphine (as hydrochloride) and 2.1 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>One 11.4 mg\/2.9 mg&nbsp;sublingual&nbsp;resorbable tablet contains 11.4 mg buprenorphine (as hydrochloride) and 2.9 mg naloxone (as hydrochloride dihydrate).<\/p>\n\n\n\n<p>Other ingredients are mannitol, citric acid, sodium citrate, microcrystalline cellulose, croscarmellose sodium, sucralose, levomenthol,\u00a0colloidal\u00a0anhydrous silica, and sodium stearyl fumarate (see section 2 &#8220;Zubsolv contains sodium&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zubsolv is available in six different strengths, distinguished by its shape and embossing:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Zubsolv resotriplet strength<\/strong>(buprenorphine\/naloxone)<\/td><td><strong>Description of the Zubsolv leaflet<\/strong><\/td><td><strong>Embossing of the Zubsolv travel card<\/strong><\/td><td><strong>Appearance<\/strong><\/td><\/tr><tr><td>0.7 mg\/0.18 mg<\/td><td>A white to off-white, oval travel label, length 6.8 mm and width 4.0 mm<\/td><td>\u201c.7\u201d on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>1.4 mg\/0.36 mg<\/td><td>A white to off-white triangular travel label, base 7.2 mm and height 6.9 mm<\/td><td>&#8220;1.4&#8221; on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>2.9mg\/0.71mg<\/td><td>A white to off-white D-shaped travel label, height 7.3 mm and width 5.65 mm<\/td><td>&#8220;2.9&#8221; on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>5.7 mg\/1.4 mg<\/td><td>A white to off-white round travel label, 7 mm in diameter<\/td><td>&#8220;5.7&#8221; on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>8.6 mg\/2.1 mg<\/td><td>A white to off-white diamond-shaped travel label, length 9.5 mm and width 8.2 mm<\/td><td>&#8220;8.6&#8221; on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>11.4 mg\/2.9 mg<\/td><td>A white to off-white capsule-shaped travel label, length 10.3 mm and width 8.2 mm<\/td><td>&#8220;11.4&#8221; on one side<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161006000020#\" rel=\"noopener\"><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Zubsolv is available in blisters with 7, 28, or 30 resorbable tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center, Moll de Barcelona, \u200b\u200bs\/n<\/p>\n\n\n\n<p>Edifici Est 6\u00aa planta<\/p>\n\n\n\n<p>08039 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zubsolv contains the active substances buprenorphine and naloxone.\u00a0Zubsolv is used to treat drug addicts who are dependent on opioid drugs (narcotics), such as heroin or morphine, who have consented to treatment for their addiction.\u00a0Treatment with Zubsolv is intended for adults and adolescents over 15 years of age, who also receive medical, social and psychological support.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[3584,3587,8219,8221,8115,8114,8220,28755,8222,28756,28754,28757],"class_list":["post-38685","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-buprenorphine","tag-buprenorphine-side-effects","tag-naloxone","tag-naloxone-side-effects","tag-what-buprenorphine-is-used-for","tag-what-is-buprenorphine","tag-what-is-naloxone","tag-what-is-zubsolv","tag-what-naloxone-is-used-for","tag-what-zubsolv-is-used-for","tag-zubsolv","tag-zubsolv-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=38685"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38685\/revisions"}],"predecessor-version":[{"id":38847,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/38685\/revisions\/38847"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=38685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=38685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=38685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}