{"id":31516,"date":"2022-11-10T12:09:56","date_gmt":"2022-11-10T12:09:56","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31516"},"modified":"2022-11-11T10:27:08","modified_gmt":"2022-11-11T10:27:08","slug":"vyepti","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vyepti\/","title":{"rendered":"Vyepti &#8211; Eptinezumab uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;Concentrate for&nbsp;infusion&nbsp;solution<br>eptinezumab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What VYEPTI is and what it is used for<\/h2>\n\n\n\n<p>VYEPTI contains the active substance eptinezumab, which prevents the activity of calcitonin gene-related&nbsp;peptide&nbsp;er (CGRP), a substance that occurs naturally in the body.&nbsp;People with&nbsp;migraines&nbsp;may have elevated levels of this substance.<\/p>\n\n\n\n<p>VYEPTI is used to&nbsp;<strong>prevent&nbsp;migraines<\/strong>&nbsp;in adults who have at least 4 migraine days per month.<\/p>\n\n\n\n<p>VYEPTI can reduce the number of&nbsp;migraine&nbsp;days and improve your quality of life.&nbsp;You can feel the preventive effect starting the day after you receive this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive VYEPTI<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use VYEPTI<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to eptinezumab or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving VYEPTI if you have a disease that affects the heart and blood vessels.<\/p>\n\n\n\n<p>VYEPTI can cause serious allergic reactions.\u00a0Such reactions can develop quickly, and can then also occur while the medicine is being given.\u00a0Tell your doctor right away if you get any symptoms of an\u00a0allergic reaction, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>breathing difficulties<\/li><li>fast or weak\u00a0pulse\u00a0or a sudden drop in blood pressure that makes you feel dizzy or light-headed<\/li><li>swelling of the lips or tongue<\/li><li>severe skin\u00a0itching\u00a0or rash while receiving VYEPTI, or afterward<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>VYEPTI is not recommended for children and adolescents under 18 years of age because it has not been studied in these age groups.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and VYEPTI<\/h2>\n\n\n\n<p>Tell your doctor if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving this medicine.<\/p>\n\n\n\n<p>Use of VYEPTI should preferably be avoided during pregnancy as the effects of this drug in pregnant women are unknown.<\/p>\n\n\n\n<p>It is unknown if VYEPTI passes into breast milk.\u00a0Doctors will help you decide if you should stop breastfeeding or if treatment with VYEPTI should be stopped.\u00a0If you are breastfeeding or plan to breastfeed, talk to your doctor before receiving treatment with VYEPTI.\u00a0You and the doctor should decide together whether you should breastfeed while receiving therapy with VYEPTI.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>VYEPTI has no or negligible effect on the ability to drive and use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">VYEPTI contains sorbitol<\/h2>\n\n\n\n<p>Sorbitol is a source of fructose.\u00a0If you have hereditary\u00a0fructose intolerance, a rare, hereditary disease, you should not receive this medicine.\u00a0Fructose cannot be broken down in patients with hereditary\u00a0fructose intolerance, which can cause serious\u00a0side effects.<\/p>\n\n\n\n<p>If you have hereditary\u00a0fructose intolerance, you must tell your doctor before receiving this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use VYEPTI<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>VYEPTI is given as a drip (\u00a0infusion\u00a0) into a vein.\u00a0Infusion\u00a0one takes about 30 minutes.\u00a0You will be given VYEPTI by healthcare professionals who prepare\u00a0an infusion\u00a0before they give it to you.\u00a0During and after the\u00a0infusion, the healthcare professional will, according to standard clinical\u00a0practice, monitor you for signs of an\u00a0allergic reaction.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 100 mg given every 12 weeks.&nbsp;Some patients may benefit from a&nbsp;dose&nbsp;of 300 mg given every 12 weeks.&nbsp;The doctor will decide the right&nbsp;dose&nbsp;for you and how long you should continue the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much VYEPTI&nbsp;<\/h2>\n\n\n\n<p>As you will be given the medicine by your healthcare professional, it is unlikely that you will be given too much VYEPTI.&nbsp;Tell your doctor if you think this has happened.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use VYEPTI<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, the doctor will decide when the next\u00a0dose\u00a0should be given.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact a doctor or nurse immediately<\/strong>\u00a0if you notice any of the following\u00a0side effects, you may need\u00a0emergency\u00a0medical treatment:<\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>allergic reaction\u00a0and other\u00a0side effects\u00a0as a result of\u00a0infusion\u00a0reactions<\/strong> can develop rapidly during\u00a0infusion\u00a0one.\u00a0Symptoms of an allergic reaction:<ul><li>breathing difficulties<\/li><li>fast or weak\u00a0pulse<\/li><li>a sudden drop in blood pressure that makes you feel dizzy or light-headed<\/li><li>swelling of the lips or tongue<\/li><li>severe\u00a0itching\u00a0of the skin, rash serious allergic reactions are less common (may affect up to 1 in 100 users).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Other symptoms that may occur due to the\u00a0infusion\u00a0include respiratory symptoms (for example, stuffy or runny nose, throat irritation, coughing, sneezing, and shortness of breath) and feeling tired.\u00a0These symptoms are usually mild and pass quickly.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;can occur with the following frequency:<\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nasal congestion<\/li><li>sore throat<\/li><li>pronounced fatigue<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store VYEPTI<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label and carton after &#8220;Expiry date&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C &#8211; 8 \u00b0C).<\/p>\n\n\n\n<p>Do not freeze or shake.<\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>After dilution, the solution can be stored at room temperature (below 25 \u00b0C) or in a refrigerator at 2 \u00b0C &#8211; 8 \u00b0C.&nbsp;The diluted infusion solution must be given within 8 hours.<\/p>\n\n\n\n<p>Do not use this medicine if you notice that the solution contains visible particles or is cloudy or discolored.<\/p>\n\n\n\n<p>Medicines should not be thrown down the drain.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is eptinezumab.\u00a0Each\u00a0vial\u00a0of concentrate contains 100 mg eptinezumab per ml.<\/li><li>Other ingredients are sorbitol (E420), L-histidine, L-histidine hydrochloride monohydrate, polysorbate 80, and water for\u00a0injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>VYEPTI concentrate for\u00a0infusion\u00a0is clear to slightly milky, and colorless to brownish yellow.\u00a0Each\u00a0vial\u00a0contains one ml of concentrate in a clear glass\u00a0vial\u00a0with a rubber stopper, aluminum seal, and snap-on cap.<\/p>\n\n\n\n<p>Each pack contains one\u00a0single-use\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>H. Lundbeck A\/S<\/p>\n\n\n\n<p>Ottiliavej 9<\/p>\n\n\n\n<p>2500 Valby<\/p>\n\n\n\n<p>Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>VYEPTI contains the active substance eptinezumab, which prevents the activity of calcitonin gene-related\u00a0peptide\u00a0er (CGRP), a substance that occurs naturally in the body.\u00a0People with\u00a0migraines\u00a0may have elevated levels of this substance.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27877,27883,27874,27879,27875,27882,27878,27876,27880,27881],"class_list":["post-31516","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-eptinezumab","tag-benefits-of-vyepti","tag-eptinezumab","tag-eptinezumab-side-effects","tag-vyepti","tag-vyepti-side-effects","tag-what-eptinezumab-is-used-for","tag-what-is-eptinezumab","tag-what-is-vyepti","tag-what-vyepti-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31516"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31516\/revisions"}],"predecessor-version":[{"id":31564,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31516\/revisions\/31564"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}