{"id":30993,"date":"2022-11-07T09:46:47","date_gmt":"2022-11-07T09:46:47","guid":{"rendered":"https:\/\/zeepedia.com\/?p=30993"},"modified":"2022-11-08T07:48:40","modified_gmt":"2022-11-08T07:48:40","slug":"voriconazole-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/voriconazole-sandoz\/","title":{"rendered":"Voriconazole Sandoz &#8211; Voriconazole uses, dose and side effects"},"content":{"rendered":"\n<p>200 mg&nbsp;film-coated tablets<br>voriconazole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Voriconazole Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Voriconazole Sandoz contains the active substance voriconazole.\u00a0Voriconazole Sandoz is a medicine against fungal infections.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection.<\/p>\n\n\n\n<p>Voriconazole Sandoz is used to treating patients (adults and children from 2 years of age) with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>invasive\u00a0aspergillosis\u00a0(a type of fungal infection caused by\u00a0<em>Aspergillus<\/em>\u00a0sp.)<\/li><li>candidemia\u00a0(another type of fungal infection caused by\u00a0<em>Candida<\/em>\u00a0sp.) in non-neutropenic\u00a0patients (patients without an abnormally low\u00a0white blood cell count\u00a0)<\/li><li>severe invasive\u00a0<em>Candida<\/em>\u00a0sp.-\u00a0infection\u00a0when the fungus is resistant to\u00a0fluconazole\u00a0(another antifungal drug)<\/li><li>severe fungal infections caused by\u00a0<em>Scedosporium<\/em>\u00a0sp.\u00a0or\u00a0<em>Fusarium<\/em>\u00a0sp.\u00a0(two different mushroom species).<\/li><\/ul>\n\n\n\n<p>Voriconazole Sandoz is intended for patients with worsening and possibly life-threatening fungal infections.<\/p>\n\n\n\n<p>Preventive treatment in stem cell transplant patients who are at high risk of developing a fungal infection.\u00a0<\/p>\n\n\n\n<p>This medicine should only be used under the supervision of a doctor.<\/p>\n\n\n\n<p>Voriconazole, found in Voriconazole Sandoz, may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Voriconazole Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Voriconazole Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to voriconazole or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>You must tell your doctor or pharmacist if you are taking or have taken any other medicines, even those without a prescription, or herbal remedies.<\/p>\n\n\n\n<p>The following medicines must not be taken during treatment with Voriconazole Sandoz:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>terfenadine (used for\u00a0allergies)<\/li><li>astemizole (used for\u00a0allergy\u00a0)<\/li><li>cisapride (used for stomach upset)<\/li><li>pimozide (used to treat mental illness)<\/li><li>quinidine\u00a0(used for irregular heartbeat)<\/li><li>ivabradine\u00a0(used for symptoms of\u00a0chronic\u00a0heart failure\u00a0)<\/li><li>rifampicin (used in the treatment of\u00a0tuberculosis\u00a0)<\/li><li>efavirenz (used to treat\u00a0HIV\u00a0) at\u00a0doses\u00a0of 400 mg or more once daily<\/li><li>carbamazepine (used to treat seizures)<\/li><li>phenobarbital (used for severe sleep disorders and convulsions)<\/li><li>ergot alkaloids (eg,\u00a0ergotamine, dihydroergotamine; used for\u00a0migraine\u00a0)<\/li><li>sirolimus (used in transplant patients)<\/li><li>ritonavir (used in the treatment of\u00a0HIV\u00a0) at a\u00a0dose\u00a0of 400 mg or more twice daily<\/li><li>St. John&#8217;s wort\u00a0(natural medicine)<\/li><li>naloxegol (used to treat constipation specifically caused by painkillers called\u00a0opioids\u00a0(eg morphine, oxycodone,\u00a0fentanyl, tramadol,\u00a0codeine\u00a0))<\/li><li>tolvaptan (used to treat\u00a0hyponatremia\u00a0(low levels of\u00a0sodium\u00a0in the blood) or to slow the deterioration of kidney function in patients with polycystic kidney disease)<\/li><li>lurasidone (used to treat depression)<\/li><li>venetoclax (used in the treatment of patients with\u00a0chronic lymphocytic leukemia\u00a0&#8211;\u00a0CLL\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Voriconazole Sandoz if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have previously had an\u00a0allergic reaction\u00a0to other azoles<\/li><li>you have or have previously had liver disease.\u00a0If you have liver disease, the doctor may prescribe a lower\u00a0dose\u00a0of Voriconazole Sandoz.\u00a0The doctor must also check your liver function through blood tests while you are being treated with Voriconazole Sandoz.<\/li><li>you have a known disease of the heart muscle, irregular heartbeats, slow heartbeats, or an\u00a0ECG\u00a0change called &#8220;long QTc syndrome&#8221;.<\/li><\/ul>\n\n\n\n<p>Avoid sunlight and exposure to the sun while you are being treated with Voriconazole Sandoz.&nbsp;It is important to cover exposed areas of the skin and to use sunscreen with a high sun protection factor (SPF), as the skin can become more sensitive to the sun&#8217;s UV rays.&nbsp;These precautions also apply to children.<\/p>\n\n\n\n<p>While you are being treated with Voriconazole Sandoz, tell your doctor immediately if you receive<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sun damage<\/li><li>severe skin rash or blisters<\/li><li>bone pain.<\/li><\/ul>\n\n\n\n<p>If you develop the above skin problems, your doctor may refer you to a dermatologist who, after a consultation, may decide that it is important for you to be examined regularly.\u00a0There is a small risk of developing skin cancer during long-term use of voriconazole.\u00a0<\/p>\n\n\n\n<p>Tell your doctor if you develop signs of &#8216;adrenal insufficiency.\u00a0This means that the adrenal glands do not produce enough of certain steroid hormones such as\u00a0cortisol, which can lead to symptoms such as\u00a0chronic\u00a0or prolonged fatigue, muscle weakness, loss of appetite, weight loss, and abdominal pain.<\/p>\n\n\n\n<p>Talk to your doctor if you develop signs of Cushing&#8217;s syndrome.\u00a0This means that the body produces too much of the\u00a0hormone cortisol,\u00a0which\u00a0can lead to symptoms such as weight gain, lumps of fat between the shoulder blades, a round face, darker skin on the stomach, thighs, breasts, and arms, thin skin, bruising more easily, high blood sugar, excessive hair growth, excessive sweating.<\/p>\n\n\n\n<p>Your doctor checks liver and kidney function by taking certain blood samples.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Voriconazole Sandoz should not be given to children under 2 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Voriconazole Sandoz<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p>Some medicines can affect or be affected by the simultaneous use of Voriconazole Sandoz.<\/p>\n\n\n\n<p>Tell the doctor if you are taking the following medicines as Voriconazole Sandoz should not be taken at the same time if it can be avoided:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ritonavir (for the treatment of&nbsp;HIV&nbsp;) at a&nbsp;dose&nbsp;of 100 mg twice daily.<\/li><li>glasdegib (for cancer treatment) &#8211; if you need to be treated with both medicines, your doctor will check your heart rhythm frequently.<\/li><\/ul>\n\n\n\n<p>Tell the doctor if you are taking any of the following medicines as concomitant treatment with Voriconazole Sandoz should be avoided if possible, and dose adjustment of voriconazole may be necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifabutin (for the treatment of\u00a0tuberculosis\u00a0).\u00a0If you are already being treated with rifabutin, your blood values \u200b\u200band\u00a0side effects\u00a0must be monitored.<\/li><li>phenytoin\u00a0(for the treatment of\u00a0epilepsy\u00a0).\u00a0If you are already being treated with\u00a0phenytoin, the concentration of phenytoin in the blood must be monitored during treatment with Voriconazole Sandoz and the dose may need to be adjusted.<\/li><\/ul>\n\n\n\n<p>Tell the doctor if you are taking any of the following medicines, as dose adjustments or monitoring may be necessary to ensure that these medicines and\/or Voriconazole Sandoz still have the desired effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>warfarin and other anticoagulants (eg phenprocoumon, acenocoumarol) (used to inhibit the blood&#8217;s ability to clot)<\/li><li>ciclosporin (used in transplant patients)<\/li><li>tacrolimus (used in transplant patients)<\/li><li>sulfonylureas (eg tolbutamide, glipizide and glyburide) (used for\u00a0diabetes\u00a0)<\/li><li>statins (eg atorvastatin,\u00a0simvastatin\u00a0) (cholesterol-lowering drugs)<\/li><li>benzodiazepines\u00a0(eg midazolam, triazolam) (used for severe sleep problems and stress)<\/li><li>omeprazole (used in the treatment of\u00a0stomach ulcers\u00a0)<\/li><li>Birth control pills\u00a0(if you take Voriconazole Sandoz at the same time as\u00a0birth control pills, you may experience\u00a0side effects\u00a0such as nausea and menstrual disturbances)<\/li><li>vinca alkaloids (eg vincristine and vinblastine) (used in the treatment of cancer)<\/li><li>tyrosine kinase inhibitors (eg axitinib, bosutinib, cabozantinib, ceritinib, cobimetinib, dabrafenib, dasatinib, nilotinib, sunitinib, ibrutinib, ribociclib) (used to treat cancer)<\/li><li>tretinoin (used in the treatment of\u00a0leukemia\u00a0)<\/li><li>indinavir and other\u00a0HIV\u00a0protease\u00a0inhibitors\u00a0(used in the treatment of\u00a0HIV\u00a0)<\/li><li>non-nucleoside reverse transcriptase inhibitors (eg efavirenz, delavirdine, nevirapine) (used in the treatment of\u00a0HIV\u00a0) (some\u00a0doses\u00a0of efavirenz must NOT be used at the same time as Voriconazole Sandoz)<\/li><li>methadone\u00a0(used to treat heroin addiction)<\/li><li>alfentanil and\u00a0fentanyl\u00a0and other short-acting opiates such as sufentanil (painkillers used in surgery)<\/li><li>oxycodone and other long-acting opiates such as hydrocodone (used for moderate to severe pain)<\/li><li>non-steroidal anti-inflammatory drugs (eg\u00a0ibuprofen,\u00a0diclofenac\u00a0) (used to treat pain and\u00a0inflammation\u00a0)<\/li><li>fluconazole\u00a0(used for fungal infections)<\/li><li>everolimus (used in the treatment of advanced kidney cancer and transplant patients)<\/li><li>tolvaptan (used to treat\u00a0hyponatremia\u00a0(low levels of\u00a0sodium\u00a0in the blood) or to slow the deterioration of kidney function in patients with polycystic kidney disease)<\/li><li>letermovir (used to prevent cytomegalovirus (\u00a0CMV\u00a0) disease after bone marrow transplantation)<\/li><li>naloxegol (used to treat constipation specifically caused by painkillers called\u00a0opioids\u00a0(eg morphine, oxycodone,\u00a0fentanyl, tramadol,\u00a0codeine\u00a0))<\/li><li>ivacaftor (used in the treatment of\u00a0cystic fibrosis\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Voriconazole Sandoz must not be taken during pregnancy unless prescribed by your doctor.\u00a0Effective contraception must be used by women of childbearing age.\u00a0Contact your doctor immediately if you become pregnant while taking Voriconazole Sandoz.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Voriconazole Sandoz may cause blurred vision or unpleasant sensitivity to light.\u00a0While experiencing something like this, do not drive, or use tools or machines.\u00a0Contact your doctor if you experience this.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Voriconazole Sandoz contains&nbsp;lactose&nbsp;and&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking this medication.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per film-coated tablet, i.e. it is almost &#8216;sodium-free&#8217;.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Voriconazole Sandoz<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will decide your&nbsp;dose&nbsp;depending on your weight and the type of infection you have.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults (including elderly patients) is as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><\/td><td><strong>Tablets<\/strong><\/td><\/tr><tr><td>Patients with 40 kg or more<\/td><td>Patients under 40 kg<\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong>(&nbsp;loading dose&nbsp;)<\/td><td>400 mg every 12 hours in the first 24 hours<\/td><td>200 mg every 12 hours in the first 24 hours<\/td><\/tr><tr><td><strong>Does\u00a0one after the first 24 hours<\/strong>(maintenance dose)<\/td><td>200 mg twice daily<\/td><td>100 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may&nbsp;prescribe&nbsp;an increase in&nbsp;dose&nbsp;from one to 300 mg twice daily.<\/p>\n\n\n\n<p>The doctor may&nbsp;prescribe&nbsp;a reduction in&nbsp;dose&nbsp;if you have mild to moderate liver dysfunction.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>The recommended\u00a0dose\u00a0for children and adolescents is:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><\/td><td><strong>Tablets<\/strong><\/td><\/tr><tr><td>Children from 2 years and up12 years and young people12\u201114 years that weigh less than 50 kg<\/td><td>Young people 12\u201114 years who weigh 50 kg or more, as well as all young people older than 14 years<\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong>(&nbsp;loading dose&nbsp;)<\/td><td>The treatment will start as\u00a0an infusion<\/td><td>400 mg every 12 hours in the first 24 hours<\/td><\/tr><tr><td><strong>Does\u00a0one after the first 24 hours<\/strong>(maintenance dose)<\/td><td>9 mg\/kg twice daily(maximum\u00a0dose\u00a0is 350 mg two times a day)<\/td><td>200 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may increase or decrease the daily\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The tablets may only be given to children who can swallow tablets.<\/li><\/ul>\n\n\n\n<p>Take the tablet at least one hour before, or one hour after, a meal.&nbsp;Swallow the tablet whole with water.<\/p>\n\n\n\n<p>If you or your child take Voriconazole Sandoz to prevent fungal infections, the doctor may stop treatment with Voriconazole Sandoz if you or your child experience&nbsp;side effects&nbsp;caused by the treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Voriconazole Sandoz<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice, or go immediately to the emergency department of the nearest hospital.\u00a0Bring your package of Voriconazole Sandoz tablets.\u00a0You may experience an abnormal sensitivity to light if you take too much Voriconazole Sandoz.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Voriconazole Sandoz<\/h2>\n\n\n\n<p>You must take your Voriconazole Sandoz tablets regularly at the same time each day.\u00a0If you forget to take a\u00a0dose, take the next\u00a0dose\u00a0as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Voriconazole Sandoz<\/h2>\n\n\n\n<p>It has been shown that the effect of your medicine can be significantly increased if all&nbsp;doses&nbsp;are taken at the right time.&nbsp;Unless your doctor tells you to stop treatment, it is therefore important to continue taking Voriconazole Sandoz as described above.<\/p>\n\n\n\n<p>Keep taking Voriconazole Sandoz until your doctor tells you to stop.\u00a0Do not stop treatment prematurely as your\u00a0infection\u00a0may not clear up.\u00a0Patients with weakened immune systems or those with severe\u00a0conditions\u00a0may need long-term treatment to prevent the infection from returning.<\/p>\n\n\n\n<p>When treatment with Voriconazole Sandoz is stopped by the doctor, you should not notice any effect from this.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If any side effects occur, most are likely to be minor or temporary.&nbsp;However, some can be serious and require medical attention.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;&#8211; stop taking Voriconazole Sandoz and see a doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>jaundice, changes in blood tests that test liver function<\/li><li>inflammation&nbsp;of the pancreas.<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>visual impairment (visual changes, including blurred vision, altered color vision, abnormal hypersensitivity to light, color blindness, eye disorders, the experience of halo phenomenon,\u00a0night blindness, oscillating visual experience, flashes in the\u00a0visual field, visual\u00a0aura, decreased\u00a0visual acuity, enhanced visual experience of light, loss of parts of the normal field of\u00a0vision\u00a0et, spots in front of the eyes (fly vision))<\/li><li>fever<\/li><li>rash<\/li><li>nausea, vomiting, diarrhea<\/li><li>headache<\/li><li>swollen arms and legs<\/li><li>stomach pains<\/li><li>breathing difficulties<\/li><li>elevated liver enzyme levels.<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sinusitis,\u00a0inflammation\u00a0of the gums, chills, weakness<\/li><li>reduced number, even severe, of certain types of red (sometimes immune-related) and\/or\u00a0white blood cells\u00a0(sometimes with fever), reduced number of\u00a0thrombocytes\u00a0(\u00a0platelets\u00a0) &#8211; cells that help with blood clotting\u00a0<\/li><li>low blood sugar, low level of\u00a0potassium\u00a0in the blood, low level of\u00a0sodium\u00a0in the blood<\/li><li>anxiety, depression, confusion, anxiety, difficulty sleeping, hallucinations<\/li><li>convulsions, tremors or uncontrolled muscle movements, tingling or abnormal skin sensations, increased muscle tension, sleepiness, dizziness<\/li><li>bleeding in the eye<\/li><li>heart rhythm disorders, e.g.\u00a0very fast heartbeat, very slow heartbeat, fainting<\/li><li>low\u00a0blood pressure,\u00a0inflammation\u00a0of a blood vessel (which can cause blood clots)<\/li><li>acute breathing difficulties, chest pain, swelling of the face (mouth, lips, and around the eyes), water in the lungs<\/li><li>constipation, indigestion,\u00a0inflammation\u00a0of the lips<\/li><li>jaundice,\u00a0inflammation\u00a0of the liver, and liver damage<\/li><li>skin rash that can lead to severe blistering and scaling of the skin characterized by a flat, red area of \u200b\u200bskin covered in small confluent bumps, redness of the skin<\/li><li>itching<\/li><li>hair loss<\/li><li>back pain<\/li><li>kidney failure, blood in the urine, and altered kidney function values.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>flu-like symptoms, irritation, and\u00a0inflammation\u00a0of the gastrointestinal tract,\u00a0inflammation\u00a0of the gastrointestinal tract causing antibiotic-associated diarrhea,\u00a0inflammation\u00a0of the lymphatic vessels<\/li><li>inflammation\u00a0of the thin membrane that covers the inside of the abdominal wall and the abdominal organs<\/li><li>lymph node swelling (sometimes painful), bone marrow failure,\u00a0increased\u00a0eosinophils<\/li><li>impaired adrenal function, underactive\u00a0thyroid gland<\/li><li>abnormal brain function, Parkinson-like symptoms, nerve damage that causes numbness, pain, tingling, or burning in the hands or feet<\/li><li>impaired balance and coordination<\/li><li>brain swelling<\/li><li>double vision, serious eye conditions, eg: pain and\u00a0inflammation\u00a0of the eyes and eyelids, abnormal eye movements, damage to the\u00a0optic nerve\u00a0leading to visual impairment, swelling of the optic nerve papilla<\/li><li>impaired sense of touch<\/li><li>altered sense of taste<\/li><li>hearing difficulties, ringing in the ears, vertigo<\/li><li>inflammation\u00a0of certain internal organs \u2013 the pancreas and\u00a0duodenum, swelling and\u00a0inflammation\u00a0of the tongue<\/li><li>liver enlargement, liver failure, gallstones,\u00a0gallstones<\/li><li>joint inflammation,\u00a0inflammation\u00a0of veins under the skin (which may be due to a blood clot)<\/li><li>nephritis, protein in the urine, kidney damage<\/li><li>high-speed\u00a0pulse\u00a0or skipped heartbeats, sometimes with irregular electrical impulses<\/li><li>abnormal\u00a0EKG<\/li><li>increased level of\u00a0cholesterol\u00a0in the blood, increased level of\u00a0urea\u00a0in the blood<\/li><li>allergic skin reactions (sometimes serious), including life-threatening skin diseases that cause painful blisters and sores on the skin and mucous membranes, especially in the mouth,\u00a0inflammation\u00a0of the skin,\u00a0hives, sunburn, or severe skin reactions after exposure to light or sun, skin redness and skin irritation, red or purple discoloration of the skin which may be due to a reduced number of\u00a0platelets,\u00a0eczema<\/li><li>infusion site reaction<\/li><li>allergic reactions or excessive\u00a0immune response.<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>overactive\u00a0thyroid<\/li><li>impaired brain function which is a serious complication of liver disease<\/li><li>loss of most of the fibers in\u00a0optic nerve\u00a0one, clouding of the cornea, involuntary eye movements<\/li><li>bullous photosensitivity<\/li><li>a disorder in which the body&#8217;s immune system attacks parts of the\u00a0peripheral nervous system<\/li><li>disturbances of the heart rhythm or conduction in the heart (sometimes life-threatening)<\/li><li>life-threatening\u00a0allergic reaction<\/li><li>changes in the blood&#8217;s ability to clot<\/li><li>allergic skin reactions (sometimes severe) including rapid swelling (edema) of the &#8220;leather skin&#8221; (\u00a0dermis\u00a0),\u00a0subcutaneous\u00a0tissue, mucous membranes and sub-mucosal\u00a0tissue, itchy or sore patches of thick, red skin with silvery scales, irritation of the skin and mucous membranes, a life-threatening skin disease which causes large parts of the skin&#8217;s outermost layer (\u00a0epidermis\u00a0) to detach from the underlying skin layer<\/li><li>small patches of dry and scaly skin, sometimes thickened with corn.<\/li><\/ul>\n\n\n\n<p>Has been reported (occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>freckles and pigment spots.<\/li><\/ul>\n\n\n\n<p>Other important\u00a0side effects\u00a0whose frequency is not known but which should be reported to the doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin cancer<\/li><li>inflammation&nbsp;of the&nbsp;tissue&nbsp;surrounding the bone<\/li><li>red, scaly patches or ring-shaped skin changes which may be symptoms of an&nbsp;autoimmune&nbsp;disease called&nbsp;cutaneous&nbsp;lupus erythematosus.<\/li><\/ul>\n\n\n\n<p>As Voriconazole Sandoz can affect the liver and kidneys, your doctor should check your liver and kidney function by taking blood tests.&nbsp;Tell your doctor if you have a stomach ache or if your stool has a different consistency.<\/p>\n\n\n\n<p>Skin cancer has been reported in patients receiving long-term treatment with Voriconazole Sandoz.<\/p>\n\n\n\n<p>Sun damage or severe skin reaction after exposure to light or sun was more common in children.&nbsp;If you or your child develop skin changes, the doctor may refer you or your child to a&nbsp;dermatologist&nbsp;who, after consultation, may decide that it is important for you or your child to have regular check-ups.<\/p>\n\n\n\n<p>Elevated liver enzyme levels were also seen more often in children.<\/p>\n\n\n\n<p>If any of these&nbsp;side effects&nbsp;do not go away or are bothersome, tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Voriconazole Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the blister card, carton, and can after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is voriconazole.\u00a0Each film-coated tablet contains 200 mg of voriconazole.<\/li><li>Other ingredients are\u00a0lactose monohydrate, pregelatinized corn starch, croscarmellose sodium, povidone, magnesium stearate (in the tablet core) and hypromellose (E464),\u00a0lactose monohydrate, titanium dioxide (E171) and triacetin (in the film coating).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>White to off-white, biconvex, capsule-shaped, film-coated tablets marked with \u201c200\u201d on one side and plain on the other side.<\/p>\n\n\n\n<p>The film-coated tablets are packed in PVC\/PVDC\/Alu blisters and placed in a carton.<\/p>\n\n\n\n<p>Pack sizes: 2, 10, 14, 20, 28, 30, 50, 56, 60, 98, 100, 500, and 1000 film-coated tablets.<\/p>\n\n\n\n<p>The film-coated tablets are packed in an HDPE jar with a child-resistant screw cap and placed in a cardboard box.<\/p>\n\n\n\n<p>Pack sizes: 30, 50, 56, and 100 film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Sandoz A\/S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Lek Pharmaceuticals dd Verovskova 57, 1526 Ljubljana, Slovenia<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>LEK SA ul.&nbsp;Domaniewska 50 C, 02672 Warsaw, Poland<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Salutas Pharma GmbH.&nbsp;Otto-von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>SC Sandoz, SRL Str. Livezeni no.&nbsp;7A, RO-540472 Targu-Mures, Romania<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Voriconazole Sandoz contains the active substance voriconazole.\u00a0Voriconazole Sandoz is a medicine against fungal infections.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27439,27698,27702,27700,27441,27442,27444,27699,27440,27701],"class_list":["post-30993","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-voriconazole","tag-voriconazole-sandoz","tag-voriconazole-sandoz-side-effects","tag-voriconazole-sandoz-tablet","tag-voriconazole-side-effects","tag-voriconazole-tablet","tag-what-is-voriconazole","tag-what-is-voriconazole-sandoz","tag-what-voriconazole-is-used-for","tag-what-voriconazole-sandoz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=30993"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30993\/revisions"}],"predecessor-version":[{"id":31228,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30993\/revisions\/31228"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=30993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=30993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=30993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}