{"id":34508,"date":"2022-11-21T06:49:02","date_gmt":"2022-11-21T06:49:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34508"},"modified":"2022-11-22T07:18:40","modified_gmt":"2022-11-22T07:18:40","slug":"zavicefta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zavicefta\/","title":{"rendered":"Zavicefta &#8211; Ceftazidime\/avibactam uses, dose and side effects"},"content":{"rendered":"\n<p>2 g\/0.5 g&nbsp;powder for concentrate for&nbsp;infusion&nbsp;solution,<br>ceftazidime\/avibactam solution<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zavicefta is and what it is used for<\/h2>\n\n\n\n<p><strong>What Zavicefta is<\/strong><\/p>\n\n\n\n<p>Zavicefta is an antibiotic medicine that contains the two active substances ceftazidime and avibactam.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ceftazidime belongs to a group of&nbsp;antibiotics&nbsp;called &#8220;cephalosporins&#8221;.&nbsp;It can kill many types of bacteria.<\/li><li>Avibactam is a &#8220;beta-lactamase inhibitor&#8221; that helps ceftazidime kill some bacteria that it cannot kill on its own.<\/li><\/ul>\n\n\n\n<p><strong>What Zavicefta is used for<\/strong><\/p>\n\n\n\n<p>Zavicefta is used in adult and&nbsp;pediatric patients&nbsp;from 3 months of age to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;in your stomach and intestines (abdomen)<\/li><li>infection&nbsp;in the bladder and kidneys, &#8220;urinary tract infections&#8221;<\/li><li>infection&nbsp;in the lung, &#8220;pneumonia&#8221;<\/li><li>infection&nbsp;caused by bacteria that other&nbsp;antibiotics&nbsp;may not be able to kill<\/li><\/ul>\n\n\n\n<p>Zavicefta is used in adults to treat\u00a0infection\u00a0in the blood linked to\u00a0infection\u00a0in the abdomen, urinary tract, or\u00a0pneumonia\u00a0.<\/p>\n\n\n\n<p><strong>How Zavicefta works<\/strong><\/p>\n\n\n\n<p>Zavicefta works by killing certain types of bacteria that can cause serious\u00a0infections.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Zavicefta<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Zavicefta<\/h2>\n\n\n\n<p><strong>Do not use Zavicefta:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ceftazidime, avibactam, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to any other\u00a0cephalosporin\u00a0&#8211;\u00a0antibiotics<\/li><li>if you have ever had a severe\u00a0allergic reaction\u00a0to other\u00a0antibiotics\u00a0belonging to the\u00a0penicillin\u00a0or carbapenem groups.<\/li><\/ul>\n\n\n\n<p>Do not use Zavicefta if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or nurse before using Zavicefta.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to a doctor or nurse before using Zavicefta:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had an\u00a0allergic reaction\u00a0(even if it was just a rash) to other\u00a0antibiotics\u00a0belonging to the\u00a0penicillin\u00a0or carbapenem groups.<\/li><li>If you have kidney problems \u2013 your doctor may give you a lower\u00a0dose\u00a0to make sure you don&#8217;t get too much medicine.\u00a0This can cause symptoms such as convulsions (see section\u00a0If you use too much Zavicefta).<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or nurse before using Zavicefta.<\/p>\n\n\n\n<p>Talk to your doctor or nurse if you suffer from diarrhea during your treatment.<\/p>\n\n\n\n<p>Other&nbsp;infection&nbsp;er<\/p>\n\n\n\n<p>There is a small risk that you will get another&nbsp;infection&nbsp;caused by another&nbsp;bacteria&nbsp;during or after treatment with Zavicefta.&nbsp;These include thrush (fungal infection of the mouth or genital area).<\/p>\n\n\n\n<p>Lab samples<\/p>\n\n\n\n<p>Tell your doctor that you are taking Zavicefta if you are going to have tests.\u00a0This is because you may get an abnormal result on a test called &#8220;DAT&#8221; or &#8220;Coombs&#8221;.\u00a0That test looks for\u00a0antibodies\u00a0that attack your\u00a0red blood cells.<\/p>\n\n\n\n<p>Zavicefta can also affect some tests for sugar in the urine.&nbsp;Tell the person taking the test that you have received Zavicefta.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pediatric patients<\/h2>\n\n\n\n<p>Zavicefta should not be used in&nbsp;pediatric patients&nbsp;younger than 3 months.&nbsp;This is because it is not known whether the drug is safe to use in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zavicefta<\/h2>\n\n\n\n<p>Tell the doctor or nurse if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines before using Zavicefta:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an\u00a0antibiotic\u00a0called Chloramphenicol<\/li><li>a type of\u00a0antibiotic\u00a0called an\u00a0aminoglycoside, such as gentamicin, tobramycin<\/li><li>a diuretic tablet called\u00a0Furosemide<\/li><li>medicine for\u00a0gout\u00a0called Probenecid<\/li><\/ul>\n\n\n\n<p>Before using Zavicefta, tell your doctor if any of the above applies to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zavicefta can cause dizziness.&nbsp;This may affect your ability to drive and use tools and machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zavicefta contains sodium<\/h2>\n\n\n\n<p>This medicine contains approximately 146 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) per\u00a0vial.\u00a0This corresponds to 7.3% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist if you need 3 or more vials every day for a longer period, especially if you have been recommended a low salt (low sodium) diet.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Zavicefta<\/h2>\n\n\n\n<p>You will be given Zavicefta by a doctor or nurse.<\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults is one&nbsp;vial&nbsp;(2 g ceftazidime and 0.5 g avibactam) every 8 hours.&nbsp;Dose&nbsp;one for&nbsp;pediatric patients&nbsp;from 3 months of age is calculated by the doctor based on the child&#8217;s weight and age.<\/p>\n\n\n\n<p>It is given as a drip into a vein, which normally takes about 2 hours.<\/p>\n\n\n\n<p>Treatment usually lasts from 5 up to 14 days depending on the type of\u00a0infection\u00a0you have and how you respond to treatment.<\/p>\n\n\n\n<p>People with kidney problems<\/p>\n\n\n\n<p>If you have problems with your kidneys, your doctor may give you a lower\u00a0dose, as Zavicefta is excreted via the kidneys.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Zavicefta&nbsp;<\/h2>\n\n\n\n<p>You will be given Zavicefta by a doctor or nurse, so it is unlikely that you will receive the wrong\u00a0dose.\u00a0If you experience\u00a0side effects\u00a0or think you have received too much Zavicefta, you must tell the doctor or nurse immediately.\u00a0If you get too much Zavicefta, it can affect the brain and cause seizures or\u00a0coma.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Zavicefta<\/h2>\n\n\n\n<p>If you think you have missed a\u00a0dose, tell your doctor or nurse immediately.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0can occur with this medicine:<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you notice any of the following serious\u00a0side effects, you may need immediate medical treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe\u00a0allergic reaction\u00a0&#8211; signs include swelling of the lips, face, throat, or tongue, a severe rash or other severe skin reaction, and difficulty swallowing or breathing.\u00a0These reactions can be life-threatening.<\/li><li>diarrhea that gets worse or doesn&#8217;t go away, blood or mucus in the stool &#8211; this can happen during or after treatment with Zavicefta.\u00a0If this happens, you must not take medicines that stop or slow down bowel movements.<\/li><\/ul>\n\n\n\n<p>Tell the doctor immediately if you notice any of the serious&nbsp;side effects&nbsp;above.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Tell the doctor or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal results on a test called &#8220;DAT&#8221; or &#8220;Coombs&#8221;.\u00a0That test looks for\u00a0antibodies\u00a0that attack your\u00a0red blood cells.\u00a0It is possible that this can cause\u00a0anemia\u00a0(which can make you feel tired) and jaundice (yellowing of the skin and eyes).<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infections, including in the mouth and abdomen<\/li><li>a change in the number of blood cells (called &#8216;eosinophils&#8217; and &#8216;thrombocytes&#8217;), which show up in blood tests<\/li><li>headache<\/li><li>dizziness<\/li><li>nausea, vomiting<\/li><li>stomach pains<\/li><li>diarrhea<\/li><li>an increase in the number of certain\u00a0enzymes\u00a0produced by the liver, which shows up in blood tests<\/li><li>raised itchy rash (&#8220;hives&#8221;)<\/li><li>itching<\/li><li>redness, pain, or swelling at the site where Zavicefta was given into a vein<\/li><li>fever<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an increase in the number of blood cells (called &#8220;lymphocytes&#8221;), which can be seen in blood tests<\/li><li>a decrease in the number of blood cells (called &#8220;leukocytes&#8221;), which can be seen in blood tests<\/li><li>tingling or numbness<\/li><li>bad taste in the mouth<\/li><li>an increase in the levels of certain types of substances in the blood (called &#8220;creatinine&#8221; and &#8220;urea&#8221;).&nbsp;These show how well your kidneys are working.<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;(may affect up to 1 in 10,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of part of the kidney that causes it to function worse than normal<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known<\/strong>&nbsp;: (frequency cannot be estimated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a\u00a0significant\u00a0decrease in\u00a0white blood cells\u00a0that fight\u00a0infection\u00a0er &#8211; shown through blood tests<\/li><li>a decrease in the number of red blood cells (hemolytic anemia) &#8211; shown by blood tests<\/li><li>severe\u00a0allergic reaction\u00a0(see\u00a0<strong>Serious\u00a0side effects\u00a0above<\/strong>\u00a0)<\/li><li>the whites of the eyes or the skin turn yellow<\/li><li>sudden onset of severe rash, blistering or peeling skin, possibly accompanied by high fever or joint pain (these may be signs of more serious conditions such as\u00a0toxic epidermal necrolysis,\u00a0Stevens-Johnson syndrome, erythema multiforme or a condition known as DRESS, drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms )<\/li><li>swelling under the skin, especially the lips and around the eyes<\/li><\/ul>\n\n\n\n<p>Tell the doctor or nurse if you notice any of the&nbsp;side effects&nbsp;described above.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zavicefta<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the container.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are ceftazidime and avibactam.&nbsp;Each&nbsp;vial&nbsp;contains ceftazidime pentahydrate corresponding to 2 g of ceftazidime and avibactam&nbsp;sodium&nbsp;corresponding to 0.5 g of avibactam.<\/li><li>The other ingredient is sodium carbonate (anhydrous) (see section 2 &#8220;Zavicefta contains sodium&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zavicefta is a white to yellow powder to concentrate for\u00a0infusion, or solution, in a\u00a0vial.\u00a0It is available in packs of 10 vials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Pfizer Ireland Pharmaceuticals<\/p>\n\n\n\n<p>Operations Support Group<\/p>\n\n\n\n<p>Ringaskiddy, County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>ACS Dobfar SpA<\/p>\n\n\n\n<p>Via Alessandro Fleming 2<\/p>\n\n\n\n<p>Verona 37135<\/p>\n\n\n\n<p>Italy<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer NV\/SATel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+370 5 251 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044fPhone: +359 2 970 4333<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.: + 36 1 488 37 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.\u00a0s iPhone: +420 283 004 111<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel.: +356 21344610<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>The Netherlands<\/strong>Pfizer by phone: +31 (0)10 406 43 01<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbHPhone: +49 (0)30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branch phone: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.Tel.: +30 210 6785800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. oTel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0)1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLPhone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, a branch of marketing, LjubljanaTel.: +386 (0)1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: +1800 633 363 (toll-free)Phone: +44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaPhone: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Telephone: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358 (0)9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABPhone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.&nbsp;(Cyprus Branch)Tel.: +357 22817690<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaPhone: + 371 670 35 775<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Zavicefta is an antibiotic medicine that contains the two active substances ceftazidime and avibactam.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[28350,28353,2465,2468,28352,28349,28351,28348,28347,28345,28344,28346],"class_list":["post-34508","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-avibactam","tag-avibactam-benefits","tag-ceftazidime","tag-ceftazidime-side-effects","tag-what-avibactam-is-used-for","tag-what-ceftazidime-is-used-for","tag-what-is-avibactam","tag-what-is-ceftazidime","tag-what-is-zavicefta","tag-what-zavicefta-is-used-for","tag-zavicefta","tag-zavicefta-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34508"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34508\/revisions"}],"predecessor-version":[{"id":35072,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34508\/revisions\/35072"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}