{"id":35091,"date":"2022-11-22T07:25:23","date_gmt":"2022-11-22T07:25:23","guid":{"rendered":"https:\/\/zeepedia.com\/?p=35091"},"modified":"2023-02-11T09:37:28","modified_gmt":"2023-02-11T09:37:28","slug":"zessly","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zessly\/","title":{"rendered":"Zessly &#8211; Infliximab Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Zessly 100 mg&nbsp;Powder for Concentrate for&nbsp;infusion Liquid, infliximab Solution<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zessly Is And What Zessly Used For<\/h2>\n\n\n\n<p>Zessly contains the active substance infliximab.\u00a0Zessly infliximab is a monoclonal\u00a0antibody\u00a0\u2013 a type of\u00a0protein\u00a0that binds to a specific target in the body called\u00a0TNF\u00a0alpha (tumor necrosis factor-alpha). Zessly belongs to a group of medicines called &#8220;TNF inhibitors.&#8221;\u00a0It is used in adults for the following inflammatory diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/rheumatoid-arthritis-ra\/\">Rheumatoid arthritis<\/a><\/li><li>Psoriatic arthritis<\/li><li>Ankylosing spondylitis&nbsp;(Bechterew&#8217;s disease)<\/li><li>Psoriasis.<\/li><\/ul>\n\n\n\n<p>Zessly is also used in adults and children 6 years and older in the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Crohn&#8217;s disease<\/li><li>Ulcerative colitis.<\/li><\/ul>\n\n\n\n<p>Zessly works by specifically binding to\u00a0TNF\u00a0alpha and blocking its function.\u00a0TNF\u00a0alpha participates in inflammatory processes in the body, and blocking their\u00a0inflammation\u00a0in your body can be reduced.<\/p>\n\n\n\n<p><strong>Rheumatoid arthritis<\/strong><\/p>\n\n\n\n<p>Rheumatoid arthritis&nbsp;is an&nbsp;inflammatory&nbsp;disease that attacks the joints.&nbsp;If you have active&nbsp;rheumatoid arthritis, you will first be given other medicines.&nbsp;If these medicines do not work well enough, you will be given Zessly to be taken in combination with another medicine called methotrexate to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Reduce the damage to the joints<\/li><li>Improve your physical function.<\/li><\/ul>\n\n\n\n<p><strong>Psoriatic arthritis<\/strong><\/p>\n\n\n\n<p>Psoriatic arthritis is an\u00a0inflammatory\u00a0disease of the joints, usually associated with\u00a0psoriasis.\u00a0If you have active psoriatic arthritis, you will first be given other medicines.\u00a0If these medicines do not work well enough, you will be given Zessly to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Reduce the damage to the joints<\/li><li>Improve your physical function<\/li><\/ul>\n\n\n\n<p><strong>Ankylosing spondylitis&nbsp;(Bechterew&#8217;s disease)<\/strong><\/p>\n\n\n\n<p>Ankylosing spondylitis&nbsp;is an&nbsp;inflammatory&nbsp;disease of the spine.&nbsp;If you have&nbsp;ankylosing spondylitis, you will first be given other medicines.&nbsp;If these medicines do not work well enough, you will be given Zessly to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduce signs and symptoms of the disease<\/li><li>Improve your physical function<\/li><\/ul>\n\n\n\n<p><strong>Psoriasis<\/strong><\/p>\n\n\n\n<p>Psoriasis\u00a0is an\u00a0inflammatory\u00a0disease of the skin.\u00a0If you have moderate or severe plaque psoriasis, you will first receive other medicines or treatments, such as light therapy.\u00a0If these medicines or treatments do not work well enough, you will be given Zessly to reduce the signs and symptoms of the disease.<\/p>\n\n\n\n<p><strong>Ulcerative colitis<\/strong><\/p>\n\n\n\n<p>Ulcerative colitis&nbsp;is an&nbsp;inflammatory&nbsp;disease of the intestine.&nbsp;If you have&nbsp;ulcerative colitis, you will first be given other medicines.&nbsp;If these medicines do not work well enough, you will be given Zessly to treat the disease.<\/p>\n\n\n\n<p><strong>Crohn&#8217;s disease<\/strong><\/p>\n\n\n\n<p>Crohn&#8217;s disease&nbsp;is an&nbsp;inflammatory&nbsp;disease of the intestine.&nbsp;If you have&nbsp;Crohn&#8217;s disease, you will first be given other medicines.&nbsp;If these medicines do not work well enough, you will be given Zessly to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Treat active\u00a0Crohn&#8217;s disease<\/li><li>Reduce the number of abnormal passages (\u00a0fistulas\u00a0) through the skin from the intestine that has not been controlled with other drugs or\u00a0surgery.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Zessly<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Receive Zessly:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to Zessly infliximab or any of the other ingredients of this medicine (listed in section 6)<\/li><li>You are allergic (hypersensitive) to\u00a0proteins\u00a0that come from mice<\/li><li>You have\u00a0tuberculosis\u00a0(TB) or another serious\u00a0infection\u00a0such as\u00a0pneumonia\u00a0or blood poisoning<\/li><li>You have\u00a0heart failure\u00a0that is moderate or severe.<\/li><\/ul>\n\n\n\n<p>Do not use Zessly if any of the above applies to you.&nbsp;If you are not sure, talk to your doctor before receiving Zessly.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Precautions<\/h2>\n\n\n\n<p>Talk to your doctor before or during treatment with Zessly if you have the following:<\/p>\n\n\n\n<p><strong>Received treatment with&nbsp;<\/strong><strong>any medicine containing infliximab before<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have previously received medicines containing infliximab and now start treatment with Zessly again.<\/li><li>If you have had a break in your treatment with infliximab for more than 16 weeks, there is an increased risk of allergic reactions when you start treatment again.<\/li><\/ul>\n\n\n\n<p><strong>Infection&nbsp;you<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before receiving Zessly, tell your doctor if you have any\u00a0infection, even if it is very mild.<\/li><li>Before receiving Zessly, tell your doctor if you have ever lived in or travelled to areas where\u00a0infections\u00a0called\u00a0histoplasmosis,\u00a0coccidioidomycosis, or\u00a0blastomycosis\u00a0are common.\u00a0These\u00a0infections\u00a0are caused by a special type of fungus that can affect the lungs or other parts of the body.<\/li><li>You can get an\u00a0infection\u00a0more easily when you are treated with Zeiss.\u00a0If you are 65 or older, the risk is higher.<\/li><li>These\u00a0infections\u00a0can be serious and include\u00a0tuberculosis,\u00a0an infection\u00a0caused by\u00a0viruses, fungi, bacteria, or other\u00a0organisms\u00a0in the environment, and blood poisoning, which can be life-threatening.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop any signs of\u00a0infection\u00a0during treatment with Zessly.\u00a0Such signs include: <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever<\/li><li>Cough<\/li><li>Flu-like symptoms<\/li><li>General malaise, red or warm skin, sores<\/li><li>Toothache<\/li><\/ul>\n\n\n\n<p>Your doctor may recommend that Zessly&#8217;s treatment be temporarily stopped.<\/p>\n\n\n\n<p><strong>Tuberculosis\u00a0(TB)<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You must tell your doctor if you have ever had TB or if you have been in close contact with someone who has or has TB<\/li><li>Your doctor will check if you have TB.\u00a0Cases of TB have been reported in patients treated with infliximab, even in patients already treated with anti-TB drugs.\u00a0Your doctor will note the examinations on your Patient&#8217;s Card.<\/li><li>If your doctor thinks you are at risk of TB, you may be given anti-TB medicines before you receive Zessly.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop any signs of TB during treatment with Zessly.\u00a0Such signs include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Persistent cough<\/li><li>Weight loss<\/li><li>Fatigue<\/li><li>Fever<\/li><li>Night sweats<\/li><\/ul>\n\n\n\n<p><strong>Hepatitis&nbsp;B&nbsp;virus<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before receiving Zessly, tell your doctor if you are a carrier of\u00a0hepatitis\u00a0B or have ever had it.<\/li><li>Tell your doctor if you think you are at risk of getting\u00a0hepatitis\u00a0B.<\/li><li>Your doctor will test you for the\u00a0hepatitis\u00a0B\u00a0virus.<\/li><li>Treatment with\u00a0TNF\u00a0inhibitors such as Zessly can cause the\u00a0hepatitis\u00a0B\u00a0virus\u00a0to reactivate in patients who carry this\u00a0virus, which in some cases can be life-threatening.<\/li><\/ul>\n\n\n\n<p><strong>Heart trouble<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have heart problems such as mild&nbsp;heart failure.<\/li><li>Your doctor will closely monitor your heart.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop new or worsening signs of\u00a0heart failure\u00a0during treatment with Zessly.\u00a0Such signs include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shortness of breath<\/li><li>Swelling feet<\/li><\/ul>\n\n\n\n<p><strong>Cancer and&nbsp;lymphoma<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before receiving Zessly, tell your doctor if you have or have ever had\u00a0lymphoma\u00a0(a type of blood cancer) or any other cancer.<\/li><li>Patients with severe\u00a0rheumatoid arthritis\u00a0who have had the disease for a long time may have a higher risk of developing\u00a0lymphoma.<\/li><li>Children and adults treated with Zessly may be at an increased risk of developing\u00a0lymphoma\u00a0or cancer.<\/li><li>Some patients who have received\u00a0TNF\u00a0inhibitors, including infliximab, have developed a rare type of cancer called T-cell lymphoma of the liver and\u00a0spleen.\u00a0Of these patients, most were teenage boys or younger men, and most had Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis.\u00a0This type of cancer usually leads to death.\u00a0In addition to\u00a0TNF\u00a0inhibitors, almost all patients received drugs containing azathioprine or 6-mercaptopurine.<\/li><li>Some patients treated with infliximab have developed certain types of skin cancer.\u00a0Tell your doctor if there are any skin changes or growths on the skin during or after treatment.<\/li><li>Some women treated for\u00a0rheumatoid arthritis\u00a0with infliximab have developed cervical cancer.\u00a0Your doctor may recommend regular screening for cervical cancer for women taking Zessly, even those over 60.<\/li><\/ul>\n\n\n\n<p><strong>Lung disease or heavy smoking<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before receiving Zessly, tell your doctor if you have a lung disease called\u00a0chronic obstructive pulmonary disease\u00a0(COPD) or if you are a heavy smoker.<\/li><li>Patients with COPD or heavy smokers may have a higher risk of developing cancer during treatment with Zessly.<\/li><\/ul>\n\n\n\n<p><strong>Diseases of the nervous system<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before receiving Zessly, tell your doctor if you have or have had problems affecting the nervous system.\u00a0These include\u00a0multiple sclerosis and Guillain-Barr\u00e9 syndrome if you have seizures or have been diagnosed with &#8220;optic neuritis.&#8221;<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop symptoms of nerve disease during treatment with Zessly.&nbsp;Such signs include changes in vision, weakness in the arms or legs, and numbness or tingling in any part of the body.<\/p>\n\n\n\n<p><strong>Fistulas<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor about an abnormal skin opening (\u00a0fistula\u00a0) before receiving Zessly.<\/li><\/ul>\n\n\n\n<p><strong>Vaccinations<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have recently received or plan to receive a vaccination.<\/li><li>You should receive the recommended vaccinations before starting treatment with Zessly.\u00a0You can receive certain vaccinations during treatment with Zessly. Still, you should not receive live vaccines (vaccines that contain a live but weakened infectious agent) because they can cause you to become\u00a0infected.<\/li><li>If you received Zessly while pregnant, your baby might also be at a higher risk of infection due to receiving a live vaccine in the first year of life.\u00a0You must tell your child&#8217;s doctor and other healthcare professionals if you have been treated with Zeiss.\u00a0They can then decide when your child should receive any vaccine, including live vaccines such as the BCG vaccine (used to prevent\u00a0tuberculosis\u00a0).<\/li><li>For more information, see the section on pregnancy and breastfeeding.<\/li><\/ul>\n\n\n\n<p><strong>Antimicrobial agents<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you have recently received or plan to receive treatment with an antimicrobial agent (such as BCG\u00a0instillation,\u00a0which is used to treat cancer).<\/li><\/ul>\n\n\n\n<p><strong>Surgeries or dental treatments<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you are going to have any surgery or dental treatment.<\/li><li>Tell the doctor or dentist that you are being treated with Zessly by showing your Patient Card.<\/li><\/ul>\n\n\n\n<p><strong>Liver problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some patients receiving treatment with medicines containing infliximab have developed serious liver problems.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop symptoms of liver problems during treatment with Zessly.\u00a0Such signs include yellowing skin and eyes, dark brown urine, pain or swelling in the upper right side of the abdomen, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a>, rash, or fever.<\/p>\n\n\n\n<p><strong>Low blood counts<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In some patients receiving treatment with infliximab medicines, the body cannot produce enough\u00a0blood cells\u00a0to help fight\u00a0infection\u00a0or help stop bleeding.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop symptoms of low blood levels during treatment with Zessly.&nbsp;Such signs include persistent fever, easy bleeding or bruising, small red or purple spots caused by bleeding under the skin, or paleness.<\/p>\n\n\n\n<p><strong>Problems with the immune system<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some patients receiving treatment with medicines containing infliximab have developed symptoms of an immune disease called lupus.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you develop lupus symptoms during treatment with Zessly.\u00a0Such signs include joint pain or a rash on the cheeks or arms that are sensitive to the sun.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p><strong>The above information also applies to children and young people.&nbsp;In addition:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some children and teenagers given&nbsp;TNF&nbsp;inhibitors, such as infliximab, have developed cancers, even rare types, that have sometimes led to the death<\/li><li>More children taking infliximab get&nbsp;infections&nbsp;compared to adults<\/li><li>Children should receive recommended vaccinations before starting treatment with Zessly.&nbsp;Children may receive certain vaccines during treatment with Zessly but should not receive live vaccines while using Zessly.<\/li><\/ul>\n\n\n\n<p>If you are unsure if any of the above apply to you, talk to your doctor before receiving Zessly.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Zessly<\/h2>\n\n\n\n<p>Patients who have inflammatory diseases are already taking drugs to treat their problems.&nbsp;These medicines can cause&nbsp;side effects.&nbsp;Your doctor will let you know which other medicines you must continue to use while receiving Zessly.<\/p>\n\n\n\n<p>Tell your doctor if you are using, have recently used, or might use any other medicines, including other medicines to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Crohn&#8217;s disease<\/li><li>Ulcerative colitis<\/li><li>Rheumatoid arthritis<\/li><li>Ankylosing spondylitis<\/li><li>Psoriatic arthritis<\/li><li>Psoriasis<\/li><\/ul>\n\n\n\n<p>Over-the-counter medicines such as\u00a0vitamins\u00a0and herbal medicines. In particular, tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines that affect the immune system<\/li><li>Kineret (anakinra).&nbsp;Zessly and Kineret should not be used together<\/li><li>Orencia (abatacept).&nbsp;Zessly and Orencia should not be used together.<\/li><\/ul>\n\n\n\n<p>You should not receive live vaccines while using Zessly.\u00a0If you have been pregnant while using Zessly or receive Zessly while breastfeeding, talk to your child&#8217;s doctor and other healthcare professionals who have contact with your child.<\/p>\n\n\n\n<p>Inform about your treatment with Zessly before the child receives any vaccine. If you are unsure if any of the above apply to you, talk to your doctor or pharmacist before receiving Zessly.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.\u00a0Zessly should only be used during pregnancy or breastfeeding if your doctor considers it necessary.<\/li><li>You must avoid becoming pregnant while being treated with Zessly and for 6 months after treatment.\u00a0Discuss the use of appropriate contraception during this time with your doctor.<\/li><li>If you received Zessly during pregnancy, your baby might have a higher risk of infection.<\/li><li>You must tell your child&#8217;s doctor and other healthcare professionals if you have been treated with Zessly before your child is given any vaccine.\u00a0Suppose you received Zessly during pregnancy, and your baby is given the BCG vaccine (used to prevent tuberculosis ) within 12 months after birth. In that case, it can cause\u00a0infection\u00a0with serious complications, even death.\u00a0Live vaccines such as the BCG vaccine should not be given to your baby within 12 months of birth unless your baby&#8217;s doctor recommends otherwise.\u00a0For more information, see the section on vaccinations.<\/li><li>If breastfeeding, you must tell your child&#8217;s doctor and other healthcare professionals that you are using Zessly before receiving any vaccine.\u00a0Live vaccines should not be given to your baby while breastfeeding unless your baby&#8217;s doctor recommends otherwise.<\/li><li>Severely decreased\u00a0white blood cell counts\u00a0have been reported in infants born to women treated with infliximab during pregnancy.\u00a0If your child has persistent febrile illness or\u00a0infection, contact your child&#8217;s doctor immediately.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving Ability And Use Of Machinery<\/h2>\n\n\n\n<p>Zessly will not likely affect the ability to drive or use tools or machines.\u00a0If you feel tired, dizzy, or sick after receiving Zessly, do not drive or use tools or machinery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zessly Contains Sodium<\/h2>\n\n\n\n<p>Zessly contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free.&#8221;\u00a0Zessly is prepared with a solution containing\u00a0sodium\u00a0before it is given to you.\u00a0Tell your doctor if you have been prescribed a low-salt (low-sodium) diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Is Zessly Given?<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Rheumatoid arthritis<\/strong>:<ul><li>The usual\u00a0dose\u00a0is 3 mg per kg of body weight.<\/li><\/ul><\/li><li><strong>Psoriatic arthritis,\u00a0Ankylosing spondylitis\u00a0(Bechterew&#8217;s disease),\u00a0psoriasis,\u00a0Ulcerative<\/strong> <strong>colitis,\u00a0and\u00a0Crohn&#8217;s disease<\/strong><ul><li>The usual\u00a0dose\u00a0is 5 mg per kg of body weight.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>How is Zessly given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Zeiss will be given to you by a doctor or nurse.<\/li><li>Your doctor or nurse will prepare the medicine for\u00a0infusion.<\/li><li>The doctor and nurse will give Zessly infusion as\u00a0(a drip) (over 2 hours) into a vein, usually in your arm.\u00a0After the third treatment, your doctor may decide to give you your\u00a0dose\u00a0of Zessly over 1 hour.<\/li><li>You will be monitored while receiving Zessly and for 1-2 hours afterward.<\/li><\/ul>\n\n\n\n<p><strong>Amount of Zessly given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will decide your\u00a0dose\u00a0and how often you should receive Zessly.\u00a0It depends on your illness, weight, and how well you respond to Zessly<\/li><li>The table below shows how you usually receive this medicine after your first\u00a0dose.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>2nd&nbsp;dose&nbsp;one<\/td><td>2 weeks after 1st&nbsp;dose&nbsp;one<\/td><\/tr><tr><td>3rd&nbsp;dose&nbsp;one<\/td><td>6 weeks after 1st&nbsp;dose&nbsp;one<\/td><\/tr><tr><td>Additional&nbsp;dose&nbsp;you<\/td><td>Every 6 to 8 weeks depending on the disease<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Use For Children And Adolescents:<\/h2>\n\n\n\n<p>Zessly should only be given to children treated for\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis.\u00a0These children must be 6 years of age or older.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Have Been Given Too Much Zessly<\/h2>\n\n\n\n<p>As a doctor or nurse gives this medicine, you are unlikely to get too much.\u00a0There are no known\u00a0side effects\u00a0after taking too much Zessly.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Have Forgotten Or Missed Your Zessly Infusion<\/h2>\n\n\n\n<p>If you have forgotten or missed a visit to receive Zessly, book a new visit as soon as possible. If you have further questions about this medicine, contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Zessly Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.\u00a0Most\u00a0side effects\u00a0are mild to moderate.\u00a0However, some patients may experience serious\u00a0side effects\u00a0that may require treatment.\u00a0Side effects\u00a0can also occur after treatment with Zessly has ended.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you notice any of the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Signs of an\u00a0allergic reaction<\/strong>\u00a0include swelling of the face, lips, mouth, or throat, which may cause difficulty swallowing or breathing, skin rash, hives, swollen hands, feet, or ankles.\u00a0Some of these reactions can be serious or life-threatening.\u00a0An\u00a0allergic reaction\u00a0can occur within 2 hours of\u00a0injection\u00a0or later.\u00a0Several signs of allergic\u00a0side effects\u00a0that can occur up to 12 days after\u00a0injection\u00a0include muscle pain, fever, joint or jaw pain, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a>, or headache.<\/li><li>Signs of heart problems\u00a0such as discomfort or pain in the chest, pain in the arm, pain in the abdomen, shortness of breath, anxiety, dizziness, lightheadedness, fainting, sweating, nausea, vomiting, fluttering or pounding beats in the chest, fast or slow heartbeat, or swelling feet.<\/li><li>Signs of\u00a0infection\u00a0(includes TB)\u00a0such as fever, feeling tired, cough which may be persistent, shortness of breath,\u00a0flu-like symptoms, weight loss, night sweats, diarrhea, ulcers, accumulation of warts in the gut or around the anus (wound abscess), toothache or burning sensation when urinating.<\/li><li>Possible signs of cancer include but are not limited to swollen\u00a0lymph nodes, weight loss, fever, unusual skin lumps, changes in skin spots or skin color, or unusual vaginal bleeding.<\/li><li>Signs of lung problems\u00a0such as coughing, difficulty breathing, or tightness in the chest.<\/li><li>Signs of nervous system problems (including eye problems)\u00a0such as signs of\u00a0stroke\u00a0(sudden numbness or weakness of the face, arms, or legs, especially on one side of the body; sudden confusion, difficulty speaking or understanding; difficulty seeing in one or both eyes, difficulty walking, dizziness, loss of balance or coordination, or severe headache), seizures, tingling\/numbness in any part of the body, or weakness in the arms or legs, changes in vision such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">double vision<\/a> or other eye problems.<\/li><li>Signs of liver problems\u00a0(including\u00a0hepatitis\u00a0B\u00a0infection\u00a0if you have previously had\u00a0hepatitis\u00a0B) such as yellowing of the skin or eyes, dark brown urine, pain or swelling in the upper right side of the abdomen, joint pain, rash, or fever.<\/li><li>Signs of an immune disease\u00a0include joint pain or a rash on cheeks or arms that is sensitive to the sun (lupus), cough, shortness of breath, fever, or skin rash (\u00a0sarcoid\u00a0).<\/li><li>Signs of low blood levels\u00a0include persistent fever, easy bleeding or bruising, small red or purple spots caused by bleeding under the skin, or paleness.<\/li><li>Signs of a serious skin problem\u00a0such as reddish spots or round spots, often with blisters in the middle, located on the upper body, large areas of scaly and tender skin (exfoliation), mouth sores, sores on the throat, nose, genitals, and eyes, or small wart-filled bumps that can spread over the body.\u00a0These skin reactions may be accompanied by fever.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you observe any of the above.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed with medicines containing infliximab:<\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 in 10 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal pain, nausea<\/li><li>Viral infections such as\u00a0herpes\u00a0or\u00a0influenza<\/li><li>An upper respiratory infection such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sinusitis\/\">sinusitis<\/a><\/li><li>Headache<\/li><li>Side effects\u00a0of an\u00a0infusion<\/li><li>Pain<\/li><\/ul>\n\n\n\n<p><strong>Common:&nbsp;<\/strong><strong>may affect up to 1 in 100 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in how the liver works, increase in liver enzyme levels (shown by blood tests)<\/li><li>Infection\u00a0in your lung or chest, such as:<ul><li>Bronchitis\u00a0or\u00a0pneumonia<\/li><\/ul><\/li><li>Difficult or painful breathing<\/li><li>Chest pain<\/li><li>Bleeding in the stomach or intestines<\/li><li>Diarrhea<\/li><li>Indigestion<\/li><li>Heartburn<\/li><li>Constipation<\/li><li>Hives (\u00a0urticaria\u00a0)<\/li><li>Itchy rash<\/li><li>Dry skin<\/li><li>Balance problems or dizziness<\/li><li>Fever<\/li><li>Increased sweating<\/li><li>Circulation problems such as:<ul><li>Low or high\u00a0blood pressure<\/li><\/ul><\/li><li>Bruising<\/li><li>Flushing or nosebleeds<\/li><li>Warm, red skin (\u00a0flushing\u00a0)<\/li><li>Feeling tired or weak<\/li><li>Bacterial infections such as:<ul><li>Blood poisoning<\/li><li>Abscess<\/li><li>Skin infection (\u00a0cellulitis\u00a0)<\/li><\/ul><\/li><li>Fungal infection of the skin<\/li><li>Blood problems such as:<ul><li>Anemia<\/li><li>Low\u00a0white blood cell count<\/li><\/ul><\/li><li>Swollen\u00a0lymph nodes<\/li><li>Depression<\/li><li>Sleep problems<\/li><li>Eye problems, including red eyes\u00a0and\u00a0infection<\/li><li>Fast heartbeats (\u00a0tachycardia\u00a0) or palpitations<\/li><li>Pain in joints, muscles, or back<\/li><li>Urinary tract infection<\/li><li>Psoriasis, skin problems such as\u00a0eczema\u00a0and hair loss<\/li><li>Reactions at the injection site, such as:<ul><li>Pain<\/li><li>Swelling<\/li><li>Redness<\/li><li>Itching<\/li><\/ul><\/li><li>Chills<\/li><li>Fluid accumulation under the skin causes swelling<\/li><li>Numbness or a tingling sensation<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Poor blood supply, swelling of a blood vessel<\/li><li>Accumulation of blood outside the blood vessels (hematoma) or bruising<\/li><li>Skin problems such as blisters, warts, abnormal skin color or\u00a0pigmentation,\u00a0or swollen lips<\/li><li>Thickening of the skin, or red, scaly, and flaky skin<\/li><li>Severe\u00a0allergic reaction\u00a0(eg\u00a0anaphylaxis\u00a0)<\/li><li>An immune disease called lupus, allergic reactions to\u00a0foreign\u00a0proteins<\/li><li>Impaired wound healing<\/li><li>Swollen liver (\u00a0hepatitis\u00a0) or gallbladder<\/li><li>Liver damage<\/li><li>Feeling forgetful, irritable, confused, nervous<\/li><li>Eye problems that include blurred or reduced vision, swollen eyes, or blurred\u00a0vision<\/li><li>New onset or worsening of existing\u00a0heart failure<\/li><li>Slow heartbeats<\/li><li>Fainting<\/li><li>Cramps<\/li><li>Nerve problems<\/li><li>Intestinal perforation or obstruction, abdominal pain or cramping<\/li><li>Swollen\u00a0pancreas\u00a0(\u00a0pancreatitis\u00a0)<\/li><li>Fungal infections such as\u00a0yeast\u00a0infections or fungal nail infection<\/li><li>Lung problems (such as\u00a0edema\u00a0)<\/li><li>Fluid around the lungs (alveolar effusion)<\/li><li>Narrowing of the airways in the lungs causes difficulty breathing<\/li><li>Pleurisy, which causes sharp chest pain that worsens when breathing<\/li><li>Tuberculosis<\/li><li>Kidney infections<\/li><li>Low\u00a0platelet count, too many\u00a0white blood cells<\/li><li>Infection\u00a0in the\u00a0vagina<\/li><li>Blood tests that show\u00a0antibodies\u00a0against your own body<\/li><li>Changes in\u00a0cholesterol\u00a0and fat levels in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Rare: may affect up to 1<\/strong>&nbsp;in&nbsp;<strong>1,000 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A type of blood cancer (\u00a0lymphoma\u00a0)<\/li><li>The blood does not supply enough oxygen to the body, and circulation problems such as the narrowing of blood vessels.<\/li><li>Inflammation of the meninges\u00a0(\u00a0meningitis\u00a0)<\/li><li>A weakened immune system causes infection<\/li><li>Hepatitis\u00a0B\u00a0infection\u00a0if you have previously had\u00a0hepatitis\u00a0B<\/li><li>Inflammation\u00a0of the liver caused by problems with the immune system (\u00a0autoimmune\u00a0hepatitis\u00a0)<\/li><li>Liver problems causing yellowing of the skin or eyes (jaundice)<\/li><li>Abnormal swelling or growth of\u00a0tissue<\/li><li>The severe\u00a0allergic reaction\u00a0can cause unconsciousness and can be life-threatening (anaphylactic\u00a0shock\u00a0)<\/li><li>Swelling of small blood vessels (\u00a0vasculitis\u00a0)<\/li><li>Immune disorders that can affect the lungs, skin, and\u00a0lymph nodes\u00a0(such as\u00a0sarcoidosis\u00a0)<\/li><li>Accumulation of immune cells resulting from an inflammatory response (granulomatous changes)<\/li><li>Lack of interest or feelings<\/li><li>Serious skin problems such as\u00a0toxic epidermal necrolysis, Stevens-Johnson syndrome, and\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis<\/li><li>Other skin problems such as erythema multiforme, lichenoid reactions (itchy red-purple skin rash and thread-like white-gray lines on mucous membranes), blisters and scaly skin, or boils (\u00a0furunculosis\u00a0)<\/li><li>Serious disorders of the nervous system, such as transverse\u00a0myelitis,\u00a0multiple sclerosis-like diseases,\u00a0optic\u00a0neuritis, and Guillain-Barr\u00e9 syndrome<\/li><li>Inflammation\u00a0of the eye that can cause changes in vision, including blindness<\/li><li>Fluid around the pericardium (pericardial effusion)<\/li><li>Serious lung problems (such as interstitial lung disease)<\/li><li>Melanoma\u00a0(a type of skin cancer)<\/li><li>Cervical cancer<\/li><li>Low blood values also greatly reduced the number of\u00a0white blood cells<\/li><li>Small red or purple spots caused by bleeding under the skin<\/li><li>Abnormal protein levels\u00a0in the blood are called the &#8216;complement factor, which is part of the immune system.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported: occurring in an unknown number of users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cancer in children and adults<\/li><li>An unusual blood cancer that mostly affects teenage boys or young men (T-cell lymphoma of the liver and\u00a0spleen\u00a0)<\/li><li>Liver failure<\/li><li>Merkel cell carcinoma (a type of skin cancer)<\/li><li>Kaposi&#8217;s sarcoma is rare cancer associated with\u00a0infection\u00a0with human herpesvirus 8.\u00a0Kaposi&#8217;s sarcoma\u00a0most often appears as purple spots on the skin<\/li><li>Worsening of a condition called\u00a0dermatomyositis\u00a0(seen as skin rash with muscle weakness)<\/li><li>Heart attack<\/li><li>Stroke<\/li><li>Temporary loss of vision during or within 2 hours of\u00a0infusion<\/li><li>A live vaccine causes infection because the immune system is weakened.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Additional Side Effects On Children And Adolescents<\/h2>\n\n\n\n<p>Children who took infliximab for Crohn&#8217;s disease had some differences in\u00a0side effects\u00a0compared to adults who took infliximab for\u00a0Crohn&#8217;s disease.<\/p>\n\n\n\n<p>The\u00a0side effects\u00a0that occurred more often in children were:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The low number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0)<\/li><li>Bloody stools<\/li><li>Low total levels of\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0)<\/li><li>Red skin or flushing (flushing)<\/li><li>Viral infections<\/li><li>Low levels of\u00a0white blood cells\u00a0that fight\u00a0infection\u00a0(\u00a0neutropenia\u00a0)<\/li><li>Broken bones<\/li><li>Bacterial\u00a0infection<\/li><li>Allergic reactions in the respiratory tract<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Zessly<\/h2>\n\n\n\n<p>Healthcare professionals usually store Zessly.\u00a0The storage instructions are as follows, in case you need to know them:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Use before the expiry date stated on the label and carton after &#8220;EXP.&#8221;\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2\u00b0C \u2011 8\u00b0C).<\/li><li>This medicine can also be stored in the original packaging outside the refrigerator at a maximum of 30\u00b0C for up to 6 months, but without passing the original expiry date.\u00a0In such a situation, it should not be stored in the refrigerator again.\u00a0Write the new expiry date on the carton, with day\/month\/year.\u00a0Discard the medicine if it is not used before the new expiry date or the expiry date printed on the carton, whichever comes first.<\/li><li>When Zessly is ready for\u00a0infusion, it is recommended to be used as soon as possible (within 3 hours).\u00a0However, if the solution is prepared under sterile conditions, it can be stored in a refrigerator at 2\u00b0C &#8211; 8\u00b0C for 24 hours.<\/li><li>Do not use this medicine if it is discolored or contains particles.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is infliximab.\u00a0Each\u00a0vial\u00a0contains 100 mg of infliximab.\u00a0After\u00a0reconstitution, each ml contains 10 mg of infliximab.<\/li><li>Other ingredients are disodium succinate hexahydrate, succinic acid, sucrose, and polysorbate 80.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance And Package Sizes Of The Medicine<\/h2>\n\n\n\n<p>Zessly is supplied in a glass&nbsp;vial&nbsp;containing a powder for concentrate for solution for&nbsp;infusion&nbsp;(powder for concentrate).&nbsp;The powder is white.<\/p>\n\n\n\n<p>Zessly is manufactured in packs of 1, 2, 3, 4, or 5 vials.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Holder<\/strong><\/p>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemistry.&nbsp;10<\/p>\n\n\n\n<p>6250 Kundl<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemistry.&nbsp;10<\/p>\n\n\n\n<p>6336 Langkampfen<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<p>Sandoz A\/S<\/p>\n\n\n\n<p>Phone: +45 63 95 10 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zessly is used to treat rheumatoid arthritis (a joint inflammation disease), Crohn&#8217;s disease (a gut inflammation disease), and ulcerative colitis (inflammation and ulcers in the lining of the gut).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[12824,28405,2796,2799,12823,12822,28402,28403,28401,28404],"class_list":["post-35091","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-infliximab","tag-benefits-of-zessly","tag-infliximab","tag-infliximab-side-effects","tag-what-infliximab-is-used-for","tag-what-is-infliximab","tag-what-is-zessly","tag-what-zessly-is-used-for","tag-zessly","tag-zessly-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=35091"}],"version-history":[{"count":41,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35091\/revisions"}],"predecessor-version":[{"id":48245,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/35091\/revisions\/48245"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=35091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=35091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=35091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}