{"id":31520,"date":"2022-11-10T12:14:52","date_gmt":"2022-11-10T12:14:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31520"},"modified":"2022-11-11T10:26:46","modified_gmt":"2022-11-11T10:26:46","slug":"vyxeos-liposomal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vyxeos-liposomal\/","title":{"rendered":"Vyxeos liposomal &#8211; Daunorubicin and cytarabine uses, dose and side effects"},"content":{"rendered":"\n<p>44 mg\/100 mg\u00a0powder for concentrate for\u00a0infusion solution, solution<br>daunorubicin and cytarabine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vyxeos liposomal is and what it is used for<\/h2>\n\n\n\n<p><strong>What Vyxeos&nbsp;<\/strong><strong>liposomal&nbsp;<\/strong><strong>is<\/strong><\/p>\n\n\n\n<p>Vyxeos liposomal\u00a0belongs to a group of medicines called antineoplastic and are used in cancer.\u00a0It contains two active substances called daunorubicin and cytarabine, in the form of very small particles called\u00a0liposomes.\u00a0These active substances work in different ways to kill cancer cells by preventing them from growing and dividing.\u00a0By packing them in\u00a0liposomes, their effect on the body is extended and makes it easier to penetrate and kill cancer cells.<\/p>\n\n\n\n<p><strong>What Vyxeos&nbsp;<\/strong><strong>liposomal&nbsp;<\/strong><strong>is used for<\/strong><\/p>\n\n\n\n<p>Vyxeos liposomal&nbsp;<strong><\/strong>is used to treat patients with newly diagnosed&nbsp;acute myeloid leukemia&nbsp;(a cancer of the white&nbsp;blood cells&nbsp;).&nbsp;It is given when the leukemia was caused by previous treatment (called therapy-related&nbsp;acute myeloid leukemia&nbsp;) or when there are special changes in the&nbsp;bone marrow&nbsp;(called&nbsp;acute myeloid leukemia&nbsp;with myelodysplasia-related changes).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Vyxeos liposomal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be given Vyxeos liposomal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to active substances (daunorubicin or cytarabine) or any other ingredient in this medicine (listed in section 6)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>The doctor will monitor you during treatment.&nbsp;Talk to your doctor or nurse before you are given Vyxeos liposomal:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have a low number of\u00a0platelets\u00a0(\u00a0thrombocytes\u00a0), and red or\u00a0white blood cells\u00a0in your blood (you must submit a blood sample before you can start the treatment).\u00a0If this applies to you:<ul><li>The doctor may also give you medicine to prevent you from getting an\u00a0infection.<\/li><li>the doctor will also check you for\u00a0infection\u00a0during treatment.<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have ever had heart problems or a heart attack, or if you have previously taken\u00a0anthracyclines\u00a0(cancer medicines).\u00a0If any of these apply to you, your doctor may check your heart before and during treatment.<\/li><li>If you think you may be pregnant.\u00a0You must use an effective method of contraception so that (you or your partner) do not become pregnant during treatment and for 6 months after the last\u00a0dose.<\/li><li>If you get allergic (hypersensitivity) reactions.\u00a0The doctor can pause or stop the treatment or give the drop more slowly if hypersensitivity occurs.<\/li><li>If you have had problems with your kidneys or liver.\u00a0The doctor will monitor you during the treatment.<\/li><li>If you have ever had a condition called Wilson&#8217;s disease or other copper-related diseases because Vyxeos liposomal contains a substance called copper gluconate.<\/li><li>If you are to be given a vaccine.<\/li><\/ul>\n\n\n\n<p>The doctor will monitor your general health during treatment and may also give you other medicines to support treatment, either before or together with Vyxeos liposomal.&nbsp;If any of the above apply to you (or if you are not sure), talk to your doctor, pharmacist or nurse before you are given Vyxeos liposomal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Vyxeos liposomal is not recommended for children and adolescents under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vyxeos liposomal<\/h2>\n\n\n\n<p>Tell the doctor or nurse if you are using, have recently used, or might be using other medicines.\u00a0This is because Vyxeos liposomal can affect how other medicines work.\u00a0Other medicines can also affect how Vyxeos liposomal works.<\/p>\n\n\n\n<p>In particular, tell the doctor or nurse if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cancer medicines that can affect the heart, such as doxorubicin<\/li><li>medications that can affect the liver.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You should not use Vyxeos liposomal during pregnancy as it may be harmful to the baby.&nbsp;Use an effective method of contraception during treatment and for 6 months after treatment.&nbsp;Tell your doctor immediately if you become pregnant during treatment.<\/p>\n\n\n\n<p>You should not breastfeed while receiving treatment with Vyxeos liposomal as it may be harmful to the baby.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You may feel tired or dizzy after receiving Vyxeos liposomal.&nbsp;If this happens, do not drive or use tools or machines.<a><\/a><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How you are given Vyxeos liposomal<\/h2>\n\n\n\n<p>Vyxeos liposomal must be given by a doctor or nurse experienced in the treatment of AML.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>It is given as a drip (&nbsp;infusion&nbsp;) into a vein.<\/li><li>Infusion&nbsp;one is given over 1\u00bd hours (90 minutes).<\/li><\/ul>\n\n\n\n<p>The doctor or nurse calculates the drug dose based on your weight and height.&nbsp;You receive the treatment in courses.&nbsp;Each course is given as a separate&nbsp;infusion&nbsp;and given weeks apart.<\/p>\n\n\n\n<p>You receive an initial course of treatment and then the doctor decides whether you should receive further courses of treatment depending on how you react to the treatment and any&nbsp;side effects&nbsp;you experience.&nbsp;The doctor will assess how you react to the treatment after each course.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>During the first course, you will receive an\u00a0infusion\u00a0on days 1, 3, and 5.<\/li><li>In subsequent courses, you receive\u00a0an infusion\u00a0on days 1 and 3. This can be repeated if necessary.<\/li><\/ul>\n\n\n\n<p>When you receive treatment with Vyxeos liposomal, your doctor will regularly take blood samples to assess how you respond to the treatment and check how well you are tolerating it.&nbsp;The doctor may also check the heart as it may be affected by Vyxeos liposomal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you are given too much Vyxeos liposomal<\/h2>\n\n\n\n<p>You will be given this medicine in a hospital by a doctor or nurse.&nbsp;It is unlikely that you will be given too much, but tell the doctor or nurse if you are worried.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget a visit<\/h2>\n\n\n\n<p>Contact a doctor or nurse as soon as possible.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;that may affect more than 1 in 10 users (very common)<\/strong><\/p>\n\n\n\n<p>Vyxeos liposomal can reduce the number of\u00a0white blood cells, which fight\u00a0infection, and also the\u00a0blood cells\u00a0that help the blood to clot (\u00a0platelets\u00a0) which leads to bleeding disorders such as nosebleeds and bruising.\u00a0Vyxeos liposomal can also cause heart problems and damage the heart muscle.<\/p>\n\n\n\n<p>Therefore<strong>, you must immediately contact a doctor<\/strong>\u00a0if you experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever, chills, sore throat, cough, mouth sores, or other symptoms of infection<\/li><li>bleeding or bruising without injury<\/li><li>chest pain or leg pain<\/li><li>respiratory distress.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get any of the&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;<\/strong>side effects&nbsp;(may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced number of\u00a0platelets\u00a0(cells that help the blood to clot) which may cause bruising or bleeding<\/li><li>fever, often with other signs of\u00a0infection\u00a0due to very low\u00a0white blood cell count\u00a0(febrile\u00a0neutropenia\u00a0)<\/li><li>slow, fast or irregular heartbeat, chest pain (which may be a sign of\u00a0infection\u00a0)<\/li><li>vision problems, blurred vision<\/li><li>pain or swelling of the lining of the digestive system (\u00a0mucositis\u00a0), or abdominal (stomach) pain, constipation, loss of appetite, diarrhea, nausea, or vomiting<\/li><li>skin redness, rash, muscle pain, headache, bone pain, joint pain, tiredness, and general swelling including swelling of arms and legs<\/li><li>headache, dizziness, confusion, difficulty sleeping, anxiety<\/li><li>kidney failure<\/li><li>shortness of breath, cough, fluid in the lungs<\/li><li>itching<\/li><li>bleeding<\/li><li>increased\u00a0blood pressure\u00a0or drop in blood pressure<\/li><li>chills, low or high body temperature<\/li><li>increased sweating.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;) and lead to fatigue and weakness<\/li><li>kidney failure&nbsp;and abnormal blood tests due to many cancer cells dying (tumor lysis syndrome)<\/li><li>stomach cramps or severe gas<\/li><li>profuse sweating at night<\/li><li>hair loss.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>numbness and rash in the hands and feet (palmoplantar erythrodysesthesia syndrome).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vyxeos liposomal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Use before the expiry date stated on the carton and vial after Utg.dat\/EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2\u00b0C to 8\u00b0C)<\/li><li>Store the vial in the outer carton.\u00a0Light sensitive.<\/li><li>Store in an upright position.<\/li><li>After dilution, vials of reconstituted Vyxeos liposomal should be stored in a refrigerator (2\u00b0C to 8\u00b0C) for up to 4 hours in an upright position.<\/li><li>After dilution, infusion bags should be stored in a refrigerator (2\u00b0C to 8\u00b0C) for up to 4 hours.\u00a0The maximum combined storage time for a reconstituted medicinal product in\u00a0a vial\u00a0stored in an upright position and reconstituted medicinal product that has been diluted in an\u00a0infusion bag\u00a0should not exceed 4 hours.\u00a0The infusion time of 90 minutes applies in addition to the storage time of up to 4 hours.<\/li><li>Do not use this medicine if you see particles in the diluted solution.<\/li><li>Medicines should not be thrown down the drain.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are daunorubicin and cytarabine.\u00a0Each 50 ml\u00a0vial\u00a0contains 44 mg daunorubicin and 100 mg cytarabine.<\/li><li>After\u00a0preparation, the solution contains 2.2 mg\/ml daunorubicin and 5 mg\/ml cytarabine encapsulated in\u00a0liposomes.<\/li><li>Other ingredients are di-stearoyl phosphatidylcholine, di-stearoyl phosphatidylglycerol,\u00a0cholesterol\u00a0, copper gluconate, trolamine, and sucrose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vyxeos liposomal is a purple powder to concentrate for solution for\u00a0infusion\u00a0supplied in a\u00a0glass\u00a0vial.<\/p>\n\n\n\n<p>Each pack contains 1, 2, or 5 vials.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Jazz Pharmaceuticals Ireland Ltd<\/p>\n\n\n\n<p>5th Floor<\/p>\n\n\n\n<p>Waterloo Exchange<\/p>\n\n\n\n<p>Waterloo Road<\/p>\n\n\n\n<p>Dublin<\/p>\n\n\n\n<p>D04 E5W7<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Phone: +353 1 968 1631<\/p>\n\n\n\n<p>(local telephone number within the Republic of Ireland)<\/p>\n\n\n\n<p>(outside the Republic of Ireland an international call charge may apply)<\/p>\n\n\n\n<p>email: medinfo-int@jazzpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vyxeos liposomal\u00a0belongs to a group of medicines called antineoplastic and are used in cancer.\u00a0It contains two active substances called daunorubicin and cytarabine, in the form of very small particles called\u00a0liposomes\u00a0.\u00a0These active substances work in different ways to kill cancer cells by preventing them from growing and dividing.\u00a0By packing them in\u00a0liposomes\u00a0, their effect in the body is extended and makes it easier to penetrate and kill cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27859,6232,6234,7412,7414,27857,27862,27863,27861,6233,27860,27856,27858],"class_list":["post-31520","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-vyxeos-liposomal","tag-cytarabine","tag-cytarabine-side-effects","tag-daunorubicin","tag-daunorubicin-side-effects","tag-vyxeos-liposomal","tag-vyxeos-liposomal-side-effects","tag-what-cytarabine-is-used-for","tag-what-daunorubicin-is-used-for","tag-what-is-cytarabine","tag-what-is-daunorubicin","tag-what-is-vyxeos-liposomal","tag-what-vyxeos-liposomal-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31520"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31520\/revisions"}],"predecessor-version":[{"id":31562,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31520\/revisions\/31562"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}