{"id":31395,"date":"2022-11-09T07:13:57","date_gmt":"2022-11-09T07:13:57","guid":{"rendered":"https:\/\/zeepedia.com\/?p=31395"},"modified":"2022-11-10T07:44:24","modified_gmt":"2022-11-10T07:44:24","slug":"votrient","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/votrient\/","title":{"rendered":"Votrient &#8211; Pazopanib uses, dose and side effects"},"content":{"rendered":"\n<p>200 mg and 400 mg\u00a0film-coated tablets<br><em>pazopanib<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Votrient and what it is used for<\/h2>\n\n\n\n<p>Votrient is a type of medicine called a\u00a0<em>protein kinase inhibitor<\/em>.\u00a0It works by preventing the activity of the\u00a0proteins\u00a0that participate in the growth and spread of cancer cells.<\/p>\n\n\n\n<p>Votrient is given to adults to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney cancer that is advanced or has spread to other organs<\/li><li>some forms of soft tissue sarcoma, which is a type of cancer that affects the supporting tissues of the body.\u00a0This type can appear in muscles, blood vessels, fatty tissue, or in other\u00a0tissues\u00a0that support, surround, and protect the organs.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Votrient<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Votrient<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to pazopanib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong>Check with your doctor<\/strong>&nbsp;if you think this is right for you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Votrient.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any\u00a0<strong>heart disease<\/strong><\/li><li>if you have any\u00a0<strong>liver disease<\/strong><\/li><li>if you have had\u00a0<strong>heart failure\u00a0or a heart attack<\/strong><\/li><li>if you have previously had\u00a0a lung collapse<\/li><li>if you have had problems with\u00a0bleeding, blood clots, or artery narrowing<\/li><li>if you have had\u00a0stomach or intestinal problems\u00a0such as\u00a0perforation\u00a0(holes) or\u00a0fistulas\u00a0(abnormal passages that form between parts of the intestine)<\/li><li>if you have\u00a0thyroid problems<\/li><li>if you have problems with your\u00a0kidney function<\/li><li>if you or have had an\u00a0<strong>aneurysm<\/strong>\u00a0(enlargement and weakening of a blood vessel wall) or a rupture in a blood vessel wall.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>\u00a0if any of these apply to you.\u00a0Your doctor will decide if Votrient is right for you.\u00a0You may need\u00a0<strong>extra tests<\/strong>\u00a0to check that your kidneys, heart, and liver are working properly.<\/p>\n\n\n\n<p><strong>High&nbsp;blood pressure&nbsp;and Votrient<\/strong><\/p>\n\n\n\n<p>Votrient can raise your\u00a0blood pressure.\u00a0Blood pressure\u00a0is checked before and while you take Votrient.\u00a0If you have high\u00a0blood pressure, you will receive treatment with medicines that lower it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell the doctor<\/strong>\u00a0if you have high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>If you are going to undergo an operation<\/strong><\/p>\n\n\n\n<p>The doctor stops treatment with Votrient at least 7 days before surgery, as it can affect wound healing.&nbsp;Your treatment will start again when the wound has healed sufficiently.<\/p>\n\n\n\n<p><strong>Conditions that you need to be observant about<\/strong><\/p>\n\n\n\n<p>Votrient can make certain conditions worse or cause serious\u00a0side effects.\u00a0You need to be aware of certain symptoms when taking Votrient to reduce the risk of problems,\u00a0see section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Votrient is not recommended for people under 18 years of age.&nbsp;It is not yet known how well it works in this age group.&nbsp;For safety reasons, this medicine should also not be given to children younger than 2 years.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Votrient<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to non-prescription ones, herbal remedies, or other natural products.<\/p>\n\n\n\n<p>Some medicines can affect Votrient or make you more likely to have\u00a0side effects.\u00a0Votrient can also affect how certain other medicines work.\u00a0These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>clarithromycin,\u00a0ketoconazole, itraconazole, rifampicin, telithromycin,\u00a0and voriconazole\u00a0(used to\u00a0treat\u00a0infections\u00a0).<\/li><li>atazanavir, indinavir, nelfinavir, ritonavir, saquinavir (used to\u00a0treat\u00a0HIV\u00a0)<\/li><li>nefazodone (used to\u00a0treat depression\u00a0)<\/li><li>simvastatin\u00a0and possibly other statins (used to\u00a0treat high cholesterol levels\u00a0)<\/li><li>medicines that\u00a0reduce stomach acid.\u00a0The type of medicine that reduces stomach acid (eg\u00a0proton pump inhibitors, H\u00a02\u00a0antagonists,\u00a0or\u00a0antacids) can affect how Votrient should be taken.\u00a0Consult your doctor or nurse for advice.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;or pharmacist if you are taking any of these.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Votrient with food and drink<\/h2>\n\n\n\n<p><strong>Do not take Votrient with food,<\/strong>&nbsp;as it affects how the medicine is absorbed by the body.&nbsp;Take it at least two hours after a meal or one hour before a meal (see section 3).<\/p>\n\n\n\n<p><strong>Do not drink grapefruit juice<\/strong>\u00a0while being treated with Votrient as it may increase the risk of\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Votrient is not recommended if you are pregnant.&nbsp;<\/strong>The effect of Votrient during pregnancy is not known.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell the doctor if you are pregnant<\/strong>&nbsp;or plan to become pregnant<\/li><li><strong>Use a reliable method of birth control<\/strong>&nbsp;while taking Votrient and for at least 2 weeks afterward to prevent pregnancy<\/li><li><strong>If you become pregnant during treatment<\/strong>&nbsp;with Votrient, tell your doctor.<\/li><\/ul>\n\n\n\n<p><strong>Do not breastfeed while taking Votrient.\u00a0<\/strong>It is not known whether the ingredients in Votrient pass into breast milk.\u00a0Talk to your doctor about this.<\/p>\n\n\n\n<p><strong>Men<\/strong>&nbsp;(including those who have undergone sterilization\/vasectomy) who have a partner who is, or could become, pregnant (even if they are using other contraceptive methods) should use a condom during intercourse during treatment with Votrient and for at least 2 weeks after the last&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p><strong>Fertility&nbsp;may be affected<\/strong>&nbsp;by treatment with Votrient.&nbsp;Talk to your doctor about this.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Votrient may have&nbsp;side effects&nbsp;that may affect your ability to drive or use machines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Avoid driving or using machines if you feel dizzy, tired, or weak or if you do not have enough energy.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Votrient contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per film-coated tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Votrient<\/h2>\n\n\n\n<p><strong>Always take&nbsp;<\/strong><strong>this medicine&nbsp;<\/strong><strong>as directed by your doctor.&nbsp;<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p><strong>The usual\u00a0dose\u00a0is two Votrient<\/strong>\u00a0400 mg tablets (800 mg pazopanib) taken once a day.\u00a0That is the maximum\u00a0dose of\u00a0one per day.\u00a0The doctor may need to reduce the\u00a0dose\u00a0if you experience\u00a0side effects.<\/p>\n\n\n\n<p><strong>When to take it<\/strong><\/p>\n\n\n\n<p><strong>Do not take Votrient with food.&nbsp;<\/strong>Take it at least two hours after a meal or one hour before a meal.&nbsp;For example, you can take it two hours after breakfast or one hour before lunch.&nbsp;Take Votrient at about the same time each day.<\/p>\n\n\n\n<p>Swallow the tablets whole, one at a time, with water.\u00a0Do not break or crush the tablets as this affects how the medicine is absorbed by the body and can increase the risk of\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Votrient<\/h2>\n\n\n\n<p><strong>Contact a doctor or pharmacist<\/strong>&nbsp;and ask for advice if you have taken too many tablets.&nbsp;Show the packaging or this leaflet if possible.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Votrient<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Just take the next\u00a0dose\u00a0at the usual time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Votrient without consulting a doctor<\/h2>\n\n\n\n<p>Take Votrient for as long as your doctor recommends.&nbsp;Do not stop unless your doctor tells you to.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Possible serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Swelling of the brain<\/strong>\u00a0(reversible posterior leukoencephalopathy syndrome).<\/p>\n\n\n\n<p>Votrient can rarely cause swelling of the brain, which can be life-threatening.&nbsp;Symptoms include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of speech<\/li><li>vision changes<\/li><li>convulsions (twitching)<\/li><li>confusion<\/li><li>high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Stop taking Votrient<\/strong>&nbsp;and&nbsp;<strong>seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms, or if you experience a headache followed by any of these symptoms.<\/p>\n\n\n\n<p><strong>Hypertensive crisis<\/strong>&nbsp;(sudden and severe increase in blood pressure)<\/p>\n\n\n\n<p>Votrient can sometimes cause a sudden and severe increase in blood pressure, a so-called\u00a0hypertensive crisis.\u00a0The doctor will therefore check your\u00a0blood pressure\u00a0during treatment with Votrient.\u00a0Symptoms of hypertensive crisis may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe chest pain<\/li><li>severe headache<\/li><li>blurred vision<\/li><li>confusion<\/li><li>nausea<\/li><li>vomiting<\/li><li>severe anxiety<\/li><li>respiratory distress<\/li><li>convulsions<\/li><li>fainting.<\/li><\/ul>\n\n\n\n<p><strong>Stop taking Votrient<\/strong>&nbsp;and&nbsp;<strong>seek medical attention immediately<\/strong>&nbsp;if you experience a hypertensive crisis.<\/p>\n\n\n\n<p><strong>Heart problems<\/strong><\/p>\n\n\n\n<p>The risk of this may be higher for people with an existing heart problem or who are taking other medicines.&nbsp;You will therefore be checked for heart problems while you are taking Votrient.<\/p>\n\n\n\n<p><em>Cardiac dysfunction\/heart failure, heart attack<\/em><\/p>\n\n\n\n<p>Votrient can affect the heart&#8217;s pumping ability and increase the risk of a heart attack.\u00a0Symptoms include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>irregular or fast heartbeat<\/li><li>heart fibrillation<\/li><li>fainting<\/li><li>chest pain or pressure in the chest<\/li><li>pain in arms, back, neck, or jaw<\/li><li>respiratory distress<\/li><li>leg swelling.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><em>Change in heart rhythm (&nbsp;QT&nbsp;prolongation<\/em>&nbsp;)<\/p>\n\n\n\n<p>Votrient can affect the heart rhythm, which in some people can develop into a heart condition that can be serious and is called\u00a0<em>torsade de pointes.\u00a0<\/em>This can cause a very fast heartbeat which can lead to sudden unconsciousness.<\/p>\n\n\n\n<p><strong>Tell the doctor<\/strong>\u00a0if you notice any\u00a0<strong>unusual changes in your heart activity<\/strong>, such as your heart beating too fast or too slowly.<\/p>\n\n\n\n<p><strong>Stroke<\/strong><\/p>\n\n\n\n<p>Votrient increases the risk of\u00a0stroke.\u00a0Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>numbness or weakness on one side of the body<\/li><li>difficulty speaking<\/li><li>headache<\/li><li>dizziness<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Bleeding<\/strong><\/p>\n\n\n\n<p>Votrient can cause severe bleeding in the digestive system (eg, stomach, esophagus, rectum, or intestines) or the lungs, kidneys, mouth, vagina, and brain, although this is uncommon.\u00a0Symptoms are, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood in the stool or black stools<\/li><li>blood in the urine<\/li><li>stomach ache<\/li><li>coughing or vomiting blood.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Rupture of the intestine and&nbsp;fistula<\/strong><\/p>\n\n\n\n<p>Votrient can cause a hole (rupture) in the gastrointestinal tract or the formation of an abnormal channel between two parts of the digestive tract (&nbsp;fistula&nbsp;).&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe abdominal pain<\/li><li>nausea and\/or vomiting<\/li><li>fever<\/li><li>holes (rupture) in the gastrointestinal tract from which bloody or foul-smelling fluid comes out.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Liver problems<\/strong><\/p>\n\n\n\n<p>Votrient can cause liver problems that can develop into serious conditions, e.g.&nbsp;liver dysfunction and liver failure, which can be life-threatening.&nbsp;Doctors will check your liver enzymes while you are taking Votrient.&nbsp;Signs that the liver may not be working normally may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>yellow skin or whites of eyes (jaundice)<\/li><li>dark colored urine<\/li><li>fatigue<\/li><li>nausea<\/li><li>vomiting<\/li><li>loss of appetite<\/li><li>pain in the right side of the abdomen<\/li><li>bruises easily.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Blood clot<\/strong><\/p>\n\n\n\n<p><em>Deep&nbsp;vein thrombosis&nbsp;and&nbsp;pulmonary embolism<\/em><\/p>\n\n\n\n<p>Votrient can cause blood clots, especially in the legs (deep&nbsp;vein thrombosis&nbsp;), which can also end up in the lungs (&nbsp;pulmonary embolism&nbsp;).&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe chest pain<\/li><li>respiratory distress<\/li><li>rapid breathing<\/li><li>pain in the leg<\/li><li>swelling of the arms and hands or legs and feet.<\/li><\/ul>\n\n\n\n<p><em>Thrombotic microangiopathy<\/em><\/p>\n\n\n\n<p>Votrient can cause blood clots in the small blood vessels of the kidneys and brain, accompanied by a decrease in&nbsp;red blood cells&nbsp;and cells involved in blood clotting.&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bruises easily<\/li><li>high&nbsp;blood pressure<\/li><li>fever<\/li><li>confusion<\/li><li>drowsiness<\/li><li>convulsions<\/li><li>decreased urine output.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Tumor lysis syndrome<\/strong><\/p>\n\n\n\n<p>Votrient can cause a rapid breakdown of cancer cells and lead to tumor lysis syndrome, which can be fatal in some people.\u00a0Symptoms may include irregular heartbeats, seizures, confusion, muscle cramps or\u00a0spasms, or decreased urine production.\u00a0<strong>Seek medical attention immediately<\/strong>\u00a0if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Infection&nbsp;you<\/strong><\/p>\n\n\n\n<p>Infections&nbsp;that occur during treatment with Votrient can be serious.&nbsp;Symptoms of&nbsp;infection&nbsp;may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>flu-like symptoms such\u00a0as cough, fatigue, and body aches that do not go away<\/li><li>shortness of breath and\/or wheezing<\/li><li>pain when urinating<\/li><li>cuts, scrapes, or red, hot, swollen, or painful sores.<\/li><\/ul>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Pneumonia<\/strong><\/p>\n\n\n\n<p>Votrient can rarely cause lung inflammation (&nbsp;pneumonitis&nbsp;), which in some people can be life-threatening.&nbsp;Symptoms include shortness of breath or a cough that does not go away.&nbsp;You will be checked for any lung problems while taking Votrient.<\/p>\n\n\n\n<p><strong>Seek medical attention immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Thyroid problems<\/strong><\/p>\n\n\n\n<p>Votrient can lower the amount of thyroid hormone produced in your body.&nbsp;This can cause weight gain and fatigue.&nbsp;Your thyroid hormone levels will be checked while you are taking Votrient.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you gain a lot of weight or feel tired.<\/p>\n\n\n\n<p><strong>Blurred or reduced vision<\/strong><\/p>\n\n\n\n<p>Votrient can cause separation or tear of the lining of the back of the eye (retinal detachment or\u00a0rupture\u00a0).\u00a0This can lead to blurred or reduced vision.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you experience any vision changes.<\/p>\n\n\n\n<p><strong>Possible&nbsp;side effects&nbsp;(including possible serious&nbsp;side effects&nbsp;are indicated under the relevant frequency range).<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high&nbsp;blood pressure<\/li><li>diarrhea<\/li><li>nausea, vomiting<\/li><li>stomach pain<\/li><li>decreased appetite<\/li><li>weight loss<\/li><li>altered taste or loss of taste<\/li><li>mouth ulcers<\/li><li>headache<\/li><li>tumor pain<\/li><li>lack of energy, feeling weak or tired<\/li><li>changed hair color<\/li><li>abnormal hair loss or thinning hair<\/li><li>reduced skin pigmentation<\/li><li>skin rash, possibly with flaking<\/li><li>redness&nbsp;and swelling of the palms of the hands or soles of the feet.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor or pharmacist<\/strong>&nbsp;if any of these&nbsp;side effects&nbsp;bother you.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;that can show up in blood or urine tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased liver enzyme values<\/li><li>decreased levels of albumin in the blood<\/li><li>protein\u00a0in the urine<\/li><li>reduced number of\u00a0platelets\u00a0(cells that help the blood to clot)<\/li><li>reduced number of\u00a0white blood cells.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upset stomach, flatulence, flatulence<\/li><li>nosebleed<\/li><li>dry mouth\u00a0or mouth ulcers<\/li><li>infection\u00a0_<\/li><li>abnormal sleepiness<\/li><li>sleep difficulties<\/li><li>chest pain, shortness of breath, leg pain, and leg\/feet swelling.\u00a0This may be a sign of a blood clot in the body (\u00a0thromboembolism\u00a0).\u00a0If a blood clot breaks loose, it can travel to the lungs, which can be life-threatening and even cause death.<\/li><li>the heart becomes less efficient at pumping blood around the body (\u00a0heart failure\u00a0)<\/li><li>slow\u00a0pulse<\/li><li>bleeding in the mouth, rectum, or lungs<\/li><li>dizziness<\/li><li>blurred vision<\/li><li>hot flashes<\/li><li>swelling caused by fluid accumulation in the face, hands, ankles, feet, or eyelids<\/li><li>tingling, weakness, or numbness in the hands, arms, legs, or feet<\/li><li>skin rash,\u00a0redness,\u00a0itching, dry skin<\/li><li>nail diseases<\/li><li>burning, stinging, itching, or stinging sensation in the skin<\/li><li>feeling cold with chills<\/li><li>profuse sweating<\/li><li>dehydration<\/li><li>muscle, joint, tendon, or chest pain, muscle cramps<\/li><li>huskiness<\/li><li>shortness of breath<\/li><li>cough<\/li><li>bloody expectoration<\/li><li>hiccup<\/li><li>lung collapse where the air comes down and gets stuck between the lung and the chest, which can often cause shortness of breath (pneumothorax).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;or pharmacist if any of these&nbsp;side effects&nbsp;bother you.<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;that may show up in blood or urine tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>interactivity of the thyroid gland<\/li><li>abnormal liver function<\/li><li>increased bilirubin (a substance produced in the liver)<\/li><li>elevated lipase (an\u00a0enzyme\u00a0that helps with digestion)<\/li><li>increased creatinine (a substance produced in muscles)<\/li><li>altered levels of other chemical substances\/enzymes in the blood.\u00a0Your doctor will inform you of the results of the blood tests.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stroke<\/li><li>temporarily reduced blood supply to the brain (\u00a0transient\u00a0ischemic attack,\u00a0TIA\u00a0)<\/li><li>interrupted blood supply to part of the heart or heart attack (myocardial infarction)<\/li><li>partially interrupted blood supply to part of the heart (cardiac ischemia)<\/li><li>blood clots are accompanied by a reduction in\u00a0red blood cells\u00a0and cells involved in\u00a0clotting\u00a0(thrombotic microangiopathy, TMA), which can damage organs such as the brain and kidneys<\/li><li>increased number of\u00a0red blood cells<\/li><li>sudden shortness of breath, especially with simultaneous severe pain in the chest and\/or rapid breathing (\u00a0pulmonary embolism\u00a0)<\/li><li>severe bleeding in the gastrointestinal tract (eg stomach, esophagus, or intestine) or the kidneys, vagina, and brain<\/li><li>cardiac arrhythmia (\u00a0QT\u00a0prolongation)<\/li><li>hole (\u00a0perforation\u00a0) in the stomach or intestine<\/li><li>formation of an abnormal passage between parts of the intestine (\u00a0fistula\u00a0)<\/li><li>heavy or irregular menstruation<\/li><li>sudden high\u00a0blood pressure\u00a0(hypertensive crisis)<\/li><li>inflammation of the pancreas (\u00a0pancreatitis\u00a0)<\/li><li>inflammation of the liver, impaired liver function, or liver damage<\/li><li>yellowing of the skin or whites of the eyes (jaundice)<\/li><li>peritonitis (\u00a0peritonitis\u00a0)<\/li><li>Runny nose<\/li><li>rash that may itch or be inflamed (smooth or raised patches or blisters)<\/li><li>frequent stools<\/li><li>increased sensitivity of the skin to sunlight<\/li><li>reduced sensation or sensitivity, especially in the skin<\/li><li>sores on the skin that do not heal (skin ulcers).<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect&nbsp;<strong>up to 1 in 1,000<\/strong>&nbsp;users).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the lung (&nbsp;pneumonitis&nbsp;)<\/li><li>an enlargement and weakening of a blood vessel wall or a rupture in a blood vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections).<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known<\/strong>&nbsp;(frequency cannot be estimated from available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tumor lysis syndrome due to a rapid breakdown of cancer cells<\/li><li>liver failure.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Votrient<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance in Votrient is pazopanib (as hydrochloride). One tablet of Votrient 200 mg contains 200 mg of pazopanib. One tablet of Votrient 400 mg contains 400 mg of pazopanib.<\/li><li>Other ingredients in the 200 mg and 400 mg tablets are hypromellose, macrogol 400, magnesium stearate, microcrystalline cellulose, polysorbate 80, povidone (K30), sodium starch glycolate, titanium dioxide (E171).\u00a0The 200 mg tablets also contain red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Votrient 200 mg film-coated tablets are capsule-shaped, pink, and marked with GS JT on one side.\u00a0They are supplied in cans of 30 or 90 tablets.<\/p>\n\n\n\n<p>Votrient 400 mg film-coated tablets are capsule-shaped, white, and marked with GS UHL on one side.\u00a0They are supplied in cans of 30 or 60 tablets.<\/p>\n\n\n\n<p>Not all pack sizes or tablet strengths may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Lek Pharmaceuticals dd<\/p>\n\n\n\n<p>Verov\u0161kova 57<\/p>\n\n\n\n<p>1526 Ljubljana<\/p>\n\n\n\n<p>Slovenia<\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstrasse 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Glaxo Wellcome, SA<\/p>\n\n\n\n<p>Abda.&nbsp;Extremadura, 3<\/p>\n\n\n\n<p>09400 Aranda De Duero, Burgos<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Novartis Farmac\u00e9utica SA<\/p>\n\n\n\n<p>Gran Via de Les Corts Catalanes, 764<\/p>\n\n\n\n<p>08013 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lietuvos filialasPhone: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODPhone: +359 2 489 98 28<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis s.r.oPhone: +420 225 775 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Novartis Hung\u00e1ria Kft.Tel.: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A\/SPhone: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Phone: +356 2122 2872<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Novartis Pharma GmbHPhone: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVPhone: +31 88 04 52 555<\/td><\/tr><tr><td><strong>Estonia<\/strong>SIA Novartis Baltics Eesti branch phone: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norway iPhone: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Greece) AEBEPhone: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHPhone: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Farmac\u00e9utica, SAPhone: +34 93 306 42 00<\/td><td><strong>Polish<\/strong>Novartis Poland Sp.\u00a0z o. iPhone: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Produtos Farmac\u00eauticos, SAPhone: +351 21 000 8600<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLPhone: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedPhone: +353 1 260 12 55<\/td><td><strong>Slovenija<\/strong>Novartis Pharma Services Inc.Phone: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Novartis Slovakia s.r.oPhone: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Pharma SpAPhone: +39 02 96 54 1<\/td><td><strong>Finland\/Finland<\/strong>Novartis Finland OyTel: +358 (0)10 6133 200<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Novartis Pharma Services Inc.Phone: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sweden ABPhone: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsPhone: +371 67 887 070<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Novartis Ireland Limited<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Votrient is a type of medicine called a\u00a0protein kinase inhibitor\u00a0.\u00a0It works by preventing the activity of the\u00a0proteins\u00a0that participate in the growth and spread of cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27795,27798,27797,27802,27803,27804,27796,27801,27799,27800],"class_list":["post-31395","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-pazopanib","tag-pazopanib-side-effects","tag-pazopanib-tablet","tag-votrient","tag-votrient-side-effects","tag-votrient-tablet","tag-what-is-pazopanib","tag-what-is-votrient","tag-what-pazopanib-is-used-for","tag-what-votrient-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=31395"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31395\/revisions"}],"predecessor-version":[{"id":31514,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/31395\/revisions\/31514"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=31395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=31395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=31395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}