{"id":33384,"date":"2022-11-16T10:42:17","date_gmt":"2022-11-16T10:42:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=33384"},"modified":"2022-11-17T10:54:42","modified_gmt":"2022-11-17T10:54:42","slug":"xylocaine-adrenaline","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/xylocaine-adrenaline\/","title":{"rendered":"Xylocaine adrenaline &#8211; Lidocaine hydrochloride and\u00a0adrenaline uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg\/ml and 5 micrograms\/ml&nbsp;solution&nbsp;<\/p>\n\n\n\n<p>for injection<br>lidocaine hydrochloride and&nbsp;adrenaline<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Xylocaine adrenaline is and what it is used for<\/h2>\n\n\n\n<p>Xylocaine\u00a0adrenaline\u00a0contains the active substance\u00a0lidocaine, which is a local anesthetic, and the active substance\u00a0adrenaline, which prolongs the effect of\u00a0lidocaine\u00a0.\u00a0It temporarily blocks the nerve signals in the area where it is injected.\u00a0Xylocaine\u00a0adrenaline\u00a0spreads out in\u00a0tissue\u00a0and prevents you from feeling pain.<\/p>\n\n\n\n<p>Lidocaine hydrochloride contained in Xylocaine\u00a0adrenaline\u00a0may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<p>Xylocaine&nbsp;adrenaline&nbsp;can be used by adults and children over 1 year of age.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Xylocaine adrenaline<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Xylocaine adrenaline<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0lidocaine, other local anesthetics similar to\u00a0lidocaine,\u00a0adrenaline,\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to the preservatives methyl or propyl parahydroxybenzoate (parabens) or para aminobenzoic acid (PABA).<\/li><li>if you have the excessive formation of\u00a0hormones\u00a0in the thyroid gland (\u00a0hyperthyroidism\u00a0).<\/li><li>if you are in severe\u00a0shock.<\/li><li>if you have heart rhythm disturbances (heart block;\u00a0AV block\u00a0), severe heart disease, or high heart rate (\u00a0tachycardia\u00a0).<\/li><li>if you are going to have a spinal anesthetic (epidural) and have a local\u00a0infection\u00a0at the injection site.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Be careful with the use of Xylocaine adrenaline:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to the elderly and people with the reduced general conditions.<\/li><li>to children.\u00a0Does\u00a0one must be reduced.<\/li><li>in case of severe liver or kidney disease.<\/li><li>if you have untreated high\u00a0blood pressure.<\/li><li>if you have\u00a0diabetes.<\/li><li>if you have the poor blood supply to the brain.<\/li><li>if you have\u00a0blood deficiency\u00a0(anemia), dilated blood vessels, or\u00a0heart failure\u00a0(\u00a0circulatory failure\u00a0).<\/li><li>during simultaneous treatment with certain agents against rhythm disturbances in the heart (\u00a0antiarrhythmics\u00a0).<\/li><li>during spinal anesthesia (epidural anesthesia), as the blocking of central nerves can cause serious\u00a0side effects.<\/li><li>in the eye, because in rare cases the medicine can cause temporary or permanent\u00a0side effects.<\/li><li>in the lips, tongue, and oral cavity, as there is a risk of injury\/bite wounds.\u00a0You should therefore wait to eat until your mouth is back to normal.<\/li><li>if you have a disease called\u00a0acute\u00a0porphyria.<\/li><li>in peripheral body parts, such as the fingers and toes, or other body parts with low blood supply.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Xylocaine adrenaline<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines, including non-prescription medicines.<\/p>\n\n\n\n<p>Xylocaine can affect or be affected by other medicines, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other local anesthetics<\/li><li>medicines against disturbed heart rhythm (so-called&nbsp;antiarrhythmics&nbsp;)<\/li><li>cimetidine (medicine against&nbsp;stomach ulcers&nbsp;) and&nbsp;beta blockers&nbsp;(medicine against, among other things, high&nbsp;blood pressure&nbsp;).<\/li><\/ul>\n\n\n\n<p>There may be a risk of serious high&nbsp;blood pressure&nbsp;if you use&nbsp;adrenaline&nbsp;at the same time as Xylocaine<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs for depression (\u00a0tricyclic antidepressants\u00a0)<\/li><li>medicines of the type\u00a0ergotamine\u00a0or certain beta-blockers.<\/li><\/ul>\n\n\n\n<p>Medicines that depress the nerves (eg phenothiazines, butyrophenones) can&nbsp;inhibit&nbsp;the effect of&nbsp;adrenaline&nbsp;and cause low&nbsp;blood pressure&nbsp;and slow heart rate.<\/p>\n\n\n\n<p>When using inhaled anesthetics (e.g. halothane and enflurane) together with Xylocaine\u00a0adrenaline, there is a risk of serious disturbances of the heart rhythm.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Adrenaline\u00a0may reduce uterine blood flow and the ability to contract, especially after accidental\u00a0injection\u00a0into the mother&#8217;s blood vessels.\u00a0If the drug is used at the cervix, the doctor must monitor the fetal\u00a0heart rate\u00a0closely.\u00a0Despite this, it is unlikely that the correct use of Xylocaine\u00a0adrenaline\u00a0would affect the fetus.<\/p>\n\n\n\n<p>Lidocaine&nbsp;passes into breast milk, but it is unlikely to have any effects on the breastfed baby.&nbsp;It is unknown whether&nbsp;adrenaline&nbsp;passes into breast milk.&nbsp;Adrenaline&nbsp;is inactivated and secreted quickly.&nbsp;It is therefore unlikely that children who are breastfed can be affected.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0Medicines can affect your ability to drive or perform work that requires increased attention.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Some of the medicine can be absorbed into the body and affect your coordination, mobility, and attention.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Xylocaine adrenaline contains methyl parahydroxybenzoate, sodium metabisulfite, and sodium<\/h2>\n\n\n\n<p>Xylocaine\u00a0adrenaline\u00a0in vials contains the preservative methyl parahydroxybenzoate, which in some cases can cause allergic reactions (possibly delayed) and exceptional spasm in the trachea.<\/p>\n\n\n\n<p>Xylocaine\u00a0adrenaline\u00a0also contains sodium metabisulphite, which in rare cases can cause serious\u00a0hypersensitivity reactions\u00a0and spasms of the airways.<\/p>\n\n\n\n<p>The medicine contains 0.11 mmol (or 2.5 mg)&nbsp;of sodium&nbsp;per milliliter.<\/p>\n\n\n\n<p>This should be taken into account by patients prescribed a low-salt diet.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Xylocaine adrenaline<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The dose\u00a0of Xylocaine\u00a0adrenaline\u00a0is determined by the doctor and depends on the type of anesthesia you need, the area to be numbed, and how long the anesthesia should last.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Xylocaine adrenaline&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.\u00a0For other questions about the medicine, contact a doctor or pharmacist.<\/p>\n\n\n\n<p>In case of overdose, poisoning reactions can occur, usually within 15-60 minutes.\u00a0If Xylocaine is accidentally injected into a blood vessel, poisoning reactions can occur immediately (within seconds or minutes).\u00a0The reactions mainly affect the\u00a0central nervous system\u00a0and the cardiovascular system, and the first signs are usually numbness in the mouth and tongue, a feeling of intoxication, sensitivity to sound,\u00a0tinnitus,\u00a0and visual disturbances.\u00a0After that, you may have more serious symptoms, such as difficulty speaking, muscle twitching or tremors, and eventually convulsions and unconsciousness.\u00a0In addition, you may experience breathing difficulties.\u00a0In severe cases, low\u00a0blood pressure can occur, slow heartbeat, heart rhythm disturbances, and even cardiac arrest.\u00a0Such reactions must be treated immediately.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Very common\u00a0side effects\u00a0(may affect more than 1 in 10 users)):<\/em>\u00a0Low\u00a0blood pressure, nausea.<\/p>\n\n\n\n<p><em>Common\u00a0side effects\u00a0(may affect up to 1 in 10 users):<\/em>\u00a0High\u00a0blood pressure, dizziness, tingling sensation in the skin, slow heart rate, vomiting.<\/p>\n\n\n\n<p><em>Uncommon\u00a0side effects\u00a0(may affect up to 1 in 100 users):<\/em>\u00a0Signs of poisoning reactions in the\u00a0central nervous system, such as convulsions, tingling or numbness around the mouth, numbness of the tongue, increased sensitivity to sound, visual disturbances, tremors,\u00a0tinnitus, difficulty speaking clearly, reduced level of consciousness.<\/p>\n\n\n\n<p><em>Rare\u00a0side effects\u00a0(may affect up to 1 in 1,000 users):<\/em>\u00a0Cardiac arrest, heart rhythm disturbances, allergic reactions, anaphylactic\u00a0shock, difficulty breathing, pathological changes or damage to the nerves,\u00a0inflammation\u00a0of the arachnoid (the middle meninges) and double vision.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Xylocaine adrenaline should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store in a refrigerator or cool (2 \u00b0C-15 \u00b0C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>The vial may be used for a maximum of three days after opening.<\/p>\n\n\n\n<p>Use before the expiry date stated on the packaging.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are lidocaine hydrochloride and\u00a0adrenaline.<\/li><li>Other ingredients are sodium chloride, sodium hydroxide and\/or\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment), sodium metabisulphite, methyl parahydroxybenzoate (E218), and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Xylocaine&nbsp;adrenaline&nbsp;is a clear, colorless solution.<\/p>\n\n\n\n<p>One package contains 5 vials with 20 ml\u00a0solution for injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive, Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p>Phone: +46 856 642 572<\/p>\n\n\n\n<p><em>Manufacturer:<\/em>&nbsp;Recipharm Monts, France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xylocaine\u00a0adrenaline\u00a0contains the active substance\u00a0lidocaine\u00a0, which is a local anesthetic, and the active substance\u00a0adrenaline\u00a0, which prolongs the effect of\u00a0lidocaine\u00a0.\u00a0It temporarily blocks the nerve signals in the area where it is injected.\u00a0Xylocaine\u00a0adrenaline\u00a0spreads out in\u00a0tissue\u00a0and prevents you from feeling pain.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22504],"tags":[4044,4046,5305,5307,11524,4045,28173,28171,28172,28170,28174],"class_list":["post-33384","post","type-post","status-publish","format-standard","hentry","category-medicines","category-x","tag-adrenaline","tag-adrenaline-side-effects","tag-lidocaine-hydrochloride","tag-lidocaine-hydrochloride-side-effects","tag-what-adrenaline-is-used-for","tag-what-is-adrenaline","tag-what-is-lidocaine-hydrochloride-is-used-for","tag-what-is-xylocaine-adrenaline","tag-what-xylocaine-adrenaline-is-used-for","tag-xylocaine-adrenaline","tag-xylocaine-adrenaline-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/33384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=33384"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/33384\/revisions"}],"predecessor-version":[{"id":33818,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/33384\/revisions\/33818"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=33384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=33384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=33384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}