{"id":36155,"date":"2022-11-25T12:58:48","date_gmt":"2022-11-25T12:58:48","guid":{"rendered":"https:\/\/zeepedia.com\/?p=36155"},"modified":"2022-11-28T07:35:42","modified_gmt":"2022-11-28T07:35:42","slug":"zoely","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zoely\/","title":{"rendered":"Zoely &#8211; Nomegestrol acetate\/estradiol uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg\/1.5 mg&nbsp;film-coated tablets<br>nomegestrol acetate\/estradiol<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zoely 2.5 mg\/1.5 mg film-coated tablets are and what they are used for<\/h2>\n\n\n\n<p>Zoely is a&nbsp;birth control pill&nbsp;used to prevent pregnancy.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>All 24 white film-coated tablets are active tablets containing a small amount of two different female sex hormones.\u00a0These are nomegestrol acetate (a\u00a0progestogen\u00a0) and estradiol (an\u00a0estrogen\u00a0).<\/li><li>The 4 yellow film-coated tablets are inactive tablets that do not contain any\u00a0hormones\u00a0and are called placebo tablets.<\/li><li>Birth control pills\u00a0that contain two different\u00a0hormones\u00a0, such as Zoely, are called combined\u00a0birth control pills.<\/li><li>Nomegestrol acetate (\u00a0gestagen\u00a0et in Zoely) and estradiol (\u00a0estrogen\u00a0et in Zoely) work together to prevent\u00a0ovulation\u00a0(ovulation, when the egg is released from the ovary) and reduce the chance of the released egg being fertilized and getting pregnant.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>Before you start using Zoely, you should read the information about blood clots (&nbsp;thrombosis&nbsp;) in section 2. It is especially important to read about the symptoms of blood clots &#8211; see section 2, &#8220;Blood clots&#8221;.<\/p>\n\n\n\n<p>Before you can start taking Zoely, your doctor\/midwife will ask you questions about your personal and your close relatives&#8217; medical history to give you individual treatment advice.<\/p>\n\n\n\n<p>The doctor\/midwife will also measure your\u00a0blood pressure\u00a0and, depending on your situation, also carry out other examinations.<\/p>\n\n\n\n<p>This leaflet describes situations that mean you should stop taking your\u00a0birth control pills\u00a0or mean that the birth control pill&#8217;s protection against pregnancy may be reduced.\u00a0In such situations, you should either avoid having sex or use additional protection that does not contain\u00a0hormones, such as a condom or another\u00a0barrier method.\u00a0Do not use safe periods or temperature methods.\u00a0These methods may not protect against pregnancy because the pill interferes with normal changes in body temperature and cervical\u00a0secretions\u00a0that occur during the menstrual cycle.<\/p>\n\n\n\n<p><strong>Zoely, like other hormonal contraceptives,\u00a0does not protect against\u00a0infection\u00a0with human immunodeficiency virus (\u00a0HIV\u00a0) (which can lead to acquired immunodeficiency syndrome,\u00a0AIDS\u00a0) or other sexually transmitted diseases.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>Do not use Zoely if you have any of the conditions listed below.&nbsp;If you have any of these conditions, you must inform your doctor\/midwife.&nbsp;Your doctor\/midwife will discuss what other type of contraception may be more appropriate.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have (or have ever had) a blood clot in a blood vessel in the legs (deep\u00a0vein thrombosis, DVT), in the lungs (\u00a0pulmonary embolism\u00a0), or any other organ<\/li><li>if you have a disease that affects blood clotting \u2013 eg\u00a0protein\u00a0C deficiency,\u00a0protein\u00a0S deficiency, antithrombin III deficiency, Factor V Leiden or antiphospholipid antibodies<\/li><li>if you need to undergo an operation or if you will be bedridden for a long time (see section &#8220;Blood clots&#8221;)<\/li><li>if you have ever had or have had a heart attack\u00a0or\u00a0stroke<\/li><li>if you have ever had angina (a condition that causes severe chest pain and can be an early sign that the blood vessels around the heart have been blocked, a so-called heart attack) or\u00a0transient\u00a0ischemic attack (\u00a0TIA\u00a0&#8211; transient stroke symptoms)<\/li><li>if you have any of the following diseases that can increase the risk of a blood clot in the arteries:<ul><li>severe\u00a0diabetes\u00a0with blood vessel damage<\/li><li>very high\u00a0blood pressure<\/li><li>very high levels of certain blood fats (cholesterol and\u00a0triglycerides\u00a0)<\/li><li>a condition called hyperhomocysteinemia.<\/li><\/ul><\/li><li>if you have ever had a type of\u00a0migraine\u00a0called &#8216;migraine with aura&#8217;<\/li><li>if you have ever had\u00a0inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0) and at the same time high levels of blood fats<\/li><li>if you have ever had severe liver disease and your liver function is not yet normal<\/li><li>if you have ever had a benign or malignant\u00a0tumor\u00a0in the liver<\/li><li>if you have ever had or if you think you may have breast or abdominal cancer<\/li><li>if you have or have had a meningioma (a usually benign\u00a0tumor\u00a0that occurs in the\u00a0tissue\u00a0between the brain and the skull).\u00a0If you are unsure, ask your doctor.<\/li><li>if you have vaginal bleeding for no known reason<\/li><li>if you are allergic to estradiol or nomegestrol acetate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of these conditions appear for the first time while using Zoely, stop treatment immediately and contact your doctor.\u00a0In the meantime, you must use a contraceptive that does not contain\u00a0hormones.\u00a0See also &#8220;General information&#8221; in section 2 above.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Zoely.<\/p>\n\n\n\n<p>When should you contact a doctor?<\/p>\n\n\n\n<p>See a doctor immediately if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>detect any signs of a blood clot that could mean you have a blood clot in the leg (so-called deep\u00a0vein thrombosis\u00a0), a blood clot in the lung (so-called\u00a0pulmonary embolism\u00a0), a heart attack, or\u00a0a stroke\u00a0(see section &#8220;Blood clots&#8221; below).<\/li><\/ul>\n\n\n\n<p>For a description of the symptoms of these serious\u00a0side effects, see the section &#8220;How to recognize a blood clot&#8221;.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>notice any change in your health, especially if it is linked to any of the conditions mentioned in this leaflet (see also section 2 \u201cDo not use Zoely\u201d, also do not forget changes in the health of your immediate family)<\/li><li>feel a lump in the chest<\/li><li>get symptoms of\u00a0angioedema\u00a0such as swelling of the face, tongue, or throat, get difficulty swallowing or\u00a0hives\u00a0along with breathing difficulties<\/li><li>must use other medicines (see also section 2 &#8220;Other medicines and Zoely&#8221;)<\/li><li>become temporarily immobile or have surgery (tell your doctor at least four weeks before surgery)<\/li><li>have unexpected, heavy abdominal bleeding<\/li><li>missed one or more tablets during the first tablet schedule and had unprotected sex during any of the previous 7 days (see also section 3 \u201cIf you forget to take Zoely\u201d)<\/li><li>have severe diarrhea or severe vomiting<\/li><li>do not have a period and suspect that you are pregnant (do not start the next tablet chart before you have spoken to your doctor\/midwife, see also section 3 &#8220;If you have missed one or more periods&#8221;).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor\/midwife if any of the following conditions apply to you<\/strong>.<\/p>\n\n\n\n<p>If the condition develops or worsens while using Zoely, you should also contact your doctor\/midwife if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hereditary and acquired\u00a0angioedema.\u00a0Consult your doctor immediately if you develop symptoms of\u00a0angioedema, such as swelling of the face, tongue, or throat, difficulty swallowing, or\u00a0hives\u00a0along with difficulty breathing.\u00a0Medicines that contain\u00a0estrogen\u00a0can induce or worsen the symptoms of\u00a0angioedema.<\/li><li>epilepsy\u00a0(see section 2 \u201cOther medicines and Zoely\u201d)<\/li><li>liver disease (e.g. jaundice) or gallbladder disease (e.g.\u00a0gallstones\u00a0)<\/li><li>diabetes<\/li><li>Depression<\/li><li>Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis\u00a0(\u00a0chronic\u00a0inflammatory\u00a0bowel disease)<\/li><li>systemic lupus erythematosus (\u00a0SLE, a disease that affects your natural immune system)<\/li><li>hemolytic uremic syndrome\u00a0(HUS, a disease that affects blood clotting and causes\u00a0kidney failure\u00a0)<\/li><li>sickle cell anemia\u00a0(an inherited disease that affects the red\u00a0blood cells\u00a0)<\/li><li>elevated levels of blood fats (\u00a0hypertriglyceridemia\u00a0) or heredity for this condition.\u00a0Hypertriglyceridemia\u00a0has been associated with an increased risk of developing\u00a0pancreatitis\u00a0(\u00a0inflammation\u00a0of the pancreas).<\/li><li>inflammation\u00a0of the veins under the skin (superficial\u00a0thrombophlebitis\u00a0)<\/li><li>varicose veins<\/li><li>a condition that first appeared, or worsened, during pregnancy or previous use of female\u00a0hormones\u00a0(eg hearing loss,\u00a0porphyria\u00a0[a blood disorder],\u00a0herpes\u00a0gestationis [blistering skin rash that occurs during pregnancy], Sydenham&#8217;s chorea [a neurological disorder in which involuntary sudden body movements occur])<\/li><li>or have ever had chloasma (yellow-brown pigment spots on the skin, so-called pregnancy spots, especially on the face).\u00a0In that case, avoid too much sunlight or ultraviolet radiation.<\/li><\/ul>\n\n\n\n<p><strong>Also tell your doctor if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a close relative has, or has ever had, breast cancer<\/li><li>you need to undergo an operation or if you are bedridden for a long time (see section 2 &#8220;Blood clots&#8221;)<\/li><li>you have just given birth, as you are at increased risk of blood clots.&nbsp;Ask your doctor how soon after delivery you can start taking Zoely.<\/li><\/ul>\n\n\n\n<p><strong>BLOOD CLOTS<\/strong><\/p>\n\n\n\n<p>If you use combined hormonal contraceptives such as Zoely, the risk of blood clots increases compared to not using these preparations.&nbsp;In rare cases, a blood clot can block blood vessels and cause serious problems.<\/p>\n\n\n\n<p>Blood clots can form<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in veins (called venous\u00a0thrombosis, venous thromboembolism, or VTE)<\/li><li>in the\u00a0arteries\u00a0(so-called\u00a0arterial\u00a0thrombosis,\u00a0arterial\u00a0thromboembolism, or ATE).<\/li><\/ul>\n\n\n\n<p>Recovery from blood clots is not always complete.&nbsp;In rare cases, they can cause serious permanent effects and, in very rare cases, be life-threatening.<\/p>\n\n\n\n<p><strong>It is important to remember that the overall risk of a harmful blood clot due to Zoely is small.<\/strong><\/p>\n\n\n\n<p><strong>THIS IS HOW YOU RECOGNIZE A BLOOD CLOT<\/strong><\/p>\n\n\n\n<p>Seek medical attention immediately\u00a0if you notice any of the following signs or symptoms.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Are you experiencing any of these signs?<\/th><th scope=\"col\">What could you possibly be suffering from?<\/th><\/tr><\/thead><tbody><tr><td>\u2022 swelling of a leg or along a blood vessel in the leg or foot, especially if you also get:<br>\u2022 pain or tenderness in the leg that is felt only when standing or walking\u2022 increased heat in the affected leg \u2022 color change of the skin on the leg eg pale, red, or blue<\/td><td>Deep&nbsp;vein thrombosis<\/td><\/tr><tr><td>\u2022 sudden unexplained shortness of breath or rapid breathing\u2022 sudden coughing for no apparent reason which could lead to you coughing up blood\u2022 severe chest pain that may increase with deep breaths\u2022 strong feeling of unsteadiness or dizziness\u2022 fast or irregular heartbeats\u2022 severe pain in the stomach.<br>If you are unsure, consult a doctor as some of these symptoms eg cough and shortness of breath can be misinterpreted as a milder condition such as a respiratory infection (eg a common cold).<\/td><td>Pulmonary embolism<\/td><\/tr><tr><td>Symptoms that usually occur in one eye:<br>\u2022 immediate vision loss or\u2022 blurred vision without pain that can develop into vision loss.<\/td><td>Retinal&nbsp;vein thrombosis&nbsp;(blood clot in the eye)<\/td><\/tr><tr><td>\u2022 chest pain, discomfort, pressure, heaviness\u2022 feeling of pressure or fullness in the chest, arm, or under the sternum\u2022 feeling of fullness, indigestion, or feeling of suffocation\u2022 discomfort in the upper body that radiates to the back, jaw, neck, arm, and stomach\u2022 sweating, nausea, vomiting or dizziness\u2022 extreme weakness, anxiety or shortness of breath\u2022 fast or irregular heartbeats.<\/td><td>Myocardial infarction<\/td><\/tr><tr><td>\u2022 sudden weakness or numbness in the face, arms, or legs, especially on one side of the body\u2022 sudden confusion, difficulty speaking or understanding\u2022 sudden difficulty seeing with one or both eyes\u2022 sudden difficulty walking, dizziness, loss of balance or coordination\u2022 sudden, severe or prolonged headache with no known cause\u2022 unconsciousness or fainting with or without seizures.<br>Sometimes the symptoms of a\u00a0stroke\u00a0can be short-lived with almost immediate or complete recovery, but you should still seek medical attention immediately because you are at risk of another\u00a0stroke.<\/td><td>Stroke<\/td><\/tr><tr><td>\u2022 swelling and slight blue discoloration of the leg or arm\u2022 severe abdominal pain (\u00a0acute\u00a0abdomen).<\/td><td>Blood clots that block other blood vessels<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>BLOOD CLOTS IN A VEIN<\/strong><\/p>\n\n\n\n<p><strong>What can happen if a blood clot forms in a vein?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The use of combined hormonal contraceptives has been associated with an increased risk of blood clots in a vein (venous\u00a0thrombosis\u00a0).\u00a0However, these\u00a0side effects\u00a0are rare.\u00a0They most often occur during the first year of using a combined hormonal contraceptive.<\/li><li>If a blood clot forms in a vein in a leg or foot, it can cause a deep\u00a0vein thrombosis\u00a0(DVT).<\/li><li>If a blood clot travels from the leg and lodges in the lung, it can cause a\u00a0pulmonary embolism.<\/li><li>In very rare cases, a blood clot can form in a vein in another organ, such as the eye (\u00a0retinal\u00a0vein thrombosis\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>When is the risk of developing a blood clot in a vein the greatest?<\/strong><\/p>\n\n\n\n<p>The risk of developing a blood clot in a vein is greatest during the first year and the first time you use combined hormonal contraceptives.&nbsp;The risk may also be higher if you start again with a combined hormonal contraceptive (the same product or a different product) after a break of 4 weeks or longer.<\/p>\n\n\n\n<p>After the first year, the risk decreases but is always slightly higher than if you do not use a combined hormonal contraceptive.<\/p>\n\n\n\n<p>When you stop using Zoely, the risk of a blood clot returns to normal within a few weeks.<\/p>\n\n\n\n<p><strong>How big is the risk of developing a blood clot?<\/strong><\/p>\n\n\n\n<p>The risk depends on your natural risk of VTE and the type of combined hormonal contraceptive you are taking.<\/p>\n\n\n\n<p>The overall risk of a blood clot in a leg or lung with Zoely is small.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Out of 10,000 women who are not using a combined hormonal contraceptive and are not pregnant, about 2 develop a blood clot within a year.<\/li><li>Out of 10,000 women who use combined hormonal contraceptives containing levonorgestrel, norethisterone, or norgestimate, about 5-7 develop a blood clot during one year.<\/li><li>The risk of blood clots with Zoely compared to a combined hormonal contraceptive containing levonorgestrel is about the same.<\/li><li>The risk of a blood clot varies depending on your personal medical history (see \u201cFactors that increase the risk of a blood clot\u201d below).<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Risk of developing a blood clot over a year<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Women who\u00a0<strong>do not use<\/strong>\u00a0combined hormonal contraceptives and who are not pregnant<\/td><td>About 2 in 10,000 women<\/td><\/tr><tr><td>Women using a combined hormonal contraceptive containing\u00a0<strong>levonorgestrel, norethisterone, or norgestimate<\/strong><\/td><td>About 5-7 out of 10,000 women<\/td><\/tr><tr><td>Women using Zoely<\/td><td>Much the same as with other combined hormonal contraceptives, including contraceptives containing levonorgestrel<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Factors that can increase the risk of a blood clot in a vein<\/strong><\/p>\n\n\n\n<p>The risk of a blood clot with Zoely is small, but certain conditions increase the risk.&nbsp;The risk is higher:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are very overweight (body mass index or\u00a0BMI\u00a0over 30 kg\/m\u00a0<sup>2<\/sup>\u00a0)<\/li><li>if a close relative has had a blood clot in the leg, lung, or other organs at a young age (e.g. younger than about 50 years).\u00a0If so, you may have an inherited blood clotting disorder.<\/li><li>if you need to undergo an operation or are bedridden for a long time due to an injury or illness, or if you have a leg cast.\u00a0The use of Zoely may need to be stopped for several weeks before an operation or while you are less mobile.\u00a0If you have to stop using Zoely, ask your doctor when you can start using it again.<\/li><li>with increasing age (especially if you are over about 35)<\/li><li>if you have given birth a few weeks ago.<\/li><\/ul>\n\n\n\n<p>The risk of developing a blood clot increases the more conditions you have.<\/p>\n\n\n\n<p>Air travel (longer than 4 hours) may temporarily increase the risk of a blood clot, especially if you have any of the other factors listed.<\/p>\n\n\n\n<p>You must tell your doctor if you have any of these conditions, even if you are not sure.\u00a0Your doctor may decide that you need to stop using Zoely.<\/p>\n\n\n\n<p>If any of the above conditions change while you are using Zoely, for example, a close relative gets a blood clot for no known reason or if you gain a lot of weight, talk to your doctor.<\/p>\n\n\n\n<p><strong>BLOOD CLOTS IN AN&nbsp;ARTERY<\/strong><\/p>\n\n\n\n<p><strong>What can happen if a blood clot forms in an\u00a0artery?<\/strong><\/p>\n\n\n\n<p>Similar to a blood clot in a vein, a blood clot in an\u00a0artery\u00a0can lead to serious problems.\u00a0It can, for example, cause a heart attack or\u00a0stroke.<\/p>\n\n\n\n<p><strong>Factors that can increase the risk of a blood clot in an&nbsp;artery<\/strong><\/p>\n\n\n\n<p>You must know that the risk of a heart attack or\u00a0stroke\u00a0as a result of using Zoely is very small but may increase:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>with increasing age (after about age 35)<\/li><li><strong>if you smoke<\/strong>.\u00a0If you are using a combined hormonal contraceptive such as Zoely, you should stop smoking.\u00a0If you cannot stop smoking and are over 35, your doctor may advise you to use another type of birth control.<\/li><li>if you are overweight<\/li><li>if you have high\u00a0blood pressure<\/li><li>if a close relative has had a heart attack or\u00a0stroke\u00a0at a young age (younger than about 50 years).\u00a0In that case, you may also be at greater risk of a heart attack or\u00a0stroke.<\/li><li>if you or a close relative have a high level of blood fats (\u00a0cholesterol\u00a0or\u00a0triglycerides\u00a0)<\/li><li>if you get\u00a0migraines, especially\u00a0migraines\u00a0with\u00a0aura<\/li><li>if you have problems with your heart (flutter, heart rhythm disorder called\u00a0atrial fibrillation\u00a0)<\/li><li>if you have\u00a0diabetes.<\/li><\/ul>\n\n\n\n<p>If you have more than one of these conditions or if any of them are particularly severe, your risk of developing a blood clot may be even greater.<\/p>\n\n\n\n<p>If any of the above conditions change while you are using Zoely, for example, if you start smoking, a close relative has a blood clot for no known reason or if you gain a lot of weight, talk to your doctor.<\/p>\n\n\n\n<p><strong><u>Cancer<\/u><\/strong><\/p>\n\n\n\n<p>Breast cancer has been detected slightly more often in women using combined contraceptives, but it is not clear whether it is caused by combined\u00a0oral contraceptives.\u00a0For example, it may be that\u00a0tumors\u00a0are detected more often in women who use combined\u00a0oral contraceptives\u00a0because they undergo more breast examinations with their doctor.\u00a0When combined\u00a0oral contraceptives\u00a0are discontinued, the increased risk gradually disappears.<\/p>\n\n\n\n<p>You must examine your breasts regularly and contact your doctor if you feel a lump.\u00a0You should also tell your doctor if a close relative has or has had breast cancer (see section 2 \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n<p>In rare cases, benign liver tumors (not cancer), and in even rarer cases, malignant liver tumors (cancer), have occurred among women using\u00a0birth control pills.\u00a0Contact a doctor immediately if you experience unusually severe abdominal pain.<\/p>\n\n\n\n<p>Cervical cancer is caused by an&nbsp;infection&nbsp;with the human papillomavirus (HPV).&nbsp;Cervical cancer has been reported more often in women using combined&nbsp;oral contraceptives&nbsp;for more than 5 years.&nbsp;It is not clear whether this is due to the use of contraceptives that contain&nbsp;hormones&nbsp;or to other factors, such as differences in sexual habits.<\/p>\n\n\n\n<p><strong><u>Meningioma<\/u><\/strong><\/p>\n\n\n\n<p>Cases of meningioma (a usually benign brain tumor) have been reported with long-term use (many years) of nomegestrol alone (without estradiol) at high&nbsp;doses&nbsp;of at least 3.75 mg or 5 mg and above (see section &#8220;Do not use Zoely&#8221;).&nbsp;If a meningioma is diagnosed, treatment with Zoely should be discontinued.<\/p>\n\n\n\n<p><strong><u>Mental disorders<\/u><\/strong><\/p>\n\n\n\n<p>Some women using hormonal birth control, including Zoely, have reported depression or low mood.&nbsp;Depression can be severe and sometimes lead to suicidal thoughts.&nbsp;If you experience mood changes and symptoms of depression, you should contact a doctor for advice as soon as possible.<\/p>\n\n\n\n<p><strong><u>Laboratory examinations<\/u><\/strong><\/p>\n\n\n\n<p>If you need to give a blood or urine sample, tell your doctor that you are using Zoely as it may affect some test results.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>No data are available regarding safety and efficacy in adolescents under 18 years of age.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>Tell your doctor\/midwife or pharmacist if you are taking, have recently taken, or might be taking other medicines.\u00a0Also, tell other healthcare professionals who prescribe or dispense medicines to you that you are using Zoely.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some medicines can reduce the contraceptive effect of Zoely or that can cause unexpected bleeding.\u00a0It applies to medicines used in the treatment of:<ul><li>epilepsy\u00a0(eg primidone,\u00a0phenytoin\u00a0, phenobarbital, carbamazepine, oxcarbazepine, topiramate, felbamate)<\/li><li>tuberculosis\u00a0(eg rifampicin)<\/li><li>HIV\u00a0infection\u00a0(eg rifabutin\u00a0, ritonavir, efavirenz)<\/li><li>hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0)\u00a0infection\u00a0(e.g.\u00a0protease inhibitors\u00a0)<\/li><li>other infectious diseases (eg griseofulvin)<\/li><li>high\u00a0blood pressure\u00a0in the blood vessels of the lungs, so-called\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0(\u00a0bosentan\u00a0).<\/li><\/ul><\/li><li>The herbal remedy St. John&#8217;s\u00a0wort\u00a0(\u00a0Hypericum perforatum\u00a0), can also prevent Zoely from functioning properly.\u00a0If you want to use herbal remedies containing St. John&#8217;s\u00a0wort\u00a0when you are already using Zoely, you should first consult your doctor.<\/li><li>If you use drugs or herbal remedies that can make Zoely less effective, a\u00a0barrier method\u00a0should be used.\u00a0Because the effect of another medicine on Zoely can remain for up to 28 days after you stop using the medicine, it is necessary to use a\u00a0barrier method\u00a0throughout this time.<\/li><li>Some medicines can increase the amount of active substances from Zoely in the blood.\u00a0The effect of the birth control pill remains, but tell your doctor if you are using any medicine against fungal infection that contains\u00a0ketoconazole.<\/li><li>Zoely can also interfere with the effect of other medicines \u2013 such as the epilepsy medicine lamotrigine.<\/li><li>The hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0) combination treatment ombitasvir\/paritaprevir\/ritonavir with or without dasabuvir, as well as the treatment glecaprevir\/pibrentasvir, may cause elevated liver function values \u200b\u200bin blood test results (increase in\u00a0ALT\u00a0liver enzyme) in women using combined hormonal contraceptives containing ethinylestradiol.\u00a0Zoely contains estradiol instead of ethinylestradiol.\u00a0It is not known whether an increase in\u00a0ALT\u00a0liver enzyme may occur when using Zoely together with this\u00a0HCV\u00a0combination therapy.\u00a0Your doctor will advise you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Zoely should not be used by women who are pregnant, or who think they may be pregnant.<\/p>\n\n\n\n<p>If you become pregnant while using Zoely, stop treatment with Zoely immediately and contact your doctor\/midwife.<\/p>\n\n\n\n<p>If you want to stop treatment with Zoely because you want to get pregnant, see section 3 &#8220;If you stop taking Zoely&#8221;.<\/p>\n\n\n\n<p>In general, Zoely is not recommended for use during breastfeeding.&nbsp;If you want to use&nbsp;birth control pills&nbsp;while breastfeeding, you should consult your doctor\/midwife.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zoely has no or negligible effect on the ability to drive and use machines.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zoely 2.5 mg\/1.5 mg film-coated tablets contain excipients<\/h2>\n\n\n\n<p><strong>Zoely contains&nbsp;lactose<\/strong><\/p>\n\n\n\n<p>If you have an intolerance to certain sugars, you should contact your doctor\/midwife before taking this medicine.<br>How to use Zoely 2.5 mg\/1.5 mg film-coated tablets<\/p>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Consult a doctor\/midwife or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>When and how to take the tablets<\/strong><\/p>\n\n\n\n<p>The Zoely tablet chart contains 28 film-coated tablets: 24 white tablets with active substances (numbers 1-24) and 4 yellow tablets without active substances (numbers 25-28).<\/p>\n\n\n\n<p>Each time you start a new tablet map with Zoely, take the white active, number 1 tablet in the upper left corner of the tablet map (see \u201cStart\u201d).&nbsp;Then, from the 7 sticky strips with the days of the week, select the strip in the gray column that starts with your &#8220;start day&#8221;.&nbsp;For example, if you start on a Wednesday, use the sticky strip that starts with &#8220;WED.&#8221;&nbsp;Place it on the tablet chart, just above the row of white active tablets where it says &#8220;Place weekday label here&#8221;.&nbsp;This will help you keep track of whether you have taken your daily tablet.<\/p>\n\n\n\n<p>Take one tablet a day at about the same time, with a little water if needed.<\/p>\n\n\n\n<p>Take the tablets in the order shown by the arrows on the tablet chart, take the white active tablets first and then the yellow (inactive) placebo tablets.<\/p>\n\n\n\n<p>Your period will start during the 4 days when you take the yellow placebo tablets (a so-called withdrawal bleed).&nbsp;It usually starts 2-3 days after you have taken the last white active tablet and does not need to have stopped before you start the next tablet chart.<\/p>\n\n\n\n<p>Start the next tablet chart immediately after taking the last yellow placebo tablet, even if the period has not stopped.&nbsp;This means that you will always start on a new tablet chart on the same day of the week and that your period will come on roughly the same days of the week each month.<\/p>\n\n\n\n<p>Some women may not get their period every month while taking the yellow placebo tablets.&nbsp;If you have taken Zoely every day as directed, it is unlikely that you are pregnant (see also section 3 &#8220;If you have missed one or more periods&#8221;).<\/p>\n\n\n\n<p><em><u>How to start taking the first pack of Zoely<\/u><\/em><\/p>\n\n\n\n<p>If you have not taken any hormonal contraception&nbsp;during&nbsp;the previous month<\/p>\n\n\n\n<p>Start taking Zoely on the first day of the natural menstrual cycle (ie on the first day of your period).&nbsp;If you start Zoely on the first day of your period, you will be protected against pregnancy immediately.&nbsp;You do not need to use any additional contraceptive method.<\/p>\n\n\n\n<p>Changing from another contraceptive method with combined\u00a0hormones\u00a0(combined\u00a0birth control pills, birth control ring, or birth control\u00a0patch\u00a0)<\/p>\n\n\n\n<p>You can advantageously start Zoely the day after you have taken the last active tablet (the last tablet containing active substances) on your current tablet chart (no tablet break).\u00a0If your current tablet chart also contains inactive placebo tablets, you can start taking Zoely the day after you have taken the last\u00a0<strong>active<\/strong>\u00a0tablet (if you are not sure which the active tablets are, ask your doctor\/midwife or pharmacist).\u00a0You can also start Zoely later but never later than the day after the tablet-free period of your current pill\u00a0(or the day after the last inactive tablet of your current\u00a0pill\u00a0).\u00a0If you change from a birth control ring or birth control\u00a0patch is best to start Zoely on the day the patch or ring is removed.\u00a0You can also start at the latest on the day you would have started with a new ring or a new\u00a0patch.<\/p>\n\n\n\n<p>If you follow the instructions, you do not need to use any additional protection.&nbsp;If you are unsure whether you are protected or not, consult your doctor\/midwife.<\/p>\n\n\n\n<p>Switching from a&nbsp;birth control pill&nbsp;with only progestogen&nbsp;hormone&nbsp;(&nbsp;minipill&nbsp;)<\/p>\n\n\n\n<p>You can switch from the progestagen-only\u00a0pill\u00a0any day to start Zoely the next day, but you must use a\u00a0barrier\u00a0method\u00a0of birth control (such as a condom) for the first seven days of taking Zoely.<\/p>\n\n\n\n<p>When switching from\u00a0injections,\u00a0implants,\u00a0or hormone coils with only\u00a0progestin<\/p>\n\n\n\n<p>Start Zoely on the day you would have had your next&nbsp;injection&nbsp;or on the day your&nbsp;implant&nbsp;or&nbsp;IUD&nbsp;is removed.&nbsp;If you have intercourse, use a&nbsp;barrier&nbsp;method of contraception for the first seven days of taking Zoely.<\/p>\n\n\n\n<p>After giving birth<\/p>\n\n\n\n<p>You can start Zoely between 21 and 28 days after giving birth.\u00a0If you start after day 28, you must use a\u00a0barrier\u00a0method of contraception (such as a condom) for the first seven days of taking Zoely.\u00a0If after giving birth you have had sex before starting Zoely, you must first make sure you are not pregnant or you will have to wait for your next period.\u00a0If you are breastfeeding and want to start Zoely after you have had a baby, see section 2 &#8216;Pregnancy and breastfeeding.<\/p>\n\n\n\n<p>Consult a doctor\/midwife or pharmacist if you are unsure.<\/p>\n\n\n\n<p>After miscarriage or abortion<\/p>\n\n\n\n<p>Follow the doctor&#8217;s\/midwife&#8217;s advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Zoely 2.5 mg\/1.5 mg film-coated tablets&nbsp;<\/h2>\n\n\n\n<p>There are no reports of serious damage from taking too many Zoely tablets.\u00a0If you have taken several tablets at the same time, you may feel sick, vomit, and have bleeding from the abdomen.\u00a0If you have taken too many Zoely tablets or if you discover that a child has swallowed some, a doctor or pharmacist should be contacted for advice.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>The following advice only applies to forgotten&nbsp;<strong>white active<\/strong>&nbsp;tablets.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If it has been\u00a0<strong>less than 24 hours<\/strong>\u00a0since you should have taken your tablet, you are still protected against pregnancy.\u00a0Take the tablet as soon as you can and then take the next tablet at the usual time.<\/li><li>If it has been\u00a0<strong>24 hours or more than 24 hours<\/strong>\u00a0since you should have taken a tablet, protection against pregnancy may be reduced.\u00a0The more tablets you have forgotten, the greater the risk of you becoming pregnant.\u00a0The risk of becoming pregnant is particularly high if you forget\u00a0<strong>white<\/strong>\u00a0active tablets at the beginning or the end of the tablet map.\u00a0Therefore, you should always follow the instructions given below.<\/li><\/ul>\n\n\n\n<p><em>Day 1-7 with the intake of white active tablets (see picture and schedule)<\/em><\/p>\n\n\n\n<p>Take the forgotten white active tablet as soon as you can, even if it means taking two tablets at the same time, and then take the next tablet at the usual time.&nbsp;Use a&nbsp;barrier&nbsp;method of contraception (such as a condom) for additional protection until you have taken your tablets correctly for 7 consecutive days.<\/p>\n\n\n\n<p>If you have had sex in the week before the forgotten tablets, there is a risk that you could become or are pregnant.&nbsp;In this case, contact your doctor\/midwife immediately.<\/p>\n\n\n\n<p><em>Day 8-17 with the intake of white active tablets (see picture and schedule)<\/em><\/p>\n\n\n\n<p>Take the last forgotten white tablet as soon as you remember (even if this means taking two tablets at the same time) and take the next tablet at the usual time.\u00a0If you have taken your tablets correctly in the previous 7 days before the forgotten tablet, the protection against pregnancy is not reduced and you do not need to use an additional protection.\u00a0If you have forgotten more than 1 tablet, use a\u00a0barrier method\u00a0such as a condom for additional protection until you have taken your tablets correctly during<\/p>\n\n\n\n<p>7 consecutive days.<\/p>\n\n\n\n<p><em>Day 18-24 with the intake of white active tablets (see picture and schedule)<\/em><\/p>\n\n\n\n<p>The risk of you becoming pregnant is particularly high if you forget a white active tablet in connection with the period of yellow inactive placebo tablets.\u00a0By adopting the tablet intake, the increased risk can be prevented.<\/p>\n\n\n\n<p>You can choose between the following two options.&nbsp;You do not need to use a supplemental&nbsp;barrier method&nbsp;if you have taken your tablets correctly in the previous 7 days before the missed tablet.&nbsp;If this is not the case, follow the first option and use a&nbsp;barrier&nbsp;method of contraception (to<\/p>\n\n\n\n<p>for example a condom) for additional protection until you have taken your tablets correctly for 7 consecutive days.<\/p>\n\n\n\n<p><em>Option 1<\/em>: Take the last missed white active tablet as soon as you can (even if this means you have to take two tablets at the same time) and then take the next tablet at the usual time.\u00a0Start on the next tablet chart immediately after the white active tablets in the current tablet chart are finished,\u00a0skip the yellow placebo tablets.\u00a0You may not have a period until you take the yellow tablets at the end of the next tablet chart, but you may have light or period-like bleeding while taking the white active tablets.<\/p>\n\n\n\n<p><em>Option 2<\/em>.\u00a0Stop taking the white active tablets.\u00a0Start taking the yellow placebo tablets for a maximum of 3 days so that the total number of placebo tablets including forgotten white active tablets does not exceed 4. Once the yellow placebo tablets have been taken, start the next tablet chart.<\/p>\n\n\n\n<p>If you are not sure how many white active tablets you have missed, follow option 1, use a\u00a0barrier method\u00a0such as a condom for additional protection until you have taken your tablets correctly for 7 consecutive days, and contact your doctor\/midwife (as you may not have been protected from getting pregnant).\u00a0If you have forgotten to take white active tablets in a tablet map and the bleeding expected to come when you take the yellow placebo tablets does not occur, you may be pregnant.\u00a0You must speak to your doctor\/midwife before starting the next tablet chart.<\/p>\n\n\n\n<p>The following advice only applies to forgotten yellow placebo tablets<\/p>\n\n\n\n<p>The last four yellow tablets on the fourth row of the tablet chart are placebo tablets that do not contain any active substance.&nbsp;If you forget to take one of these tablets, Zoely still protects against pregnancy.&nbsp;Throw away the yellow tablets that you forgot and start taking the tablets on the next tablet chart at the usual time.<\/p>\n\n\n\n<p>Picture<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20090917000020#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p>Schedule if you are 24 hours or more than 24 hours late taking a white active tablet<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20090917000020#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p><strong>If you vomit or have severe diarrhea<\/strong><\/p>\n\n\n\n<p>If you vomit within 3-4 hours after taking a white active tablet or have severe diarrhea, there is a risk that the active substances in the Zoely tablets are not fully absorbed in your body.\u00a0The situation is equivalent if you forget a white active tablet.\u00a0After vomiting or diarrhea, you must take a new white active tablet from a reserve tablet chart as soon as possible.\u00a0If possible, take it\u00a0within 24 hours\u00a0of when you normally take your tablet.\u00a0Take the next tablet at the usual time.\u00a0If this is not possible or if 24 hours or more have passed, follow the advice given under &#8216;If you forget to take Zoely&#8217;.\u00a0If you have severe diarrhea, contact your doctor\/midwife.<\/p>\n\n\n\n<p>The yellow tablets are placebo tablets that do not contain any active substances.\u00a0If you vomit or have severe diarrhea within 3-4 hours of taking a yellow placebo tablet, Zoey&#8217;s protection against pregnancy remains.<\/p>\n\n\n\n<p><strong>If you want to postpone your period<\/strong><\/p>\n\n\n\n<p>Although not recommended, you can delay your period by skipping the yellow placebo tablets from the fourth row and immediately starting the next tablet chart with Zoely.\u00a0You may experience light or menstrual-like bleeding while using the second tablet chart.\u00a0When you want menstruation to start, during the second tablet map, stop taking the white active tablets and start taking the yellow placebo tablets.\u00a0Finish this second tablet chart by taking the 4 yellow placebo tablets and then start the next tablet chart (the third).\u00a0<strong><em>If you are not sure how to proceed, ask your doctor\/midwife or pharmacist.<\/em><\/strong><\/p>\n\n\n\n<p><strong>If you want to change the start day of your period<\/strong><\/p>\n\n\n\n<p>If you take your tablets correctly, you will have your period during the placebo interval.&nbsp;If you want to change the start day, you can reduce the days in the placebo interval &#8211; when you take the yellow placebo tablets &#8211; but never extend it (4 is the maximum number).&nbsp;For example, if you start with the yellow placebo tablets on a Friday and you want to change this to a Tuesday (3 days earlier), you must start on a new tablet chart 3 days earlier than usual.&nbsp;You may not get any<\/p>\n\n\n\n<p>menstruation during the shortened placebo interval.&nbsp;You may have light or menstrual-like bleeding while taking the white active tablets in the next tablet chart.<\/p>\n\n\n\n<p><strong><em>If you are not sure how to proceed, ask your doctor\/midwife or pharmacist.<\/em><\/strong><\/p>\n\n\n\n<p><strong>If you have unexpected bleeding<\/strong><\/p>\n\n\n\n<p>During the first few months of using combined\u00a0oral contraceptives, you may have irregular bleeding (breakthrough bleeding or spotting).\u00a0You may need to use menstrual protection, but still, continue to take your tablets as usual.\u00a0The irregular bleeding usually disappears when the body has adapted to the pill (usually after about three months).\u00a0Talk to your doctor\/midwife if the bleeding continues after three months, if it gets heavier or if it recurs.<\/p>\n\n\n\n<p><strong>If you have missed your period one or more times<\/strong><\/p>\n\n\n\n<p>In&nbsp;clinical studies&nbsp;with Zoely, it has been seen that menstruation can sometimes not occur after Day 24.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have taken all your tablets correctly, and you have not vomited, had severe diarrhea, or used other medicines at the same time, it is unlikely that you are pregnant.\u00a0Continue taking Zoely as usual.\u00a0See also section 3 &#8220;If you vomit or have severe diarrhea&#8221; or section 2 &#8220;Other medicines and Zoely&#8221;.<\/li><li>If you have\u00a0<strong>not<\/strong>\u00a0taken all the tablets correctly or if you miss your period twice in a row, you may be pregnant.\u00a0Contact your doctor\/midwife immediately.\u00a0Do not start your next tablet chart with Zoely until it has been checked that you are not pregnant.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>You can unsubscribe from Zoely at any time.&nbsp;If you do not want to get pregnant, you should consult your doctor\/midwife about another contraceptive method.<\/p>\n\n\n\n<p>If you stop taking Zoely because you want to get pregnant, it is best to wait until you have had a natural period before trying to get pregnant.&nbsp;This will help you calculate when the baby will be born.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0If you experience any\u00a0side effects, especially if they are severe or do not go away, or if your health changes and you think it may be due to Zoely, talk to your doctor.<\/p>\n\n\n\n<p>An increased risk of blood clots in the veins (venous thromboembolism (VTE)) or blood clots in the&nbsp;arteries&nbsp;(&nbsp;arterial&nbsp;thromboembolism (ATE)) exists in all women using combined hormonal contraceptives.&nbsp;For more detailed information about the different risks of using combined hormonal contraceptives, see section 2, &#8220;What you need to know before you use Zoely&#8221;.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been associated with Zoely:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>acne<\/li><li>menstrual disorders (e.g. missed or irregular menstruation)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased interest in sex, depression\/low mood, mood changes headache or&nbsp;migraine<\/li><li>nausea<\/li><li>heavy periods, breast pain, pelvic pain<\/li><li>weight gain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased appetite, fluid retention (\u00a0edema\u00a0)<\/li><li>hot flashes<\/li><li>distended abdomen (stomach)<\/li><li>increased sweating, hair loss,\u00a0itching, dry skin, oily skin<\/li><li>heaviness in arms and legs<\/li><li>regular but sparse bleeding, larger breasts, lumps in the breasts, milk production despite not being pregnant, premenstrual syndrome, pain during sex, dryness in the vagina or around the labia, uterine spasms<\/li><li>irritability<\/li><li>elevated liver enzymes.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>harmful blood clots in a vein or an\u00a0artery, eg:<ul><li>in a leg or foot (so-called DVT)<\/li><li>in the lungs<\/li><li>myocardial infarction<\/li><li>stroke<\/li><li>mini-stroke\u00a0or transient stroke-like symptoms called\u00a0transient\u00a0ischemic attack (\u00a0TIA\u00a0)<\/li><li>blood clots in the liver, stomach\/intestines, kidneys, or eyes.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>The risk of developing a blood clot may be higher if you have any other conditions that increase this risk.&nbsp;(See Section 2 for more information about the conditions that increase the risk of blood clots and symptoms of a blood clot.)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased appetite<\/li><li>increased sexual desire<\/li><li>disturbances in attention<\/li><li>dry eyes, difficulty using contact lenses<\/li><li>dry mouth<\/li><li>golden brown pigment spots, mostly on the face, increased hair growth<\/li><li>the odor from the vagina, discomfort from the vagina or around the labia<\/li><li>hunger<\/li><li>the disease of the gallbladder.<\/li><\/ul>\n\n\n\n<p>Allergic reactions (hypersensitivity) have been reported in users of Zoely but the frequency cannot be estimated from the available data.<\/p>\n\n\n\n<p>More information about menstrual disorders (eg missed or irregular periods) when using Zoely can be found under section 3 &#8220;When and how to take the tablets&#8221;, &#8220;If you have unexpected bleeding&#8221; and &#8220;If you have missed one or more periods&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zoely 2.5 mg\/1.5 mg film-coated tablets<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the tablet map and carton after &#8220;EXP&#8221; and &#8220;Expiry Date&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine does not require any special storage instructions.<\/p>\n\n\n\n<p>Leftover combined\u00a0birth control pills\u00a0(including Zoely) should not be thrown down the drain or through municipal waste disposal.\u00a0The hormonally active substances in the tablet can have harmful effects if they reach the aquatic environment.\u00a0The tablets should be returned to the pharmacy or disposed of in another safe manner by local requirements.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>&#8211; The active substances are: nomegestrol acetate and estradiol<\/p>\n\n\n\n<p>White active film-coated tablets: one tablet contains 2.5 mg nomegestrol acetate and 1.5 mg estradiol as hemihydrate.<\/p>\n\n\n\n<p>The yellow film-coated placebo tablets: tablets contain no active substances.<\/p>\n\n\n\n<p>&#8211; Other ingredients are:<\/p>\n\n\n\n<p>Tablet core (white active film-coated tablets and yellow film-coated placebo tablets):<\/p>\n\n\n\n<p>Lactose monohydrate&nbsp;(see section 2 &#8220;Zoely contains lactose&#8221;), microcrystalline cellulose (E460), crospovidone (E1201), talc (E553b), magnesium stearate (E572) and&nbsp;colloidal&nbsp;anhydrous silica.<\/p>\n\n\n\n<p>Tablet casing (white active film-coated tablets):<\/p>\n\n\n\n<p>Polyvinyl alcohol (E1203), titanium dioxide (E171), macrogol 3350 and talc (E553b).<\/p>\n\n\n\n<p>Tablet casing (yellow film-coated placebo tablets):<\/p>\n\n\n\n<p>Polyvinyl alcohol (E1203), titanium dioxide (E171), macrogol 3350, talc (E553b), yellow iron oxide (E172), and black iron oxide (E172).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The active film-coated tablets are white, round, and marked with &#8220;no&#8221; on both sides.\u00a0The placebo tablets are yellow, round, and marked with &#8220;p&#8221; on both sides.<\/p>\n\n\n\n<p>Zoely is available in packs containing tablet charts of 28 film-coated tablets (24 white active film-coated tablets and 4 yellow placebo film-coated tablets) packed in a carton.\u00a0Pack sizes: 28, 84, 168, and 364 film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Theramex Ireland Limited<\/p>\n\n\n\n<p>3rd Floor, Kilmore House,<\/p>\n\n\n\n<p>Park Lane, Spencer Dock,<\/p>\n\n\n\n<p>Dublin 1<\/p>\n\n\n\n<p>D01 YE64<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Delpharm Lille SAS<\/p>\n\n\n\n<p>Parc d&#8217;Activit\u00e9s Roubaix-Est<\/p>\n\n\n\n<p>22 Rue de Toufflers<\/p>\n\n\n\n<p>CS 50070<\/p>\n\n\n\n<p>59452&nbsp;LYS&nbsp;-LEZ-LANNOY France<\/p>\n\n\n\n<p>Teva Operations Poland Sp.&nbsp;z o. o<\/p>\n\n\n\n<p>ul.&nbsp;Mogilska 80<\/p>\n\n\n\n<p>31-546 Cracow<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<p>NV Organon<\/p>\n\n\n\n<p>Kloosterstraat 6<\/p>\n\n\n\n<p>5349 AB Us<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>Waarderweg 39<\/p>\n\n\n\n<p>2031 BN Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2.5 mg\/1.5 mg\u00a0film-coated tablets<br \/>\nnomegestrol acetate\/estradiol<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[3093,10344,28500,28504,10343,5414,28503,28499,28505,28502,28501,28498],"class_list":["post-36155","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-estradiol","tag-estradiol-tablet","tag-nomegestrol-acetate","tag-nomegestrol-acetate-tablet","tag-what-estradiol-is-used-for","tag-what-is-estradiol","tag-what-is-nomegestrol-acetate","tag-what-is-zoely","tag-what-nomegestrol-acetate-is-used-for","tag-what-zoely-is-used-for","tag-zoely","tag-zoely-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/36155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=36155"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/36155\/revisions"}],"predecessor-version":[{"id":36448,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/36155\/revisions\/36448"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=36155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=36155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=36155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}