{"id":30847,"date":"2022-11-06T16:25:03","date_gmt":"2022-11-06T16:25:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=30847"},"modified":"2022-11-07T09:34:59","modified_gmt":"2022-11-07T09:34:59","slug":"vizimpro","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vizimpro\/","title":{"rendered":"Vizimpro &#8211; Dacomitinib uses, dose and side effects"},"content":{"rendered":"\n<p>15 mg, 30 mg, and 45 mg\u00a0film-coated tablets<br>dacomitinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vizimpro is and what it is used for<\/h2>\n\n\n\n<p>Vizimpro contains the active substance dacomitinib, which belongs to a group of medicines called&nbsp;protein&nbsp;tyrosine kinase inhibitors used to treat cancer.<\/p>\n\n\n\n<p>Vizimpro is used to treat adults with a type of lung cancer called non-small cell lung cancer.\u00a0If a test has shown that your cancer has certain changes (\u00a0mutations\u00a0) in a gene called EGFR (\u00a0epidermal\u00a0growth factor receptor) and has spread to your other lung or other organs, your cancer is likely to respond to treatment with Vizimpro.<\/p>\n\n\n\n<p>Vizimpro can be used as the first treatment when your lung cancer has spread to your second lung or other organs.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Vizimpro<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Vizimpro<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to dacomitinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Vizimpro:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had other lung problems.&nbsp;Some lung problems may worsen when treated with Vizimpro because Vizimpro can cause&nbsp;inflammation&nbsp;in the lungs during treatment.&nbsp;The symptoms can be similar to those of lung cancer.&nbsp;Tell your doctor immediately if you develop new or worsening symptoms, such as&nbsp;difficulty breathing, shortness of breath, cough with or without phlegm, or fever.<\/li><li>if you are being treated with any of the medicines listed in the&nbsp;<em>Other medicines and Vizimpro section.<\/em><\/li><\/ul>\n\n\n\n<p>Inform the doctor immediately when taking this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you get diarrhea.\u00a0Diarrhea must be treated immediately.<\/li><li>if you get a rash.\u00a0Treatment of skin rashes must be started early.<\/li><li>if you get symptoms of liver problems, e.g.\u00a0yellow-colored skin or whites of the eyes (jaundice), dark or brown (tea-colored) urine, or light-colored stools.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Vizimpro has not been studied in children and adolescents and must not be given to patients under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vizimpro<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This is important because some medicines&nbsp;can have an enhanced effect&nbsp;if taken together with Vizimpro.&nbsp;This applies, among other things:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>procainamide, which is used for irregular heart rhythms<\/li><li>pimozide and thioridazine, used in schizophrenia and\u00a0psychosis.<\/li><\/ul>\n\n\n\n<p>You should not take these medicines while you are being treated with Vizimpro.<\/p>\n\n\n\n<p>The following medicines&nbsp;may reduce the effect&nbsp;&nbsp;of Vizimpro:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Long-acting medicines to reduce the amount of stomach acid, e.g.\u00a0proton pump inhibitors\u00a0(for\u00a0stomach ulcers, indigestion, and heartburn).<\/li><\/ul>\n\n\n\n<p>You should not take these medicines while you are being treated with Vizimpro.&nbsp;Instead, you can take a short-acting medicine, such as an antacid or a medicine called an H2 blocker.&nbsp;If you take H2 blockers, take your&nbsp;dose&nbsp;of Vizimpro at least 2 hours before or 10 hours after taking the H2 blocker.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>You must not have children during treatment with Vizimpro.\u00a0This medicine can harm the fetus.\u00a0If there is any risk that you could become pregnant, you must use effective contraception during treatment and for at least 17 days afterward.\u00a0Contact your doctor immediately if you become pregnant while taking this medicine.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>You should not breastfeed while taking this medicine because it is not known whether it can harm the baby.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Fatigue and eye irritation may occur in patients taking Vizimpro.&nbsp;If you feel tired or if your eyes are irritated, be careful when driving any vehicle or using machinery.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vizimpro contains lactose and sodium<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;(found in milk and dairy products).&nbsp;If you have an intolerance to some sugars, you should contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vizimpro<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 45 mg by mouth every day.<\/li><li>Take the tablet at about the same time each day.<\/li><li>Swallow the tablet whole with a glass of water.<\/li><li>You can take the tablet with or without food.<\/li><\/ul>\n\n\n\n<p>The doctor may reduce the&nbsp;dose&nbsp;of this medicine depending on how well you tolerate it.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vizimpro<\/h2>\n\n\n\n<p>If you have taken too much Vizimpro, see a doctor or go to the hospital immediately.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vizimpro<\/h2>\n\n\n\n<p>If you miss a&nbsp;dose&nbsp;or vomit it up, take the next&nbsp;dose&nbsp;as planned.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Vizimpro<\/h2>\n\n\n\n<p>Do not stop taking Vizimpro unless your doctor tells you to.\u00a0If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Contact the doctor immediately if you experience any of the following&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the lungs (common, may affect up to 1 in 10 people)<\/li><\/ul>\n\n\n\n<p>Breathing problems, shortness of breath, possibly with cough or fever.&nbsp;This may indicate an&nbsp;inflammation&nbsp;of the lungs called interstitial lung disease, which can be fatal.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea (very common, may affect more than 1 in 10 people)<\/li><\/ul>\n\n\n\n<p>Diarrhea can lead to dehydration (common), low potassium in the blood (very common), and impaired lung function, and can lead to death.\u00a0At the first sign of more frequent bowel movements, contact the doctor immediately, drink plenty of fluids and start anti-diarrhea medication as soon as possible.\u00a0Before you start taking Vizimpro, you should have anti-diarrhea medicine at home.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash (very common)<\/li><\/ul>\n\n\n\n<p>The rash must be treated early.\u00a0Tell your doctor if you get a rash.\u00a0If the treatment for the rash does not work or the rash worsens (if your skin e.g. flakes or cracks), tell the doctor immediately.\u00a0The doctor may decide that you should stop treatment with Vizimpro.\u00a0Skin rashes may appear or worsen in areas exposed to the sun.\u00a0The use of protective clothing and sunscreen is recommended.<\/p>\n\n\n\n<p>Tell your doctor as soon as possible if you get any of the following side effects:<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation\u00a0in the mouth and lips<\/li><li>Problems with the nails<\/li><li>Dry skin<\/li><li>Loss of appetite<\/li><li>Dry, red, or itchy eyes<\/li><li>Weight loss<\/li><li>Hair loss<\/li><li>Itching<\/li><li>Abnormal liver enzymes in blood tests<\/li><li>Nausea or vomiting<\/li><li>Reddened or painful palms or soles of feet<\/li><li>Fatigue<\/li><li>Weakness<\/li><li>Skin cracks<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Taste changes<\/li><li>Scaly skin<\/li><li>Eye inflammation<\/li><li>Abnormal body hair<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vizimpro<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister pack after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>This medicine may pose a risk to the environment.\u00a0Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is dacomitinib (as dacomitinib monohydrate).\u00a0Vizimpro tablets are available in different strengths. Vizimpro 15 mg tablet: each tablet contains 15 mg dacomitinibVizimpro 30 mg tablet: each tablet contains 30 mg dacomitinibVizimpro 45 mg tablet: each tablet contains 45 mg dacomitinib<\/li><li>Other ingredients are Tablet core:\u00a0lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, and magnesium stearate (see section 2\u00a0Vizimpro contains\u00a0lactose\u00a0and\u00a0sodium\u00a0).Film coating: Opadry II blue 85F30716 containing polyvinyl alcohol &#8211; partially hydrolyzed (E1203), talc (E553b), titanium dioxide (E171), macrogol (E1521), indigo carmine aluminum lake (E132).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Vizimpro 15 mg film-coated tablets are blue, film-coated, round, biconvex tablets debossed with \u201cPfizer\u201d on one side and \u201cDCB15\u201d on the other side.<\/li><li>Vizimpro 30 mg film-coated tablets are blue, film-coated, round, biconvex tablets debossed with \u201cPfizer\u201d on one side and \u201cDCB30\u201d on the other side.<\/li><li>Vizimpro 45 mg film-coated tablets are blue, film-coated, round, biconvex tablets debossed with \u201cPfizer\u201d on one side and \u201cDCB45\u201d on the other side.<\/li><\/ul>\n\n\n\n<p>They are available in blister packs of 30 film-coated tablets (tablets).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;<\/p>\n\n\n\n<p>Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n<p>Betriebsst\u00e4tte Freiburg<\/p>\n\n\n\n<p>Mooswaldallee 1<\/p>\n\n\n\n<p>79090 Freiburg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer NV\/SATel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044fTel.: +359 2 970 4333<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.: +36-1-488-37-00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.&nbsp;s roTel.: +420 283 004 111<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Phone: + 35621 344610<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>The Netherlands<\/strong>Pfizer BVPhone: +31 (0)10 406 43 01<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbHPhone: +49 (0)30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branches.: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer Hellas AETel.: +30 210 6785 800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. oTel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0)1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLPhone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, a branch of marketing, LjubljanaTel.: + 386 (0)1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandPhone: 1800 633 363 (toll-free)+44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaTel.: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Telephone: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyTel.\/Tel: +358 (0)9 43 00 40<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABPhone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.&nbsp;(Cyprus Branch)Phone: +357 22 817690<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaTel.: + 371 670 35 775<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Vizimpro contains the active substance dacomitinib, which belongs to a group of medicines called\u00a0protein\u00a0tyrosine kinase inhibitors used to treat cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27637,27642,27640,27643,27646,27645,27639,27638,27641,27644],"class_list":["post-30847","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-dacomitinib","tag-dacomitinib-side-effects","tag-dacomitinib-tablet","tag-vizimpro","tag-vizimpro-side-effects","tag-vizimpro-tablet","tag-what-dacomitinib-is-used-for","tag-what-is-dacomitinib","tag-what-is-vizimpro","tag-what-vizimpro-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=30847"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30847\/revisions"}],"predecessor-version":[{"id":30973,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30847\/revisions\/30973"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=30847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=30847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=30847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}