{"id":32412,"date":"2022-11-14T07:22:34","date_gmt":"2022-11-14T07:22:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=32412"},"modified":"2022-11-15T09:16:36","modified_gmt":"2022-11-15T09:16:36","slug":"xeomin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/xeomin\/","title":{"rendered":"Xeomin &#8211; Botulinum neurotoxin type A uses, dose and side effects"},"content":{"rendered":"\n<p>50 units, 100 units, 200 units&nbsp;powder for&nbsp;injection, solution<br>Clostridium&nbsp;Botulinum\u2011neurotoxin type A (150 kD),&nbsp;free from complexing&nbsp;proteins<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Xeomin is and what it is used for<\/h2>\n\n\n\n<p>Xeomin is a medicine that contains the active substance botulinum neurotoxin type A, which has a relaxing effect on the injected muscles or reduces the flow of saliva at the respective injection site.<\/p>\n\n\n\n<p>Xeomin is used to treat the following conditions in adults<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>spasm in the eyelids (&nbsp;blepharospasm&nbsp;) and spasms in one half of the face (hemifacial&nbsp;spasm&nbsp;)<\/li><li>twisted neck (spastic&nbsp;torticollis&nbsp;)<\/li><li>increased muscle tension\/uncontrolled muscle stiffness in the shoulders, arms, and\/or hands (spasticity in the upper&nbsp;extremities&nbsp;)<\/li><li>chronic drooling (hypersalivation) due to neurological diseases.<\/li><\/ul>\n\n\n\n<p>Xeomin is used in children and adolescents aged 2 to 17 years who weigh 12 kg or more for the treatment of<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>chronic drooling (hypersalivation) due to neurological\/developmental neurological diseases.<\/li><\/ul>\n\n\n\n<p><br>The Clostridium&nbsp;botulinum neurotoxin type A contained in Xeomin may also be approved to treat other diseases not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Xeomin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Xeomin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to botulinum neurotoxin type A or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you suffer from a disease affecting the muscles (eg&nbsp;myasthenia gravis&nbsp;or Eaton-Lambert syndrome).<\/li><li>if you have an&nbsp;infection&nbsp;or&nbsp;inflammation&nbsp;at the intended injection site.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Side effects&nbsp;can occur from misplaced&nbsp;injections&nbsp;of botulinum neurotoxin type A that temporarily paralyze nearby muscle groups.&nbsp;There have been very rare reports of&nbsp;side effects&nbsp;that may be related to the spread of&nbsp;toxin&nbsp;far from the injection site and may produce symptoms consistent with effects from botulinum toxin type A (eg, marked muscle weakness, difficulty swallowing, or getting food or liquid into the airways). .&nbsp;Patients receiving the recommended&nbsp;doses&nbsp;may experience increased muscle weakness.<\/p>\n\n\n\n<p>If the&nbsp;dose&nbsp;is too high or if botulinum toxin is injected too often, the risk of&nbsp;antibody&nbsp;formation may increase.&nbsp;Antibody formation can lead to botulinum toxin type A treatment failure regardless of the reason for treatment.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before using Xeomin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any kind of bleeding disorder<\/li><li>if you receive medicines that prevent the blood from clotting (e.g. coumarin,&nbsp;heparin,&nbsp;aspirin, clopidogrel)<\/li><li>if you suffer from pronounced weakness or reduced muscle volume in the muscles where the&nbsp;injection&nbsp;is to be given<\/li><li>if you suffer from amyotrophic lateral sclerosis (&nbsp;ALS&nbsp;), which can lead to generalized muscle wasting.<\/li><li>if you suffer from any disease that disrupts the interaction between nerves and skeletal muscles (peripheral neuromuscular disorders)<\/li><li>if you have or have had to swallow difficulties you suffer or have suffered from convulsions<\/li><li>if you have had problems&nbsp;injecting&nbsp;yourself with botulinum toxin type A before<\/li><li>if you are going to have surgery.<\/li><\/ul>\n\n\n\n<p>Contact your doctor and seek hospital care immediately if you experience any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing, swallowing, or speaking<\/li><li>hives, swelling including swelling of the face or throat, wheezing, feeling faint and difficulty breathing (may be symptoms of a serious&nbsp;allergic reaction&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Repeated&nbsp;injection&nbsp;with Xeomin<\/strong><\/p>\n\n\n\n<p>If you receive repeated&nbsp;injections&nbsp;of Xeomin, the effect may increase or decrease.&nbsp;Possible reasons for this are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your doctor may apply different preparation methods when preparing the solution for injection<\/li><li>different injection intervals<\/li><li>the injection&nbsp;is given in another muscle<\/li><li>marginally varying effect of the active substance in Xeomin<\/li><li>absence of effect\/treatment failure during treatment<\/li><\/ul>\n\n\n\n<p><strong><em>Eyelid spasm (&nbsp;blepharospasm&nbsp;)&nbsp;<\/em><\/strong><strong><em>and spasms in one half of the face (hemifacial&nbsp;spasm&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p>Talk to your doctor before starting treatment with Xeomin if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>previously operated on the eyes.\u00a0The doctor will take the necessary safety measures.<\/li><li>are at risk of developing a disease called\u00a0narrow-angle glaucoma\u00a0(\u00a0glaucoma\u00a0).\u00a0This disease can cause increased pressure in the eye which can lead to damage to the\u00a0optic nerve. Your doctor can determine if you are at any risk for this.<\/li><\/ul>\n\n\n\n<p>During the treatment, small hemorrhages may appear in the soft tissue of the eyelid.&nbsp;Your doctor can limit this by applying light pressure to the injection site&nbsp;immediately after the&nbsp;injection.<\/p>\n\n\n\n<p>After a Xeomin\u00a0injection\u00a0into the eye muscles, you may have reduced blinking.\u00a0This can lead to prolonged exposure to the cornea.\u00a0This exposure can lead to permanent damage to the surface layer and inflammation\u00a0(ulceration of the cornea).<\/p>\n\n\n\n<p><strong><em>Twisted neck (Spastic&nbsp;torticollis&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p>After&nbsp;the injection&nbsp;of Xeomin t,  there is a risk of mild to severe swallowing difficulties.&nbsp;This can lead to breathing problems and you may be at a higher risk of inhaling foreign substances or liquids.&nbsp;Foreign substances in your lungs can lead to inflammation&nbsp;or&nbsp;infection&nbsp;(&nbsp;pneumonia&nbsp;).&nbsp;Your doctor will give you medical treatment if necessary (eg in the form of tube feeding).<\/p>\n\n\n\n<p>Difficulty swallowing may persist for up to two to three weeks after&nbsp;injection, t has been reported in one patient to persist for up to five months.<\/p>\n\n\n\n<p>If you have had a physically inactive lifestyle for a long period, the start of all physical activity should be done gradually after&nbsp;injection&nbsp;with Xeomin.<\/p>\n\n\n\n<p><strong><em>Increased muscle tension\/uncontrolled muscle stiffness<\/em><\/strong><\/p>\n\n\n\n<p>Xeomin can be used to treat increased muscle tension\/uncontrolled muscle stiffness in parts of your upper&nbsp;extremities,e.g.&nbsp;your arm or hand.&nbsp;Xeomin is effective in combination with the usual standard treatment methods.&nbsp;Xeomin should be used in conjunction with these methods.<\/p>\n\n\n\n<p>It is unlikely that this medicine will improve joint mobility if surrounding musculature has lost its ability to move<\/p>\n\n\n\n<p>If you have had a physically inactive lifestyle for a long period, the start of all physical activity should be done gradually after&nbsp;injection&nbsp;with Xeomin.<\/p>\n\n\n\n<p><strong><em>Chronic drooling (hypersalivation)<\/em><\/strong><\/p>\n\n\n\n<p>Certain drugs (eg clozapine, aripiprazole, pyridostigmine) can lead to excessive salivation.&nbsp;First of all, the possibility of changing, reducing o,r even discontinuing the drug that causes drooling should be considered before Xeomin is used as an anti-drooling treatment.&nbsp;The use of Xeomin to reduce drug-induced drooling has not been studied.<\/p>\n\n\n\n<p>If cases of &#8220;dry mouth&#8221; develop in connection with\u00a0the administration\u00a0of Xeomin, the doctor will consider reducing the\u00a0dose.<\/p>\n\n\n\n<p>If your saliva flow is reduced with Xeomin, oral health problems such as\u00a0caries\u00a0in the teeth, develop or existing problems may worsen.\u00a0Consult a dentist when you start using Xeomin for the treatment of chronic drooling.\u00a0The dentist can decide which measures should be taken to prevent\u00a0caries, if necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children under 2 years of age, to children weighing less than 12 kg, or to children and adolescents for treatments other than&nbsp;chronic&nbsp;drooling because the use of Xeomin has not been established in these groups and therefore cannot be recommended.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Xeomin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The effect of Xeomin may increase:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>of medicines used to treat certain infectious diseases (spectinomycin or aminoglycoside antibiotics [eg\u00a0neomycin, kanamycin, tobramycin])<\/li><li>of other medicines that relax muscles (eg tubocurarine-type muscle relaxants).\u00a0Such drugs are used e.g.\u00a0in case of general\u00a0anesthesia\u00a0(sedation\/anesthesia).\u00a0If you are going to have surgery, tell your anesthetist if you have received Xeomin.<\/li><li>when used to treat chronic drooling: by other medicines that also reduce saliva flow (eg anticholinergics such as atropine, glycopyrronium, or scopolamine) or by radiation therapy to the head and neck, including the salivary glands.\u00a0Tell your doctor if you are receiving radiation therapy or if radiation therapy is planned for you.<\/li><\/ul>\n\n\n\n<p>In these cases, Xeomin must be used with caution.<\/p>\n\n\n\n<p>The effect of Xeomin can be reduced by certain medicines against&nbsp;malaria&nbsp;and rheumatism (called aminoquinolines).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before administering this medicine.<\/p>\n\n\n\n<p>Xeomin should not be used during pregnancy unless the doctor judges that the need and possible benefit of the treatment outweigh the possible risk to the fetus.<\/p>\n\n\n\n<p>Xeomin is not recommended if you are breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You should not drive or participate in other potentially dangerous activities if droopy eyelids, weakness (&nbsp;asthenia&nbsp;), muscle weakness, dizziness or vision problems occur.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Xeomin<\/h2>\n\n\n\n<p>Xeomin may only be administered by doctors with appropriate specialist skills for treatment with botulinum neurotoxin type A.<\/p>\n\n\n\n<p>Your doctor adjusts the optimal\u00a0dose, treatment interval, and the number of injection sites individually for you.\u00a0The result of the first\u00a0injection\u00a0of Xeomin is evaluated and may lead to an adjustment of the\u00a0dose\u00a0until the desired effect is achieved.\u00a0Your doctor will determine the length of time intervals between treatments based on your actual need.<\/p>\n\n\n\n<p>Tell your doctor if you feel that the effect of Xeomin is too strong or too weak.&nbsp;If no effect is achieved, other treatment options should be considered.<\/p>\n\n\n\n<p><strong><em>Eyelid spasm (&nbsp;blepharospasm&nbsp;) and spasms in one half of the face (hemifacial&nbsp;spasm&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p>The recommended initial&nbsp;dose&nbsp;is up to 25 units per eye and the total recommended&nbsp;dose&nbsp;for follow-up treatment is up to 50 units per eye.&nbsp;Usually, the first effect can be observed within four days after&nbsp;injection&nbsp;one.&nbsp;The effect of each treatment generally lasts about 3-5 months, but it can be significantly longer or shorter.&nbsp;Treatment intervals of less than 12 weeks are not recommended.<\/p>\n\n\n\n<p>Normally, no further improvement is obtained if the treatment is done more often than every three months.<\/p>\n\n\n\n<p>If you have spasms in one half of the face (hemifacial\u00a0spasm\u00a0), your doctor will follow the treatment recommendations for eyelid spasms (\u00a0blepharospasm\u00a0) limited to one half of the face.\u00a0The spasm affecting one half of the face (hemifacial\u00a0spasm\u00a0) is treated only in the upper part of the face because Xeomin\u00a0injections\u00a0in the lower part of the face can lead to an increased risk of\u00a0side effects\u00a0such as a pronounced risk of local weakness.<\/p>\n\n\n\n<p><strong><em>Twisted neck (spastic&nbsp;torticollis&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose of\u00a0one per individual injection site is up to 50 units and the total\u00a0dose of\u00a0one at the first treatment is 200 units.\u00a0A dose\u00a0er up to 300 units can be administered by your doctor in subsequent treatments depending on treatment response. Usually, the first effect can be observed within seven days after\u00a0injection\u00a0one.\u00a0The effect of each treatment lasts about 3-4 months, but it can be significantly shorter or longer.\u00a0Treatment intervals shorter than 10 weeks are not recommended.<\/p>\n\n\n\n<p><strong><em><strong><em>Increased muscle tension\/uncontrolled muscle stiffness in the shoulders, arms, or hands (spasticity in the upper\u00a0extremities\u00a0)<\/em><\/strong><\/em><\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is up to 500 units per treatment and a maximum of 250 units should be given to the shoulder muscles.\u00a0Patients reported that the effect started 4 days after treatment.\u00a0An improvement in muscle tone was noticed within 4 weeks.\u00a0The effect lasted 12 weeks, but it can be significantly longer or shorter.\u00a0The period between each treatment session should be at least 12 weeks.<\/p>\n\n\n\n<p><strong><em>Chronic drooling (hypersalivation, adults)<\/em><\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is 100 units per treatment session.\u00a0This maximum dose must not be exceeded.\u00a0The period between each treatment session should be at least 16 weeks.<br><br><strong><em>Chronic drooling (hypersalivation, children\/adolescents)<\/em><\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose of\u00a0one per treatment session depends on body weight.\u00a0This maximum dose should not exceed 75 units.\u00a0The period between each treatment session should be at least 16 weeks.<\/p>\n\n\n\n<p><strong><em><strong><em>Mode of administration<\/em><\/strong><\/em><\/strong><\/p>\n\n\n\n<p>Ready-made Xeomin is intended for\u00a0injection\u00a0into the muscles (\u00a0intramuscular\u00a0use) and the salivary glands (intraglandular use) (see information for healthcare professionals at the end of the leaflet).\u00a0When it comes to locating the salivary glands in adults, the doctor can use both anatomical landmarks and ultrasound guidance, but the ultrasound method is preferred for efficiency reasons.\u00a0For children and adolescents, ultrasound guidance should be used.<br>Before\u00a0injection, children and young people may be given a\u00a0local anesthetic\u00a0(e.g. local anesthetic cream), sedative, or an anesthetic combined with a sedative.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you are given too much Xeomin<\/h2>\n\n\n\n<p>If you have received too much medicine or if, for example,&nbsp;a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Symptoms of overdose<\/p>\n\n\n\n<p>Symptoms of overdose do not come immediately after\u00a0injection\u00a0one.\u00a0They may consist of general weakness, drooping eyelids, double vision, difficulty breathing, difficulty speaking, and paralysis of respiratory muscles or difficulty swallowing which may lead to\u00a0pneumonia.<\/p>\n\n\n\n<p>Measures in case of overdose<\/p>\n\n\n\n<p>If you notice symptoms of overdose, you should immediately seek hospital care or ask your loved ones for help in seeking hospital care.&nbsp;Medical monitoring for several days and artificial respiration may be required.<\/p>\n\n\n\n<p>Ask your doctor, pharmacist, or nurse if you have any further questions about this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects\u00a0are usually observed\u00a0within the first week after treatment and are transient.\u00a0Side effects\u00a0can be related to the drug, the injection technique, or both.\u00a0Adverse effects\u00a0may be limited to the area around the injection site (e.g. local muscle weakness, local pain,\u00a0inflammation, tingling (\u00a0paresthesia\u00a0), reduced sense of touch (\u00a0hypoesthesia\u00a0), tenderness, swelling (general), swelling of soft tissues (\u00a0edema\u00a0), skin redness (\u00a0erythema\u00a0),\u00a0itching, local\u00a0infection, hemorrhage, bleeding and\/or bruising).<\/p>\n\n\n\n<p>The needle injection may cause pain.\u00a0This pain or the fear of needles can lead to fainting, nausea,\u00a0tinnitus\u00a0(ringing in the ears), or a drop in blood pressure.<\/p>\n\n\n\n<p>Side effects&nbsp;such as significant muscle weakness or difficulty swallowing can be caused by muscle relaxation far from the site where Xeomin was injected.&nbsp;Difficulty swallowing can lead to&nbsp;inhalation&nbsp;of foreign bodies leading to&nbsp;pneumonia&nbsp;and sometimes death.<\/p>\n\n\n\n<p>An\u00a0allergic reaction\u00a0may occur during treatment with Xeomin.\u00a0Serious and\/or immediate allergic reactions (\u00a0anaphylaxis\u00a0) or allergic reactions to the\u00a0serum\u00a0et in the product (serum sickness) which for example lead to difficulty breathing (\u00a0dyspnoea\u00a0),\u00a0hives\u00a0(\u00a0urticaria\u00a0), or swelling of the soft parts (\u00a0edema\u00a0) have been reported in rare cases.\u00a0Some of these reactions have been observed following the use of a common botulinum toxin type A complex.\u00a0They occurred when\u00a0toxin\u00a0it was given alone or in combination with other drugs known to cause similar reactions.\u00a0An\u00a0allergic reaction may cause any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing, swallowing, or speaking due to swelling of the face, lips, mouth, or throat.<\/li><li>swelling of the hands, feet, or ankles<\/li><\/ul>\n\n\n\n<p><strong>Immediately inform your doctor or ask your relatives to contact you if you notice any of these&nbsp;side effects&nbsp;and visit the emergency department of the nearest hospital.<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed during treatment with Xeomin:<\/p>\n\n\n\n<p><strong><em>Eyelid spasm (&nbsp;blepharospasm&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Droopy eyelids (&nbsp;ptosis&nbsp;)<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Dry eyes, blurred vision, visual impairment,\u00a0dry mouth, pain at the injection site<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<p>Headache, facial muscle weakness (facial paralysis), double vision (&nbsp;diplopia&nbsp;), increased lacrimation, difficulty swallowing (&nbsp;dysphagia&nbsp;), fatigue, muscle weakness, rash<\/p>\n\n\n\n<p><strong><em>Cramps in one half of the face (hemifacial&nbsp;spasm&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p>Similar\u00a0side effects\u00a0as for eyelid spasms can be expected when treating spasms in one half of the face.<\/p>\n\n\n\n<p><strong><em>Twisted neck (spasmodic&nbsp;torticollis&nbsp;)<\/em><\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Difficulty swallowing (&nbsp;dysphagia&nbsp;)<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Neck pain, muscle weakness, musculoskeletal pain (\u00a0myalgia\u00a0), musculoskeletal stiffness, muscle spasm, headache, dizziness, injection site pain, weakness (\u00a0asthenia\u00a0),\u00a0dry mouth, nausea, increased sweating (\u00a0hyperhidrosis\u00a0), upper respiratory tract infection, feeling faint (presyncope)<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<p>Difficulty speaking (&nbsp;dysphonia&nbsp;), shortness of breath (&nbsp;dyspnea&nbsp;), rash<\/p>\n\n\n\n<p>The treatment of a twisted neck can cause difficulty in swallowing of varying degrees of severity, which may entail a risk of inhaling foreign objects and thus may require medical attention.\u00a0Difficulty swallowing may persist for two to three weeks after\u00a0injection, but in one case has been reported to last up to five months.\u00a0Difficulty swallowing appears to be dose-dependent.<\/p>\n\n\n\n<p><strong><em>Increased muscle tension\/uncontrolled muscle stiffness in the shoulders, arms, or hands (spasticity in the upper\u00a0extremities\u00a0)<\/em><\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Dry mouth<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<p>Headache, decreased sense of touch (&nbsp;hypoaesthesia&nbsp;), muscle weakness, pain in arm or leg, weakness (&nbsp;asthenia&nbsp;), muscle pain (&nbsp;myalgia&nbsp;), difficulty swallowing (&nbsp;dysphagia&nbsp;), nausea<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Pain at the injection site<\/p>\n\n\n\n<p><strong><em>Chronic drooling (hypersalivation) in adults<\/em><\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Dry mouth, difficulty swallowing (\u00a0dysphagia\u00a0), tingling (\u00a0paraesthesia\u00a0)<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<p>Thicker saliva, speech difficulties, taste disturbance (&nbsp;dysgeusia&nbsp;)<\/p>\n\n\n\n<p>Cases of persistent\u00a0dry mouth\u00a0(more than 110 days) of severe\u00a0intensity\u00a0have been reported, which can lead to further complications such as gingivitis (\u00a0gingivitis\u00a0), difficulty swallowing, and\u00a0caries\u00a0.<br><br><strong><em>Chronic drooling (hypersalivation) in children\/adolescents<br><br><\/em><\/strong><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<p>Difficulty swallowing (&nbsp;dysphagia&nbsp;)<br><br><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Dry mouth, thicker saliva, pain in the mouth, dental caries<br><br><strong><em>Post-marketing experience<\/em><\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported as &#8220;no frequency known&#8221; when using Xeomin after launch and regardless of indication:<\/p>\n\n\n\n<p>Flu-like symptoms, wasting of injected muscle, and\u00a0hypersensitivity reactions, such as swelling, soft\u00a0tissue\u00a0swelling (\u00a0edema, even far from the injection site),\u00a0redness,\u00a0itching, skin rash (local and generalized), and shortness of breath.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Xeomin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and vial after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Unopened vial:&nbsp;Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Reconstituted solution for injection:\u00a0\u00a0Chemical and physical stability of the reconstituted preparation has been demonstrated for 24 hours at 2\u00b0C to 8\u00b0C.\u00a0From a\u00a0microbiological\u00a0point of view, the product should be used immediately.\u00a0If not used immediately, in-use storage times and conditions before use are the responsibility of the user and would normally not be longer than 24 hours at 2\u00b0C to 8\u00b0C, unless\u00a0reconstitution\u00a0has taken place under controlled and validated aseptic conditions.<\/p>\n\n\n\n<p>Your doctor should not use Xeomin if the solution looks cloudy or contains visible particles.<\/p>\n\n\n\n<p>For disposal instructions, please see the information for healthcare professionals at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0Clostridium\u00a0Botulinum\u2011neurotoxin type A (150 kD), free of complex\u00a0proteins. Xeomin 50 units powder for\u00a0solution for\u00a0injection\u00a0One\u00a0vial\u00a0contains 50 units\u00a0of Clostridium\u00a0Botulinum\u2011neurotoxin type A (150 kD), free from complexing proteins*.Xeomin 100 units powder for\u00a0solution for\u00a0injection\u00a0vial\u00a0contains 100 units\u00a0of Clostridium\u00a0Botulinum\u2011neurotoxin type A (150 kD), free from complexing proteins*. Xeomin 200 units powder for\u00a0solution for\u00a0injection\u00a0vial\u00a0contains 200 units\u00a0of Clostridium\u00a0Botulinum\u2011neurotoxin type A (150 kD), free from complexing proteins*.* Botulinum\u2011neurotoxin type A, purified from cultures of\u00a0Clostridium\u00a0Botulinum (Hall strain)<\/li><li>Other ingredients are human albumin, and sucrose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Xeomin is a powder solution for\u00a0injection.\u00a0The powder is white.<\/p>\n\n\n\n<p>After\u00a0preparation, the powder becomes a clear, colorless solution.<\/p>\n\n\n\n<p>Xeomin 50 units powder for solution for\u00a0injection: Pack sizes of 1, 2, 3, or 6 bottles.<\/p>\n\n\n\n<p>Xeomin 100 units powder for solution for\u00a0injection: Pack sizes of 1, 2, 3, 4, or 6 bottles.<\/p>\n\n\n\n<p>Xeomin 200 units powder for solution for\u00a0injection: Pack sizes of 1, 2, 3, 4, or 6 bottles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Merz Pharmaceuticals GmbH<\/p>\n\n\n\n<p>Eckenheimer Landstrasse 100<\/p>\n\n\n\n<p>60318 Frankfurt\/Main<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Box 11 13 53<\/p>\n\n\n\n<p>60048 Frankfurt\/Main<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Phone: +49-69\/1503-1<\/p>\n\n\n\n<p>Fax: +49-69\/1503-200<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area and the United Kingdom (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Xeomin:<\/td><td>Austria, Bulgaria, Cyprus, Croatia, Czech Republic, Denmark, Estonia, Germany, Greece, Finland, France, Hungary, Ireland, Iceland, Italy, Latvia, Lichtenstein, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom (Northern Ireland)<\/td><\/tr><tr><td>XEOMIN:<\/td><td>Belgium<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>50 units, 100 units, 200 units&nbsp;powder for&nbsp;injection, solutionClostridium&nbsp;Botulinum\u2011neurotoxin type A (150 kD),&nbsp;free from complexing&nbsp;proteins What Xeomin is and what it is used for Xeomin is a medicine that contains the active substance botulinum neurotoxin type A, which has a relaxing effect on the injected muscles or reduces the flow of saliva at the respective injection [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22504],"tags":[28054,28053,28058,28055,28056,28057,28049,28051,28050,28052],"class_list":["post-32412","post","type-post","status-publish","format-standard","hentry","category-medicines","category-x","tag-benefits-of-botulinum-neurotoxin-type-a","tag-benefits-of-xeomin","tag-botulinum-neurotoxin-type-a","tag-botulinum-neurotoxin-type-a-side-effects","tag-what-botulinum-neurotoxin-type-a-is-used-for","tag-what-is-botulinum-neurotoxin-type-a","tag-what-is-xeomin","tag-what-xeomin-is-used-for","tag-xeomin","tag-xeomin-side-effects"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=32412"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32412\/revisions"}],"predecessor-version":[{"id":32929,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/32412\/revisions\/32929"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=32412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=32412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=32412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}