{"id":32413,"date":"2022-11-14T07:24:22","date_gmt":"2022-11-14T07:24:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=32413"},"modified":"2022-11-15T09:16:31","modified_gmt":"2022-11-15T09:16:31","slug":"xermelo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/xermelo\/","title":{"rendered":"Xermelo &#8211; Telotristatethyl uses, dose and side effects"},"content":{"rendered":"\n<p>250 mg&nbsp;film-coated tablets<br>telotristatethyl<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Xermelo is and what it is used for<\/h2>\n\n\n\n<p><strong>What Xermelo is<\/strong><\/p>\n\n\n\n<p>This medicine contains the active substance telotristatethyl.<\/p>\n\n\n\n<p><strong>What Xermelo is used for<\/strong><\/p>\n\n\n\n<p>This medicine is used in adults with a condition called carcinoid syndrome.\u00a0This occurs when a\u00a0tumor, called a neuroendocrine\u00a0tumor, releases the substance\u00a0serotonin\u00a0into the blood.<\/p>\n\n\n\n<p>The doctor will prescribe this medicine if your diarrhea is not well controlled with\u00a0injections\u00a0of other medicines called somatostatin analogs (lanreotide or octreotide).\u00a0You should continue\u00a0injecting\u00a0the other medicines while taking Xermelo.<\/p>\n\n\n\n<p><strong>How Xermelo works<\/strong><\/p>\n\n\n\n<p>When a&nbsp;tumor&nbsp;releases too much&nbsp;serotonin&nbsp;into the blood, you can get diarrhea.<\/p>\n\n\n\n<p>This medicine works by reducing the amount of&nbsp;serotonin&nbsp;that the&nbsp;tumor&nbsp;produces.&nbsp;This reduces your diarrhea.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Xermelo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Xermelo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to telotristat or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Xermelo:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver problems.\u00a0This is because the medicine is not recommended for use in patients with serious liver problems.\u00a0The doctor may decide to reduce your daily\u00a0dose\u00a0of Xermelo in cases where your liver problems are assessed as mild or moderate.\u00a0The doctor will also check your liver.<\/li><li>if you have end-stage kidney disease or are\u00a0on dialysis, talk to your doctor.\u00a0This is because this medicine has not been tested in patients with an end-stage renal disease requiring\u00a0dialysis.<\/li><\/ul>\n\n\n\n<p><strong><em>Be aware of&nbsp;side&nbsp;effects<\/em><\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you experience any of the following signs or symptoms that your liver may not be working properly:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea or vomiting (unexplained), abnormally dark urine, yellowish skin or yellow whites of the eyes, and pain in the upper right part of the stomach.<\/li><\/ul>\n\n\n\n<p>The doctor will take blood tests to check your liver function and decide whether you should continue to take this medicine.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you feel low, depressed, or if you feel that you are not interested in or do not enjoy doing your usual activities while taking this medicine because depression, low mood, and decreased interest have been reported in patients treated with telotristat.<\/li><li>if you have signs of constipation, telotristat reduces the number of bowel movements.<\/li><\/ul>\n\n\n\n<p><strong><em>Tests<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The doctor may take blood tests before you start taking this medicine and while you are taking it.&nbsp;This is to check that your liver is working normally.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine is not recommended for patients under 18 years of age.&nbsp;This is because the drug has not been studied in this age group.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Xermelo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This is because Xermelo can affect the way other medicines work, or other medicines can affect the way Xermelo works.\u00a0This may mean that the doctor needs to change the\u00a0dose\u00a0you are taking.\u00a0You must tell your doctor about each medicine.\u00a0It includes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anti-diarrhea medicine.\u00a0Xermelo and these medicines reduce the number of bowel movements and, if taken at the same time, can cause severe constipation.\u00a0The doctor may need to change the\u00a0dose\u00a0of one of your medicines.<\/li><li>medicines used to treat\u00a0epilepsy, such as\u00a0valproic acid.<\/li><li>medicines used to treat your neuroendocrine\u00a0tumors, such as sunitinib or everolimus.<\/li><li>medicines used to treat depression, such as bupropion or\u00a0sertraline.<\/li><li>medicines used to avoid transplant rejection, such as cyclosporin.<\/li><li>medicines used to reduce cholesterol levels, such as\u00a0simvastatin.<\/li><li>oral contraceptives such as ethinylestradiol.<\/li><li>medicines used to treat high\u00a0blood pressure\u00a0such as amlodipine.<\/li><li>medicines used to treat certain types of cancer, such as irinotecan, capecitabine, and flutamide.<\/li><li>medicines used to reduce the risk of a blood clot forming, such as prasugrel<\/li><li>octreotide.\u00a0If you need treatment with an octreotide\u00a0subcutaneous\u00a0injection\u00a0(injected under the skin), you should take the\u00a0injection\u00a0at least 30 minutes after taking Xermelo.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Do not take this medicine if you are pregnant or planning to become pregnant.&nbsp;It is not known how telotristat may affect the baby.<\/p>\n\n\n\n<p>Women should use effective contraception while taking this medicine.<\/p>\n\n\n\n<p>Do not breastfeed if you are taking Xermelo, as this medicine can be passed to the baby and may harm the baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Xermelo may have a small effect on your ability to drive or use tools or machines.&nbsp;If you feel tired, wait until you feel better before driving or using tools or machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Xermelo contains lactose<\/h2>\n\n\n\n<p>Xermelo contains&nbsp;lactose&nbsp;(a type of sugar).&nbsp;If you have an intolerance to some sugars, you should consult your doctor before taking this medicine<\/p>\n\n\n\n<p><strong>Xermelo contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Xermelo<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is one tablet (250 mg) three times daily.\u00a0The maximum\u00a0amount\u00a0of Xermelo is 750 mg in 24 hours.<\/p>\n\n\n\n<p>The doctor will decide how long you should take Xermelo.<\/p>\n\n\n\n<p>If you have liver problems, your doctor may decide to reduce your daily&nbsp;dose&nbsp;of Xermelo.<\/p>\n\n\n\n<p><strong>Taking this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine with a meal or with some food.<\/li><li>You should continue to\u00a0inject\u00a0yourself with somatostatin analogs (lanreotide or octreotide) while taking Xermelo.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Xermelo<\/h2>\n\n\n\n<p>You may feel sick or vomit, or have diarrhea or stomach pain.\u00a0Talk to a doctor.\u00a0Bring the medicine package with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Xermelo<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take the next\u00a0dose\u00a0as planned and skip the missed\u00a0dose.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Xermelo<\/h2>\n\n\n\n<p>Do not stop taking Xermelo without first talking to your doctor.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you experience any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea or vomiting, abnormally dark urine, yellowish skin or yellow whites of the eyes, and pain in the upper right part of the stomach.\u00a0These may be signs that your liver is not working correctly.\u00a0This can also be shown by changes in your blood tests, such as an increase in liver enzymes: gamma-glutamyltransferase (very common, may affect more than 1 in 10 people),\u00a0transaminases,\u00a0and alkaline phosphatases in the blood (common, may affect up to 1 in 10 users).<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you experience any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(&nbsp;<\/strong><strong>may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach pain<\/li><li>Feeling tired or weak<\/li><li>Feeling sick (nausea)<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(&nbsp;<\/strong><strong>may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gases<\/li><li>Fever<\/li><li>Headache<\/li><li>Constipation<\/li><li>Swollen stomach<\/li><li>Decreased appetite<\/li><li>Swelling (accumulation of fluid in the body)<\/li><li>In depression, you may experience decreased self-confidence, lack of motivation, sadness, or low mood<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Affected stool (intestinal obstruction, fecaloma).&nbsp;You may experience constipation, watery diarrhea, pale skin (&nbsp;anemia&nbsp;), nausea, vomiting, weight loss, back pain or stomach discomfort, especially after eating, or a decrease in urine (urination).<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor immediately<\/strong>&nbsp;if you experience any of the following side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty breathing, fast heartbeat, fever,\u00a0incontinence\u00a0(uncontrolled urination), confusion, dizziness, or restlessness.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you experience any of the\u00a0side effects\u00a0described above.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Xermelo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after EXP.<\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<p>This medicine does not require any special storage conditions.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is telotristatethyl.\u00a01 film-coated tablet contains telotristate tip equivalent to 250 mg telotristatethyl.<\/li><li>Other\u00a0ingredients are\u00a0Tablet core:\u00a0lactose (see section 2 under &#8221;\u00a0Xermelo\u00a0contains lactose&#8221;), hydroxypropyl cellulose, croscarmellose sodium, magnesium stearate, and\u00a0colloidal\u00a0anhydrous silica,\u00a0Film coating: poly(vinyl alcohol) (E1203), titanium dioxide (E171), macrogol 3350 (E1521) and talc (E553b).<br><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Xermelo is white to off-white film-coated oval tablets.\u00a0Each tablet is approx.\u00a017mm long and 7.5mm wide with &#8220;TE&#8221; embossed on one side and &#8220;250&#8221; embossed on the other.\u00a0The tablets are packed in PVC\/PCTFE\/PVC\/Al blisters.\u00a0The blisters are packed in an outer carton.<\/p>\n\n\n\n<p>Packs of 90 and 180 tablets.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>SERB SAS<\/p>\n\n\n\n<p>40 Avenue George V<\/p>\n\n\n\n<p>75008 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Tjoapack Netherlands BV<\/p>\n\n\n\n<p>Nieuwe Donk 9<\/p>\n\n\n\n<p>4879AC Etten-Leur<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This medicine is used in adults with a condition called carcinoid syndrome.\u00a0This occurs when a\u00a0tumor\u00a0, called a neuroendocrine\u00a0tumor\u00a0, releases the substance\u00a0serotonin\u00a0into the blood.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22504],"tags":[28034,28037,28036,28035,28039,28038,28041,28040,28042,28043],"class_list":["post-32413","post","type-post","status-publish","format-standard","hentry","category-medicines","category-x","tag-telotristatethyl","tag-telotristatethyl-side-effects","tag-telotristatethyl-tablet","tag-what-is-telotristatethyl","tag-what-is-xermelo","tag-what-telotristatethyl-is-used-for","tag-what-xermelo-is-used-for","tag-xermelo","tag-xermelo-side-effects","tag-xermelo-tablet"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=32413"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32413\/revisions"}],"predecessor-version":[{"id":32928,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32413\/revisions\/32928"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=32413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=32413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=32413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}