If you have problems with your kidneys or liver<\/strong><\/p>\n\n\n\nIf you have problems with your kidneys or liver, you may need to check your blood sugar level more often.\u00a0Talk to your doctor about changes to your\u00a0dose.<\/p>\n\n\n\n
If you use too much Xultophy <\/h2>\n\n\n\n
If you have used too much Xultophy, your blood sugar may become low (hypoglycemia) or you may feel sick and vomit.\u00a0If your blood sugar becomes low, you must follow the advice in section 4 “Low blood sugar (hypoglycemia)”.<\/p>\n\n\n\n
If you forget to use Xultophy<\/h2>\n\n\n\n
If you forget a\u00a0dose, inject the missed\u00a0dose\u00a0once you realize the mistake, but make sure there are at least 8 hours between\u00a0doses.\u00a0If you find that you have missed the previous\u00a0dose, when it is time to take the next scheduled\u00a0dose, do not take a double\u00a0dose.<\/p>\n\n\n\n
If you stop using Xultophy<\/h2>\n\n\n\n
Do not stop using Xultophy without first talking to your doctor.\u00a0If you stop using Xultophy, it can lead to very high blood sugar.\u00a0Follow the advice in section 4 “High blood sugar (hyperglycemia)”.<\/p>\n\n\n\n
If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following serious\u00a0side effects\u00a0may occur with this medicine:<\/p>\n\n\n\n
\u2022 Low blood sugar (very common: may affect more than 1 in 10 people).<\/p>\n\n\n\n
If your blood sugar level becomes low, you may pass out. Severe hypoglycemia can cause brain damage and be life-threatening. If you have signs of low blood sugar (insulin sensitivity), you should immediately ensure that the blood sugar level is raised. Follow the advice in “Low blood sugar ( hypoglycemia )” further down in this section.<\/p>\n\n\n\n
\u2022 Severe allergic reaction ( anaphylactic reaction ) (frequency not known: frequency cannot be estimated from available data).<\/p>\n\n\n\n
If you have a serious allergic reaction to any of the ingredients in Xultophy, you should stop using Xultophy and see a doctor immediately. The signs of a serious allergic reaction are that:<\/p>\n\n\n\n
\u2022 local reactions spread to other parts of the body<\/p>\n\n\n\n
\u2022 you suddenly feel sick and sweat<\/p>\n\n\n\n
\u2022 you have difficulty breathing<\/p>\n\n\n\n
\u2022 you have palpitations or feel dizzy.<\/p>\n\n\n\n
Skin changes at the injection site<\/strong><\/p>\n\n\n\nIf you inject\u00a0insulin\u00a0in the same place, the fat tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy) (may affect up to 1 in 100 people).\u00a0Nodules under the skin can also be caused by the accumulation of a\u00a0protein\u00a0called amyloid (\u00a0cutaneous\u00a0amyloidosis. How often this occurs is not known).\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules or a thickened or shriveled area.\u00a0Change the injection site for each\u00a0injection\u00a0to prevent these skin changes.<\/p>\n\n\n\n
Other side effects include:<\/p>\n\n\n\n
Common<\/strong> (may affect up to 1 in 10 users)<\/p>\n\n\n\n\u2022 Decreased appetite, nausea and vomiting, diarrhea, constipation, indigestion (\u00a0dyspepsia\u00a0), gastritis (\u00a0gastritis\u00a0), stomach pain, heartburn, and bloating.\u00a0These are usually transient and disappear after a few days or weeks.<\/p>\n\n\n\n
\u2022 Injection site reactions.\u00a0The signs can include bruising, bleeding, pain,\u00a0redness,\u00a0hives, swelling, or\u00a0itching.\u00a0These usually go away after a few days.\u00a0See your doctor if they don’t go away after a few weeks.\u00a0Stop using Xultophy and see a doctor immediately if the reactions become severe.<\/p>\n\n\n\n
\u2022 Increase in pancreatic enzymes, such as lipase and amylase.<\/p>\n\n\n\n
Uncommon<\/strong> (may affect up to 1 in 100 users)<\/p>\n\n\n\n\u2022 Hives (red bumps on the skin that sometimes itch).<\/p>\n\n\n\n
\u2022 Allergic reactions (hypersensitivity), e.g.\u00a0rash,\u00a0itching,\u00a0and swelling of the face.<\/p>\n\n\n\n
\u2022 Dehydration (fluid loss from the body) \u2013 it is important to drink a lot to restore the body’s fluid balance.<\/p>\n\n\n\n
\u2022 Belching and gas in the stomach ( flatulence ).<\/p>\n\n\n\n
\u2022 Rash.<\/p>\n\n\n\n
\u2022\u00a0Itching.<\/p>\n\n\n\n
\u2022 Increased heart rate.<\/p>\n\n\n\n
\u2022\u00a0Gallstones.<\/p>\n\n\n\n
\u2022 Inflamed gallbladder.<\/p>\n\n\n\n
Frequency not known<\/strong> (frequency cannot be calculated from available data)<\/p>\n\n\n\n\u2022 Inflammation of the pancreas ( pancreatitis ).<\/p>\n\n\n\n
\u2022 Swelling of the arms or legs (peripheral\u00a0edema) \u2013 When you start treatment, more fluid than normal may accumulate in the body.\u00a0This causes swelling around the ankles and other joints.\u00a0Most of the time it is short-lived.<\/p>\n\n\n\n
General complications of diabetes treatment<\/strong><\/p>\n\n\n\nLow blood sugar ( hypoglycemia )<\/em><\/strong><\/p>\n\n\n\nYou may have low blood sugar if you:<\/strong><\/p>\n\n\n\n\u2022 drinks alcohol<\/p>\n\n\n\n
\u2022 exercise more than usual<\/p>\n\n\n\n
\u2022 eats too little or skips meals<\/p>\n\n\n\n
\u2022 using too much Xultophy.<\/p>\n\n\n\n
Low blood sugar warning signs \u2013 these can come on suddenly<\/strong><\/p>\n\n\n\nHeadache, slurred speech, palpitations, cold sweats, cool and pale skin, nausea, strong hunger, tremors, nervousness or anxiety, unusual tiredness, weakness and drowsiness or confusion, difficulty concentrating, and short-term vision changes.<\/p>\n\n\n\n
Here’s what to do if you get low blood sugar:<\/strong><\/p>\n\n\n\n\u2022 Eat dextrose tablets or any other snack that contains a lot of sugar \u2013 such as candy, cookies, or fruit juice.\u00a0(Always carry dextrose tablets or high-sugar snacks with you just in case.)<\/p>\n\n\n\n
\u2022 If possible, check your blood sugar and rest. You may need to check your blood sugar more than once, as the improvement in your blood sugar level does not always happen all at once.<\/p>\n\n\n\n
\u2022 When the symptoms of low blood sugar have disappeared or when your blood sugar level has stabilized, you should continue with the treatment as usual.<\/p>\n\n\n\n
What others should do if you lose consciousness:<\/strong><\/p>\n\n\n\nTell everyone you associate with that you have\u00a0diabetes.\u00a0Tell them what can happen if your blood sugar gets low, for example, you may lose consciousness.<\/p>\n\n\n\n
Tell them that if they lose consciousness, they must do the following:<\/p>\n\n\n\n
\u2022 turn on your side<\/p>\n\n\n\n
\u2022 get medical attention immediately<\/p>\n\n\n\n
\u2022 do not<\/strong> give yourself anything to eat or drink as you may suffocate.<\/p>\n\n\n\nYou may regain consciousness more quickly if you receive an injection of glucagon. Such an injection should only be given by a person who knows how to use it.<\/p>\n\n\n\n
\u2022 If you are given glucagon, you will need sugar or a snack containing sugar as soon as you regain consciousness.<\/p>\n\n\n\n
\u2022 If you do not respond to the glucagon injection, you must be treated in the hospital.<\/p>\n\n\n\n
\u2022 If severe low blood sugar is not treated, it can eventually cause brain damage. These can be short or long-term. Low blood sugar can even cause death.<\/p>\n\n\n\n
Talk to your doctor about:<\/strong><\/p>\n\n\n\n\u2022 you have had blood sugar so low that you have lost consciousness<\/p>\n\n\n\n
\u2022 you have received an injection of glucagon<\/p>\n\n\n\n
\u2022 you have had low blood sugar several times recently.<\/p>\n\n\n\n
Dose\u00a0on your Xultophy\u00a0injection, your meals or exercise habits may need to be changed.<\/p>\n\n\n\n
High blood sugar ( hyperglycemia )<\/em><\/strong><\/p>\n\n\n\nYou can get high blood sugar if you:<\/strong><\/p>\n\n\n\n\u2022 drinks alcohol<\/p>\n\n\n\n
\u2022 exercise less than usual<\/p>\n\n\n\n
\u2022 eats more than usual<\/p>\n\n\n\n
\u2022 get an infection or fever<\/p>\n\n\n\n
\u2022 have not used enough Xultophy, regularly use fewer Xultophy than you need, forget to use Xultophy, or stop using Xultophy without first talking to your doctor.<\/p>\n\n\n\n
Warning signals for high blood sugar \u2013 these usually occur gradually<\/strong><\/p>\n\n\n\nReddened dry skin;\u00a0drowsiness or tiredness;\u00a0dry mouth, fruity (acetone-like) breath;\u00a0frequent urination, thirst;\u00a0loss of appetite, nausea, or vomiting.<\/p>\n\n\n\n
These signs may indicate a very serious condition called\u00a0ketoacidosis.\u00a0It means an accumulation of acid in the blood because the body breaks down fat instead of sugar.\u00a0If left untreated, it can lead to diabetic coma and eventually death.<\/p>\n\n\n\n
Here’s what to do if you get high blood sugar:<\/strong><\/p>\n\n\n\n\u2022 Test your blood sugar level.<\/p>\n\n\n\n
\u2022 Do a blood or urine ketone test.<\/p>\n\n\n\n
\u2022 Seek medical attention immediately.<\/p>\n\n\n\n
How to store Xultophy<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Use before the expiry date stated on the pen label and carton after “EXP”. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Before first use<\/strong><\/p>\n\n\n\nStore in a refrigerator (2\u00b0C to 8\u00b0C).\u00a0Do not place it near the cooling element.\u00a0Do not freeze.<\/p>\n\n\n\n
During use<\/strong><\/p>\n\n\n\nDo not freeze. You can take Xultophy with you and store it at room temperature (up to 30\u00b0C) or in a refrigerator (2\u00b0C to 8\u00b0C) for up to 21 days. Discarded 21 days after opening.<\/p>\n\n\n\n
To protect the pre-filled pen from light, always put the pen cap on when not in use.<\/p>\n\n\n\n
Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.
<\/p>\n\n\n\n
Contents of the packaging and other information<\/h2>\n\n\n\nContents declaration<\/h2>\n\n\n\n- The active substances are\u00a0insulin\u00a0degludec and liraglutide.\u00a0Each ml of solution contains 100 units of\u00a0insulin\u00a0degludec and 3.6 mg of liraglutide.\u00a0Each unused pre-filled\u00a0pen\u00a0(3 ml) contains 300 units of\u00a0insulin\u00a0degludec and 10.8 mg of liraglutide.<\/li>
- Other ingredients are\u00a0glycerol, phenol, zinc acetate,\u00a0hydrochloric acid\u00a0and sodium hydroxide (for\u00a0pH\u00a0adjustment), and water for injections.\u00a0See also section 2 “Important information about some of the ingredients of Xultophy” for information on\u00a0sodium.<\/li><\/ul>\n\n\n\n
Appearance and package sizes of the medicine<\/h2>\n\n\n\n
Xultophy is a clear and colorless solution.<\/p>\n\n\n\n
Pack sizes: 1, 3, and 5 as well as multipacks of 10 (2 packs x 5) pre-filled pens of 3 ml.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing authorization holder and manufacturer<\/h2>\n\n\n\n
Novo Nordisk A\/S<\/p>\n\n\n\n
Novo All\u00e9<\/p>\n\n\n\n
DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"
100 units\/ml + 3.6 mg\/ml solution for injectioninsulin degludec + liraglutide What Xultophy is and what it is used for What Xultophy is used for Xultophy is used to improve blood glucose (sugar) levels in adult patients with\u00a0type 2\u00a0diabetes mellitus. You have\u00a0diabetes\u00a0because your body: \u2022 not producing enough insulin to control blood sugar or \u2022 cannot use insulin properly. How Xultophy […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22504],"tags":[26401,23726,23729,26398,26399,23727,28075,23728,28076,28074,28077],"class_list":["post-32949","post","type-post","status-publish","format-standard","hentry","category-medicines","category-x","tag-insulin-degludec","tag-liraglutide","tag-liraglutide-side-effects","tag-what-insulin-degludec-is-used-for","tag-what-is-insulin-degludec","tag-what-is-liraglutide","tag-what-is-xultophy","tag-what-liraglutide-is-used-for","tag-what-xultophy-is-used-for","tag-xultophy","tag-xultophy-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=32949"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32949\/revisions"}],"predecessor-version":[{"id":33374,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32949\/revisions\/33374"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=32949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=32949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=32949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}