{"id":31526,"date":"2022-11-10T12:18:58","date_gmt":"2022-11-10T12:18:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31526"},"modified":"2022-11-11T10:26:07","modified_gmt":"2022-11-11T10:26:07","slug":"warfarin-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/warfarin-orion\/","title":{"rendered":"Warfarin Orion &#8211; Warfarin sodium uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg&nbsp;tablets<br>warfarin sodium<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Warfarin Orion is and what it is used for<\/h2>\n\n\n\n<p>Warfarin\u00a0Orion is used to preventing or treat blood clots or their complications.\u00a0Warfarin\u00a0Orion reduces the risk of blood clots.<\/p>\n\n\n\n<p><strong>This medicine is used to:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>prevent and treat deep&nbsp;vein thrombosis&nbsp;(blood clots in the blood vessels of the legs) and pulmonary embolism (blood clots in the blood vessels of the lungs)<\/li><li>prevent the formation of blood clots in some patients with&nbsp;atrial fibrillation&nbsp;(a heart rhythm disorder)<\/li><li>prevent new blood clots after a major heart attack<\/li><li>prevent the formation of blood clots in some patients with prosthetic valves (after heart valve replacement).<\/li><\/ul>\n\n\n\n<p>The warfarin contained\u00a0in\u00a0Warfarin\u00a0Orion may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Warfarin Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Warfarin Orion:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to warfarin sodium or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are pregnant in the first third of pregnancy, or the last four weeks of pregnancy (see also the Pregnancy and breast-feeding section)<\/li><li>if you have an increased tendency to bleed (\u00a0hemophilia,\u00a0von Willebrand&#8217;s disease, lack of\u00a0platelets\u00a0(\u00a0thrombocytopenia\u00a0), or impaired function of the platelets).<\/li><li>if you have severe liver dysfunction or\u00a0liver cirrhosis\u00a0(cirrhosis).<\/li><li>if you have untreated or uncontrolled high\u00a0blood pressure.<\/li><li>if you have recently had a brain hemorrhage.<\/li><li>if you tend to fall frequently due to neurological or other problems with your health.<\/li><li>if you have recently had surgery on the nervous system or the eye, or if you are going to undergo such surgery shortly.<\/li><li>if you have previously had to bleed in the gastrointestinal tract (e.g. ruptured\u00a0stomach ulcer, bloody or black stools, bloody vomit) or to bleed in the urinary tract (unexplained blood in the urine).<\/li><li>if you have\u00a0inflammation\u00a0in a heart valve (\u00a0endocarditis\u00a0) or the pericardium (pericarditis) or if you have fluid accumulation in the pericardium.<\/li><li>in the case of dementia,\u00a0psychosis, alcoholism, or in any other situation where this type of treatment cannot be given safely<\/li><li>if you take\u00a0St. John&#8217;s wort\u00a0<em>(\u00a0<\/em><em>Hypericum perforatum\u00a0<\/em><em>)<\/em><\/li><li>if you are taking other medicines that prevent blood clots (e.g. dabigatran, apixaban, rivaroxaban, edoxaban) except when changing blood thinning treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking&nbsp;Warfarin&nbsp;Orion.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are already using, start using or stop using other medicines during treatment with&nbsp;Warfarin&nbsp;Orion (see section Other medicines and&nbsp;Warfarin&nbsp;Orion).<\/li><li>if you have hyper- or&nbsp;hypothyroidism&nbsp;(increased or decreased function of the thyroid gland).<\/li><li>if you have&nbsp;heart failure&nbsp;associated with sudden worsening (periods of increased fluid retention (&nbsp;edema&nbsp;) and shortness of breath).<\/li><li>if you have other forms of impaired liver function than those mentioned above, or jaundice.<\/li><li>if you have impaired kidney function.<\/li><li>if you are going to undergo dental or other&nbsp;surgery&nbsp;soon, consult your doctor.<\/li><\/ul>\n\n\n\n<p>Major changes in eating habits should be avoided because the amount of\u00a0vitamin K\u00a0in the food can affect the effectiveness of the treatment with\u00a0warfarin.\u00a0Transition to a vegetarian diet, extreme diet, depression, vomiting, or diarrhea are conditions that can affect the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Warfarin Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><em>Medicines<\/em><br>Many medicines affect the effect of&nbsp;Warfarin&nbsp;Orion, either by increasing or decreasing it.&nbsp;Glucosamine (against&nbsp;osteoarthritis&nbsp;) can increase the effect of&nbsp;Warfarin&nbsp;Orion.<\/p>\n\n\n\n<p><strong>Treatment with new or old medicines must not be started or stopped without first consulting a doctor.&nbsp;<\/strong>Any changes in concomitant medication may alter the balance of coagulation therapy and more frequent blood tests may be required.<\/p>\n\n\n\n<p>If you need painkillers, you should contact a doctor.\u00a0Most over-the-counter pain relievers must not be used with\u00a0Warfarin\u00a0Orion.\u00a0However, if temporary pain relief or fever reduction is needed, medicines containing only\u00a0paracetamol\u00a0as an active ingredient can be used.<\/p>\n\n\n\n<p><em>Natural Remedies and Natural Remedies<\/em><br>If you are already using any of the following herbal remedies, consult a doctor before discontinuing that treatment.\u00a0Ginkgo (\u00a0<em>Ginkgo biloba<\/em>\u00a0), garlic (\u00a0<em>Allium sativum<\/em>\u00a0), dong Quai\u00a0preparation\u00a0(\u00a0Angelica Sinensis\u00a0), papaya (\u00a0Carica papaya\u00a0), and danshen (\u00a0<em>Salvia miltiorrhiza<\/em>\u00a0) may increase the effect of\u00a0Warfarin\u00a0Orion.\u00a0St. John&#8217;s wort\u00a0(\u00a0<em>Hypericum perforatum<\/em>\u00a0) and ginseng (\u00a0<em>Panax spp.<\/em>\u00a0), on the other hand, can reduce the effect.\u00a0Treatment with these agents must therefore not be started or stopped during treatment with\u00a0WarfarinOrion, without consulting a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warfarin Orion with food, drink, and alcohol<\/h2>\n\n\n\n<p>Taking\u00a0vitamin K\u00a0reduces the effect of\u00a0Warfarin\u00a0Orion.\u00a0Therefore, the intake of food containing\u00a0vitamin K\u00a0should be kept as constant as possible during warfarin treatment.\u00a0Sudden changes in eating habits should be avoided.\u00a0The biggest sources of\u00a0vitamin K\u00a0are green vegetables, leaves, and herbs.<\/p>\n\n\n\n<p>Some foods that contain plenty of&nbsp;vitamin K&nbsp;are listed below.&nbsp;It is not necessary to avoid the use of these, but the daily intake should be as regular as possible:<br>amaranth leaves, avocado, broccoli, Brussels sprouts, cabbage, rapeseed oil, leaves from pear squash, chives, cilantro, cucumber skin (but not cucumber without skin), endive, kale, kiwi, lettuce leaves, mint leaves, mustard leaves, olive oil, parsley, peas, pistachios, red seaweed, spinach leaves, spring onions, soybeans, soybean oil, tea leaves (but not brewed tea), turnips, watercress.<\/p>\n\n\n\n<p>Cranberry juice and other products containing cranberries may increase the effect of\u00a0warfarin.\u00a0Concomitant use should therefore be avoided.<\/p>\n\n\n\n<p>Do not drink large amounts of alcohol while taking\u00a0warfarin.\u00a0Heavy alcohol intake and concurrent liver failure can enhance the effect of\u00a0warfarin.<\/p>\n\n\n\n<p><em>Warfarin&nbsp;Orion and smoking<\/em><\/p>\n\n\n\n<p>Smoking can affect the effect of\u00a0warfarin.\u00a0You may need to do laboratory tests more often if you have smoked for a long time and if you stop smoking while being treated with\u00a0warfarin.\u00a0Contact your doctor if this applies to you<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0Warfarin\u00a0Orion should not be used during the first third of pregnancy, nor the last four weeks of pregnancy.\u00a0If possible,\u00a0Warfarin\u00a0Orion should be avoided throughout pregnancy but in special circumstances treatment under the supervision of a specialist physician may be considered.<\/p>\n\n\n\n<p>Warfarin&nbsp;is not excreted in breast milk.&nbsp;Breastfeeding can therefore continue during treatment with&nbsp;Warfarin&nbsp;Orion.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Warfarin&nbsp;Orion does not affect the ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warfarin Orion contains lactose<\/h2>\n\n\n\n<p>The tablets contain&nbsp;lactose&nbsp;(51.4 mg\/tablet).&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Other excipients<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Warfarin Orion<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>It is necessary to do laboratory tests at regular intervals.\u00a0The dosage\u00a0is adjusted individually for you and the\u00a0dosage\u00a0may differ from day to day.\u00a0It is necessary to follow the dosing instructions and to take the agreed laboratory samples.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Warfarin Orion<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<br>Do not induce vomiting.\u00a0If a large overdose has been ingested, medical charcoal can be taken as first aid, but a doctor must still be contacted immediately as further treatment may be required.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Warfarin Orion<\/h2>\n\n\n\n<p>If you forget a\u00a0dose\u00a0and discover it within 12 hours, you can take the missed\u00a0dose\u00a0immediately.\u00a0Take the next\u00a0dose\u00a0as usual.\u00a0If more than 12 hours have passed since you forgot to take a\u00a0dose, divide the missed\u00a0dose\u00a0into two or three parts and take it together with the next\u00a0dose\u00a0so that the weekly dose does not change.\u00a0If you have missed more than one\u00a0dose, you must contact your doctor for further instructions.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Warfarin Orion<\/h2>\n\n\n\n<p>If treatment with&nbsp;Warfarin&nbsp;Orion is stopped, the anticoagulant effect may persist for 2-5 days.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Contact your&nbsp;<\/em><em>doctor&nbsp;<\/em><em>immediately&nbsp;<\/em><em>if you experience any of the following during treatment with&nbsp;<\/em><em>Warfarin<\/em><em>&nbsp;Orion:<\/em><em><\/em><em><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased tendency to bruise, nose or gum bleeding, blood in the urine, black or bloody stools, bloody vomiting, heavy or prolonged menstrual bleeding.\u00a0These symptoms may be signs of an excessively high effect of\u00a0warfarin.<\/li><li>Painful skin rash.\u00a0In rare cases,\u00a0warfarin\u00a0can cause serious skin conditions, including a condition called calciphylaxis which may start as a painful skin rash but can lead to other serious complications.\u00a0This\u00a0side effect\u00a0is more common in patients with\u00a0chronic\u00a0kidney disease.<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Bleeding, nausea, vomiting, diarrhea.<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users):<\/em><\/p>\n\n\n\n<p>Coumarin-induced tissue damage, &#8220;purple toe syndrome&#8221; (purple-colored and painful skin change on toes or soles of feet).<\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users):<\/em><\/p>\n\n\n\n<p>Hypersensitivity reaction, which usually manifests itself as skin rash, temporary increase in liver enzyme values, bile pain, vein inflammation, temporary hair loss, prolonged painful\u00a0erection\u00a0(usually at the beginning of treatment), calcification in the airways, a fatty clot in blood vessels.<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Accumulation of\u00a0calcium\u00a0in the blood vessel wall, leads to enlarging and painful ulcers in the skin.<\/p>\n\n\n\n<p>Impaired kidney function in severe anticoagulation and the presence of blood in the urine (anticoagulation-related nephropathy\u00a0).<\/p>\n\n\n\n<p><strong>Reporting of\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>If you get\u00a0side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to\u00a0side effects\u00a0that are not mentioned in this information.\u00a0You can also report\u00a0side effects\u00a0directly to:<\/p>\n\n\n\n<p>The Swedish Medicines Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<p><a href=\"http:\/\/www.lakemedelsverket.se\/\" target=\"_blank\" rel=\"noreferrer noopener\">www.lakemedelsverket.se<\/a><\/p>\n\n\n\n<p>By reporting\u00a0side effects, you can contribute to increasing information about drug safety.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Warfarin Orion<\/h2>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p><br>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p><br>Use before the expiry date stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><br>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is 2.5 mg of warfarin sodium per tablet.<\/li><li>Other ingredients are\u00a0lactose, corn starch, calcium phosphate, povidone, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>White to off-white, round biconvex uncoated tablet, 7 mm in diameter.&nbsp;Cross notches on both sides.<\/p>\n\n\n\n<p>The tablet can be divided into two equal parts.<\/p>\n\n\n\n<p>Package size:<br>100 tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Orion Corporation<br>Orionintie 1<br>FI- 02200 Espoo<br>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Joensuunkatu 7<\/p>\n\n\n\n<p>FI-24100 Salo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information about this medicine, contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Denmark:&nbsp;Warfarin&nbsp;Orion<\/p>\n\n\n\n<p>Norway:\u00a0Warfarin\u00a0Orion 2.5 mg tablets<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Warfarin\u00a0Orion is used to prevent or treat blood clots or their complications.\u00a0Warfarin\u00a0Orion reduces the risk of blood clots.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22503],"tags":[27837,27840,27838,27834,27832,27833,27841,27835,27839,27836],"class_list":["post-31526","post","type-post","status-publish","format-standard","hentry","category-medicines","category-w","tag-warfarin-orion","tag-warfarin-orion-side-effects","tag-warfarin-orion-tablet","tag-warfarin-sodium","tag-warfarin-sodium-side-effects","tag-warfarin-sodium-tablet","tag-what-is-warfarin-orion","tag-what-is-warfarin-sodium","tag-what-warfarin-orion-is-used-for","tag-what-warfarin-sodium-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31526"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31526\/revisions"}],"predecessor-version":[{"id":31559,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31526\/revisions\/31559"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}