{"id":34553,"date":"2022-11-21T09:36:04","date_gmt":"2022-11-21T09:36:04","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34553"},"modified":"2022-11-22T07:17:57","modified_gmt":"2022-11-22T07:17:57","slug":"zelboraf","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zelboraf\/","title":{"rendered":"Zelboraf &#8211; Vemurafenib uses, dose and side effects"},"content":{"rendered":"\n<p>240 mg&nbsp;film-coated tablets<br>Vemurafenib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zelboraf is and what it is used for<\/h2>\n\n\n\n<p>Zelboraf is an anti-cancer medicine that contains the active substance vemurafenib.\u00a0It is used to treat adult patients with\u00a0melanoma\u00a0that has spread to other parts of the body or cannot be removed with\u00a0surgery.<\/p>\n\n\n\n<p>It can only be used by patients whose cancer has a change (\u00a0mutation\u00a0) in the &#8220;BRAF&#8221; gene.\u00a0This change may have resulted in the development of\u00a0melanoma.<\/p>\n\n\n\n<p>Zelboraf targets&nbsp;proteins&nbsp;from this altered gene and delays or stops the development of your cancer.<br><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Zelboraf<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Zelboraf:<\/h2>\n\n\n\n<p>if you are\u00a0<strong>allergic<\/strong>\u00a0(hypersensitive) to vemurafenib or any of the other ingredients of this medicine (listed in section 6).\u00a0Symptoms of allergic reactions may include swelling of the face, lips, or tongue, difficulty breathing, skin rash, or feeling faint.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Zelboraf.<\/p>\n\n\n\n<p><strong>Allergic&nbsp;<\/strong><strong>reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Allergic reactions can occur while taking Zelboraf and they can be serious.\u00a0<\/strong>Stop taking Zelboraf and get medical help immediately if you get any symptoms of an\u00a0allergic reaction\u00a0such as swelling of the face, lips, or tongue, difficulty breathing, skin rash, or feeling faint.<\/li><\/ul>\n\n\n\n<p><strong>Serious skin reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Serious skin reactions can occur while taking Zelboraf.\u00a0<\/strong>Stop taking Zelboraf and tell your doctor immediately if you develop a skin rash with any of the following symptoms: blisters on the skin, blisters or sores in the mouth, peeling skin, fever,\u00a0redness\u00a0or swelling of the face, hands, or soles of the feet.<\/li><\/ul>\n\n\n\n<p><strong>Previously had cancer<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you have had a type of cancer other than\u00a0melanoma<\/strong>, as Zelboraf can cause some types of cancer to get worse.<\/li><\/ul>\n\n\n\n<p><strong>Radiotherapy reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you have received, or will receive, radiation therapy<\/strong>, as Zelboraf may worsen the\u00a0side effects\u00a0of radiation therapy.<\/li><\/ul>\n\n\n\n<p><strong>Heart problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you have heart problems, such as a change in the electrical activity of the heart, the <\/strong>so-called &#8220;prolonged\u00a0QT\u00a0interval&#8221;.\u00a0Your doctor will do tests to check that your heart is working properly before and during your treatment with Zelboraf.\u00a0If necessary, in some cases your doctor may decide to temporarily interrupt the treatment or stop it completely.<\/li><\/ul>\n\n\n\n<p><strong>Eye problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Your eyes should be examined by your doctor while you are taking Zelboraf.\u00a0<\/strong>Tell your doctor immediately if you experience eye pain, swelling,\u00a0redness, blurred vision, or other vision changes during your treatment.<\/li><\/ul>\n\n\n\n<p><strong>Musculoskeletal system and connective tissue<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor if you notice an unusual thickening of the palms of your hands with accompanying tightening of the fingers inward, or an unusual thickening of the soles of your feet that may be painful.<\/li><\/ul>\n\n\n\n<p><strong>Control of your skin before, during, and after treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you notice any changes in your skin while taking this medicine, tell your doctor as soon as possible.<\/strong><\/li><li>Regularly during your treatment and up to 6 months after your treatment, your doctor will need to examine your skin for a type of cancer called &#8216;cutaneous squamous cell carcinoma&#8217;.<\/li><li>Usually, this change occurs in sun-damaged skin, stays within a limited area, and can be cured by surgical removal.<\/li><li>If your doctor detects this type of skin cancer, he or she will treat it or see you to another doctor for treatment.<\/li><li>In addition, your doctor needs to examine your head, neck, mouth, your\u00a0lymph nodes\u00a0and you will be regularly examined with\u00a0computed tomography.\u00a0This is a precaution in case\u00a0cutaneous\u00a0squamous\u00a0cell carcinoma changes develop in your body.\u00a0Genital examination (for women) and anal examinations are also recommended before and at the end of your treatment.<\/li><li>You may develop new melanoma changes while taking Zelboraf.\u00a0These changes are usually removed with\u00a0surgery\u00a0and patients continue their treatment.\u00a0Monitoring of these changes is done in the same way as described above for\u00a0cutaneous\u00a0squamous\u00a0cell carcinoma.<\/li><\/ul>\n\n\n\n<p><strong>Kidney or liver problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you have kidney or liver problems.&nbsp;<\/strong>This may affect the effect of Zelboraf.&nbsp;Your doctor will also take some blood tests to check your liver and kidney function before you start taking Zelboraf and during treatment.<\/li><\/ul>\n\n\n\n<p><strong>Sun protection<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Taking Zelboraf can make you more sensitive to sunlight and cause sun damage, which can be serious.\u00a0<strong>Avoid\u00a0exposing\u00a0the skin to direct sunlight<\/strong>\u00a0during treatment.<\/li><li>If you plan to stay in the sun:<ul><li>wear clothing that protects your skin, including your head and face, arms, and legs.<\/li><li>use lip balm and broad-spectrum sunscreen (minimum sun protection factor (SPF) 30, reapply every two to three hours).<\/li><\/ul><\/li><li>This will help protect you from sun damage\/burn.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Zelboraf is not recommended for children and adolescents.\u00a0The effects of Zelboraf on people younger than 18 years are not known<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zelboraf<\/h2>\n\n\n\n<p><strong>Before starting treatment, tell your doctor if you are taking, have recently taken,<\/strong> or might take any other medicines\u00a0(including those you have bought yourself at a pharmacy, grocery, or health shop).\u00a0This is very important because the use of more than one drug at the same time can strengthen or weaken the effect of drugs.<\/p>\n\n\n\n<p><strong>You must tell your doctor if you are taking\u00a0<\/strong><strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines are known to affect how your heart beats:<ul><li>medicines for heart rhythm disorders (e.g.\u00a0quinidine,\u00a0amiodarone\u00a0)<\/li><li>medicines for depression (eg amitriptyline, imipramine)<\/li><li>medicines against bacterial infections (e.g. azithromycin, clarithromycin)<\/li><li>medicines for nausea and vomiting (ondansetron, domperidone)<\/li><\/ul><\/li><li>Medicines that are mainly metabolized by a\u00a0protein\u00a0called CYP1A2 (eg caffeine, olanzapine, theophylline), CYP3A4 (eg some\u00a0birth control pills\u00a0) or CYP2C8<\/li><li>Medicines that affect a\u00a0protein\u00a0called P-GP or BCRP (eg, verapamil, cyclosporine, ritonavir,\u00a0quinidine, itraconazole, gefitinib)<\/li><li>Medicines that may be affected by a\u00a0protein\u00a0called P-GP (eg aliskiren, colchicine,\u00a0digoxin, everolimus, fexofenadine) or a\u00a0protein\u00a0called BCRP (eg methotrexate, mitoxantrone, rosuvastatin)<\/li><li>Medicines that stimulate the metabolizing\u00a0protein\u00a0are called CYP3A4 or a metabolizing process called glucuronidation (eg rifampicin, rifabutin, carbamazepine,\u00a0phenytoin,\u00a0or\u00a0St. John&#8217;s wort ).<\/li><li>Medicines that strongly inhibit the metabolizing\u00a0protein\u00a0called CYP3A4 (eg ritonavir, saquinavir, telithromycin,\u00a0ketoconazole\u00a0, itraconazole, voriconazole, posaconazole, nefazodone, atazanavir)<\/li><li>A medicine used to prevent blood clots called\u00a0warfarin<\/li><li>A drug called ipilimumab, is another drug used to treat\u00a0melanoma.\u00a0The combination of this drug and Zelboraf is not recommended due to increased\u00a0toxicity\u00a0to the liver.<\/li><\/ul>\n\n\n\n<p>If you are taking any of these medicines (or if you are not sure), tell your doctor before taking Zelboraf.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Use an appropriate method of contraception during your treatment<\/strong>\u00a0and for at least 6 months after you finish your treatment.\u00a0Zelboraf can reduce the effectiveness of some\u00a0birth control pills.\u00a0Tell your doctor if you are using an oral contraceptive.<\/li><li>Zelboraf is not recommended for use during pregnancy unless your doctor considers that the benefit to the mother outweighs the risk to the baby.\u00a0There is no information on the safety of Zelboraf in pregnant women.\u00a0Tell your doctor if you are pregnant or planning to become pregnant.<\/li><li>It is not known whether the content of Zelboraf passes into breast milk.\u00a0Breastfeeding is not recommended during treatment with Zelboraf.<\/li><\/ul>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zelboraf has&nbsp;side effects&nbsp;that may affect your ability to drive or use machines.&nbsp;Be aware that fatigue or eye problems may be reasons not to drive.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some ingredients in Zelboraf<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Zelboraf<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>How many tablets to take<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0is 4 tablets twice daily (8 tablets in total).<\/li><li>Take 4 tablets in the morning.\u00a0Then take 4 tablets in the evening.<\/li><li>If you experience\u00a0side effects, your doctor may decide to continue the treatment but lower your\u00a0dose.\u00a0Always take Zelboraf as directed by your doctor.<\/li><li>If you vomit, continue taking Zelboraf as usual, and do not take an additional\u00a0dose.<\/li><\/ul>\n\n\n\n<p><strong>How to take your tablets<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not take Zelboraf regularly on an empty stomach.<\/li><li>Swallow the tablets whole with a glass of water.&nbsp;Do not chew or crush the tablet<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Zelboraf<\/h2>\n\n\n\n<p>If you take more Zelboraf than you should, contact your doctor immediately.\u00a0Taking too much Zelboraf can increase the risk and severity of\u00a0side effects.\u00a0No cases of overdose have been observed with Zelboraf.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Zelboraf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have forgotten a\u00a0dose\u00a0and it is more than 4 hours until your next\u00a0dose, take your\u00a0dose\u00a0as soon as you remember.\u00a0Take the next\u00a0dose\u00a0at the usual time.<\/li><li>If it is less than 4 hours until your next\u00a0dose, skip the missed\u00a0dose.\u00a0Take the next\u00a0dose\u00a0at the usual time.<\/li><li>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Zelboraf<\/h2>\n\n\n\n<p>You must continue to take Zelboraf for as long as your doctor prescribes it for you.\u00a0If you have any further questions about how to take this medicine, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Zelboraf can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Severe allergic reactions<\/strong><\/p>\n\n\n\n<p>If you get any of these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, lips, or tongue<\/li><li>Difficulty breathing<\/li><li>Rash<\/li><li>Fainting feeling<\/li><\/ul>\n\n\n\n<p>Contact a doctor immediately.&nbsp;Do not take more Zelboraf until you have spoken to a doctor.<\/p>\n\n\n\n<p>Worsening side effects\u00a0caused by radiotherapy may occur in patients treated with radiation before, during, or after treatment with Zelboraf.\u00a0This can occur in the area that was treated with radiation such as the skin, esophagus,\u00a0bladder, liver, rectum, and lungs.<\/p>\n\n\n\n<p>Tell your doctor immediately if you experience any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash, blistering, scaling, or discoloration of the skin<\/li><li>Shortness of breath which may be accompanied by cough, fever, or chills (\u00a0pneumonitis\u00a0)<\/li><li>Difficulty or pain in swallowing, chest pain, heartburn, or acid reflux (\u00a0oesophagitis\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor as soon as possible if you notice any changes in your skin.<\/strong><\/p>\n\n\n\n<p>The side effects&nbsp;below are listed by frequency:<\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash,\u00a0itching, dry or flaky skin<\/li><li>Skin problems, including warts<\/li><li>A type of skin cancer (cutaneous squamous cell carcinoma)<\/li><li>The hand-foot syndrome (\u00a0redness, peeling, or blistering of the hands and feet)<\/li><li>Tan, increased sensitivity to sunlight<\/li><li>Loss of appetite<\/li><li>Headache<\/li><li>Taste changes<\/li><li>Diarrhea<\/li><li>Constipation<\/li><li>Nausea, vomiting<\/li><li>Hair loss<\/li><li>Joint or muscle pain, musculoskeletal pain<\/li><li>Pain in arms and legs<\/li><li>Back pain<\/li><li>Fatigue<\/li><li>Dizziness<\/li><li>Fever<\/li><li>Swelling usually in the legs (peripheral\u00a0edema\u00a0)<\/li><li>Cough<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Types of skin cancer (\u00a0basal cell carcinoma, new primary\u00a0melanoma\u00a0)<\/li><li>Thickening of\u00a0tissue\u00a0under the palm which can cause tightening of the fingers inwards;\u00a0in severe cases, it can be disabling<\/li><li>Inflammation\u00a0of the eye (\u00a0uveitis\u00a0)<\/li><li>Bell&#8217;s palsy (a form of facial paralysis that is often\u00a0reversible\u00a0(transient))<\/li><li>Tingling or a burning sensation in the hands and feet<\/li><li>Arthritis<\/li><li>Inflammation\u00a0in hair roots<\/li><li>Weight loss<\/li><li>Inflammation\u00a0in the blood vessels<\/li><li>Problems with nerves that can cause pain, loss of sensation, and\/or muscle weakness (\u00a0peripheral\u00a0neuropathy\u00a0)<\/li><li>Changes in liver test results (increase in\u00a0ALT, alkaline phosphatases,\u00a0bilirubin\u00a0)<\/li><li>Changes in the electrical activity of the heart (\u00a0QT\u00a0prolongation)<\/li><li>Inflammation\u00a0of the fatty tissue under the skin.<\/li><li>Abnormal kidney test results (creatinine increase in the blood)<\/li><li>Changes in liver test results (GGT increase)<\/li><li>Decreased number of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0).<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The allergic reactions\u00a0which may include swelling of the face and difficulty breathing<\/li><li>Blockage of blood flow to parts of the\u00a0retina\u00a0of the eye (\u00a0retinal vein\u00a0occlusion)<\/li><li>Inflammation\u00a0of\u00a0the\u00a0pancreas<\/li><li>Changes in liver test results or liver damage, including severe liver damage where the liver is damaged to such an extent that it does not function completely<\/li><li>A type of cancer (non-cutaneous\u00a0squamous\u00a0cell carcinoma )<\/li><li>Thickening of deep\u00a0tissue\u00a0under the sole can be disabling in severe cases.<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Progression (progression) of a type of previously existing cancer with RAS\u00a0mutations\u00a0(\u00a0chronic\u00a0myelomonocytic\u00a0leukemia, pancreatic\u00a0adenocarcinoma\u00a0)<\/li><li>A type of severe skin reaction characterized by a rash along with fever and\u00a0inflammation\u00a0of internal organs such as the liver and kidneys.<\/li><li>An inflammatory\u00a0disease that mainly affects the skin, lungs, and eyes (\u00a0sarcoid\u00a0)<\/li><li>Kidney damage is characterized by\u00a0inflammation\u00a0(\u00a0acute\u00a0interstitial nephritis) or damage to the renal tubules (\u00a0acute\u00a0tubular\u00a0necrosis\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zelboraf<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and blister pack after the Issue.\u00a0data\/EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is vemurafenib.\u00a0Each film-coated tablet contains 240 milligrams (mg) of vemurafenib (as a combined\u00a0precipitate\u00a0of vemurafenib and hypromellose acetate succinate).<\/li><li>Other ingredients are:<ul><li>Core: silica,\u00a0colloidal, anhydrous, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate<\/li><li>Film coating: red iron oxide, macrogol 3350, polyvinyl alcohol, talc, and titanium dioxide.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zelboraf 240 mg film-coated tablets are light pink to light orange.&nbsp;They are oval with &#8216;VEM&#8217; engraved on one side.<\/p>\n\n\n\n<p>They are available in aluminum perforated unit dose blisters in packs of 56 x 1 tablet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>D-79639<\/p>\n\n\n\n<p>Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th scope=\"col\"><\/th><th scope=\"col\"><\/th><\/tr><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>NV Roche SATel\/Tel: +32 (0) 2 525 82 11<\/td><td><strong>Lithuania<\/strong>UAB \u201cRoche Lietuva\u201dPhone: +370 5 2546799<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>\u0420\u043e\u0448 \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044f \u0415\u041e\u041e\u0414Phone: +359 2 818 44 44<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>(Voir\/siehe Belgique\/Belgium)<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Roche s.r.oPhone: +420 &#8211; 2 20382111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Roche (Magyarorsz\u00e1g) Kft.Phone: +36 &#8211; 1 279 4500<\/td><\/tr><tr><td><strong>Denmark<\/strong>Roche a\/sPhone: +45 &#8211; 36 39 99 99<\/td><td><strong>Malta<\/strong>(See United Kingdom)<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Roche Pharma AGPhone: +49 (0) 7624 140<\/td><td><strong>The Netherlands<\/strong>Roche Netherlands BVPhone: +31 (0) 348 438050<\/td><\/tr><tr><td><strong>Estonia<\/strong>Roche Eesti O\u00dcPhone: + 372 &#8211; 6 177 380<\/td><td><strong>Norway<\/strong>Roche Norway ASPhone: +47 &#8211; 22 78 90 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Roche (Greece) AETel: +30 210 61 66 100<\/td><td><strong>Austria<\/strong>Roche Austria GmbHPhone: +43 (0) 1 27739<\/td><\/tr><tr><td><strong>Spain<\/strong>Roche Pharma SAPhone: +34 &#8211; 91 324 81 00<\/td><td><strong>Polish<\/strong>Roche Polska Sp. z o. oPhone: +48 &#8211; 22 345 18 88<\/td><\/tr><tr><td><strong>France<\/strong>RocheTel: +33 (0) 1 47 61 40 00<\/td><td><strong>Portugal<\/strong>Roche Farmac\u00eautica Qu\u00edmica, LdaPhone: +351 &#8211; 21 425 70 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Roche d.o.oPhone: + 385 1 47 22 333<\/td><td><strong>Romania<\/strong>Roche Rom\u00e2nia SRLPhone: +40 21 206 47 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Roche Products (Ireland) Ltd.Phone: +353 (0) 1 469 0700<\/td><td><strong>Slovenija<\/strong>Roche farmacevtska dru\u017eba dooPhone: +386 &#8211; 1 360 26 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Roche a\/sc\/o Icepharma hfTelephone: +354 540 8000<\/td><td><strong>Slovenian Republic<\/strong>Roche Slovensko, s.r.oPhone: +421 &#8211; 2 52638201<\/td><\/tr><tr><td><strong>Italy<\/strong>Roche S.p.APhone: +39 &#8211; 039 2471<\/td><td><strong>Finland\/Finland<\/strong>Roche OyTel: +358 (0) 10 554 500<\/td><\/tr><tr><td><strong>Cyprus<\/strong>\u0393.\u0391.\u03a3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c2 &amp; \u03a3\u03b9\u03b1 \u039b\u03c4\u03b4.Tel: +357 &#8211; 22 76 62 76<\/td><td><strong>Sweden<\/strong>Roche ABPhone: +46 (0) 8 726 1200<\/td><\/tr><tr><td><strong>Latvia<\/strong>Roche Latvija SIAPhone: +371 &#8211; 6 7039831<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Roche Products (Ireland) L<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Zelboraf is an anti-cancer medicine that contains the active substance vemurafenib.\u00a0It is used to treat adult patients with\u00a0melanoma\u00a0that has spread to other parts of the body or cannot be removed with\u00a0surgery\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[28318,28320,28321,28319,28324,28322,28325,28323,28327,28326],"class_list":["post-34553","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-vemurafenib","tag-vemurafenib-side-effects","tag-vemurafenib-tablet","tag-what-is-vemurafenib","tag-what-is-zelboraf","tag-what-vemurafenib-is-used-for","tag-what-zelboraf-is-used-for","tag-zelboraf","tag-zelboraf-side-effects","tag-zelboraf-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34553"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34553\/revisions"}],"predecessor-version":[{"id":35068,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34553\/revisions\/35068"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}