{"id":31522,"date":"2022-11-10T12:16:46","date_gmt":"2022-11-10T12:16:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31522"},"modified":"2022-11-11T10:26:30","modified_gmt":"2022-11-11T10:26:30","slug":"wakix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/wakix\/","title":{"rendered":"Wakix &#8211; Pitolisant uses, dose and side effects"},"content":{"rendered":"\n<p>4.5 mg and 18 mg&nbsp;film-coated tablets<br>pitolisant respectively<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Wakix is \u200b\u200band what it is used for<\/h2>\n\n\n\n<p>Wakix contains the active substance pitolisant.\u00a0It is a drug used to treat adult patients with\u00a0narcolepsy, with or without\u00a0cataplexy.<\/p>\n\n\n\n<p>Narcolepsy\u00a0is a condition that causes excessive daytime sleepiness and a tendency to fall asleep suddenly in inappropriate situations (sleep attacks).\u00a0Cataplexy\u00a0is a sudden muscle weakness or paralysis without loss of consciousness in response to a sudden emotional reaction, e.g.\u00a0anger, fear, joy, laughter, or surprise.<\/p>\n\n\n\n<p>The active substance, pitolisant, attacks the\u00a0receptors\u00a0on the cells in the brain that stimulate wakefulness.\u00a0This helps combat daytime sleepiness and\u00a0cataplexy\u00a0and promotes alertness.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Wakix<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Wakix:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to pitolisant or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have severe liver problems, pitolisant is normally broken down in the liver and high levels may accumulate in patients whose liver function is severely impaired.<\/li><li>If you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Wakix if any of the situations below apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have ever had anxiety or depression with suicidal thoughts?<\/li><li>You have liver or kidney problems, and your\u00a0dose\u00a0may need to be adjusted.<\/li><li>You have a\u00a0stomach ulcer\u00a0or are taking medicines that can irritate the stomach, e.g.\u00a0medicines against\u00a0inflammation, as\u00a0side effects\u00a0in the gastrointestinal tract have been reported with Wakix.<\/li><li>You suffer from obesity or\u00a0anorexia, as your body weight may change (increase or decrease) when taking Wakix.<\/li><li>You have heart problems.\u00a0Your doctor must check this regularly while you are taking Wakix.<\/li><li>You have severe epilepsy.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Wakix if any of these apply to you.<\/p>\n\n\n\n<p>Other things to talk to your doctor or pharmacist about:<\/p>\n\n\n\n<p>Some people with mental illnesses have been reported to have suicidal thoughts while taking this medicine.&nbsp;Tell your doctor straight away if you notice that you are becoming depressed or have suicidal thoughts (see section 4).&nbsp;You may want to ask a family member or close friend to help you spot signs of depression or other changes in your behavior.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Wakix should not be taken by children and adolescents.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Wakix<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Wakix can affect the way other medicines work, and other medicines can affect how Wakix works.\u00a0The doctor may need to adjust your\u00a0dose.<\/p>\n\n\n\n<p>In particular, you should be careful if you take Wakix together with certain antidepressants (eg imipramine, clomipramine, and mirtazapine) and certain medicines for the treatment of allergic conditions (\u00a0antihistamines, eg pheniramine maleate, chlorpheniramine, diphenhydramine, promethazine, mepyramine, doxylamine).<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking any of the following medicines: rifampicin (an&nbsp;antibiotic&nbsp;),&nbsp;phenytoin&nbsp;, carbamazepine and phenobarbital (mainly used to control seizures),&nbsp;quinidine&nbsp;,&nbsp;digoxin&nbsp;(used to treat abnormal heart rhythms),&nbsp;paroxetine&nbsp;,&nbsp;fluoxetine&nbsp;,&nbsp;venlafaxine&nbsp;, duloxetine (anti-depressant),&nbsp;St. John&nbsp;&#8216;s wort (&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) a natural remedy for mild depression and mild anxiety, bupropion (an anti-depressant or smoking cessation agent), cinacalcet (used to treat parathyroid disorders), terbinafine (used to treat fungal infections ),metformin&nbsp;, repaglinide (used to treat&nbsp;diabetes&nbsp;), docetaxel, irinotecan (used to treat cancer), cisapride (used to treat acid reflux), pimozide (used to treat certain mental illnesses), halofantrine (used to treat&nbsp;malaria&nbsp;) , efavirenz (antiviral medicine to treat&nbsp;HIV&nbsp;), morphine,&nbsp;paracetamol&nbsp;(used to treat pain), dabigatran (used to treat problems with the veins),&nbsp;warfarin&nbsp;(used to treat heart disease), probenecid (used to treat&nbsp;gout&nbsp;and gouty arthritis ).&nbsp;Pitolisant can be used with modafinil and sodium oxybate.<\/p>\n\n\n\n<p>Wakix can reduce the effectiveness of hormonal contraceptives and therefore an alternative effective contraceptive must be used (see section &#8220;Pregnancy&#8221;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Wakix should not be used during pregnancy unless prescribed by the doctor.\u00a0There is not enough information to determine whether there are any particular risks associated with the use of Wakix during pregnancy.\u00a0If you are a woman, you must use contraception during your treatment with Wakix and for at least another 21 days after treatment.\u00a0As Wakix can reduce the effectiveness of hormonal contraceptives, an alternative effective contraceptive must be used.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Wakix is \u200b\u200bexcreted in the breast milk of animals.&nbsp;Patients taking Wakix must stop breastfeeding.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You should be careful with activities that require attention, e.g.\u00a0driving vehicles and using machines.\u00a0Talk to your doctor if you are not sure whether your condition hurts your ability to drive.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Wakix<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Treatment normally starts with a\u00a0dose\u00a0of 9 mg once a day and is gradually increased over three weeks to a suitable\u00a0dose.\u00a0Your doctor may increase or decrease your\u00a0dose\u00a0at any time depending on how well the medicine works for you and how well you tolerate it.<\/p>\n\n\n\n<p>It may take a few days before you notice any effect of the medicine, and the greatest effect usually appears after a few weeks.<\/p>\n\n\n\n<p>Do not change the&nbsp;dose&nbsp;of Wakix on your own.&nbsp;Any change in&nbsp;dosage&nbsp;must be prescribed and supervised by a physician.<\/p>\n\n\n\n<p>For a 4.5 mg\u00a0dose, take one 4.5 mg tablet.<\/p>\n\n\n\n<p>For a 9 mg\u00a0dose, take two 4.5 mg tablets.<\/p>\n\n\n\n<p>For an 18 mg\u00a0dose, take one 18 mg tablet.<\/p>\n\n\n\n<p>For a 36 mg\u00a0dose, take two 18 mg tablets.<\/p>\n\n\n\n<p>Take Wakix once a day by mouth, in the morning with breakfast.<\/p>\n\n\n\n<p>Do not take a&nbsp;dose&nbsp;of Wakix in the afternoon, as it may make it difficult to sleep.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Wakix<\/h2>\n\n\n\n<p>If you have taken too many Wakix tablets, immediately contact the emergency department of the nearest hospital or tell your doctor or pharmacist.\u00a0You may get a headache, abdominal pain, and feel nauseous, or irritable.\u00a0You may also have difficulty sleeping.\u00a0Take this leaflet and any remaining tablets with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Wakix<\/h2>\n\n\n\n<p>If you forget to take your medicine, take the next\u00a0dose\u00a0at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Wakix<\/h2>\n\n\n\n<p>You should continue to take Wakix as long as your doctor has instructed.&nbsp;Do not suddenly stop taking Wakix on your own.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>This medicine can cause\u00a0side effectslike all medicines, although not everybody gets them.\u00a0Contact a doctor if you experience any\u00a0side effects.<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty sleeping, anxiety, irritation, depression, sleep problems<\/li><li>Headache, a feeling of &#8220;spinning&#8221; (dizziness), poor balance, tremors<\/li><li>Nausea, vomiting, digestive problems<\/li><li>Fatigue (exhaustion)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sweating<\/li><li>Decreased or increased appetite<\/li><li>Edema<\/li><li>Jerking, nervousness, seeing or hearing things that aren&#8217;t there<\/li><li>Alternating emotional states<\/li><li>Abnormal dreams<\/li><li>Voltage<\/li><li>Difficulty falling asleep at the beginning of the night or in the middle of the night or towards the end of the night, difficulty staying asleep, extensive sleepiness, morbid fatigue (\u00a0somnolence\u00a0)<\/li><li>State of indifference with a lack of emotions<\/li><li>Nightmares<\/li><li>Restlessness and inability to stay still<\/li><li>Panic reaction<\/li><li>Suicidal thoughts<\/li><li>Changed or increased interest in sex<\/li><li>Sudden and transient episodes of muscle weakness, uncontrollable muscle twitching or movement in one leg<\/li><li>Attention deficit disorder<\/li><li>Migraine<\/li><li>Epilepsy<\/li><li>Weakness<\/li><li>Movement disorder, slow body movements<\/li><li>A sensation of tingling, tickling, stinging, or burning in the skin<\/li><li>Sudden and unpredictable phases of mobility and immobility<\/li><li>A feeling of being unsteady<\/li><li>Decreased\u00a0visual acuity, abnormal contractions, or twitching of the eyelids<\/li><li>Hearing sounds when there are no external sounds<\/li><li>Abnormal heartbeats, slow or fast heart rate, increased or decreased blood pressure, hot flashes<\/li><li>Yawns<\/li><li>Dry mouth<\/li><li>Diarrhea, abdominal pain, discomfort or pain in the stomach (abdomen), constipation, heartburn, stomach pain and discomfort,\u00a0inflammation of the\u00a0lining\u00a0of the stomach\u00a0(\u00a0gastritis\u00a0), high acidity in the gastrointestinal tract<\/li><li>Itching, a facial skin condition where the nose and cheeks are unusually red, profuse sweating<\/li><li>Joint pain, back pain, muscle stiffness, muscle weakness, pain in muscles and bones, pain in toes and fingers<\/li><li>Abnormal urination<\/li><li>Irregular bleeding from the uterus<\/li><li>Loss of strength or extreme tiredness, chest pain, malaise, edema<\/li><li>Weight gain, weight loss, abnormal\u00a0ECG\u00a0values \u200b\u200bfor the heart, abnormal blood values \u200b\u200brelated to liver function.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased appetite, increased appetite<\/li><li>Abnormal behavior, confusion, low mood, irritability, emotional and mental discomfort, a feeling of seeing or hearing things that are not there while sleeping<\/li><li>Unconsciousness, tension headaches, memory problems, poor sleep quality<\/li><li>Abdominal discomfort, difficulty swallowing or pain when swallowing, flatulence,\u00a0inflammation\u00a0of the digestive system<\/li><li>Skin infection, abnormally high sensitivity to sunlight<\/li><li>Neck pain, chest pain<\/li><li>Spontaneous abortion<\/li><li>Pain, night sweats, heaviness<\/li><li>High blood levels of the\u00a0enzyme\u00a0creatinine phosphokinase, abnormal general condition, altered electrical recording of the heart (\u00a0ECG\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Wakix<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is pitolisant.<\/p>\n\n\n\n<p><em>Wakix 4.5 mg tablet<\/em><\/p>\n\n\n\n<p>Each tablet contains pitolisant hydrochloride, equivalent to 4.45 mg pitolisant<\/p>\n\n\n\n<p><em>Wakix 18 mg tablet<\/em><\/p>\n\n\n\n<p>Each tablet contains pitolisant hydrochloride, equivalent to 17.8 mg pitolisant<\/p>\n\n\n\n<p>Other ingredients are microcrystalline cellulose, crospovidone (type A), talc, magnesium stearate,&nbsp;colloidal&nbsp;anhydrous silica, poly(vinyl alcohol), titanium dioxide<\/p>\n\n\n\n<p>(E 171), macrogol 3350.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Wakix 4.5 mg is a white, round, coated tablet of 3.7 mm, biconvex, and marked with &#8220;5&#8221; on one side.<\/p>\n\n\n\n<p>Wakix 18 mg is a white, round, coated tablet of 7.5 mm, biconvex, and marked with &#8220;20&#8221; on one side.<\/p>\n\n\n\n<p>Wakix is \u200b\u200bsupplied in a jar of 30 or 90 tablets.<\/p>\n\n\n\n<p>Wakix 4.5 mg: Available in packs of 1 jar of 30 tablets.<\/p>\n\n\n\n<p>Wakix 18 mg: Available in packs of 1 jar of 30 tablets or packs of 1 jar of 90 tablets, or multipacks of 90 (3 jars of 30) tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Bio project Pharma<\/p>\n\n\n\n<p>9, rue Rameau<\/p>\n\n\n\n<p>75002 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p><em>Wakix 18 mg<\/em><\/p>\n\n\n\n<p>Pharmacy<\/p>\n\n\n\n<p>ZI N\u00b02 de Prouvy-Rouvignies<\/p>\n\n\n\n<p>1 rue Nungesser<\/p>\n\n\n\n<p>59121 Prouvy<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><em>Wakix 4.5 mg<\/em><\/p>\n\n\n\n<p>Patheon<\/p>\n\n\n\n<p>40 Boulevard de Champaret<\/p>\n\n\n\n<p>38300 Bourgoin-Jallieu<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Bioproject Benelux0032(0)78050202<a href=\"http:\/\/info@bioprojet.be\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@bioprojet.be<\/a><\/td><td><strong>Lithuania<\/strong>AOP Orphan Pharmaceuticals GmbH00370 672 12222<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Bulgaria<\/strong>AOP Orphan Pharmaceuticals GmbH00359 88 6666096<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>Luxembourg\/Luxemburg<\/strong><br>Bioproject Benelux0032(0)78050202<a href=\"http:\/\/info@bioprojet.be\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@bioprojet.be<\/a><\/td><\/tr><tr><td><strong>Czech Republic<\/strong>AOP Orphan Pharmaceuticals GmbH00420 251 512 947<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>Magyarorsz\u00e1g<\/strong>AOP Orphan Pharmaceuticals GmbH0036 1 3192633<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Denmark<\/strong>AOP Orphan Pharmaceuticals GmbH0046 70578 61 00<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>Malta<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><\/tr><tr><td><strong>Deutschland<\/strong>Bioprojet Deutschland GmbH030\/3465 5460-0<a href=\"http:\/\/info@bioprojet.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@bioprojet.de<\/a><\/td><td><strong>The Netherlands<\/strong>Bioprojet Benelux NV088 34 34 100<a href=\"http:\/\/info@bioprojet.nl\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@bioprojet.nl<\/a><\/td><\/tr><tr><td><strong>Estonia<\/strong>AOP Orphan Pharmaceuticals GmbH00370 672 12222<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>Norway<\/strong>AOP Orphan Pharmaceuticals GmbH0046 70578 61 00<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Greece<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><td><strong>Austria<\/strong>AOP Orphan Pharmaceuticals GmbH0043 1 503 72 44<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Spain<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><td><strong>Polish<\/strong>AOP Orphan Pharmaceuticals GmbH0048 22 542 81 80<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>France<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><td><strong>Portugal<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><\/tr><tr><td><strong>Hrvatska<\/strong>AOP Orphan Pharmaceuticals GmbH0043 1 503 72 44<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>Romania<\/strong>AOP Orphan Pharmaceuticals GmbH00407 303 522 42<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Ireland<\/strong>Lincoln Medical Ltd.0330 1003684<a href=\"http:\/\/info@lincolnmedical.co.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@lincolnmedical.co.uk<\/a><\/td><td><strong>Slovenija<\/strong>AOP Orphan Pharmaceuticals GmbH0043 1 503 72 44<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Iceland<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><td><strong>Slovenian Republic<\/strong>AOP Orphan Pharmaceuticals GmbH00421 902 566 333<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Italy<\/strong>Bioprojet Italia srl+39 02 84254830<a href=\"http:\/\/info@bioprojet-italia.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@bioprojet.it<\/a><\/td><td><strong>Finland\/Finland<\/strong>AOP Orphan Pharmaceuticals GmbH0046 70578 61 00<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Cyprus<\/strong>Bioproject Pharma0033 (0)1 47 03 66 33<a href=\"http:\/\/contact@bioprojet.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">contact@bioprojet.com<\/a><\/td><td><strong>Sweden<\/strong>AOP Orphan Pharmaceuticals GmbH0046 70578 61 00<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><\/tr><tr><td><strong>Latvia<\/strong>AOP Orphan Pharmaceuticals GmbH00370 672 12222<a href=\"http:\/\/office@aoporphan.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">office@aoporphan.com<\/a><\/td><td><strong>United Kingdom<\/strong>Lincoln Medical Ltd.0330 1003684<a href=\"http:\/\/info@lincolnmedical.co.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">info@lincolnmedical.co.uk<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Wakix contains the active substance pitolisant.\u00a0It is a drug used to treat adult patients with\u00a0narcolepsy\u00a0, with or without\u00a0cataplexy\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22503],"tags":[27846,27849,27850,27852,27855,27854,27847,27851,27848,27853],"class_list":["post-31522","post","type-post","status-publish","format-standard","hentry","category-medicines","category-w","tag-pitolisant","tag-pitolisant-side-effects","tag-pitolisant-tablet","tag-wakix","tag-wakix-side-effects","tag-wakix-tablet","tag-what-is-pitolisant","tag-what-is-wakix","tag-what-pitolisant-is-used-for","tag-what-wakix-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31522"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31522\/revisions"}],"predecessor-version":[{"id":31561,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31522\/revisions\/31561"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}