{"id":35112,"date":"2022-11-22T07:38:27","date_gmt":"2022-11-22T07:38:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=35112"},"modified":"2022-11-24T08:07:34","modified_gmt":"2022-11-24T08:07:34","slug":"ziextenzo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ziextenzo\/","title":{"rendered":"Ziextenzo &#8211; Pegfilgrastim uses, dose and side effects"},"content":{"rendered":"\n<p>6 mg solution for injection\u00a0in a pre-filled\u00a0syringe<br>pegfilgrastim<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ziextenzo is and what it is used for<\/h2>\n\n\n\n<p>Extenze contains the active substance pegfilgrastim.\u00a0Pegfilgrastim is a\u00a0protein\u00a0that, with the help of biotechnology, is produced in a\u00a0bacterium\u00a0called\u00a0E. coli.\u00a0It belongs to a group of\u00a0proteins\u00a0called\u00a0cytokines\u00a0and it is very similar to a natural\u00a0protein\u00a0(granulocyte colony-stimulating factor) produced in the body.<\/p>\n\n\n\n<p>Extenze is used to reduce the duration of\u00a0neutropenia\u00a0(low\u00a0white blood cell count\u00a0) and the occurrence of febrile\u00a0neutropenia\u00a0(low\u00a0white blood cell count\u00a0with concomitant fever) that may result from the use of\u00a0cytotoxic\u00a0chemotherapy\u00a0(medicines that destroy rapidly growing cells).\u00a0The white\u00a0blood cells\u00a0are important because they help your body fight\u00a0infection.\u00a0These\u00a0blood cells\u00a0are very sensitive to\u00a0chemotherapy\u00a0and this treatment can lead to a decrease in their number in the body.\u00a0About the number of\u00a0white blood cells drops to a low level, there may not be enough left in the body to fight bacteria, and then you may become more susceptible to\u00a0infection.<\/p>\n\n\n\n<p>Your doctor has given you Ziextenzo to help your\u00a0bone marrow\u00a0(the part of the bone where\u00a0blood cells\u00a0are made) make more\u00a0white blood cells\u00a0to help your body fight\u00a0infection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Ziextenzo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ziextenzo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Ziextenzo:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suffer from an\u00a0allergic reaction, which may manifest as a feeling of weakness, drop in blood pressure, difficulty breathing, swelling of the face (\u00a0anaphylaxis\u00a0),\u00a0redness\u00a0and swelling, rash, and itchy skin\u00a0areas.<\/li><li>if you have a cough, fever, and breathing difficulties.\u00a0This may be a sign of\u00a0acute\u00a0respiratory distress syndrome.<\/li><li>if you suffer from one or more of the following side effects:<ul><li>swelling or fluid retention, which may occur while you urinate less often than usual;\u00a0difficulty breathing;\u00a0swollen abdomen and a feeling of oversaturation;\u00a0general feeling of tiredness there may be symptoms of a condition called capillary leak syndrome, which causes blood to leak out of the small blood vessels.\u00a0See section 4.<\/li><\/ul><\/li><li>if you suffer from pain in the upper part of the abdomen on the left side of the tip of the left shoulder blade.\u00a0This may be a sign of spleen problems (\u00a0splenomegaly\u00a0).<\/li><li>if you have recently had a serious lung infection (\u00a0pneumonia\u00a0), fluid in the lungs (\u00a0pulmonary edema),\u00a0inflammation\u00a0of the lungs (interstitial lung disease), or abnormal chest X-ray results (pulmonary infiltration).<\/li><li>if you know that you have changed the number of\u00a0blood cells\u00a0(e.g. increased number of\u00a0white blood cells\u00a0or\u00a0anemia\u00a0) or decreased the number of\u00a0platelets, which reduces the blood&#8217;s ability to clot (\u00a0thrombocytopenia\u00a0).\u00a0The doctor may want to check this more often than usual.<\/li><li>if you have\u00a0sickle cell anemia.\u00a0The doctor may want to check this more often than usual.<\/li><li>if you are a patient with breast cancer or lung cancer, then Ziextenzo in combination with\u00a0chemotherapy\u00a0and\/or radiotherapy may increase the risk of a pre-cancer called\u00a0myelodysplastic syndrome\u00a0(MDS) or a blood cancer called\u00a0acute myeloid leukemia\u00a0(AML).\u00a0Symptoms may include fatigue, fever, and easy bruising and bleeding.<\/li><li>if you experience sudden signs of\u00a0allergy, such as rash,\u00a0itching\u00a0or\u00a0hives, swelling of the face, lips, tongue, or other parts of the body, shortness of breath, wheezing, or difficulty breathing.\u00a0These may be signs of a severe\u00a0allergic reaction.<\/li><li>if you have symptoms indicating\u00a0inflammation\u00a0of the aorta (the large blood vessel that transports blood from the heart to the body).\u00a0This has been reported with a frequency of \u201crare\u201d in cancer patients and healthy donors.\u00a0Symptoms may include fever, abdominal pain, malaise, back pain, and increased inflammatory markers.\u00a0Tell your doctor if you experience these symptoms.<\/li><\/ul>\n\n\n\n<p>You will have regular blood and urine tests because pegfilgrastim can damage the tiny filters in your kidneys (glomerulonephritis).<\/p>\n\n\n\n<p>Serious skin reactions (Stevens-Johnson syndrome) have been reported with the use of Ziextenzo.&nbsp;Stop using Ziextenzo and seek medical attention immediately if you experience any of the symptoms described in section 4.<\/p>\n\n\n\n<p>Talk to your doctor about your risk of developing blood cancer.&nbsp;If you develop or are at high risk of developing blood cancer, you should not use Ziextenzo unless your doctor tells you to.<\/p>\n\n\n\n<p><strong>Impaired treatment response to pegfilgrastim<\/strong><\/p>\n\n\n\n<p>If you stop responding to treatment with pegfilgrastim or if the response to treatment decreases, your doctor will investigate the reasons for this.&nbsp;Among other things, your doctor will check whether you have developed&nbsp;antibodies&nbsp;that neutralize pegfilgrastim&#8217;s activity.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ziextenzo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.\u00a0Pegfilgrastim has not been tested in pregnant women.\u00a0You must tell your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is pregnant,<\/li><li>think you are pregnant or,<\/li><li>planning to have children.<\/li><\/ul>\n\n\n\n<p>If you become pregnant while being treated with Ziextenzo, talk to your doctor.<\/p>\n\n\n\n<p>Unless otherwise instructed by your doctor, you must stop breastfeeding if you are using Ziextenzo.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Extenze has no or negligible effect on the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Extenze contains sorbitol (E 420) and sodium<\/h2>\n\n\n\n<p>This medicine contains 30 mg of sorbitol per pre-filled&nbsp;syringe&nbsp;corresponding to 50 mg\/ml.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per 6 mg\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Ziextenzo<\/h2>\n\n\n\n<p>Extenze is intended for use by adults aged 18 and over.<\/p>\n\n\n\n<p>Always use Ziextenzo as directed by your doctor.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0The usual\u00a0dose\u00a0is a 6 mg\u00a0subcutaneous\u00a0injection\u00a0(\u00a0injection\u00a0under the skin) with a pre-filled\u00a0syringe.\u00a0Does\u00a0one should be given at least 24 hours after your last\u00a0dose\u00a0of\u00a0chemotherapy\u00a0at the end of each cycle of chemotherapy.<\/p>\n\n\n\n<p><strong>How&nbsp;to inject yourself with&nbsp;Ziextenzo<\/strong><\/p>\n\n\n\n<p>Your doctor may decide that you should inject Ziextenzo yourself.\u00a0Your doctor or nurse will show you how to give yourself an\u00a0injection.\u00a0Do not try to inject yourself unless the doctor or nurse has shown you how to do it.<\/p>\n\n\n\n<p>More information about how to inject yourself with&nbsp;Ziextenzo&nbsp;can be found at the end of this leaflet.<\/p>\n\n\n\n<p>Do not shake Ziextenzo vigorously as this may affect its effectiveness.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Ziextenzo&nbsp;<\/h2>\n\n\n\n<p>If you use more Ziextenzo than you should, contact your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Ziextenzo<\/h2>\n\n\n\n<p>If you inject Ziextenzo yourself and forget your\u00a0dose, you should contact your doctor to discuss when you should inject your next\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you experience any of the following\u00a0side effects, contact your doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling or fluid retention, which may occur while urinating less often than usual;&nbsp;difficulty breathing;&nbsp;swollen abdomen and a feeling of oversaturation;&nbsp;and a general feeling of tiredness.&nbsp;These symptoms often develop quickly.<\/li><\/ul>\n\n\n\n<p>These symptoms may be signs of a less common condition (which may affect up to 1 in 100 people) called &#8216;capillary leak syndrome, which causes blood to leak from small blood vessels into the body.\u00a0This condition must be treated immediately.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bone pain.&nbsp;Your doctor can recommend what you can take to relieve the bone pain.<\/li><li>headache and nausea.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain at the injection site.<\/li><li>general joint and muscle pain.<\/li><li>some changes in blood values \u200b\u200bmay occur, but these are detected during routine blood tests.\u00a0Your\u00a0white blood cell count\u00a0may increase for a limited period.\u00a0The number of\u00a0platelets\u00a0may decrease which may lead to bruising.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergy-like reactions, including\u00a0redness\u00a0and swelling, rash, and raised itchy areas of skin.<\/li><li>severe allergic reactions, including\u00a0anaphylaxis\u00a0(weakness, drop in blood pressure, difficulty breathing, swelling of the face).<\/li><li>increased spleen size.<\/li><li>splenic hernia.\u00a0Some cases of splenic rupture were fatal.\u00a0You must contact your doctor immediately if you experience pain in the upper left side of the abdomen or above the left shoulder, as this may indicate a problem with the spleen.<\/li><li>breathing problems.\u00a0If you have a cough, fever, and breathing difficulties, contact a doctor.<\/li><li>Sweet&#8217;s syndrome (plum-colored, raised, painful skin changes on the arms and legs and sometimes on the face and neck with fever) has occurred, but other factors may play a role.<\/li><li>cutaneous\u00a0vasculitis\u00a0(\u00a0inflammation\u00a0of the skin&#8217;s blood vessels).<\/li><li>damage to the small filters in the kidneys (\u00a0glomerulonephritis\u00a0).<\/li><li>redness\u00a0at the injection site.<\/li><li>coughing up blood (hemoptysis)<\/li><li>blood disorders (\u00a0myelodysplastic syndrome\u00a0[MDS] or\u00a0acute myeloid leukemia\u00a0[AML]).<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the aorta (the large blood vessel that transports blood from the heart to the body), see section 2.<\/li><li>bleeding from the lungs (\u00a0pulmonary\u00a0hemorrhage).<\/li><li>Stevens-Johnson syndrome may begin as reddish, target-like, or round spots on the trunk, often with blisters in the center.\u00a0Skin peeling and sores in the mouth, throat, nose, genitals, and eyes can also occur.\u00a0These reactions are often preceded by fever and\u00a0flu-like symptoms.\u00a0If you develop any of these symptoms, stop using Ziextenzo and contact your doctor or seek medical attention immediately.\u00a0See also section 2.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ziextenzo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and syringe label (EXP).&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20118 \u00b0C).<\/p>\n\n\n\n<p>You can take Ziextenzo out of the refrigerator and store it at room temperature (maximum 35 \u00b0C) for a maximum of 120 hours.&nbsp;Once a&nbsp;syringe&nbsp;has been removed from the refrigerator and reached room temperature (maximum 35 \u00b0C), it must be used within 120 hours or discarded.<\/p>\n\n\n\n<p>Do not freeze.\u00a0Extenze can be used if the solution has been accidentally frozen for less than 24 hours at one time.<\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if it is cloudy or contains particles.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is pegfilgrastim.\u00a0Each pre-filled\u00a0syringe\u00a0contains 6 mg pegfilgrastim in 0.6 ml solution.<\/li><li>Other ingredients are concentrated acetic acid, sorbitol (E 420), polysorbate 20, sodium hydroxide, and water for injections.\u00a0See section 2 &#8220;Ziextenzo contains sorbitol (E 420) and sodium&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Extenze is a clear, colorless slightly yellowish\u00a0solution for injection\u00a0in a pre-filled\u00a0syringe\u00a0(6 mg\/0.6 ml).<\/p>\n\n\n\n<p>Each pack contains 1 glass pre-filled\u00a0syringe\u00a0with a rubber plunger stopper, a plunger rod, and an attached stainless steel cannula with a needle sleeve.\u00a0The syringes are supplied with an automatic needle guard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemistr.&nbsp;10<\/p>\n\n\n\n<p>6250 Kundl<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemistr.&nbsp;10<\/p>\n\n\n\n<p>6336 Langkampfen<\/p>\n\n\n\n<p>Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ziextenzo contains the active substance pegfilgrastim.\u00a0Pegfilgrastim is a\u00a0protein\u00a0that, with the help of biotechnology, is produced in a\u00a0bacterium\u00a0called\u00a0E. coli\u00a0.\u00a0It belongs to a group of\u00a0proteins\u00a0called\u00a0cytokines\u00a0and it is very similar to a natural\u00a0protein\u00a0(granulocyte colony stimulating factor) produced in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[18710,28373,2393,2396,18708,28371,18709,28372,28370,28374],"class_list":["post-35112","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-pegfilgrastim","tag-benefits-of-ziextenzo","tag-pegfilgrastim","tag-pegfilgrastim-side-effects","tag-what-is-pegfilgrastim","tag-what-is-ziextenzo","tag-what-pegfilgrastim-is-used-for","tag-what-ziextenzo-is-used-for","tag-ziextenzo","tag-ziextenzo-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=35112"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35112\/revisions"}],"predecessor-version":[{"id":35402,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35112\/revisions\/35402"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=35112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=35112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=35112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}