{"id":30988,"date":"2022-11-07T09:43:54","date_gmt":"2022-11-07T09:43:54","guid":{"rendered":"https:\/\/zeepedia.com\/?p=30988"},"modified":"2022-11-08T07:48:51","modified_gmt":"2022-11-08T07:48:51","slug":"voriconazole-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/voriconazole-accord\/","title":{"rendered":"Voriconazole Accord &#8211; Voriconazole uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg and 200 mg&nbsp;film-coated tablets<br>voriconazole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Voriconazole Accord is and what it is used for<\/h2>\n\n\n\n<p>Voriconazole Accord contains the active substance voriconazole.\u00a0Voriconazole Accord is a medicine against fungal infections.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection.<\/p>\n\n\n\n<p>Voriconazole Accord is used to treat patients (adults and children from 2 years of age) with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>invasive\u00a0aspergillosis\u00a0(a type of fungal infection caused by\u00a0<em>Aspergillus sp.<\/em>\u00a0)<\/li><li>candidemia\u00a0(another type of fungal infection caused by\u00a0<em>Candida sp.)<\/em>\u00a0in non-neutropenic\u00a0patients (patients without an abnormally low\u00a0white blood cell count\u00a0)<\/li><li>severe invasive\u00a0<em>Candida sp.\u00a0<\/em>infection\u00a0when the fungus is resistant to\u00a0fluconazole\u00a0(another antifungal medicine)<\/li><li>severe fungal infections caused by\u00a0<em>Scedosporium sp.\u00a0<\/em>or\u00a0<em>Fusarium sp<\/em>\u00a0.\u00a0(two different mushroom species).<\/li><\/ul>\n\n\n\n<p>Voriconazole Accord is intended for patients with worsening and possibly life-threatening fungal infections.<\/p>\n\n\n\n<p>Preventive treatment in stem cell transplant patients who are at high risk of developing a fungal infection.<\/p>\n\n\n\n<p>This product should only be used under medical supervision.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Voriconazole Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Voriconazole Accord<\/h2>\n\n\n\n<p>if you are allergic to voriconazole or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<p>You must tell your doctor or pharmacist if you are taking or have taken any other medicines, even those without a prescription, or herbal remedies.<\/p>\n\n\n\n<p>The following medicines must not be taken during your treatment with Voriconazole Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>terfenadine (used for\u00a0allergies)<\/li><li>astemizole (used for\u00a0allergy\u00a0)<\/li><li>cisapride (used for stomach upset)<\/li><li>pimozide (used to treat mental illness)<\/li><li>quinidine\u00a0(used for irregular heartbeat)<\/li><li>ivabradine\u00a0(used for symptoms of\u00a0chronic\u00a0heart failure\u00a0)<\/li><li>rifampicin (used in the treatment of\u00a0tuberculosis\u00a0)<\/li><li>efavirenz (used in the treatment of\u00a0HIV\u00a0) at a\u00a0dose\u00a0of 400 mg or more once daily<\/li><li>carbamazepine (used to treat seizures)<\/li><li>phenobarbital (used for severe sleep disorders and convulsions)<\/li><li>ergot alkaloids (eg,\u00a0ergotamine, dihydroergotamine; used for\u00a0migraine\u00a0)<\/li><li>sirolimus (used in transplant patients)<\/li><li>ritonavir (used in the treatment of\u00a0HIV\u00a0) at a\u00a0dose\u00a0of 400 mg or more twice daily<\/li><li>St. John&#8217;s wort\u00a0(natural medicine)<\/li><li>naloxegol (used to treat constipation specifically caused by painkillers called\u00a0opioids\u00a0(eg morphine, oxycodone,\u00a0fentanyl, tramadol,\u00a0codeine\u00a0))<\/li><li>tolvaptan (used to treat\u00a0hyponatremia\u00a0(low levels of\u00a0sodium\u00a0in the blood) or to slow the deterioration of kidney function in patients with polycystic kidney disease)<\/li><li>lurasidone (used to treat depression)<\/li><li>venetoclax (used in the treatment of patients with\u00a0chronic lymphocytic leukemia\u00a0&#8211;\u00a0CLL\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Voriconazole Accord if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have previously had an\u00a0allergic reaction\u00a0to other azoles<\/li><li>you have or have previously had liver disease.\u00a0If you have liver disease, the doctor may prescribe a lower\u00a0dose\u00a0of Voriconazole Accord.\u00a0The doctor must also check your liver function through blood tests during the time you are treated with Voriconazole Accord<\/li><li>you have a known disease of the heart muscle, irregular heartbeats, slow heartbeats, or an\u00a0ECG\u00a0change called &#8220;long QTc syndrome&#8221;.<\/li><\/ul>\n\n\n\n<p>Avoid all sunlight and exposure to the sun while you are being treated with Voriconazole Accord.&nbsp;It is important to cover exposed areas of the skin and to use sunscreen with a high sun protection factor (SPF), as the skin can become more sensitive to the sun&#8217;s UV rays.&nbsp;These precautions also apply to children.<\/p>\n\n\n\n<p>While you are being treated with Voriconazole Accord should<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you immediately tell the doctor if you get<ul><li>sun damage<\/li><li>skin rash or blisters<\/li><li>bone pain<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you develop the above skin problems, your doctor may refer you to a dermatologist who, after a consultation, may decide that it is important for you to be examined regularly.\u00a0There is a small risk of developing skin cancer during long-term use of Voriconazole Accord.<\/p>\n\n\n\n<p>Tell your doctor if you develop signs of &#8216;adrenal insufficiency.\u00a0This means that the adrenal glands do not produce enough of certain steroid hormones such as\u00a0cortisol, which can lead to symptoms such as\u00a0chronic\u00a0or prolonged fatigue, muscle weakness, loss of appetite, weight loss, and abdominal pain.<\/p>\n\n\n\n<p>Talk to your doctor if you develop signs of Cushing&#8217;s syndrome.\u00a0This means that the body produces too much of the\u00a0hormone cortisol,\u00a0which\u00a0can lead to symptoms such as weight gain, lumps of fat between the shoulder blades, a round face, darker skin on the stomach, thighs, breasts, and arms, thin skin, bruising more easily, high blood sugar, excessive hair growth, excessive sweating.<\/p>\n\n\n\n<p>Your doctor checks liver and kidney function by taking certain blood samples.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Voriconazole Accord should not be given to children under 2 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Voriconazole Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p>Some medicines can affect or be affected by the simultaneous use of the Voriconazole Accord.<\/p>\n\n\n\n<p>Tell your doctor if you are taking the following medicines as Voriconazole Accord should not be taken at the same time if it can be avoided:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ritonavir (for the treatment of&nbsp;HIV&nbsp;) in a&nbsp;dose&nbsp;of 100 mg twice daily<\/li><li>Glasdegib (for cancer treatment) &#8211; if you need to be treated with both medicines, your doctor will do frequent checks on your heart rhythm.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines as concomitant treatment with Voriconazole Accord should be avoided if possible, and dose adjustment of voriconazole may be necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifabutin (for the treatment of\u00a0tuberculosis\u00a0).\u00a0If you are already being treated with rifabutin, your blood values \u200b\u200band\u00a0side effects\u00a0from rifabutin must be monitored.<\/li><li>Phenytoin\u00a0(for the treatment of\u00a0epilepsy\u00a0).\u00a0If you are already being treated with\u00a0phenytoin, the concentration of\u00a0phenytoin\u00a0in the blood must be monitored during treatment with Voriconazole Accord and the\u00a0dose\u00a0may need to be adjusted.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines as a dose adjustment or control may be needed to ensure that these medicines and Voriconazole Accord are still having the desired effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>warfarin\u00a0and other\u00a0anticoagulants\u00a0(eg phenprocoumon, acenocoumarol; used to\u00a0inhibit\u00a0the blood&#8217;s ability to clot)<\/li><li>ciclosporin (used in transplant patients)<\/li><li>tacrolimus (used in transplant patients)<\/li><li>sulfonylureas (tolbutamide, glipizide and glyburide) (used for\u00a0diabetes\u00a0)<\/li><li>statins (atorvastatin,\u00a0simvastatin\u00a0) (cholesterol-lowering drugs)<\/li><li>benzodiazepines (midazolam, triazolam) (used for severe sleep disorders and stress)<\/li><li>omeprazole (used in the treatment of\u00a0stomach ulcers\u00a0)<\/li><li>Oral contraceptives\u00a0(if you take Voriconazole Accord at the same time as using\u00a0oral contraceptives, you may experience\u00a0side effects\u00a0such as nausea and menstrual disturbances)<\/li><li>vinca alkaloids (vincristine and vinblastine) (used in the treatment of cancer)<\/li><li>tyrosine kinase inhibitors (eg axitinib, bosutinib, cabozantinib, ceritinib, cobimetinib, dabrafenib, dasatinib, nilotinib, sunitinib, ibrutinib, ribociclib) (used to treat cancer)<\/li><li>tretinoin (used in the treatment of\u00a0leukemia\u00a0)<\/li><li>indinavir and other\u00a0HIV\u00a0protease\u00a0inhibitors\u00a0(used in the treatment of\u00a0HIV\u00a0)<\/li><li>non-nucleoside reverse transcriptase inhibitors (efavirenz, delavirdine, nevirapine) (used in the treatment of\u00a0HIV\u00a0) (some\u00a0doses\u00a0of efavirenz must NOT be used at the same time as Voriconazole Accord)<\/li><li>methadone\u00a0(used to treat heroin addiction)<\/li><li>alfentanil and\u00a0fentanyl\u00a0and other short-acting opiates such as sufentanil (painkillers used in surgery)<\/li><li>oxycodone and other long-acting opiates such as hydrocodone (used for moderate to severe pain)<\/li><li>non-steroidal anti-inflammatory drugs (eg\u00a0ibuprofen,\u00a0diclofenac\u00a0) (used to treat pain and\u00a0inflammation\u00a0)<\/li><li>fluconazole\u00a0(used for fungal infections)<\/li><li>everolimus (used in the treatment of advanced kidney cancer and transplant patients)<\/li><li>letermovir (used to prevent cytomegalovirus (\u00a0CMV\u00a0) disease after bone marrow transplantation)<\/li><li>ivacaftor (used in the treatment of\u00a0cystic fibrosis\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Voriconazole Accord must not be taken during pregnancy unless prescribed by your doctor.\u00a0Effective contraception must be used by women of\u00a0childbearing\u00a0age.\u00a0Contact your doctor immediately if you become pregnant while taking Voriconazole Accord.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Voriconazole Accord may cause blurred vision or unpleasant sensitivity to light.\u00a0While you are experiencing something like this, do not drive, or use tools or machines.\u00a0Contact your doctor if you experience this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Voriconazole Accord contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking Voriconazole Accord.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Voriconazole Accord contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per 50 mg tablet, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per 200 mg tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Voriconazole Accord<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will decide your&nbsp;dose&nbsp;depending on your weight and the type of&nbsp;infection&nbsp;you have.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults (including elderly patients) is as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th scope=\"row\"><\/th><td><strong>Tablets<\/strong><\/td><\/tr><tr><td>Patients with 40 kg or more<\/td><td>Patients under 40 kg<\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong><br>(Loading Dose)<\/td><td>400 mg every 12 hours<br>for the first 24 hours<\/td><td>200 mg every 12 hours<br>for the first 24 hours<\/td><\/tr><tr><td><strong>Dose&nbsp;after the first 24 hours<\/strong><br>(Maintenance dose)<\/td><td>200 mg twice daily<\/td><td>100 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may&nbsp;prescribe&nbsp;an increase in&nbsp;dose&nbsp;from one to 300 mg twice daily.<\/p>\n\n\n\n<p>The doctor may&nbsp;prescribe&nbsp;a reduction in&nbsp;dose&nbsp;if you have mild to moderate liver dysfunction.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>The recommended\u00a0dose\u00a0for children and adolescents is:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th scope=\"row\"><\/th><td><strong>Tablets<\/strong><\/td><\/tr><tr><td>Children from 2 years and up to 12 years and young people 12-14 years weighing less than 50 kg<\/td><td>Young people aged 12-14 years who weigh more than 50 kg, as well as young people older than 14 years<\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong><br>(Loading Dose)<\/td><td>Treatment will be started as an&nbsp;infusion<\/td><td>400 mg every 12 hours<br>for the first 24 hours<\/td><\/tr><tr><td><strong>Dose&nbsp;after the first 24 hours<\/strong><br>(Maintenance dose)<\/td><td>9 mg\/kg twice daily<br>(maximum&nbsp;dose&nbsp;is 350 mg twice daily)<\/td><td>200 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may increase or decrease the daily\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tablets may only be given to children who can swallow tablets.<\/li><\/ul>\n\n\n\n<p>Take your tablet at least one hour before, or one hour after, a meal.&nbsp;Swallow the tablet whole with water.<\/p>\n\n\n\n<p>If you or your child are taking Voriconazole Accord to prevent fungal infections, the doctor may stop giving Voriconazole Accord if you or your child develop&nbsp;side effects&nbsp;caused by the treatment<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Voriconazole Accord<\/h2>\n\n\n\n<p>If you take more Voriconazole Accord than prescribed (or if someone else takes your tablets), you must consult a doctor or go immediately to the emergency department of the nearest hospital.&nbsp;Bring your pack of Voriconazole Accord tablets.&nbsp;You may experience an abnormal sensitivity to light if you take too much Voriconazole Accord.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Voriconazole Accord<\/h2>\n\n\n\n<p>You must take your Voriconazole Accord tablets regularly at the same time every day.\u00a0If you forget to take a\u00a0dose, take the next\u00a0dose\u00a0as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Voriconazole Accord<\/h2>\n\n\n\n<p>It has been shown that the effect of your medicine can be significantly increased if all&nbsp;doses&nbsp;are taken at the right time.&nbsp;Therefore, unless your doctor tells you to stop treatment, it is important to continue taking Voriconazole Accord as described above.<\/p>\n\n\n\n<p>Keep taking Voriconazole Accord until your doctor tells you to stop.&nbsp;Do not stop treatment prematurely as your&nbsp;infection&nbsp;may not clear up.&nbsp;Patients with weakened immune systems or those with severe&nbsp;infections&nbsp;may need long-term treatment to prevent&nbsp;infection&nbsp;from returning.<\/p>\n\n\n\n<p>When treatment with Voriconazole Accord is stopped by your doctor, you should not notice any effect from this.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If any&nbsp;side effects&nbsp;occur, most are likely to be minor or temporary.&nbsp;However, some can be serious and require medical attention.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;&#8211; Stop taking Voriconazole Accord and see a doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>jaundice;&nbsp;changes in blood tests that test liver function<\/li><li>inflammation&nbsp;of the pancreas<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>visual impairment (visual changes, including blurred vision, altered color vision, abnormal hypersensitivity to light, color blindness, eye disorders, the experience of halo phenomenon,\u00a0night blindness, oscillating visual experience, flashes in the\u00a0visual field, visual\u00a0aura, decreased\u00a0visual acuity, enhanced visual experience of light, loss of parts of the normal field of\u00a0vision\u00a0et, spots in front of the eyes [fly vision])<\/li><li>fever<\/li><li>rash<\/li><li>nausea, vomiting, diarrhea<\/li><li>headache<\/li><li>swollen arms and legs<\/li><li>stomach pains<\/li><li>breathing difficulties<\/li><li>elevated liver enzyme levels<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sinusitis,\u00a0inflammation\u00a0of the gums, chills, weakness<\/li><li>reduced number, even severe, of certain types of red (sometimes immune-related) and\/or\u00a0white blood cells\u00a0(sometimes with fever), reduced number of\u00a0thrombocytes\u00a0(\u00a0platelets\u00a0) \u2013 cells that help blood clot<\/li><li>low blood sugar, low level of\u00a0potassium\u00a0in the blood, low level of\u00a0sodium\u00a0in the blood<\/li><li>anxiety, depression, confusion, restlessness, difficulty sleeping, hallucinations<\/li><li>seizures, tremors or uncontrolled muscle movements, tingling or abnormal skin sensations, increased muscle tension, sleepiness, dizziness<\/li><li>bleeding in the eye<\/li><li>heart rhythm disorders, including very fast heartbeats, very slow heartbeats, fainting low\u00a0blood pressure,\u00a0inflammation\u00a0of a blood vessel (which can cause blood clots)<\/li><li>acute breathing problems, chest pain, swelling of the face (mouth, lips, and around the eyes), water in the lungs<\/li><li>constipation, indigestion,\u00a0inflammation\u00a0of the lips<\/li><li>jaundice,\u00a0inflammation\u00a0of the liver, and liver damage<\/li><li>skin rash that can lead to severe blistering and scaling of the skin characterized by a flat, red area of \u200b\u200bskin covered in small confluent bumps, redness of the skin<\/li><li>itching<\/li><li>hair loss<\/li><li>back pain<\/li><li>kidney failure, blood in the urine, altered kidney function values<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>flu-like symptoms, irritation, and\u00a0inflammation\u00a0of the gastrointestinal tract,\u00a0inflammation\u00a0of the gastrointestinal tract causing antibiotic-associated diarrhea,\u00a0inflammation\u00a0of the lymphatic vessels<\/li><li>inflammation\u00a0of the thin membrane that covers the inside of the abdominal wall and the abdominal organs<\/li><li>enlarged\u00a0lymph nodes\u00a0(sometimes painful), bone marrow failure, increased level of eosinophils<\/li><li>impaired adrenal function, underactive\u00a0thyroid gland<\/li><li>abnormal brain function, Parkinson-like symptoms, nerve damage that causes numbness, pain, tingling, or burning in the hands or feet<\/li><li>impaired balance and coordination skills<\/li><li>brain swelling<\/li><li>double vision, serious eye conditions, including pain and\u00a0inflammation\u00a0of the eye and eyelid, abnormal eye movements, damage to the\u00a0optic nerve\u00a0leading to visual impairment, swelling of the optic nerve papilla<\/li><li>impaired sense of touch<\/li><li>altered sense of taste<\/li><li>hearing difficulties, ringing in the ears,\u00a0vertigo<\/li><li>inflammation\u00a0of specific internal organs \u2013 the pancreas and\u00a0duodenum, swelling of and\u00a0inflammation\u00a0of the tongue<\/li><li>liver enlargement, liver failure, gallstones,\u00a0gallstones<\/li><li>joint inflammation,\u00a0inflammation\u00a0of veins under the skin (which may be associated with blood clot formation)<\/li><li>nephritis, protein in the urine, kidney damage<\/li><li>very fast\u00a0pulse\u00a0or skipped heartbeats, sometimes with irregular electrical impulses<\/li><li>abnormal\u00a0EKG<\/li><li>increased level of\u00a0cholesterol\u00a0in the blood, increased level of\u00a0urea\u00a0in the blood<\/li><li>allergic skin reactions (sometimes serious), including life-threatening skin diseases that cause painful blisters and sores on the skin and mucous membranes, especially in the mouth,\u00a0inflammation\u00a0of the skin,\u00a0hives, sunburn, or severe skin reactions after exposure to light or sun, skin redness and skin irritation, red or purple discoloration of the skin which may be due to a reduced number of\u00a0platelets,\u00a0eczema<\/li><li>infusion site reaction<\/li><li>allergic reactions or excessive\u00a0immune response<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>overactive\u00a0thyroid<\/li><li>impaired brain function which is a serious complication of liver disease<\/li><li>loss of most of the fibers in\u00a0optic nerve\u00a0one, clouding of the cornea, involuntary eye movements<\/li><li>bullous\u00a0photosensitivity<\/li><li>a disorder in which the body&#8217;s immune system attacks parts of the\u00a0peripheral nervous system<\/li><li>disturbances of the heart rhythm or conduction in the heart (sometimes life-threatening)<\/li><li>life-threatening\u00a0allergic reaction<\/li><li>changes in the blood&#8217;s ability to clot<\/li><li>allergic skin reactions (sometimes severe) including rapid swelling (edema) of the &#8220;leathery skin&#8221; (\u00a0dermis\u00a0),\u00a0subcutaneous\u00a0tissue, mucous membranes and\u00a0submucosal tissue, itchy or sore patches of thick, red skin with silvery scales, irritation of the skin and mucous membranes, a life-threatening skin disease which causes large parts of the skin&#8217;s outermost layer (\u00a0epidermis\u00a0) to detach from the underlying skin layer<\/li><li>small patches of dry and scaly skin, sometimes thickened with corn<\/li><\/ul>\n\n\n\n<p>Adverse effects&nbsp;with no known frequency:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>freckles and pigment spots<\/li><\/ul>\n\n\n\n<p>Other important\u00a0side effects\u00a0whose frequency is not known but which should be reported to the doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin cancer<\/li><li>inflammation&nbsp;of the&nbsp;tissue&nbsp;surrounding the bone<\/li><li>red, scaly patches or ring-shaped skin changes that may be symptoms of an&nbsp;autoimmune&nbsp;disease called&nbsp;cutaneous&nbsp;lupus erythematosus<\/li><\/ul>\n\n\n\n<p>As Voriconazole Accord can affect the liver and kidneys, your doctor should check your liver and kidney function by taking blood tests.&nbsp;Tell your doctor if you have a stomach ache or if your stool has a different consistency.<\/p>\n\n\n\n<p>Skin cancer has been reported in patients treated with Voriconazole Accord during long-term treatment.<\/p>\n\n\n\n<p>Sun damage or severe skin reaction after exposure to light or sun was more common in children.&nbsp;If you or your child develop skin changes, the doctor may refer you or your child to a&nbsp;dermatologist&nbsp;who, after consultation, may decide that it is important for you or your child to have regular check-ups.&nbsp;Elevated liver enzyme levels were also seen more often in children.<\/p>\n\n\n\n<p>If any of these&nbsp;side effects&nbsp;do not go away or are bothersome, tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Voriconazole Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is voriconazole.\u00a0Each tablet contains 50 mg voriconazole (for Voriconazole Accord 50 mg film-coated tablets) or 200 mg voriconazole (for Voriconazole Accord 200 mg film-coated tablets).<\/li><li>Other ingredients are\u00a0lactose monohydrate, pregelatinized\u00a0starch, croscarmellose sodium, povidone, and magnesium stearate which make up the tablet core, and hypromellose, titanium dioxide (E171),\u00a0lactose monohydrate,\u00a0and triacetin which make up the film coating (see section 2, Voriconazole Accord 50 mg film-coated tablets or Voriconazole Accord 200 mg film-coated tablets contain\u00a0lactose\u00a0and\u00a0sodium\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Voriconazole Accord 50 mg film-coated tablets are supplied as white to off-white round film-coated tablets, approximately 7 mm in diameter, marked with &#8220;V50&#8221; on one side and unmarked on the other side.<\/p>\n\n\n\n<p>Voriconazole Accord 200 mg film-coated tablets are supplied as white to off-white oval film-coated tablets, approximately 15.5 mm long and 7.8 mm wide, marked with &#8220;V200&#8221; on one side and unmarked on the other side.<\/p>\n\n\n\n<p>Voriconazole Accord 50 mg film-coated tablets and 200 mg film-coated tablets are available in pack sizes of 2, 10, 14, 20, 28, 30, 50, 56, and 100 tablets or single-dose blister packs (PVC\/aluminum) containing 10 x 1, 14 x 1, 28 x 1, 30 x 1, 56 x 1 and 100 x 1 film-coated tablet.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center, Moll de Barcelona,<\/p>\n\n\n\n<p>s\/n, Edifici Est 6\u00aa planta,<\/p>\n\n\n\n<p>08039 Barcelona,<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Paradox Healthcare Ltd.\u00a0<\/p>\n\n\n\n<p>KW20A Kordin Industrial Park,&nbsp;<\/p>\n\n\n\n<p>Paola, PLA 3000<\/p>\n\n\n\n<p>Malta<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomirska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>Accord Healthcare BV,<\/p>\n\n\n\n<p>Winthontlaan 200,<\/p>\n\n\n\n<p>3526 VK Utrecht,<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Voriconazole Accord contains the active substance voriconazole.\u00a0Voriconazole Accord is a medicine against fungal infections.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27439,27709,27712,27713,27441,27442,27444,27711,27710,27440],"class_list":["post-30988","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-voriconazole","tag-voriconazole-accord","tag-voriconazole-accord-side-effects","tag-voriconazole-accord-tablet","tag-voriconazole-side-effects","tag-voriconazole-tablet","tag-what-is-voriconazole","tag-what-is-voriconazole-accord","tag-what-voriconazole-accord-is-used-for","tag-what-voriconazole-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30988","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=30988"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30988\/revisions"}],"predecessor-version":[{"id":31230,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30988\/revisions\/31230"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=30988"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=30988"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=30988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}