{"id":31396,"date":"2022-11-09T07:17:20","date_gmt":"2022-11-09T07:17:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31396"},"modified":"2022-11-10T07:44:17","modified_gmt":"2022-11-10T07:44:17","slug":"votubia","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/votubia\/","title":{"rendered":"Votubia &#8211; Everolimus uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg, 2 mg, 3 mg, and 5 mg\u00a0dispersible tablets<br>everolimus<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Votubia is and what it is used for<\/h2>\n\n\n\n<p>Votubia dispersible tablets contain the active substance everolimus.\u00a0Votubia is used to treat children from the age of 2 and adults with\u00a0partial-onset seizures\u00a0with or without secondary generalization (\u00a0epilepsy\u00a0) associated with a genetic disease called tuberous sclerosis complex (TSC) and when other anti-epileptic drugs\u00a0do not work well enough.\u00a0Partial seizures\u00a0start from one side of the brain but can spread and extend over larger areas on both sides of the brain (so-called &#8220;secondary generalization&#8221;).\u00a0Votubia dispersible tablets are given together with other medicines against\u00a0epilepsy.<\/p>\n\n\n\n<p>Votubia is also an anti-tumour\u00a0drug that can prevent the growth of certain cells in the body.\u00a0It can reduce the size of a type of brain tumor called subependymal giant cell astrocytoma (SEGA), which is also caused by TSC.<\/p>\n\n\n\n<p>Votubia dispersible tablets are used to treat SEGA associated with TSC in adults and children when&nbsp;surgery&nbsp;is not appropriate.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Votubia<\/h2>\n\n\n\n<p>Votubia is only prescribed by doctors with experience in treating patients with SEGA or seizures and who can measure the amount of Votubia in the blood through a blood test.<\/p>\n\n\n\n<p>Follow your doctor&#8217;s instructions carefully.&nbsp;They may differ from the general information contained in this leaflet.&nbsp;If you have any questions about Votubia or why you have been prescribed it, ask your doctor.<\/p>\n\n\n\n<p><strong>Do not take Votubia<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>\u00a0to everolimus or related substances, such as\u00a0sirolimus, temsirolimus, or any other ingredient in this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If you have had allergic reactions before, ask your doctor for advice.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor before taking Votubia:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have problems with your liver or if you have ever had any disease that may have affected your liver.\u00a0In that case, the doctor may need to\u00a0prescribe\u00a0another\u00a0dose\u00a0of Votubia or stop the treatment, either for a shorter period or permanently.<\/li><li>if you have\u00a0diabetes\u00a0(high blood sugar).\u00a0Votubia can increase blood sugar levels and worsen\u00a0diabetes mellitus.\u00a0This may result in the need for\u00a0insulin\u00a0and\/or oral diabetes medication.\u00a0Tell your doctor if you experience any abnormal thirst or need to urinate more often.<\/li><li>if you need to be vaccinated while you are receiving treatment with Votubia, as the vaccination may then be less effective.\u00a0For children with SEGA or seizures, it is important to discuss the childhood vaccination program with the doctor before starting treatment with Votubia.<\/li><li>if you have high cholesterol levels, as Votubia can increase cholesterol levels and\/or other blood fats.<\/li><li>if you have recently had major surgery or if you still have an unhealed wound after surgery.\u00a0Votubia may increase the risk of problems with wound healing.<\/li><li>if you have an\u00a0infection, it may be necessary to treat the\u00a0infection\u00a0before starting treatment with Votubia.<\/li><li>if you previously had\u00a0hepatitis\u00a0B, as the\u00a0infection\u00a0may reoccur during treatment with Votubia (see section 4, Possible\u00a0side effects\u00a0).<\/li><li>if you have received or will receive radiotherapy.<\/li><\/ul>\n\n\n\n<p>Votubia can also:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cause mouth ulcers<\/li><li>weaken your immune system.\u00a0There is therefore a risk that you will get an\u00a0infection\u00a0while you are taking Votubia.\u00a0If you develop a fever or other signs of an\u00a0infection, consult your doctor.\u00a0Some\u00a0infections\u00a0can be severe and can lead to death in adults and children.<\/li><li>affect kidney function.\u00a0Therefore, your doctor will check your kidney function while you are taking Votubia.<\/li><li>cause shortness of breath, cough, and fever (see section 4, Possible\u00a0side effects\u00a0).<\/li><li>cause complications of radiotherapy.\u00a0Severe complications of radiotherapy (such as shortness of breath, nausea, diarrhea, skin rash, and soreness of the mouth, gums, and throat), including death, have been observed in some patients taking everolimus at the same time or shortly after they received radiotherapy at.\u00a0So-called radiation-induced skin reaction (including\u00a0reddening\u00a0of the skin or\u00a0pneumonia\u00a0at the site of the previous radiotherapy) has also been reported in patients who have received the previous radiotherapy. Tell the doctor if you are planning to have radiation therapy shortly or if you have had radiation therapy in the past.<\/li><\/ul>\n\n\n\n<p><strong>Contact your doctor immediately<\/strong>&nbsp;if you experience these symptoms.<\/p>\n\n\n\n<p>Blood samples will be taken before and regularly during the treatment.\u00a0With the help of these, you can check the number of\u00a0blood cells\u00a0(\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets\u00a0) in the body and see if Votubia has any unwanted effect on these cells.\u00a0Blood samples are also taken to check your kidney function (creatinine level, blood urea or\u00a0protein\u00a0in urine), liver function (transaminase levels), and blood sugar and blood lipid levels.\u00a0This is because these can also be affected by Votubia.<\/p>\n\n\n\n<p>Regular blood tests are also necessary to measure how much Votubia is in the blood, as this helps the doctor decide how much Votubia you need to take.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Votubia can be used in children and adolescents with SEGA associated with TSC.<\/p>\n\n\n\n<p>Votubia should not be used in children under 2 years of age with TSC and seizures.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Votubia<\/h2>\n\n\n\n<p>Votubia can affect the way some other medicines work.\u00a0If you take other medicines simultaneously as Votubia, the doctor may need to change the\u00a0dose\u00a0of Votubia or the other medicines.<\/p>\n\n\n\n<p><strong>Tell your doctor or pharmacist<\/strong>\u00a0if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The following may increase the risk of&nbsp;side effects&nbsp;with Votubia:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole, itraconazole, voriconazole, or\u00a0fluconazole,\u00a0and other medicines used to treat fungal infections<\/li><li>clarithromycin, telithromycin, or erythromycin &#8211;\u00a0antibiotics\u00a0used to treat bacterial infections<\/li><li>ritonavir or other medicines used to treat\u00a0HIV\u00a0infection\/AIDS<\/li><li>verapamil or\u00a0diltiazem\u00a0used to treat heart conditions or high\u00a0blood pressure<\/li><li>dronedarone, a medicine that regulates heart rhythm<\/li><li>ciclosporin, a medicine used to prevent the body from rejecting transplanted organs<\/li><li>imatinib, a drug that inhibits the growth of tumor cells<\/li><li>ACE inhibitors (eg ramipril), used to treat high\u00a0blood pressure\u00a0and other cardiovascular diseases<\/li><li>cannabidiol (used, among other things, for the treatment of epileptic seizures)<\/li><\/ul>\n\n\n\n<p>The following may reduce the effect of Votubia:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifampicin \u2011 used to treat\u00a0tuberculosis\u00a0(TB)<\/li><li>efavirenz or nevirapine used to treat\u00a0HIV\u00a0infection\/AIDS<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0), an herbal remedy used to treat depression and other conditions<\/li><li>dexamethasone, a\u00a0corticosteroid\u00a0used to treat several conditions, including inflammation and immune disorders<\/li><li>phenytoin, carbamazepine or phenobarbital, and other\u00a0antiepileptics\u00a0\u2013 used to stop seizures.<\/li><\/ul>\n\n\n\n<p>All medicines listed above should be avoided during treatment with Votubia.\u00a0If you are taking any of these medicines, your doctor may switch you to another drug or change the\u00a0dose\u00a0of Votubia.<\/p>\n\n\n\n<p>If you are taking any medicine for\u00a0epilepsy, a change in the\u00a0dose\u00a0of that medicine (increase or decrease) may make it necessary to change the\u00a0dose\u00a0of Votubia.\u00a0Your doctor will decide this.\u00a0If the\u00a0dose\u00a0of one of your epilepsy medicines is changed, inform your doctor.<\/p>\n\n\n\n<p>Before taking Votubia, tell your doctor if you follow a certain diet to reduce the number of seizures.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Votubia with food and drink<\/h2>\n\n\n\n<p>Avoid grapefruit and grapefruit juice while you are being treated with Votubia.&nbsp;They can increase the amount of Votubia in the blood to a potentially harmful level.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>Votubia can hurt the fetus and is not recommended during pregnancy.\u00a0Tell the doctor if you are pregnant or if you think you may be pregnant.<\/p>\n\n\n\n<p>Women who could become pregnant must use a highly effective method of contraception during treatment and up to 8 weeks after stopping treatment.&nbsp;If, despite these measures, you think you may have become pregnant, consult your doctor&nbsp;<strong>before<\/strong>&nbsp;taking any more Votubia.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>Votubia can hurt children who are breastfed.\u00a0You should not breastfeed during treatment and up to 2 weeks after the last\u00a0dose\u00a0of Votubia.\u00a0Tell the doctor if you are breastfeeding.<\/p>\n\n\n\n<p>Fertility<\/p>\n\n\n\n<p>Votubia can affect&nbsp;fertility&nbsp;in women and men.&nbsp;Talk to your doctor if you want to have children.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>If you feel unusually tired (fatigue is a common side effect), take special care when driving or using machinery.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Votubia contains lactose<\/h2>\n\n\n\n<p>Votubia contains&nbsp;lactose&nbsp;(milk sugar).&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medication.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Votubia<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Votubia is available as tablets and dispersible tablets.&nbsp;Always take either the tablets or the dispersible tablets and never a combination of both.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>What&nbsp;dose&nbsp;of Votubia you should take<\/strong><\/p>\n\n\n\n<p>Your doctor will decide which&nbsp;dose&nbsp;of Votubia you need based on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your age<\/li><li>your body size<\/li><li>liver function<\/li><li>what other medicines you are taking.<\/li><\/ul>\n\n\n\n<p>During treatment with Votubia, blood samples will be taken to measure the amount of Votubia in the blood so that the&nbsp;dose&nbsp;is adapted specifically for you.<\/p>\n\n\n\n<p>If you experience particular&nbsp;side effects&nbsp;(see section 4) while taking Votubia, your doctor may lower your&nbsp;dose&nbsp;or stop treatment, either for a short time or permanently<\/p>\n\n\n\n<p><strong>How to take this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take Votubia dispersible tablets once a day.<\/li><li>Take them at the same time each day.<\/li><li>You can either take them with food and drink or without food and drink, but you should take them the same way every day.<\/li><\/ul>\n\n\n\n<p><strong>Only take Votubia dispersible tablets as an&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<p>Do not chew or crush the dispersible tablets.&nbsp;Do not swallow them whole.&nbsp;You must mix the dispersible tablets with water to form a cloudy liquid (a so-called&nbsp;oral&nbsp;suspension&nbsp;).<\/p>\n\n\n\n<p><strong>How to prepare and take the oral&nbsp;suspension&nbsp;a<\/strong><\/p>\n\n\n\n<p>Prepare the oral\u00a0suspension\u00a0by mixing the dispersible tablets with water, either in an\u00a0oral\u00a0syringe\u00a0or in a small glass.\u00a0After\u00a0preparation, you must drink the\u00a0suspension\u00a0immediately.\u00a0If not taken within 30 minutes when using an\u00a0oral\u00a0syringe\u00a0or within 60 minutes when using a small glass, discard the\u00a0suspension\u00a0and prepare a new one.\u00a0Read the detailed instructions at the end of this leaflet on how to do this.\u00a0Ask your doctor or pharmacist if you are unsure<\/p>\n\n\n\n<p><strong>Important information for caregivers<\/strong><\/p>\n\n\n\n<p>Caregivers should avoid direct contact with\u00a0the suspension\u00a0of one of the Votubia tablets.\u00a0Wash your hands thoroughly before and after\u00a0preparing\u00a0the\u00a0suspension.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Votubia<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have taken too much Votubia, or if someone else accidentally takes your dispersible tablets, contact your doctor or hospital immediately.&nbsp;Urgent medical treatment may be necessary.<\/li><li>Bring the tablet package and this leaflet with you, so that the doctor knows what you have taken.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Votubia<\/h2>\n\n\n\n<p>If you miss a\u00a0dose, take the next\u00a0dose\u00a0as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dispersible\u00a0tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Votubia<\/h2>\n\n\n\n<p>Do not stop taking Votubia dispersible tablets unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>STOP taking Votubia and seek medical help immediately if you or your child experience any of the following signs of an allergic reaction:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing or swallowing<\/li><li>swelling of the face, lips, tongue, or throat (signs of\u00a0angioedema\u00a0)<\/li><li>severe skin itching with red or raised rashes.<\/li><\/ul>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;of Votubia can be:<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(&nbsp;<\/strong>&nbsp;<em>may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever, cough, difficulty breathing, wheezing (signs of&nbsp;pneumonia&nbsp;due to&nbsp;infection&nbsp;&#8211;&nbsp;pneumonia&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(&nbsp;<\/strong>&nbsp;<em>may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling, the feeling of heaviness or tension, pain, limited movement of body parts (this can occur anywhere in the body and is a possible sign of an abnormal accumulation of fluid in soft\u00a0tissue\u00a0due to a blockage in the lymphatic system, called lymphoedema)<\/li><li>rash,\u00a0itching,\u00a0hives, difficulty breathing or swallowing, dizziness (signs of severe\u00a0allergic reaction\u00a0&#8211;\u00a0hypersensitivity reaction\u00a0)<\/li><li>fever, cough, difficulty breathing, and wheezing (signs of\u00a0pneumonia\u00a0&#8211;\u00a0pneumonitis\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(&nbsp;<\/strong>&nbsp;<em>may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash with small fluid-filled blisters on\u00a0reddened\u00a0skin (a sign of viral disease which may be severe &#8211;\u00a0shingles\u00a0)<\/li><li>fever, chills, rapid breathing and heart rate, skin rash, and possible confusion and disorientation (signs of serious\u00a0infection\u00a0&#8211;\u00a0sepsis\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>If you experience any of these\u00a0side effects, talk to your doctor immediately as they can have life-threatening consequences.<\/strong><\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;of Votubia can be:<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(&nbsp;<\/strong>&nbsp;<em>may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract infection<\/li><li>sore throat and runny nose<\/li><li>headache, pressure over eyes, nose, and cheeks (signs of sinusitis)<\/li><li>urinary tract infection<\/li><li>high blood fats (\u00a0hypercholesterolemia\u00a0)<\/li><li>decreased appetite<\/li><li>headache<\/li><li>cough<\/li><li>mouth ulcers<\/li><li>diarrhea<\/li><li>vomiting<\/li><li>acne<\/li><li>rash<\/li><li>feeling of fatigue<\/li><li>fever<\/li><li>menstrual disorders such as missed periods (\u00a0amenorrhea\u00a0) or irregular periods<\/li><li>sore throat (\u00a0pharyngitis\u00a0)<\/li><li>headache, dizziness &#8211; signs of high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(&nbsp;<\/strong><em>may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>otitis<\/li><li>swollen and bleeding gums or signs of inflamed gums<\/li><li>skin inflammation<\/li><li>high blood fats\u00a0and\u00a0triglycerides<\/li><li>low phosphate levels in the blood<\/li><li>high blood sugar<\/li><li>tiredness, shortness of breath, pale skin (signs of low levels of\u00a0red blood cells\u00a0&#8211;\u00a0anemia)<\/li><li>fever, sore throat, mouth ulcers due to\u00a0infection\u00a0(signs of low levels of\u00a0white blood cells\u00a0&#8211;\u00a0leukopenia, lymphopenia,\u00a0neutropenia\u00a0)<\/li><li>bleeding or bruising that occurs without reason (signs of low levels of\u00a0platelets\u00a0&#8211;\u00a0thrombocytopenia\u00a0)<\/li><li>mouth pain<\/li><li>nosebleed<\/li><li>stomach upset e.g.\u00a0nausea<\/li><li>abdominal pain<\/li><li>severe pain, which may be sharp, in the abdomen and pelvic floor along with irregular periods (ovarian cysts)<\/li><li>the increased amount of gases in the intestines, tension<\/li><li>constipation<\/li><li>abdominal pain, nausea, vomiting, diarrhea, swollen and bloated abdomen (signs of\u00a0inflammation\u00a0of the stomach\u00a0lining\u00a0&#8211;\u00a0gastritis\u00a0or viral\u00a0gastroenteritis\u00a0)<\/li><li>dry skin,\u00a0itching<\/li><li>inflammation\u00a0of the skin characterized by\u00a0redness,\u00a0itching,\u00a0and fluid-filled cysts that are scaly, scaly, or hard (\u00a0dermatitis\u00a0acneiform)<\/li><li>hair loss<\/li><li>protein\u00a0in the urine<\/li><li>menstrual disturbances such as heavy bleeding or\u00a0vaginal\u00a0bleeding<\/li><li>sleep difficulties<\/li><li>irritability<\/li><li>aggressiveness<\/li><li>high blood levels of\u00a0lactate dehydrogenase, an\u00a0enzyme\u00a0that provides information about the condition of certain organs<\/li><li>elevated levels of the\u00a0hormone\u00a0that triggers ovulation (\u00a0luteinizing hormone\u00a0)<\/li><li>weight loss.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(&nbsp;<\/strong><em>may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle cramps, fever, dark colored urine, which may be symptoms of muscle damage (&nbsp;rhabdomyolysis&nbsp;)<\/li><li>mucus cough, chest pain, fever (signs of&nbsp;inflammation&nbsp;of the respiratory tract &#8211; viral&nbsp;bronchitis&nbsp;)<\/li><li>taste changes<\/li><li>menstrual disorders such as delayed menstruation<\/li><li>elevated levels of female sex hormones (follicle-stimulating&nbsp;hormone&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(&nbsp;<em>occurs in an unknown number of users<\/em>&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reaction at the area of \u200b\u200bprevious radiation treatment, e.g.&nbsp;redness&nbsp;of the skin or&nbsp;pneumonia&nbsp;(so-called radiation-induced skin reaction (radiation recall syndrome))<br>worsening of&nbsp;side effects&nbsp;from radiotherapy<\/li><\/ul>\n\n\n\n<p><strong>If these&nbsp;side effects&nbsp;become severe, contact a doctor and\/or pharmacist.&nbsp;Most&nbsp;side effects&nbsp;are mild to moderate and generally disappear if treatment is discontinued for a few days.<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported in patients using everolimus for conditions other than TSC:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney problems: altered frequency or absence of urination may be a sign of\u00a0kidney failure\u00a0and has been observed in some patients treated with everolimus.\u00a0Other symptoms may be altered kidney function tests (elevated\u00a0creatinine\u00a0).<\/li><li>Symptoms of\u00a0heart failure, e.g.\u00a0shortness of breath, difficulty breathing when lying down, and swelling in the feet or legs.<\/li><li>Blockage or narrowing of a blood vessel (vein) in the leg (deep\u00a0vein thrombosis\u00a0) &#8211; symptoms of this can be swelling and\/or pain in one of the legs, usually in the calf, as well as\u00a0redness\u00a0or feeling of warmth in the affected area.<\/li><li>Problems with wound healing.<\/li><li>High blood sugar.<\/li><\/ul>\n\n\n\n<p>Recurrence (reactivation) of\u00a0hepatitis\u00a0B has been observed in several patients receiving everolimus.\u00a0Tell your doctor if you experience any symptoms of\u00a0hepatitis\u00a0B during treatment with everolimus.\u00a0Examples of early symptoms are fever, skin rash, joint pain, and\u00a0inflammation.\u00a0Other symptoms may include fatigue, decreased appetite, nausea, jaundice (yellowing of the skin), and pain in the upper, right side of the abdomen.\u00a0Pale stools or dark urine can also be signs of\u00a0hepatitis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Votubia<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Use before the expiry date stated on the carton and blister pack.\u00a0The expiration date is the last day of the specified month.<\/li><li>No special temperature instructions.<\/li><li>Store in the original packaging.\u00a0Light sensitive.\u00a0Moisture sensitive.<\/li><li>Open the blister just before using Votubia dispersible tablets.<\/li><li>The durability of\u00a0suspension\u00a0one is 60 minutes.\u00a0The suspension\u00a0must be taken immediately after\u00a0preparation.\u00a0If not used within 60 minutes, it must be discarded and a new\u00a0suspension\u00a0prepared.<\/li><li>Do not use the medicine if you see that the package is damaged or appears to have been opened before.<\/li><\/ul>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is everolimus.One&nbsp;Votubia 1 mg&nbsp;dispersible tablet contains 1 mg everolimus.One&nbsp;Votubia 2 mg&nbsp;dispersible tablet contains 2 mg everolimus.One&nbsp;Votubia 3 mg&nbsp;dispersible tablet contains 3 mg everolimus.One&nbsp;Votubia 5 mg&nbsp;dispersible tablet contains 5 mg everolimus.<\/li><li>Other ingredients are butyl hydroxytoluene (E321), magnesium stearate,&nbsp;lactose&nbsp;monohydrate, hypromellose, crospovidone type A, mannitol, microcrystalline cellulose and&nbsp;colloidal&nbsp;silicon dioxide, anhydrous (see section 2 &#8220;Votubia contains lactose&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Votubia 1 mg dispersible tablets are white to yellowish, round, flat tablets with beveled edges and no score.&nbsp;They are stamped with &#8220;D1&#8221; on one side and &#8220;NVR&#8221; on the other.<\/p>\n\n\n\n<p>Votubia 2 mg dispersible tablets are white to yellowish, round, flat tablets with beveled edges and no score.\u00a0They are stamped with \u201cD2\u201d on one side and \u201cNVR\u201d on the other.<\/p>\n\n\n\n<p>Votubia 3 mg dispersible tablets are white to yellowish, round, flat tablets with beveled edges and no score.\u00a0They are stamped with \u201cD3\u201d on one side and \u201cNVR\u201d on the other.<\/p>\n\n\n\n<p>Votubia 5 mg dispersible tablets are white to yellowish, round, flat tablets.&nbsp;They are stamped with \u201cD5\u201d on one side and \u201cNVR\u201d on the other<\/p>\n\n\n\n<p>Votubia 1 mg dispersible tablets are available in packages containing 30 dispersible tablets in perforated single-dose blisters of 10 x 1 tablet each.<\/p>\n\n\n\n<p>Votubia 2 mg dispersible tablets are available in packs containing 10 x 1, 30 x 1, or 100 x 1 dispersible tablets in perforated single-dose blisters of 10 x 1 tablet each.<\/p>\n\n\n\n<p>Votubia 3 mg and 5 mg dispersible tablets are available in packs containing 30 x 1 or 100 x 1 dispersible tablet in perforated unit dose blisters of 10 x 1 tablet each<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Novartis Farmac\u00e9utica SA<\/p>\n\n\n\n<p>Gran Via de Les Corts Catalanes, 764<\/p>\n\n\n\n<p>08013 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstrasse 25<\/p>\n\n\n\n<p>D\u201190429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lietuvos filialasPhone: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel.: +359 2 489 98 28<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis s.r.oPhone: +420 225 775 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Novartis Hung\u00e1ria Kft.Tel.: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A\/SPhone: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Phone: +356 2122 2872<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Novartis Pharma GmbHPhone: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVPhone: +31 88 04 52 555<\/td><\/tr><tr><td><strong>Estonia<\/strong>SIA Novartis Baltics Eesti branch phone: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norway iPhone: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Greece) AEBEPhone: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHPhone: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Farmac\u00e9utica, SAPhone: +34 93 306 42 00<\/td><td><strong>Polish<\/strong>Novartis Poland Sp.\u00a0z o. iPhone: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Produtos Farmac\u00eauticos, SAPhone: +351 21 000 8600<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLPhone: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedPhone: +353 1 260 12 55<\/td><td><strong>Slovenija<\/strong>Novartis Pharma Services Inc.Phone: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Novartis Slovakia s.r.oPhone: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Pharma SpAPhone: +39 02 96 54 1<\/td><td><strong>Finland\/Finland<\/strong>Novartis Finland OyTel: +358 (0)10 6133 200<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Novartis Pharma Services Inc.Phone: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sweden ABPhone: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsPhone: +371 67 887 070<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Votubia dispersible tablets contain the active substance everolimus.\u00a0Votubia is used to treat children from the age of 2 and adults with\u00a0partial-onset seizures\u00a0with or without secondary generalization (\u00a0epilepsy\u00a0) associated with a genetic disease called tuberous sclerosis complex (TSC) and when other anti-\u00a0epileptic drugs\u00a0do not work well enough.\u00a0Partial seizures\u00a0start from one side of the brain, but can spread and extend over larger areas on both sides of the brain (so-called &#8220;secondary generalization&#8221;).\u00a0Votubia dispersible tablets are given together with other medicines against\u00a0epilepsy\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[7420,7422,7423,27790,27793,27794,11427,7421,27791,27792],"class_list":["post-31396","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-everolimus","tag-everolimus-side-effects","tag-everolimus-tablet","tag-votubia","tag-votubia-side-effects","tag-votubia-tablet","tag-what-everolimus-is-used-for","tag-what-is-everolimus","tag-what-is-votubia","tag-what-votubia-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31396"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31396\/revisions"}],"predecessor-version":[{"id":31513,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31396\/revisions\/31513"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}