{"id":34506,"date":"2022-11-21T06:46:35","date_gmt":"2022-11-21T06:46:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34506"},"modified":"2022-11-22T07:18:48","modified_gmt":"2022-11-22T07:18:48","slug":"zavesca","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zavesca\/","title":{"rendered":"Zavesca &#8211; Miglustat uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;capsules<br>miglustat<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Zavesca is and what it is used for<\/h2>\n\n\n\n<p>Zavesca contains the active substance miglustat which belongs to a group of medicines that affect\u00a0metabolism.\u00a0It is used to treat two diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Zavesca is used to treat mild to moderate type 1&nbsp;Gaucher disease&nbsp;in adults.<\/strong><\/li><\/ul>\n\n\n\n<p>For type 1\u00a0Gaucher disease, a substance called glucosylceramide is not removed from your body.\u00a0It begins to be stored in certain cells that belong to the body&#8217;s immune system.\u00a0This can lead to liver and spleen enlargement, changes in the blood, and bone disease.<\/p>\n\n\n\n<p>Gaucher disease&nbsp;type 1 is normally treated with enzyme replacement therapy.&nbsp;Zavesca is only used if the patient is not considered suitable for treatment with enzyme replacement therapy.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Zavesca is also used to treat worsening neurological symptoms in Niemann-Pick disease type C in adults and children.<\/strong><\/li><\/ul>\n\n\n\n<p>If you have Niemann-Pick disease type C, fats, such as glycosphingolipids, are stored in your brain cells.\u00a0This can lead to disturbances in neurological functions such as slow eye movements, balance, swallowing ability, memory, and to convulsions.<\/p>\n\n\n\n<p>Zavesca works by&nbsp;inhibiting&nbsp;an&nbsp;enzyme&nbsp;called &#8216;glucosylceramide synthetase&#8217;, which is responsible for the first step in the production of most glycosphingolipids.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Zavesca<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Zavesca:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to miglustat or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Zavesca<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any kidney disease<\/li><li>if you have any liver disease<\/li><\/ul>\n\n\n\n<p>Your doctor will carry out the following checks before and during treatment with Zavesca:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>examination to check the nerves in your arms and legs<\/li><li>measurement of&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;value<\/li><li>follow your growth if you are a child or adolescent with Niemann-Pick type C disease<\/li><li>check the&nbsp;platelet count<\/li><\/ul>\n\n\n\n<p>The reason for these checks is that some patients have experienced tingling or numbness in the hands and feet or lost weight during treatment with Zavesca.&nbsp;The checks make it easier for the doctor to decide whether these problems are due to your illness or something you have had in the past, or whether they are due to&nbsp;side effects&nbsp;of Zavesca (for more information see section 4).<\/p>\n\n\n\n<p>If you get diarrhea, your doctor may ask you to change your diet so that you reduce your intake of milk sugar and carbohydrates such as sucrose (plain sugar).\u00a0The doctor may also ask you not to take Zavesca with food.\u00a0In some cases, the doctor may temporarily lower your\u00a0dose\u00a0or prescribe an anti-diarrhea medicine (such as loperamide).\u00a0If your diarrhea does not respond to these measures, or if you have any other stomach problems, consult your doctor.\u00a0In such a case, your doctor may decide on further investigations.<\/p>\n\n\n\n<p>Male patients should use reliable contraception during treatment with Zavesca and for 3 months after stopping treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents (under 18 years of age) with type 1&nbsp;Gaucher disease&nbsp;because it is not known whether it works against that disease.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Zavesca<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking medicines containing imiglucerase, which is sometimes used at the same time as Zavesca.&nbsp;They can lower the amount of Zavesca in your body.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You should not take Zavesca if you are pregnant or planning to become pregnant.\u00a0Your doctor can give you more information.\u00a0You must use safe contraception while taking Zavesca.\u00a0Do not breastfeed while taking Zavesca.<\/p>\n\n\n\n<p>Male patients should use reliable contraceptive methods during treatment with Zavesca and for 3 months after stopping treatment.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Zavesca may make you feel dizzy.&nbsp;Do not drive a vehicle or use any tools or machinery if you feel dizzy.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Zavesca contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per capsule, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Zavesca<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>For\u00a0Gaucher disease\u00a0type 1<\/strong>: for adult patients, the usual\u00a0dose\u00a0is one capsule (100 mg) three times a day (morning, afternoon, and evening).\u00a0This means a maximum daily dose of three capsules (300 mg).<\/li><li>For\u00a0Niemann-Pick disease type C: For adults and adolescents (over 12 years of age), the usual\u00a0dose\u00a0is one or two capsules (200 mg) three times a day (morning, afternoon, and evening).\u00a0This means a maximum daily dose of 6 capsules (600 mg).<\/li><\/ul>\n\n\n\n<p>For children&nbsp;<strong>under the age of 12<\/strong>&nbsp;who have Niemann-Pick disease type C, the doctor will adjust the&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p>If you have problems with your kidneys, you may receive a lower starting dose.\u00a0Your doctor can lower your\u00a0dose, e.g.\u00a0to one capsule (100 mg) once or twice a day if you suffer from diarrhea during treatment with Zavesca (see section 4).\u00a0Your doctor will tell you how long you will be treated.<\/p>\n\n\n\n<p><strong>Take out the capsule as follows<\/strong>&nbsp;:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20021120000019#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Actelion20Pharmaceuticals\/Media\/Zavesca\/Blister20bild.gif\" alt=\"Take out the capsule as follows:\" title=\"Take out the capsule as follows:\"\/><\/a><\/figure>\n\n\n\n<ol class=\"wp-block-list\"><li>Separate at the perforations<\/li><li>Pull the paper back at the arrows<\/li><li>Push the medicine through the foil<\/li><\/ol>\n\n\n\n<p>Zavesca can be taken with or without food.&nbsp;You should swallow the capsule whole with a glass of water.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Zavesca<\/h2>\n\n\n\n<p>Consult your doctor immediately if you have taken more capsules than you should.&nbsp;Zavesca has been used in&nbsp;clinical trials&nbsp;at&nbsp;doses&nbsp;up to 3,000 mg: this caused a decrease in the number of&nbsp;white blood cells&nbsp;and other&nbsp;side effects&nbsp;similar to those described in section 4.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Zavesca<\/h2>\n\n\n\n<p>Take the next capsule at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Zavesca<\/h2>\n\n\n\n<p>Do not stop taking Zavesca without talking to your doctor.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Most serious side effects:<\/p>\n\n\n\n<p><strong>Some patients have experienced tingling or numbness in the hands and feet (common)<\/strong>.\u00a0This may be a sign of\u00a0peripheral\u00a0neuropathy\u00a0due to\u00a0side effects\u00a0of Zavesca or due to pre-existing conditions.\u00a0Your doctor will carry out some checks before and during treatment with Zavesca to assess this (see section 2).<\/p>\n\n\n\n<p><strong>If you experience any of these symptoms, consult your doctor as soon as possible.<\/strong><\/p>\n\n\n\n<p><strong>If you get mild tremors<\/strong>, usually in the\u00a0<strong>hands, consult your doctor<\/strong>\u00a0as soon as possible.\u00a0These tremors usually disappear without having to stop the treatment.\u00a0Sometimes your doctor may need to reduce your\u00a0dose\u00a0or stop Zavesca to help you get rid of your tremors.<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<p>The most common\u00a0side effects\u00a0are diarrhea, gas, abdominal (stomach) pain, weight loss, and decreased appetite.<\/p>\n\n\n\n<p>Do not worry\u00a0<strong>if you lose some weight<\/strong>\u00a0when you start treatment with Zavesca.\u00a0Usually, you stop losing weight as the treatment continues.<\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<p>Common&nbsp;side effects&nbsp;of treatment include headache, dizziness, paraesthesia (tingling or numbness), abnormal coordination,&nbsp;hypoesthesia&nbsp;(diminished sensation), acid reflux (heartburn), nausea, constipation and vomiting, abdominal (stomach) swelling or discomfort, and&nbsp;thrombocytopenia&nbsp;(decreased level of&nbsp;platelets&nbsp;).&nbsp;The neurological symptoms and thrombocytopenia may be caused by the underlying disease.<\/p>\n\n\n\n<p>Other possible\u00a0side effects\u00a0are muscle spasms or weakness, fatigue, chills and general malaise, depression, difficulty sleeping, forgetfulness, and reduced\u00a0libido.<\/p>\n\n\n\n<p>Most patients experience one or more of these\u00a0side effects, usually at the beginning of treatment or periodically during treatment.\u00a0In most cases,\u00a0side effects\u00a0are mild and disappear fairly quickly.\u00a0If any of these\u00a0side effects\u00a0cause problems, consult your doctor.\u00a0He or she can then reduce the\u00a0dose\u00a0of Zavesca or suggest other medications that can help reduce the\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Zavesca<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substance<\/strong>&nbsp;is miglustat 100 mg.<\/p>\n\n\n\n<p><strong>Other ingredients are:<\/strong><\/p>\n\n\n\n<p>Sodium starch glycolate,<\/p>\n\n\n\n<p>Povidone (K30),<\/p>\n\n\n\n<p>Magnesium stearate.<\/p>\n\n\n\n<p>Gelatine,<\/p>\n\n\n\n<p>Titanium dioxide (E171).<\/p>\n\n\n\n<p>Black iron oxide (E172),<\/p>\n\n\n\n<p>Shellac.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Zavesca is a white 100 mg capsule with &#8220;OGT 918&#8221; printed in black on the end and &#8220;100&#8221; printed in black on the side.<\/p>\n\n\n\n<p>A box contains 4 pressure packs with 21 capsules each, which gives a total of 84 capsules.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Janssen\u2011Cilag International NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B\u20112340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Janssen Pharmaceutica NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B-2340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zavesca contains the active substance miglustat which belongs to a group of medicines that affect\u00a0metabolism\u00a0.\u00a0It is used to treat two diseases:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[28358,17542,17545,17546,17543,28355,17544,28357,28354,28356],"class_list":["post-34506","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-benefits-of-zavesca","tag-miglustat","tag-miglustat-capsule","tag-miglustat-side-effects","tag-what-is-miglustat","tag-what-is-zavesca","tag-what-miglustat-is-used-for","tag-what-zavesca-is-used-for","tag-zavesca","tag-zavesca-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34506"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34506\/revisions"}],"predecessor-version":[{"id":35073,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34506\/revisions\/35073"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}