{"id":34551,"date":"2022-11-21T09:34:14","date_gmt":"2022-11-21T09:34:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34551"},"modified":"2022-11-22T07:18:10","modified_gmt":"2022-11-22T07:18:10","slug":"zejula","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zejula\/","title":{"rendered":"Zejula &#8211; Niraparib uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;film-coated tablets<br>niraparib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zejula is and what it is used for<\/h2>\n\n\n\n<p><strong>What Zejula is and how it works<\/strong><\/p>\n\n\n\n<p>Zejula contains the active substance niraparib.\u00a0Niraparib is a type of cancer drug called a PARP inhibitor.\u00a0PARP inhibitors block an\u00a0enzyme\u00a0called PARP (poly[adenosine diphosphate\u2011ribose] polymerase).\u00a0PARP helps cells repair damaged\u00a0DNA.\u00a0When niraparib blocks PARP, the\u00a0DNA\u00a0in the cancer cells cannot be repaired, leading to tumor cell death.<\/p>\n\n\n\n<p><strong>What Zejula is used for<\/strong><\/p>\n\n\n\n<p>Zejula is used in adult women to treat cancer of the ovaries, fallopian tubes (part of the female reproductive system that runs from the ovaries to the uterus), or the peritoneum (the membrane that surrounds the abdominal cavity).<\/p>\n\n\n\n<p>It is used after cancer has:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>responded to the first treatment with platinum-based cytostatics\u00a0(\u00a0chemotherapy\u00a0er), or<\/li><li>has come back (recurred) after cancer has responded to previous standard treatment with platinum-based cytostatics.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Zejula<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Zejula<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to niraparib or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse\u00a0before or while\u00a0taking this medicine if any of the following apply to you:<\/p>\n\n\n\n<p>Low blood counts<\/p>\n\n\n\n<p>Zejula lowers your blood values, such as the number of\u00a0red blood cells\u00a0(anemia;\u00a0anemia\u00a0), the number of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0), or the number of\u00a0platelets\u00a0(\u00a0thrombocytopenia\u00a0).\u00a0You should look out for signs and symptoms such as fever or\u00a0infection\u00a0and abnormal bruising or bleeding (see section 4 for more information).\u00a0Your doctor will take blood samples regularly during treatment.<\/p>\n\n\n\n<p>Myelodysplastic syndrome\/acute&nbsp;myelogenous&nbsp;leukemia<\/p>\n\n\n\n<p>In rare cases, low blood counts can be a sign of a more serious\u00a0bone marrow\u00a0problem, such as\u00a0myelodysplastic syndrome\u00a0(MDS) or\u00a0acute myeloid leukemia\u00a0(AML).\u00a0Your doctor may want to check your\u00a0bone marrow\u00a0to see if you have developed such problems.<\/p>\n\n\n\n<p>High&nbsp;blood pressure<\/p>\n\n\n\n<p>Zejula can cause high\u00a0blood pressure, which in some cases can be serious.\u00a0Your doctor will measure your\u00a0blood pressure\u00a0regularly throughout your treatment.\u00a0The doctor can also give you medicine for high\u00a0blood pressure\u00a0and, if necessary, adjust your\u00a0dose\u00a0of Zejula.\u00a0Your doctor can advise you to measure your\u00a0blood pressure\u00a0at home and inform you when to contact him or her if\u00a0your blood pressure\u00a0rises.<\/p>\n\n\n\n<p>Posterior reversible encephalopathy syndrome (PRES)<\/p>\n\n\n\n<p>A rare neurological\u00a0side effect\u00a0called PRES has been associated with treatment with Zejula.\u00a0If you get a headache, vision changes, seizures, or become confused, with or without high\u00a0blood pressure, you should contact a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Children under 18 should not take Zejula.&nbsp;The drug has not been studied in that age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zejula<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>You should not take Zejula if you are pregnant, as it may harm your baby.\u00a0If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<p>If you are a woman and could become pregnant, you must use effective contraception while taking Zejula, and you must continue to use effective contraception for 1 month after you have taken the last\u00a0dose.\u00a0Your doctor will ask you to take a pregnancy test to confirm that you are not pregnant before starting treatment.\u00a0Contact your doctor immediately if you become pregnant while taking Zejula.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Breast-feeding<\/h2>\n\n\n\n<p>You should not take Zejula if you are breastfeeding, as it is not known whether the medicine passes into breast milk.\u00a0If you are breastfeeding, you must stop breastfeeding before you start taking Zejula, and you must not start breastfeeding again until 1 month after you have taken the last\u00a0dose.\u00a0Consult a doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zejula can make you feel weak, unfocused, tired, or dizzy so that your ability to drive and use machines is affected.\u00a0Be careful when driving or using machinery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zejula contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Zejula<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><em>For ovarian cancer that has responded to the first treatment with platinum-based chemotherapy<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 200 mg (two 100 mg tablets) taken at the same time once a day, with or without food.&nbsp;If you weigh 77 kg or more and have a platelet count of 150,000\/\u00b5l or more before starting treatment, the recommended starting dose is 300 mg (three 100 mg tablets) taken at the same time once a day, with or without food.<\/p>\n\n\n\n<p><em>For ovarian cancer that has come back (recurred)<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 300 mg (three 100 mg tablets) taken at the same time once a day, with or without food.<\/p>\n\n\n\n<p>Take Zejula at about the same time each day.&nbsp;Taking Zejula at bedtime can reduce the risk of possible nausea.<\/p>\n\n\n\n<p>Your doctor may adjust your starting dose if you have liver problems.<\/p>\n\n\n\n<p>If you experience\u00a0side effects\u00a0(eg nausea, tiredness, abnormal bleeding\/bruising,\u00a0anemia\u00a0(\u00a0lack of blood\u00a0)) your doctor may recommend a lower\u00a0dose.<\/p>\n\n\n\n<p>The doctor will carry out regular checks, and you will usually continue to take Zejula as long as you benefit from the treatment and do not experience unacceptable\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Zejula<\/h2>\n\n\n\n<p>If you have taken more than your normal\u00a0dose, contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Zejula<\/h2>\n\n\n\n<p>Do not take an extra\u00a0dose\u00a0if you miss a\u00a0dose\u00a0or vomit after taking Zejula.\u00a0Take the next\u00a0dose\u00a0at the same time as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor&nbsp;<u>immediately<\/u>&nbsp;if you get any of the following serious&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical attention:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bruising or bleeding that lasts longer than usual when you injure yourself.\u00a0It may be a sign of a low number of\u00a0blood platelets\u00a0(\u00a0thrombocytopenia\u00a0).<\/li><li>Shortness of breath, pronounced tiredness, pale skin, or fast\u00a0pulse.\u00a0It may be a sign of a low number of\u00a0red blood\u00a0cells\u00a0(\u00a0anemia\u00a0).<\/li><li>Fever or\u00a0infection\u00a0\u2013 low\u00a0white blood cell count\u00a0(\u00a0neutropenia\u00a0) can increase the risk of\u00a0infection.\u00a0Signs may include fever, chills, feeling weak or confused, cough, pain, or a burning sensation when urinating.\u00a0Some\u00a0infections\u00a0can be serious and lead to death.<\/li><li>Decreased number of\u00a0white blood cells\u00a0in the blood (\u00a0leukopenia\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users):&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction\u00a0(includes severe allergic reactions that can be life-threatening).\u00a0Signs of this include raised and itchy skin rashes (\u00a0hives\u00a0) and swelling \u2013 sometimes swelling of the face or mouth (\u00a0angioedema\u00a0) which can cause breathing difficulties, collapse, or loss of consciousness.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A sudden increase in blood pressure.\u00a0This can be an\u00a0acute\u00a0medical condition that can lead to organ damage or be life-threatening.<\/li><li>A condition of the brain with symptoms such as seizures, headaches, confusion, and visual changes (posterior reversible encephalopathy syndrome or PRES).\u00a0This is an\u00a0acute\u00a0medical condition that can lead to organ damage or be life-threatening.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you get any other\u00a0side effects.\u00a0It can be about:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Heartburn (&nbsp;dyspepsia&nbsp;)<\/li><li>Decreased number of&nbsp;white blood cells&nbsp;in the blood<\/li><li>Decreased number of&nbsp;platelets&nbsp;in the blood<\/li><li>Decreased number of&nbsp;red blood cells&nbsp;in the blood (&nbsp;anemia&nbsp;)<\/li><li>Fatigue<\/li><li>Impotence<\/li><li>Constipation<\/li><li>Vomiting<\/li><li>Stomach pains<\/li><li>Insomnia<\/li><li>Headache<\/li><li>Decreased appetite<\/li><li>Runny or stuffy nose<\/li><li>Diarrhea<\/li><li>Shortness of breath<\/li><li>Back pain<\/li><li>Joint pain<\/li><li>High&nbsp;blood pressure<\/li><li>Indigestion<\/li><li>Dizziness<\/li><li>Cough<\/li><li>Urinary tract infection<\/li><li>Palpitations (feeling like your heart is skipping beats or beating faster than usual)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin reactions after exposure to light that is similar to those you get after getting sunburned<\/li><li>Swollen feet, ankles, legs, and\/or hands<\/li><li>Low levels of potassium in the blood<\/li><li>Inflammation\u00a0or swelling of the airways between the mouth, nose, and lungs (\u00a0bronchitis\u00a0)<\/li><li>Bloated stomach<\/li><li>Anxiety, nervousness\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li><li>Low mood, depression<\/li><li>Nosebleed<\/li><li>Weight loss<\/li><li>Muscle pain<\/li><li>Impaired concentration, understanding, memory, and thinking ability (\u00a0cognitive\u00a0impairment)<\/li><li>Inflamed red eyes<\/li><li>Fast heartbeat (may cause dizziness, chest pain, or shortness of breath)<\/li><li>Dry mouth<\/li><li>Inflammation\u00a0of the mouth and\/or gastrointestinal tract<\/li><li>Rash<\/li><li>Elevated blood test values<\/li><li>Abnormal blood test values<\/li><li>Abnormal taste in the mouth<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0red blood cells,\u00a0white blood cells,\u00a0and\u00a0platelets<\/li><li>State of confusion<\/li><li>Inflammation\u00a0of the lungs that can cause shortness of breath and breathing difficulties (non-infectious pneumonia)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zejula<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special instructions on storage temperature.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is niraparib.&nbsp;Each film-coated tablet contains niraparib tosylate monohydrate equivalent to 100 mg niraparib.<\/li><li>Other ingredients (excipients) are:<\/li><\/ul>\n\n\n\n<p>Tablet core: crospovidone,\u00a0lactose monohydrate, magnesium stearate, microcrystalline cellulose (E 460), povidone (E 1201),\u00a0colloidal\u00a0hydrogenated silicon dioxide.<\/p>\n\n\n\n<p>Film coating: polyvinyl alcohol (E 1203), titanium dioxide (E 171), macrogol (E 1521), talc (E 553b), black iron oxide (E 172).<\/p>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;&#8211; see section 2 for more information.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zejula 100 mg film-coated tablets are grey, oval, film-coated tablets debossed with \u201c100 mg\u201d on one side and \u201cZejula\u201d on the other side.<\/p>\n\n\n\n<p>The film-coated tablets are packed in blister packs with<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>84 \u00d7 1 film-coated tablets<\/li><li>56 \u00d7 1 film-coated tablets<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>GlaxoSmithKline (Ireland) Limited<\/p>\n\n\n\n<p>12 Riverwalk<\/p>\n\n\n\n<p>Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>GlaxoSmithKline Trading Services Ltd.<\/p>\n\n\n\n<p>12 Riverwalk<\/p>\n\n\n\n<p>Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Millmount Healthcare Ltd.<\/p>\n\n\n\n<p>Block 7, City North Business Campus,<\/p>\n\n\n\n<p>Stamullen, Co Meath<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Glaxo Wellcome, SA<\/p>\n\n\n\n<p>Abda.&nbsp;Extremadura, 3<\/p>\n\n\n\n<p>09400 Aranda de Duero<\/p>\n\n\n\n<p>Burgos<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>GlaxoSmithKline Pharmaceuticals sa\/nvTel\/Tel: + 32 (0) 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>GlaxoSmithKline (Ireland) LimitedTel.: + 359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>GlaxoSmithKline Pharmaceuticals sa\/nvBelgique\/BelgiumTel\/Tel: + 32 (0) 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline, Serophene: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>GlaxoSmithKline (Ireland) Limited.Tel.: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGTel.: + 49 (0)89 36044 8701product.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVPhone: + 31 (0)33 2081100<\/td><\/tr><tr><td><strong>Estonia<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0)1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SAPhone: + 34 900 202 700es-ci@gsk.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (0)22 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>Laboratory GlaxoSmithKlineTel: + 33 (0)1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>GlaxoSmithKline \u2013 Produtos Farmac\u00eauticos, Lda.Phone: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: +385 800787089<strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 353 (0)1 4955000<\/td><td><strong>Romania<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 40 800672524<strong>Slovenija<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Telephone: + 354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpAPhone: + 39 (0)45 7741111<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPhone\/Tel: + 358 (0)10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>GlaxoSmithKline (Ireland) LtdTel: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 44 (0)800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Zejula contains the active substance niraparib.\u00a0Niraparib is a type of cancer drug called a PARP inhibitor.\u00a0PARP inhibitors block an\u00a0enzyme\u00a0called PARP (poly[adenosine diphosphate\u2011ribose] polymerase).\u00a0PARP helps cells repair damaged\u00a0DNA\u00a0.\u00a0When niraparib blocks PARP, the\u00a0DNA\u00a0in the cancer cells cannot be repaired, leading to tumor cell death.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[28337,28328,28332,28331,28329,28334,28330,28335,28333,28336,28338],"class_list":["post-34551","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-zejula","tag-niraparib","tag-niraparib-side-effects","tag-niraparib-tablet","tag-what-is-niraparib","tag-what-is-zejula","tag-what-niraparib-is-used-for","tag-what-zejula-is-used-for","tag-zejula","tag-zejula-side-effects","tag-zejula-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34551"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34551\/revisions"}],"predecessor-version":[{"id":35069,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34551\/revisions\/35069"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}