{"id":32938,"date":"2022-11-15T09:25:39","date_gmt":"2022-11-15T09:25:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=32938"},"modified":"2022-11-16T10:36:15","modified_gmt":"2022-11-16T10:36:15","slug":"xonvea","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/xonvea\/","title":{"rendered":"Xonvea &#8211; Doxylamine hydrogen succinate\/pyridoxine hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg\/10 mg&nbsp;enteric tablet&nbsp;er<br>doxylamine hydrogen succinate\/pyridoxine hydrochloride<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Xonvea is and what it is used for<\/h2>\n\n\n\n<p><strong>What Xonvea is<\/strong><\/p>\n\n\n\n<p>Xonvea contains two medicines (active substances): doxylamine hydrogen succinate and pyridoxine hydrochloride.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Doxylamine belongs to the drug group\u00a0antihistamines.<\/li><li>Pyridoxine hydrochloride is another name for vitamin B\u00a06.<\/li><\/ul>\n\n\n\n<p><strong>What Xonvea is used for<\/strong><\/p>\n\n\n\n<p>Xonvea is used for nausea and vomiting in pregnant women.&nbsp;It is used when diet or other non-medical treatments have not worked.<\/p>\n\n\n\n<p>Doxylamine hydrogen succinate and pyridoxine hydrochloride found in Xonvea may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Xonvea<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Xonvea<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to doxylamine hydrogen succinate or other\u00a0antihistamines\u00a0(eg diphenhydramine), pyridoxine hydrochloride, or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are taking\u00a0monoamine oxidase inhibitors\u00a0(\u00a0MAOIs\u00a0) to treat depression.<\/li><\/ul>\n\n\n\n<p>Do not take Xonvea if any of the above apply to you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse before taking Xonvea.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Xonvea if you have or have had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma<\/li><li>increased eye pressure<\/li><li>an eye disease called&nbsp;narrow-angle glaucoma<\/li><li>gastric ulcer<\/li><li>constipation, i.e.&nbsp;an obstruction between the stomach and the small intestine<\/li><li>obstruction in the neck of the bladder.<\/li><\/ul>\n\n\n\n<p>Also talk to your doctor, pharmacist, or nurse before taking Xonvea if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you take medicines for colds or coughs, sleeping medicines, or certain pain-relieving medicines<\/li><li>you have drunk alcohol.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor, pharmacist or nurse before taking Xonvea.<\/p>\n\n\n\n<p>If you suffer from severe nausea and vomiting during pregnancy, a condition called\u00a0hyperemesis gravidarum, you must be treated by a specialist.<\/p>\n\n\n\n<p>If you provide urine for a drug test, some test methods may give false positive results for\u00a0methadone, opiates, and phencyclidine phosphate (PCP) after taking Xonvea.\u00a0If this occurs, a test with better specificity can be used.<\/p>\n\n\n\n<p><strong>Reporting of\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Xonvea may make you feel drowsy.\u00a0Do not drive, ride a bicycle, or use tools or machines while taking this medicine.\u00a0Also, don&#8217;t do activities that require your full attention, unless your doctor says it&#8217;s okay.<\/li><li>Do not take Xonvea while taking cough and cold medicines, sleeping medicines, certain pain relievers, or if you have been drinking alcohol.\u00a0Taking Xonvea with other medicines that affect the\u00a0central nervous system\u00a0can make you very tired, which can cause falls or other accidents.<\/li><li>Xonvea contains trace amounts of the azo dye E129.\u00a0This dye can cause allergic reactions.<\/li><\/ul>\n\n\n\n<p>Do not stop taking Xonvea without first talking to your doctor.\u00a0If you stop treatment with this medicine suddenly, nausea and vomiting may return.\u00a0Your doctor will tell you how to slowly taper off the medicine to avoid this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Xonvea is not intended for children under 18 years of age.&nbsp;It is not known whether Xonvea is safe and effective in this age group.<\/p>\n\n\n\n<p><strong>B&nbsp;vitamins<\/strong><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking additional B\u00a0vitamins.\u00a0This can be through food, supplements, or multivitamins.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Xonvea<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to over-the-counter medicines and herbal medicines.<\/p>\n\n\n\n<p>It is especially important that you do not take Xonvea and that you tell your doctor, pharmacist, or nurse if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>monoamine oxidase inhibitors\u00a0(\u00a0MAOIs\u00a0) to treat depression.\u00a0Using these medicines together with Xonvea can make\u00a0side effects\u00a0worse and last longer.<\/li><li>medicines such as cough and cold medicines, sleeping medicines, and certain painkillers (so-called\u00a0CNS\u00a0depressants).\u00a0Using these together with Xonvea can make you very tired.\u00a0This may cause falls or other accidents.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Xonvea with alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol while taking Xonvea.&nbsp;See section 3 for information on how to take Xonvea.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Xonvea is intended for use in pregnant women.<\/p>\n\n\n\n<p>If you are breastfeeding, a decision should be made in consultation with your doctor whether to discontinue breastfeeding or treatment.&nbsp;The reason for this is that Xonvea can pass into breast milk and can harm your baby.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Do not drive, ride a bicycle, or use tools or machines while taking this medicine.&nbsp;This is because you may feel tired after taking Xonvea.&nbsp;If this happens, don&#8217;t do activities that require your full attention, unless your doctor says it&#8217;s okay.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Xonvea contains carnauba wax, croscarmellose sodium, hypromellose (E464), indigo carmine aluminum lake (E132), macrogol (400, 8000) (E1521), magnesium stearate, magnesium trisilicate, methacrylic acid-ethyl acrylate copolymer (1:1), microcrystalline cellulose, Allura red AC aluminum lake (E129), polysorbate 80 (E433), propylene glycol (E1520), colloidal anhydrous silica, shellac, simethicone emulsion, sodium bicarbonate (E500), sodium lauryl sulfate (E487), talc (E553b), titanium dioxide (E171), triethyl citrate.<\/h2>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Xonvea<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor, pharmacist or nurse has told you.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The doctor will start the treatment with a low&nbsp;dose&nbsp;which may be increased, depending on how well the medicine works for you.<\/p>\n\n\n\n<p>How treatment with Xonvea is started and how the&nbsp;dose&nbsp;is increased if necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Day 1<\/strong>&nbsp;&nbsp;<\/li><li>Take 2 tablets orally at bedtime.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Day 2<\/strong>&nbsp;&nbsp;<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Take 2 tablets orally at bedtime.<\/li><li>If nausea and vomiting have improved or are under control on day 2, continue to take 2 tablets each evening at bedtime.\u00a0This will be your usual\u00a0dose\u00a0unless your doctor, pharmacist, or nurse tells you otherwise.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Day 3<\/strong>&nbsp;&nbsp;<\/li><li>If you still experienced nausea and vomiting on day 2, take 3 tablets by mouth on day 3 (1 tablet in the morning and 2 tablets at bedtime).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Day 4<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If nausea and vomiting were better or under control on day 3, continue taking 3 tablets each day (1 tablet in the morning and 2 tablets at bedtime).\u00a0This will be your usual\u00a0dose\u00a0unless your doctor, pharmacist, or nurse tells you otherwise.<\/li><li>If you still experienced nausea and vomiting on day 3, take 4 tablets by mouth each day (1 tablet in the morning, 1 tablet in the middle of the day, and 2 tablets at bedtime).<\/li><\/ul>\n\n\n\n<p>Do not take more than 4 tablets each day (1 in the morning, 1 in the middle of the day, and 2 at bedtime).<\/p>\n\n\n\n<p><strong>How to take this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take Xonvea on an empty stomach.<\/li><li>Swallow the tablet whole with a glass of water.<\/li><li>The tablet should not be crushed, chewed, or divided before swallowing.<\/li><\/ul>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you cannot swallow Xonvea tablets whole.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Xonvea<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.\u00a0Take the medicine package with you.\u00a0The following effects may occur restlessness, sleepiness or dizziness,\u00a0dry mouth, dilated\u00a0pupils, confusion, and fast heart rate.<\/p>\n\n\n\n<p>If the amount of medicine in your body is very high, you may also have seizures, muscle pain or weakness, or sudden serious kidney problems.&nbsp;These can even be life-threatening.&nbsp;If you have these signs &#8211; stop taking Xonvea and contact a doctor or hospital immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Xonvea<\/h2>\n\n\n\n<p>Do not stop taking Xonvea without first talking to your doctor.\u00a0If you stop treatment with this medicine suddenly, nausea and vomiting may return.\u00a0Your doctor will tell you how to taper off the medicine slowly to avoid this.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common (<\/strong>&nbsp;may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe sleepiness<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>fatigue<\/li><li>dry mouth<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypersensitivity (\u00a0allergic reaction\u00a0)<\/li><li>anxiety, difficulty sleeping (insomnia), nightmares, disorientation<\/li><li>headache or\u00a0migraine<\/li><li>tingling, tickling, and numbness of the skin<\/li><li>restlessness and a need to be in constant motion<\/li><li>vision problems or blurred vision<\/li><li>a feeling that the surroundings are spinning<\/li><li>difficulty breathing, palpitations, or increased heart rate<\/li><li>feeling the full or bloated stomach, stomach pain, constipation, or diarrhea<\/li><li>profuse sweating, skin reactions such as\u00a0itching\u00a0or rash<\/li><li>Difficulty urinating or that it hurts when you urinate<\/li><li>chest discomfort<\/li><li>general discomfort or irritability<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;have been reported with drugs in the same drug group as doxylamine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anticholinergic effects (blocking of activity in organs that receive nerve impulses via the signaling substance\u00a0acetylcholine\u00a0): dryness of the mouth, nose, and throat;\u00a0difficulty urinating or pain when urinating;\u00a0dizziness;\u00a0difficulty seeing or blurred vision;\u00a0double vision (\u00a0diplopia\u00a0);\u00a0ringing in the ears or ringing in the ears (\u00a0tinnitus\u00a0);\u00a0inflammation of the inner ear that occurs quickly (\u00a0acute\u00a0otitis media);\u00a0difficulty sleeping (insomnia);\u00a0tremors and\u00a0nervousness;\u00a0irritability and involuntary repetitive movements (\u00a0dyskinesia) in the face.\u00a0In addition, have a feeling of tightness in the chest;\u00a0thick mucus in the lungs (pulmonary secretions);\u00a0high-pitched wheezing often accompanied by difficulty breathing (wheezing);\u00a0nasal congestion;\u00a0sweating and chills;\u00a0early menstruation;\u00a0altered state of mind such as hallucinations, delusions, confusion and thought disorders (toxic\u00a0psychosis\u00a0);\u00a0headache;\u00a0tingling, tickling, and numbness of the skin and fainting have been reported.<\/li><li>Rare cases of a low number of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0), reduced blood volume in the body due to increased breakdown of\u00a0blood cells\u00a0(\u00a0hemolytic anemia\u00a0), reduced number of\u00a0blood platelets\u00a0(\u00a0thrombocytopenia\u00a0), reduced number of red and\u00a0white blood cells\u00a0and\u00a0platelets\u00a0(pancytopenia) and increased appetite, sometimes with weight gain has been reported.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Xonvea<\/h2>\n\n\n\n<p>Store out of sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are doxylamine hydrogen succinate (an\u00a0antihistamine\u00a0) and pyridoxine hydrochloride (vitamin B\u00a06\u00a0).\u00a0Each tablet contains 10 mg of doxylamine hydrogen succinate and 10 mg of pyridoxine hydrochloride.<\/li><li>Other ingredients are Carnauba wax, croscarmellose sodium, hypromellose (E464), indigo carmine aluminum lacquer (E132), macrogol (400, 8000) (E1521), magnesium stearate, magnesium trisilicate, methacrylic acid-ethyl acrylate copolymer (1:1), microcrystalline cellulose, Allura red AC aluminum lacquer (E129 ), polysorbate 80 (E433), propylene glycol (E1520),\u00a0colloidal, anhydrous silica, shellac, simethicone emulsion, sodium bicarbonate (E500), sodium lauryl sulfate (E487), talc (E553b), titanium dioxide (E171), triethyl citrate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Xonvea gastro-resistant\u00a0tablets\u00a0are white, round, and film-coated tablets with a pink picture of a pregnant woman on one side.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Xonvea is available in blister cards containing 20, 30, or 40 tablets.\u00a0Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Elara Pharmaservices Europe Limited<\/p>\n\n\n\n<p>239 Blanchardstown<\/p>\n\n\n\n<p>Corporate Park<\/p>\n\n\n\n<p>Ballycoolin<\/p>\n\n\n\n<p>Dublin<\/p>\n\n\n\n<p>D15 KV21<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area and the United Kingdom (Northern Ireland) under the names<\/strong><\/p>\n\n\n\n<p>Denmark Xonvea 10 mg\/10 mg&nbsp;enteric tablet<\/p>\n\n\n\n<p>Finland Xonvea 10 mg\/10 mg gastro-resistant tablet<\/p>\n\n\n\n<p>United Kingdom Xonvea 10 mg\/10 mg gastro-resistant tablets<\/p>\n\n\n\n<p>Ireland Xonvea 10 mg\/10 mg gastro-resistant tablets<\/p>\n\n\n\n<p>Iceland Xonvea 10 mg\/10 mg magasy\u00fcru\u013eonnar tavrel<\/p>\n\n\n\n<p>The Netherlands Xonvea 10 mg\/10 mg gastric-resistant tablet<\/p>\n\n\n\n<p>Norway Xonvea 10 mg\/10 mg\u00a0enteric tablet<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xonvea contains two medicines (active substances): doxylamine hydrogen succinate and pyridoxine hydrochloride.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22504],"tags":[28099,28106,28105,22171,22175,22174,28104,28103,22172,28100,22173,28101,28098,28102],"class_list":["post-32938","post","type-post","status-publish","format-standard","hentry","category-medicines","category-x","tag-doxylamine-hydrogen","tag-doxylamine-hydrogen-side-effects","tag-doxylamine-hydrogen-tablet","tag-pyridoxine-hydrochloride","tag-pyridoxine-hydrochloride-side-effects","tag-pyridoxine-hydrochloride-tablet","tag-what-doxylamine-hydrogen-is-used-for","tag-what-is-doxylamine-hydrogen","tag-what-is-pyridoxine-hydrochloride","tag-what-is-xonvea","tag-what-pyridoxine-hydrochloride-is-used-for","tag-what-xonvea-is-used-for","tag-xonvea","tag-xonvea-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=32938"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32938\/revisions"}],"predecessor-version":[{"id":33378,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32938\/revisions\/33378"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=32938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=32938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=32938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}