30 ME\/0.5 ml and 48 ME\/0.5 ml\u00a0injection\u00a0or\u00a0infusion solution, solution, in a pre-filled\u00a0syringe
Filgrastim<\/p>\n\n\n\n
Zarzio is a growth factor for\u00a0white blood cells\u00a0(granulocyte colony-stimulating factor) and belongs to a group of\u00a0proteins\u00a0called\u00a0cytokines.\u00a0Growth factors are\u00a0proteins\u00a0that are produced naturally in the body, but they can also be manufactured with biotechnology to be used in medicines.\u00a0Marzio works by stimulating the\u00a0bone marrow\u00a0so that it forms more\u00a0white blood cells.<\/p>\n\n\n\n
A decrease in the number of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0) can occur for various reasons and weakens the body’s ability to fight\u00a0infection.\u00a0Marzio stimulates the\u00a0bone marrow\u00a0to rapidly produce new\u00a0white blood cells.<\/p>\n\n\n\n
Marzio can be used:<\/strong><\/p>\n\n\n\n <\/a><\/p>\n\n\n\n Talk to your doctor, pharmacist, or nurse before using Zarzio.<\/p>\n\n\n\n Inform your doctor before starting treatment if you have<\/strong> :<\/p>\n\n\n\n During treatment with Zarzio, inform your doctor immediately if you:<\/p>\n\n\n\n Inflammation\u00a0of the aorta (the large blood vessel that carries blood from the heart to the body) has been reported at a frequency of “rare” in cancer patients and healthy donors.\u00a0Symptoms may include fever, abdominal pain, malaise, back pain, and increased inflammatory markers.\u00a0Tell your doctor if you experience these symptoms.<\/p>\n\n\n\n Decreased response to filgrastim<\/strong><\/p>\n\n\n\n If you feel that you no longer respond to the filgrastim treatment or your response to treatment decreases, the doctor will investigate the reasons for this, i.a. whether you have developed antibodies that neutralize the effects of filgrastim.<\/p>\n\n\n\n The doctor may want to monitor you closely, see section 4 of the package leaflet.<\/p>\n\n\n\n If you are a patient with severe\u00a0chronic\u00a0neutropenia, you may be at risk of developing blood cancer (\u00a0leukemia,\u00a0myelodysplastic syndrome\u00a0[MSD]).\u00a0You should talk to the doctor about your risk of developing blood cancer and what tests should be done.\u00a0If you develop or are at risk of developing blood cancer, you should not use Zarzio unless your doctor tells you to.<\/p>\n\n\n\n If you are a stem cell donor, you must be between 16 and 60 years old.<\/p>\n\n\n\n Be especially careful with other products that stimulate white blood cells<\/strong><\/p>\n\n\n\n Marzio belongs to a group of drugs that stimulate the production of\u00a0white blood cells.\u00a0Healthcare professionals should always record exactly which product they use.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n Zarzio has not been tested on pregnant or lactating women.<\/p>\n\n\n\n Zarzio is not recommended during pregnancy.<\/p>\n\n\n\n You must tell your doctor if you:<\/p>\n\n\n\n Inform the doctor if you become pregnant during treatment with Zarzio.<\/p>\n\n\n\n Unless your doctor tells you otherwise, you must stop breastfeeding if you are using Zarzio.<\/a><\/p>\n\n\n\n Marzio may have a minor influence on the ability to drive and use machines.\u00a0This medicine may cause dizziness.\u00a0It is wise to wait and see how you feel after taking Zarzio and before driving or using machines.<\/p>\n\n\n\n Zarzio contains sorbitol (E420).<\/p>\n\n\n\n Sorbitol is a source of fructose.\u00a0If you (or your child) have\u00a0hereditary\u00a0fructose intolerance, a rare, hereditary disease, you (or your child) should not use this medicine.\u00a0Patients with\u00a0hereditary\u00a0fructose intolerance\u00a0cannot break down fructose, which can cause serious\u00a0side effects.<\/p>\n\n\n\n Consult a doctor before using this medicine if you (or your child) have\u00a0hereditary\u00a0fructose intolerance, or if your child can no longer eat sweet foods or drinks without feeling sick, vomiting, or experiencing discomforts such as bloating, stomach cramps, or diarrhea. Always use this medicine as directed by your doctor. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n How is Zarzio given and how much should I take?<\/strong><\/p>\n\n\n\n Zarzio is usually given as a daily injection into a tissue just under the skin (so-called subcutaneous injection ). It can also be given as a slow injection into the vein (so-called intravenous infusion ). The usual dose varies depending on your illness and weight. The doctor will tell you how much Zarzio you should take.<\/p>\n\n\n\n Patients undergoing bone marrow transplantation after chemotherapy:<\/p>\n\n\n\n You will normally receive your first dose of Zarzio at least 24 hours after chemotherapy and at least 24 hours after you have had a bone marrow transplant.<\/p>\n\n\n\n You, or the people caring for you, can be trained in how to give a\u00a0subcutaneous\u00a0injection\u00a0so that you can continue your treatment at home.\u00a0However, you should not attempt to do this unless you have first been properly trained by healthcare professionals.<\/p>\n\n\n\n How long do I need to take Zarzio?<\/strong><\/p>\n\n\n\n You need to take Zarzio until the white blood cell count is normal. Blood samples will be taken regularly to check the number of white blood cells in the body. The doctor will tell you how long you need to take Zarzio.<\/a><\/p>\n\n\n\n Zarzio is used to treat children who are receiving chemotherapy or who have very low white blood cell counts ( neutropenia ). The dose for children receiving chemotherapy is the same as for adults.<\/a><\/p>\n\n\n\nWhat you need to know before you use Zarzio<\/h2>\n\n\n\n
Do not use Zarzio<\/h2>\n\n\n\n
Warnings and precautions<\/h2>\n\n\n\n
Other medicines and Zarzio<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving ability and use of machinery<\/h2>\n\n\n\n
Zarzio contains sorbitol<\/h2>\n\n\n\n
<\/p>\n\n\n\nHow to use Zarzio<\/h2>\n\n\n\n
Use for children<\/h2>\n\n\n\n
If you use too much Zarzio <\/h2>\n\n\n\n