{"id":34494,"date":"2022-11-21T06:35:42","date_gmt":"2022-11-21T06:35:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=34494"},"modified":"2022-11-21T08:03:21","modified_gmt":"2022-11-21T08:03:21","slug":"zaltrap","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/zaltrap\/","title":{"rendered":"ZALTRAP &#8211; Aflibercept uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg\/ml&nbsp;concentrate for&nbsp;infusion&nbsp;solution<br>aflibercept<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What ZALTRAP is and what it is used for<\/h2>\n\n\n\n<p><strong>What Z\u00a0<small>ALTRAP<\/small>\u00a0is and how it works<\/strong><br>Z\u00a0<small>ALTRAP<\/small>\u00a0contains the active substance aflibercept, which is a\u00a0protein\u00a0that blocks the growth of new blood vessels within a\u00a0tumor.\u00a0A tumor\u00a0needs nutrients and oxygen from the blood to grow.\u00a0By blocking the growth of blood vessels, Z\u00a0<small>ALTRAP<\/small>\u00a0can cause the growth of a\u00a0tumor\u00a0to stop or slow down.<\/p>\n\n\n\n<p><strong>What Z\u00a0<small>ALTRAP is<\/small>\u00a0used for<\/strong><br>Z\u00a0<small>ALTRAP<\/small>\u00a0is a medicine used to treat advanced\u00a0colon\u00a0or rectal cancer (parts of the colon) in adults.\u00a0It will be given with other medicines, called &#8216;chemotherapy&#8217;, such as 5-fluorouracil, folinic acid, and irinotecan.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use ZALTRAP<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use ZALTRAP<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to aflibercept or any of the other ingredients of this medicine (listed in section 6).<\/li><li>in your eyes as it can seriously damage them.<\/li><\/ul>\n\n\n\n<p>Also, read the package leaflet for the other medicines (&#8220;chemotherapy&#8221;) that are part of your treatment to see if they are right for you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse if there is any reason why you cannot use these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before you receive Z\u00a0<small>ALTRAP<\/small>\u00a0and during your treatment if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have problems with bleeding or notice any bleeding after treatment (see section 4) or if you feel extremely tired, weak, dizzy, or have a change in the color of your stools.\u00a0If the bleeding is severe, your doctor will stop treatment with Z\u00a0ALTRAP.\u00a0This is because Z\u00a0ALTRAP\u00a0can increase the risk of bleeding.<\/li><li>you have any problem in your mouth or with your teeth such as poor dental status, gum disease, or planned tooth extraction, especially if you have previously been treated with bisphosphonates (used to treat or prevent bone diseases).\u00a0A\u00a0side effect\u00a0called\u00a0osteonecrosis\u00a0(bone damage in the jaw) has been reported in cancer patients treated with ZALTRAP.\u00a0You may be advised to have a dental examination before starting ZALTRAP treatment. While being treated with ZALTRAP, you should maintain good oral hygiene (including regular tooth brushing) and have routine dental check-ups.\u00a0If you wear dentures\/dentures, make sure they fit properly.\u00a0If you have previously received or if you receive\u00a0intravenous bisphosphonate treatment, dental treatment or dental surgery (e.g. tooth extraction) should be avoided.\u00a0Inform your doctor about your dental treatment and tell your dentist that you are being treated with ZALTRAP.\u00a0Contact your doctor or dentist immediately if during and after treatment with ZALTRAP you develop any problems in your mouth or with your teeth such as loose teeth, pain or swelling, or non-healing or oozing sores as these may be signs of\u00a0osteonecrosis\u00a0of the jaw.<\/li><li>you have diseases where your bowel is inflamed, such as an infected part of the bowel wall (also called\u00a0diverticulitis\u00a0),\u00a0peptic ulcer,\u00a0or\u00a0colitis.\u00a0This is because Z\u00a0ALTRAP\u00a0can increase the risk of developing holes in the intestinal wall.\u00a0If this should happen to you, your doctor will stop treatment with Z\u00a0ALTRAP.<\/li><li>you have had an abnormal tube-like connection or passage inside your body between internal organs and skin or other\u00a0tissue\u00a0(also called a\u00a0fistula\u00a0).\u00a0If such a connection or passage develops during your treatment, your doctor will stop treatment with Z\u00a0ALTRAP.<\/li><li>you have high\u00a0blood pressure.\u00a0Z\u00a0ALTRAP\u00a0may increase your\u00a0blood pressure\u00a0(see section 4) and your doctor will need to monitor your\u00a0blood\u00a0pressure and may change your blood pressure medicines or your\u00a0Z\u00a0ALTRAP\u00a0dose.\u00a0It is therefore also important to tell your doctor, pharmacist, or nurse if you have any other heart problems as high\u00a0blood pressure\u00a0can make them worse.<\/li><li>if you or have had an\u00a0aneurysm\u00a0(enlargement and weakening of a vessel wall) or a rupture in a vessel wall.<\/li><li>if you experience shortness of breath (\u00a0dyspnoea\u00a0) when you exert yourself or when you lie down, feel very tired, or have swollen legs, these symptoms may be signs of\u00a0heart failure.<\/li><li>you have seen signs of a blood clot (see section 4).\u00a0Signs of a blood clot can vary depending on where it is located (e.g. lungs, bones, heart, or brain) but can cause symptoms such as chest pain, cough, shortness of breath, or difficulty breathing.\u00a0Other signs may include swelling in one or both legs, pain or tenderness in one or both legs, discoloration, and warmth in the skin of the affected leg, or visible veins.\u00a0It can also appear as a sudden feeling of numbness or weakness in the face, arms, or legs.\u00a0Other signs may include feeling confused, having problems with vision, walking, coordination, or balance, problems pronouncing words, or slurred speech.\u00a0If you experience any of these symptoms, contact your doctor immediately as your doctor may want to treat your symptoms and stop treatment with Z\u00a0ALTRAP.<\/li><li>you have kidney problems (\u00a0protein\u00a0in the urine) because your doctor will monitor your kidney function and may need to adjust Z\u00a0ALTRAP\u00a0&#8211;\u00a0dose\u00a0one.<\/li><li>your\u00a0white blood cell count\u00a0is too low.\u00a0Z\u00a0ALTRAP\u00a0can reduce the number of\u00a0white blood cells\u00a0in your blood and your doctor will monitor the levels of your\u00a0white blood cells\u00a0and may give you additional medicines to increase the levels.\u00a0If your\u00a0white blood cell count\u00a0is low, your doctor may need to delay your treatment.<\/li><li>you have severe or persistent diarrhea, feel sick (nausea), or have vomiting, this can cause a large loss of body fluids (\u00a0dehydration\u00a0).\u00a0Your doctor may need to treat you with other medicines and\/or fluids\u00a0intravenously.<\/li><li>you have or have ever had an\u00a0allergy\u00a0&#8211; serious allergic reactions may occur during treatment with Z\u00a0ALTRAP\u00a0(see section 4).\u00a0Your doctor may need to treat the allergic reaction or stop treatment with Z\u00a0ALTRAP.<\/li><li>you have had a tooth extracted or other surgery in the last 4 weeks, or if you are going to have surgery or dental or medical treatment, or if you have a surgical wound that has not healed.\u00a0Your doctor may temporarily pause your treatment before and after surgery.<\/li><li>you have seizures (convulsions).\u00a0If you experience vision changes or become confused, your doctor may stop your treatment with Z\u00a0ALTRAP.<\/li><li>you are 65 years of age or older and develop diarrhea, dizziness, weakness, weight loss, or severe loss of body fluids (so-called &#8216;dehydration&#8217;).\u00a0Your doctor will monitor you closely.<\/li><li>your daily activities are limited or worsened during treatment.\u00a0Your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor, pharmacist, or nurse before you receive Z\u00a0<small>ALTRAP<\/small>\u00a0and during your treatment.<\/p>\n\n\n\n<p>During your treatment, your doctor will carry out several tests to monitor your body function and see how the medicine is working.\u00a0The tests may include blood and urine samples, X-rays, or other scanning techniques, and\/or other tests.<\/p>\n\n\n\n<p>Z\u00a0<small>ALTRAP<\/small>\u00a0is given by drip (\u00a0infusion\u00a0) into one of your veins (\u00a0intravenously\u00a0) to treat advanced cancer of the\u00a0colon\u00a0or\u00a0rectum.\u00a0Z\u00a0<small>ALTRAP<\/small>\u00a0must not be injected into the eyes as it can seriously damage them.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine is not for children and adolescents under 18 years of age.&nbsp;Safety and benefit have not been demonstrated when using Z&nbsp;<small>ALTRAP<\/small>&nbsp;in children and adolescents.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and ZALTRAP<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0This also includes over-the-counter medicines and herbal remedies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You should not use Z\u00a0<small>ALTRAP<\/small>\u00a0during pregnancy unless you and your doctor decide that the benefit to you is greater than the possible risk to you and your unborn baby.<br>If you are a woman of\u00a0childbearing potential, you should use an effective method of contraception (see the section on \u201cContraceptive methods\u201d below for further details on male and female methods of contraception).\u00a0This medicine can harm the unborn baby because it can stop the development of new blood vessels.<\/p>\n\n\n\n<p>Talk to your doctor before receiving this medicine if you are breastfeeding.\u00a0It is not known whether this drug is excreted in breast milk.<\/p>\n\n\n\n<p>Z\u00a0<small>ALTRAP<\/small>\u00a0can affect male and female\u00a0fertility.\u00a0Talk to your doctor for advice before you plan to become a parent of a child.<\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><br>methods Men and women of&nbsp;childbearing&nbsp;age must use effective contraception:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>during treatment with Z&nbsp;<small>ALTRAP<\/small>&nbsp;and<\/li><li>until at least 6 months after the last treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You may have\u00a0side effects\u00a0that affect your vision, concentration, or ability to react.\u00a0If this happens, do not drive or use tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ZALTRAP contains sodium<\/h2>\n\n\n\n<p>This medicine contains up to 22 mg of\u00a0sodium\u00a0(the main component of cooking\/table salt) in each\u00a0vial.\u00a0This corresponds to 1.1% of the recommended maximum daily intake of\u00a0sodium\u00a0for an adult.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How ZALTRAP is given<\/h2>\n\n\n\n<p>Z&nbsp;<small>ALTRAP<\/small>&nbsp;will be given to you by a doctor or nurse experienced in the use of &#8216;chemotherapy&#8217;.&nbsp;It is given as a drip (&nbsp;infusion&nbsp;) into one of your veins (&nbsp;intravenously&nbsp;).&nbsp;Z&nbsp;<small>ALTRAP<\/small>&nbsp;should not be injected into the eyes as it can seriously damage them.<\/p>\n\n\n\n<p>This medicine must be diluted before it is given.\u00a0Practical information regarding the handling and\u00a0administration\u00a0of Z\u00a0<small>ALTRAP<\/small>\u00a0for doctors, nurses, and\u00a0pharmacists\u00a0is provided in this leaflet.<\/p>\n\n\n\n<p><strong>How much and how often you will receive treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The drip (&nbsp;infusion&nbsp;one) lasts for about 1 hour.<\/li><li>You will usually receive an&nbsp;infusion&nbsp;every two weeks.<\/li><li>The recommended&nbsp;dose&nbsp;is 4 mg per kilogram of your body weight.&nbsp;Your doctor will determine the right&nbsp;dose&nbsp;for you.<\/li><li>Your doctor will decide how often you should receive the medicine and if the&nbsp;dose&nbsp;needs to be changed.<\/li><\/ul>\n\n\n\n<p>Z\u00a0<small>ALTRAP<\/small>\u00a0will be given with other chemotherapy drugs such as 5-fluorouracil, folinic acid, and irinotecan.\u00a0Your doctor will determine the appropriate\u00a0dose\u00a0of these other chemotherapy drugs.<\/p>\n\n\n\n<p>The treatment will continue as long as your doctor thinks the treatment is beneficial for you and the&nbsp;side effects&nbsp;are acceptable.<\/p>\n\n\n\n<p>If you have any further questions about the use of this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The side effects\u00a0listed below have been seen when Z\u00a0ALTRAP was\u00a0given together with\u00a0chemotherapy.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Talk to your doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;ar- you may need urgent medical treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Bleeding: Very common<\/strong>\u00a0(may affect more than 1 in 10 people) &#8211; this includes bleeding from the nose but also serious bleeding in the gut and other parts of the body, which can lead to death.\u00a0Symptoms may include feeling very tired, weak, and\/or dizzy, or your stool changing color.<\/li><li>Pain in the mouth, teeth, and\/or jaw, swelling or non-healing sores in the mouth or jaw, oozing sores, numbness or a feeling of heaviness in the jaw or tooth loss: Uncommon\u00a0(may affect up to 1 in 100 people) &#8211; These symptoms may be signs of bone damage in the jaw (\u00a0osteonecrosis\u00a0).\u00a0Tell your doctor and dentist immediately if you experience such symptoms during treatment with ZALTRAP or after stopping treatment.<\/li><li>Hole in the gut\u00a0(also called\u00a0gastrointestinal\u00a0perforation\u00a0):\u00a0Uncommon\u00a0(may affect up to 1 in 100 people) &#8211; this is a hole in the stomach, esophagus, or intestine.\u00a0This can lead to death.\u00a0Symptoms of it can be stomach pain, nausea (vomiting), fever, or chills.<\/li><li>Connections or passages inside the body between internal organs and the skin or other\u00a0tissues\u00a0(also called\u00a0fistulas\u00a0).\u00a0Common\u00a0(may affect up to 1 in 10 people) \u2013 these abnormal tube-like connections or passages can form between your gut and your skin, for example.\u00a0Depending on where it occurs, you may sometimes get an unusual discharge from this spot.\u00a0If you are unsure, consult your doctor.<\/li><li>High\u00a0blood pressure\u00a0(also called\u00a0hypertension\u00a0):\u00a0Very common\u00a0(may affect more than 1 in 10 people) \u2013 this may develop or worsen.\u00a0If\u00a0blood pressure\u00a0it is not under control, it can cause a\u00a0stroke, and heart and kidney problems.\u00a0Your doctor will monitor your\u00a0blood pressure\u00a0throughout your treatment.<\/li><li>Heart failure;\u00a0Uncommon (\u00a0may affect up to 1 in 100 people) &#8211; Symptoms may include shortness of breath when you lie down or exert yourself, extensive tiredness, or swollen legs.<\/li><li>Blockage of an\u00a0artery\u00a0due to a blood clot\u00a0(also called arterial thromboembolic events):\u00a0Common\u00a0(may affect up to 1 in 10 people) \u2013 this can lead to a\u00a0stroke\u00a0or heart attack.\u00a0Symptoms can be chest pain or heaviness in the chest, sudden numbness or weakness in the face, arms, or legs.\u00a0Other symptoms may include confusion, vision problems, problems with walking, coordination or balance, or problems with speaking or slurred speech.<\/li><li>Blockage of veins due to a blood clot\u00a0(also called venous thromboembolic events):\u00a0Common\u00a0(may affect up to 1 in 10 people) \u2013 this may include a blood clot in the lungs or legs.\u00a0Symptoms may include chest pain, cough, weakness, difficulty breathing, or coughing up blood.\u00a0Other symptoms may include swelling of one or both legs, pain or tenderness in one or both legs when standing or walking, warmth on the skin of the affected leg, red or discolored skin on the affected leg, or visible veins.<\/li><li>Protein\u00a0in the urine\u00a0(also called\u00a0proteinuria\u00a0).\u00a0Very common\u00a0(may affect more than 1 in 10 people) &#8211; this is often seen in tests.\u00a0It may include swelling of the feet or the whole body and may be linked to kidney disease.<\/li><li>Low\u00a0white blood cell count\u00a0(also called\u00a0neutropenia\u00a0):\u00a0Very common\u00a0(may affect more than 1 in 10 people) \u2013 this can cause serious\u00a0infection.\u00a0Your doctor will test your blood regularly and check your\u00a0white blood cell count\u00a0throughout your treatment.\u00a0They may also prescribe a medicine called &#8220;G-CSF&#8221; which helps prevent complications if the number of\u00a0white blood cells\u00a0is too low.\u00a0Symptoms of\u00a0the infection\u00a0can be fever, chills, cough, burning when throwing up, or muscle aches.\u00a0You should check your body temperature frequently during treatment with this medicine.<\/li><li>Diarrhea and dehydration: Very common\u00a0(may affect more than 1 in 10 people) diarrhea\u00a0Common\u00a0(may affect up to 1 in 10 people) dehydration &#8211; severe diarrhea and nausea (vomiting) can cause you to lose too much body fluid (\u00a0dehydration\u00a0) and body salts (\u00a0electrolyte\u00a0er).\u00a0Symptoms may include dizziness, especially when standing up from a sitting position.\u00a0You may need to go to the hospital for treatment.\u00a0Your doctor may give you medicine to stop or treat diarrhea and nausea (vomiting).<\/li><li>Allergic reactions: Common\u00a0(may affect up to 1 in 10 people) \u2013 this can happen within minutes of your\u00a0infusion.\u00a0Symptoms of an\u00a0allergic reaction\u00a0may include rash or\u00a0itching, red skin, feeling dizzy or faint, shortness of breath, the feeling of tightness in the chest or throat, or facial swelling.\u00a0Tell your doctor or nurse immediately if you experience any of these symptoms during or shortly after\u00a0an infusion\u00a0of Z\u00a0ALTRAP.<\/li><li>Slow wound healing or wounds that do not heal: Uncommon\u00a0(may affect up to 1 in 100 people) \u2013 this is when a scar has difficulty healing or staying together or when a healed wound comes back up.\u00a0Your doctor will stop treatment with this medicine for at least 4 weeks before a planned operation and until the wounds are completely healed.<\/li><li>A side effect affecting your nervous system\u00a0(called posterior\u00a0reversible\u00a0encephalopathic syndrome or &#8216;PRES&#8217;):\u00a0Uncommon\u00a0(may affect up to 1 in 100 people) &#8211; symptoms may include headache, vision changes, feeling confused, or seizures involving consciousness with or without high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor immediately if you notice any of the&nbsp;side effects&nbsp;above.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;white blood cells&nbsp;(&nbsp;leukopenia&nbsp;)<\/li><li>reduced number of cells in the blood that help it clot (&nbsp;thrombocytopenia&nbsp;)<\/li><li>decreased appetite<\/li><li>headache<\/li><li>nosebleed<\/li><li>change in the voice, eg development of a hoarse voice<\/li><li>breathing difficulties<\/li><li>painful sores in the mouth<\/li><li>stomach pain<\/li><li>swelling and numbness in the hands and feet that may occur due to&nbsp;chemotherapy&nbsp;(called Hand-Foot Syndrome or &#8220;Palmar Plantar Erythrodyesthesia&#8221;)<\/li><li>feeling tired or weak<\/li><li>weight loss<\/li><li>kidney problems with an increase in&nbsp;creatinine&nbsp;(a marker of kidney function)<\/li><li>liver problems with an increase in liver enzymes.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>urinary tract infection<\/li><li>inflammation\u00a0of the nose and upper part of the throat<\/li><li>pain in the mouth or throat<\/li><li>Runny nose<\/li><li>hemorrhoids, bleeding, or pain in the rectum<\/li><li>inflammation\u00a0inside the mouth<\/li><li>toothache<\/li><li>changes in the skin pigment<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an increase in\u00a0protein\u00a0in the urine, an increase in\u00a0cholesterol\u00a0in the blood, and swelling due to excess fluid (\u00a0edema\u00a0) (also called &#8220;nephrotic syndrome&#8221;)<\/li><li>blood clots in very small blood vessels (also called &#8220;thrombotic microangiopathy&#8221;).<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known<\/strong>&nbsp;(cannot be estimated from available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store ZALTRAP<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the outer carton and the vial label after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C &#8211; 8 \u00b0C).<br>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Information on the storage and shelf life of Z&nbsp;<small>ALTRAP<\/small>&nbsp;after dilution when it is ready for use is described in the section &#8220;Practical information for healthcare professionals regarding&nbsp;the preparation&nbsp;and handling of Z&nbsp;<small>ALTRAP<\/small>&nbsp;25 mg\/ml concentrate for solution for&nbsp;infusion&nbsp;&#8221; at the end of this package insert.<\/p>\n\n\n\n<p>Do not use Z&nbsp;<small>ALTRAP<\/small>&nbsp;if you notice particles or discoloration in the vial or infusion bag<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of ZALTRAP<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is aflibercept.&nbsp;One ml of the concentrate contains 25 mg of aflibercept.&nbsp;A 4 ml&nbsp;vial&nbsp;of concentrate contains 100 mg of aflibercept.&nbsp;One 8 ml&nbsp;vial&nbsp;of concentrate contains 200 mg of aflibercept.<\/li><li>Other ingredients are: sucrose, sodium chloride, sodium citrate dihydrate, citric acid monohydrate, polysorbate 20, sodium phosphate dibasic heptahydrate, sodium phosphate monobasic monohydrate, sodium hydroxide and\/or&nbsp;hydrochloric acid&nbsp;and water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Z\u00a0<small>ALTRAP<\/small>\u00a0is a concentrate for\u00a0infusion liquid, solution (sterile concentrate).\u00a0The concentrate is a clear, colorless pale yellow solution.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>4 ml concentrate in a 5 ml&nbsp;vial&nbsp;of clear borosilicate glass (type 1) sealed with a flanged stopper with a flip-off cap and an inset, coated sealing stopper.&nbsp;Pack size of 1 or 3 vials.<\/li><li>8 ml of concentrate in a 10 ml&nbsp;vial&nbsp;of clear borosilicate glass (type 1) sealed with a flanged cap with a flip-off cap and an inserted, coated sealing stopper.<br>Pack size of 1 vial.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>sanofi-aventis groupe<br>54, rue La Bo\u00e9tie<br>75008 Paris<br>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>Sanofi-Aventis Deutschland GmbH<br>Industriepark Hoechst<br>65926 Frankfurt am Main<br>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<p>Sanofi AB<\/p>\n\n\n\n<p>Phone: +46 (0)8 634 50 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Z\u00a0ALTRAP\u00a0contains the active substance aflibercept, which is a\u00a0protein\u00a0that blocks the growth of new blood vessels within a\u00a0tumor\u00a0.\u00a0A tumor\u00a0needs nutrients and oxygen from the blood in order to grow.\u00a0By blocking the growth of blood vessels, Z\u00a0ALTRAP\u00a0can cause the growth of a\u00a0tumor\u00a0to stop or slow down.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22506],"tags":[3264,3267,28249,28256,28251,28252,28254,28253,28250,28255],"class_list":["post-34494","post","type-post","status-publish","format-standard","hentry","category-medicines","category-z","tag-aflibercept","tag-aflibercept-side-effects","tag-benefits-of-aflibercept","tag-benefits-of-zaltrap","tag-what-aflibercept-is-used-for","tag-what-is-aflibercept","tag-what-is-zaltrap","tag-what-zaltrap-is-used-for","tag-zaltrap","tag-zaltrap-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=34494"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34494\/revisions"}],"predecessor-version":[{"id":34539,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/34494\/revisions\/34539"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=34494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=34494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=34494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}