2.5 mg, 5 mg, and 10 mg\u00a0film-coated tablets
ambrisentan<\/p>\n\n\n\n
Volibris contains the active substance ambrisentan. It belongs to a group of medicines called other antihypertensives (used to treat high blood pressure ).<\/p>\n\n\n\n
It is used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0(PAH) in adults, adolescents, and children aged 8 and over.\u00a0PAH is high\u00a0blood pressure\u00a0in the blood vessels (pulmonary arteries) that transport blood from the heart to the lungs.\u00a0In people with PAH, these\u00a0arteries\u00a0become narrower so the heart has to work harder to pump blood through them.\u00a0This makes you feel tired, dizzy, and short of breath.<\/p>\n\n\n\n
Volibris widens the pulmonary arteries and makes it easier for the heart to pump blood through them. This lowers blood pressure and relieves symptoms.<\/p>\n\n\n\n
Volibris can also be used in combination with other medicines used to treat PAH. Talk to your doctor before taking this medicine:<\/p>\n\n\n\n \u2192 Your doctor will decide<\/strong> if Volibris is suitable for you.<\/p>\n\n\n\n You need to take blood tests regularly<\/p>\n\n\n\n Before you start taking Volibris and regularly while you are taking it, your doctor will take blood tests to check:<\/p>\n\n\n\n \u2192 you must submit these regular blood tests as long as you are taking Volibris.<\/p>\n\n\n\n Signs that your liver may not be working as it should include:<\/p>\n\n\n\n If you notice any of these signs:<\/p>\n\n\n\n \u2192 Tell your doctor immediately.<\/strong><\/a><\/p>\n\n\n\n Do not give this medicine to children under 8 years of age as safety and efficacy are not known in this age group.<\/a><\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n If you start taking ciclosporin A<\/strong> (a medicine used after transplantation or to treat psoriasis ), your doctor may need to adjust your dose of Volibris.<\/p>\n\n\n\n If you are taking rifampicin<\/strong> (an antibiotic used to treat serious infections ), your doctor will monitor you more frequently when you start taking Volibris.<\/p>\n\n\n\n If you are taking other medicines used to treat PAH (eg iloprost, epoprostenol, sildenafil) your doctor may need to monitor you more often.<\/p>\n\n\n\n \u2192 Tell your doctor or pharmacist<\/strong> if you are taking any of these medicines.<\/a><\/p>\n\n\n\n Volibris can harm the unborn baby if you become pregnant before, during, or shortly after treatment.<\/p>\n\n\n\n \u2192 If it is possible that you could become pregnant, you should use reliable contraception<\/strong> while taking Volibris. Discuss this with your doctor.<\/p>\n\n\n\n \u2192 Do not take Volibris if you are pregnant or planning to become pregnant.<\/strong><\/p>\n\n\n\n \u2192 If you become pregnant or suspect you may be pregnant<\/strong> while taking Volibris, contact your doctor immediately.<\/strong><\/p>\n\n\n\n If you are a woman and could become pregnant, your doctor will ask you to do a pregnancy test<\/strong> before you start taking Volibris and regularly while you are taking Volibris.<\/a><\/p>\n\n\n\n It is not known whether the active substance in Volibris can pass into breast milk.<\/p>\n\n\n\n \u2192 Do not breastfeed while taking Volibris. <\/strong>Discuss this with your doctor.<\/p>\n\n\n\n If you are a man and take Volibris, there may be a risk that Volibris reduces the number of sperm. Talk to your doctor if you have any questions about this.<\/a><\/p>\n\n\n\n Volibris can cause\u00a0side effects, such as low\u00a0blood pressure, dizziness, and fatigue (see section 4) which can affect your ability to drive or use machines.\u00a0The symptoms of your illness may also make you less fit to drive or use machinery.<\/p>\n\n\n\n \u2192 Do not drive a vehicle or use machinery if you do not feel well.<\/strong><\/a><\/p>\n\n\n\n Volibris tablets contain small amounts of sugar called\u00a0lactose.\u00a0If your doctor has told you that you have an intolerance to certain sugars:<\/p>\n\n\n\n \u2192 Consult your doctor<\/strong> before taking this medicine.<\/p>\n\n\n\n Volibris contains lecithin that comes from soy<\/strong><\/p>\n\n\n\n If you are allergic to soya, do not take this medicine (see section 2 \u201cDo not take Volibris\u201d).<\/p>\n\n\n\n Volibris 5 mg and 10 mg tablets contain a dye called Allura red AC aluminum lake (E129)<\/strong><\/p>\n\n\n\n This can cause allergic reactions (see section 4).<\/p>\n\n\n\n Volibris contains sodium<\/strong><\/p>\n\n\n\n This medicine contains less than 1 mmol (23 mg) of sodium per tablet, i.e. is almost “sodium-free”. Always use this medicine as directed by your doctor or pharmacist. <\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n How much Volibris you should take<\/strong><\/p>\n\n\n\n Adults<\/strong><\/p>\n\n\n\n The usual dose of Volibris is one 5 mg tablet once a day. The doctor may decide to increase the dose by one to 10 mg once a day.<\/p>\n\n\n\n If you are taking cyclosporine A, do not take more than one 5 mg tablet of Volibris once a day.<\/p>\n\n\n\n Young people and children aged 8 to younger than 18 years<\/strong><\/p>\n\n\n\n
<\/a><\/p>\n\n\n\nWhat you need to know before you take Volibris<\/h2>\n\n\n\n
Do not take Volibris<\/h2>\n\n\n\n
Warnings and precautions<\/h2>\n\n\n\n
Children<\/h2>\n\n\n\n
Other medicines and Volibris<\/h2>\n\n\n\n
Pregnancy<\/h2>\n\n\n\n
Breast-feeding<\/h2>\n\n\n\n
Fertility<\/strong><\/p>\n\n\n\nDriving ability and use of machinery<\/h2>\n\n\n\n
Volibris contains lactose<\/h2>\n\n\n\n
<\/a><\/p>\n\n\n\nHow to take Volibris<\/h2>\n\n\n\n