{"id":34560,"date":"2022-11-21T09:41:31","date_gmt":"2022-11-21T09:41:31","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34560"},"modified":"2022-11-22T07:17:27","modified_gmt":"2022-11-22T07:17:27","slug":"zercepac","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zercepac\/","title":{"rendered":"Zercepac &#8211; Trastuzumab uses, dose and side effects"},"content":{"rendered":"\n<p>60 mg, 150 mg, and 420 mg\u00a0powder for concentrate for\u00a0solution for\u00a0infusion<br>trastuzumab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zercepac is and what it is used for<\/h2>\n\n\n\n<p>Zercepac contains the active ingredient trastuzumab, which is a monoclonal\u00a0antibody.\u00a0Monoclonal\u00a0antibodies\u00a0attach to specific\u00a0proteins\u00a0or\u00a0antigens.\u00a0Trastuzumab is designed to bind selectively to an\u00a0antigen\u00a0called\u00a0human\u00a0epidermal\u00a0growth factor receptor 2 (\u00a0HER2\u00a0).\u00a0HER2\u00a0is found in large quantities on the surface of certain cancer cells (\u00a0HER2\u00a0-positive cancer) and then stimulates cell growth.\u00a0When Zercepac binds to\u00a0HER2, the growth of the cancer cells is stopped and this leads to their death.<\/p>\n\n\n\n<p>Your doctor may prescribe Zercepac for the treatment of breast cancer and gastric cancer when:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have early breast cancer with high levels of\u00a0protein\u00a0et\u00a0HER2.<\/li><li>You have metastatic breast cancer (breast cancer that has spread beyond the original\u00a0tumor) with high levels of\u00a0HER2.\u00a0Zercepac can be prescribed in combination with the\u00a0chemotherapy\u00a0agents paclitaxel or docetaxel as first-line treatment for metastatic breast cancer, or it can be prescribed as the only treatment for conditions where other treatments have not shown an effect.\u00a0It is also used in combination with medicines called aromatase inhibitors to treat patients with high levels of\u00a0HER2\u00a0and hormone receptor-positive metastatic (spread) breast cancer (cancer that is sensitive to the presence of female sex hormones).<\/li><li>You have metastatic gastric cancer with high levels of\u00a0HER2\u00a0when it is used in combination with capecitabine or 5\u2011fluorouracil and cisplatin.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Zercepac<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zercepac if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to trastuzumab, murine (mouse)\u00a0protein, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>you have severe breathing problems at rest due to your cancer or if you need oxygen therapy.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Your doctor will closely monitor your treatment.<\/p>\n\n\n\n<p><strong>Control of the heart<\/strong><\/p>\n\n\n\n<p>Treatment with Zercepac alone or with a taxane may affect the heart, especially if you have previously been treated with anthracycline\u00a0(taxanes and\u00a0anthracyclines\u00a0are two other types of medicine used to treat cancer).\u00a0Effects can be moderate to severe and some patients have died.\u00a0Your heart function will therefore be checked before and during treatment (every three months) and after (up to two to five years) treatment with Zercepac.\u00a0If you develop signs of\u00a0heart failure\u00a0(insufficient pumping of blood from the heart), your heart function may be checked more frequently (every six to eight weeks).\u00a0You may then receive treatment for\u00a0heart failure\u00a0or you may need to stop treatment with Zercepac.<\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before receiving Zercepac if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had\u00a0heart failure, coronary artery disease, valvular heart disease (heart\u00a0murmur\u00a0), or high\u00a0blood pressure\u00a0if you have taken or are currently taking medicines for high\u00a0blood pressure.<\/li><li>you have previously received or are currently receiving a medicine called doxorubicin or epirubicin (medicines used to treat cancer).\u00a0These medicines (or other\u00a0anthracyclines\u00a0) can damage the heart muscle and increase the risk of heart problems with Zercepac.<\/li><li>you suffer from shortness of breath, especially if you are also being treated with taxidermy.\u00a0Zercepac can cause breathing difficulties, especially when it is given for the first time.\u00a0This can be more serious if you are already short of breath.\u00a0Patients with severe breathing difficulties have very rarely died in connection with Zercepac treatment.<\/li><li>you have previously received any other cancer treatment.<\/li><\/ul>\n\n\n\n<p>If you receive Zercepac together with other medicines to treat cancer, such as paclitaxel, docetaxel, an aromatase inhibitor, capecitabine, 5-fluorouracil, or cisplatin, you should also carefully read the package leaflets for these products.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Zercepac is not recommended for anyone under the age of 18.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zercepac<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It can take up to 7 months for Zercepac to be removed from the body.\u00a0You should therefore tell the doctor, pharmacist, or nurse that you have been treated with Zercepac if you start any new medication within 7 months of finishing treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist, or nurse for advice before using this medicine.<\/li><li>You should use effective contraception during treatment with Zercepac and for at least 7 months after treatment ends.<\/li><li>Your doctor will advise you about the pros and cons of taking Zercepac during pregnancy.\u00a0In rare cases, pregnant women treated with Zercepac have seen a reduction in the amount of (amniotic) fluid that surrounds the growing fetus in the womb.\u00a0This condition can be harmful to your baby in the womb and has been associated with the lungs not developing fully resulting in fetal death.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Breast-feeding<\/h2>\n\n\n\n<p>Do not breastfeed your child during treatment with Zercepac and within 7 months after the last\u00a0dose\u00a0of Zercepac because Zercepac can pass to your child through breast milk.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zercepac can affect your ability to drive or use machines.\u00a0If you experience symptoms such as dizziness, sleepiness, chills, or fever during treatment, you should not drive or operate machinery until these symptoms have disappeared.<\/p>\n\n\n\n<p><strong>Sodium<\/strong><\/p>\n\n\n\n<p>Zercepac contains less than 1 mmol\u00a0sodium\u00a0per\u00a0dose, i.e.\u00a0is almost sodium-free.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Zercepac<\/h2>\n\n\n\n<p>Before starting treatment, your doctor will determine whether your\u00a0tumor\u00a0is\u00a0HER2-positive.\u00a0Only patients with\u00a0HER2\u00a0-positive cancer (high amounts of\u00a0HER2\u00a0) will be treated with Zercepac.\u00a0Zercepac should only be given by a doctor or nurse.\u00a0Your doctor will prescribe the right\u00a0dose\u00a0and treatment regimen for\u00a0you.\u00a0The Zercepac dose depends on your body weight.<\/p>\n\n\n\n<p>Zercepac\u00a0intravenous\u00a0formulation is given as an\u00a0intravenous\u00a0infusion\u00a0(\u201cdrip\u201d) directly into a blood vessel by healthcare professionals.\u00a0The first\u00a0dose\u00a0is given over 90 minutes and you will be observed by healthcare professionals while you receive it in case you experience any\u00a0side effects.\u00a0If the first\u00a0dose\u00a0is well tolerated, the subsequent\u00a0dose\u00a0can be given within 30 minutes (see section 2 under &#8220;Warnings and precautions&#8221;).\u00a0The number of\u00a0infusions\u00a0you receive depends on the effect of the treatment you have.\u00a0Your doctor will discuss this with you.<\/p>\n\n\n\n<p>To prevent medication errors, it is important to check the vial labeling to ensure that the drug being prepared and administered is Zercepac (trastuzumab) and not trastuzumab emtansine.<\/p>\n\n\n\n<p>In early breast cancer, metastatic breast cancer, and metastatic stomach cancer, Zercepac is given every three weeks.\u00a0Zercepac can also be given once a week for metastatic breast cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Zercepac<\/h2>\n\n\n\n<p>Do not stop using this medicine without talking to your doctor first.&nbsp;All&nbsp;doses&nbsp;should be taken at the correct time each week or every three weeks (depending on your dosing interval).&nbsp;This helps the medicine work as well as possible.<\/p>\n\n\n\n<p>It can take up to 7 months for Zercepac to disappear from the body.&nbsp;Therefore, your doctor may decide to continue to monitor your heart function even after treatment has ended.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Zercepac can cause\u00a0side effects, although not everybody gets them.\u00a0Some of these\u00a0side effects\u00a0can be serious and may require hospitalization.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>During an\u00a0infusion\u00a0with Zercepac, chills, fever and other\u00a0flu-like symptoms\u00a0may occur.\u00a0These\u00a0side effects\u00a0are very common (may affect more than 1 in 10 users).\u00a0Other symptoms caused by\u00a0infusion\u00a0one are nausea, vomiting, pain, increased muscle tension and tremors, headache, dizziness, difficulty breathing, high or low\u00a0blood pressure, altered heart rhythm (palpitations, fluttering or irregular heartbeat), swelling of the face and lips, skin rash and weakness.\u00a0Some of these symptoms can be serious and some patients have died (see section 2 under \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n<p>These effects mainly occur in connection with the first intravenous\u00a0infusion\u00a0(the &#8220;drip&#8221;) and during the first hours after the start of the\u00a0infusion.\u00a0They are usually temporary.\u00a0You will be monitored by healthcare professionals during the\u00a0infusion\u00a0and for at least six hours after the start of the first\u00a0infusion\u00a0and one and two hours after the start of the other\u00a0infusions.\u00a0If you develop symptoms, the healthcare professional will slow down or stop the\u00a0infusion\u00a0and they may give you treatment to counteract the\u00a0side effects.\u00a0After the improvement of the symptoms, the\u00a0infusion\u00a0can be continued.<\/p>\n\n\n\n<p>Sometimes symptoms may occur later than six hours after the&nbsp;infusion&nbsp;is started.&nbsp;If this happens to you, contact your doctor immediately.&nbsp;Sometimes the symptoms may improve and later worsen.<\/p>\n\n\n\n<p>Other serious&nbsp;side effects&nbsp;can occur at any time during treatment with Zercepac and are not associated with the actual&nbsp;infusion&nbsp;of Zercepac.&nbsp;<strong>Tell a doctor or nurse immediately if you notice any of the following side effects:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart problems can sometimes occur during treatment and sometimes after treatment has ended and can be serious.\u00a0They include weakening of the heart muscle which can eventually lead to\u00a0heart failure,\u00a0inflammation\u00a0(swelling,\u00a0redness, heat, and pain) around the heart, and changes in heart rhythm.\u00a0This can lead to symptoms such as shortness of breath (including shortness of breath at night), cough, fluid retention (swelling) in the legs or arms, and palpitations (fluttering or irregular heartbeats) (see section 2 \u201cMonitoring the heart\u201d).<\/li><\/ul>\n\n\n\n<p>Your doctor will regularly check your heart during and after treatment, but you should tell your doctor immediately if you experience any of the above symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tumor lysis syndrome (a group of metabolic complications that occur after cancer treatment and are characterized by high levels of\u00a0potassium\u00a0and\u00a0phosphate\u00a0in the blood and low levels of\u00a0calcium\u00a0in the blood).\u00a0Symptoms may include kidney problems (weakness, shortness of breath, tiredness, and confusion), heart problems (palpitations with a faster or slower heartbeat), seizures, vomiting or diarrhea, and tingling in the mouth, hands, or feet.<\/li><\/ul>\n\n\n\n<p>If you experience any of the above symptoms after stopping treatment with Zercepac, consult your doctor and tell the doctor that you have previously been treated with Zercepac.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p><strong>Very common\u00a0side effects\u00a0of Zercepac<\/strong>: may affect more than 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0_<\/li><li>diarrhea<\/li><li>constipation<\/li><li>heartburn (\u00a0dyspepsia\u00a0)<\/li><li>fatigue<\/li><li>rash<\/li><li>chest pain<\/li><li>abdominal pain<\/li><li>joint pain<\/li><li>low levels of\u00a0red blood cells\u00a0and\u00a0white blood cells\u00a0(which help fight\u00a0infection\u00a0) sometimes with fever<\/li><li>muscle pain<\/li><li>conjunctivitis\u00a0(inflammation of the conjunctiva of the eye)<\/li><li>watery eyes<\/li><li>nosebleed<\/li><li>runny nose<\/li><li>hair loss<\/li><li>tremors<\/li><li>hot flashes<\/li><li>dizziness<\/li><li>nail changes<\/li><li>weight loss<\/li><li>loss of appetite<\/li><li>insomnia\u00a0_\u00a0_<\/li><li>taste changes<\/li><li>decreased number of\u00a0platelets<\/li><li>bruises<\/li><li>numbness or tingling in the fingers and toes<\/li><li>redness, swelling, or sores in the mouth and\/or throat<\/li><li>pain, swelling,\u00a0redness,\u00a0or tingling in the hands and\/or feet<\/li><li>shortness of breath<\/li><li>headache<\/li><li>cough<\/li><li>vomiting<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p><strong>Common\u00a0side effects:<\/strong>\u00a0may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions<\/li><li>throat infection<\/li><li>infection&nbsp;in the&nbsp;bladder&nbsp;and on the skin<\/li><li>inflammation&nbsp;of the chest<\/li><li>inflammation&nbsp;of the liver<\/li><li>kidney damage<\/li><li>increased&nbsp;muscle tone&nbsp;or tension (hypertonus)<\/li><li>pain in arms and\/or legs<\/li><li>itchy rash<\/li><li>sleepiness (&nbsp;somnolence&nbsp;)<\/li><li>hemorrhoids<\/li><li>itching<\/li><li>dry mouth and skin<\/li><li>dry eyes<\/li><li>sweating<\/li><li>feeling weak and not feeling well<\/li><li>concern<\/li><li>Depression<\/li><li>asthma<\/li><li>lung infection<\/li><li>lung impact<\/li><li>back pain<\/li><li>neck pain<\/li><li>bone pain<\/li><li>acne<\/li><li>leg cramps<\/li><\/ul>\n\n\n\n<p><strong>Uncommon side effects:<\/strong>&nbsp;&nbsp;may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>deafness<\/li><li>bumpy skin rash<\/li><li>wheezing\/wheezing<\/li><li>inflammation&nbsp;or scarring of the lungs<\/li><\/ul>\n\n\n\n<p><strong>Rare\u00a0side effects:<\/strong>\u00a0may occur in up to 1 in 1,000 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>jaundice<\/li><li>anaphylactic reactions<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal or impaired blood clotting<\/li><li>high potassium levels<\/li><li>swelling or bleeding behind the eyes<\/li><li>shock<\/li><li>abnormal heart rhythm<\/li><li>respiratory distress<\/li><li>breathing problems<\/li><li>acute\u00a0accumulation of fluid in the lungs<\/li><li>acute\u00a0narrowed airways<\/li><li>abnormally low oxygen content in the blood<\/li><li>difficulty breathing when lying flat<\/li><li>liver damage<\/li><li>swelling of the face, lips, and throat<\/li><li>kidney failure<\/li><li>abnormally little amniotic fluid around the fetus in the womb<\/li><li>underdeveloped lungs of the fetus in the womb<\/li><li>abnormal development of the kidneys of the fetus in the womb<\/li><\/ul>\n\n\n\n<p>Some of the\u00a0side effects\u00a0you experience may be due to your underlying disease cancer.\u00a0If you are treated with Zercepac together with\u00a0chemotherapy, some of the\u00a0side effects\u00a0may also be due to the\u00a0chemotherapy.<\/p>\n\n\n\n<p>If you get\u00a0side effects, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zercepac<\/h2>\n\n\n\n<p>Zercepac should be stored by healthcare professionals in the hospital or clinic.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the outer carton and the vial label (EXP).\u00a0The expiration date is the last day of the specified month.<\/li><li>The unopened vial should be stored in a refrigerator (2 \u00b0C-8 \u00b0C).<\/li><li>The prepared solution must not be frozen.<\/li><li>Infusion solutions should be used immediately after dilution.\u00a0If not used immediately, the applied storage time and storage conditions before use are the responsibility of the user.<\/li><li>Do not use Zercepac if you see particles or discoloration before\u00a0administration.<\/li><li>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is trastuzumab.\u00a0Each\u00a0vial\u00a0contains either:<\/li><li>60 mg of trastuzumab to be dissolved in 3.0 ml of sterile water for injections or<\/li><li>150 mg of trastuzumab to be dissolved in 7.2 ml of sterile water for injections or<\/li><li>420 mg of trastuzumab to be dissolved in 20.0 ml of sterile water for injections.<\/li><li>The prepared solution contains approximately 21 mg\/ml of trastuzumab.<\/li><li>Other ingredients are L\u2011histidine hydrochloride monohydrate, L\u2011histidine, \u03b1,\u03b1\u2011trehalose dihydrate, and polysorbate 20.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zercepac is a powder for concentrate for\u00a0intravenous\u00a0infusion, a solution supplied in a glass\u00a0vial\u00a0with a rubber stopper and containing 60 mg, 150 mg, or 420 mg of trastuzumab.\u00a0The powder is freeze-dried and white to slightly yellow.\u00a0Each carton contains 1\u00a0vial\u00a0of powder.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center,<\/p>\n\n\n\n<p>Moll de Barcelona, \u200b\u200bs\/n,<\/p>\n\n\n\n<p>Edifici Est 6\u00aa planta,<\/p>\n\n\n\n<p>08039 Barcelona, \u200b\u200bSpain<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.&nbsp;Zoo<\/p>\n\n\n\n<p>ul Lutomirska 50, 95-200 Pabianice<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<p>Accord Healthcare BV,<\/p>\n\n\n\n<p>Winthontlaan 200,<\/p>\n\n\n\n<p>3526 VK Utrecht,<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>60 mg, 150 mg and 420 mg\u00a0powder for concentrate for\u00a0solution for\u00a0infusion<br \/>\ntrastuzumab<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[13803,28294,13800,13804,13801,28291,13802,28292,28290,28293],"class_list":["post-34560","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-trastuzumab","tag-benefits-of-zercepac","tag-trastuzumab","tag-trastuzumab-side-effects","tag-what-is-trastuzumab","tag-what-is-zercepac","tag-what-trastuzumab-is-used-for","tag-what-zercepac-is-used-for","tag-zercepac","tag-zercepac-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34560"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34560\/revisions"}],"predecessor-version":[{"id":35064,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34560\/revisions\/35064"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}