{"id":30843,"date":"2022-11-06T16:21:53","date_gmt":"2022-11-06T16:21:53","guid":{"rendered":"https:\/\/zeepedia.com\/?p=30843"},"modified":"2022-11-07T09:35:10","modified_gmt":"2022-11-07T09:35:10","slug":"vivotif","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vivotif\/","title":{"rendered":"Vivotif &#8211; Salmonella\u00a0Typhi Ty21a uses, dose and side effects"},"content":{"rendered":"\n<p>hard enteric capsules<br>Salmonella&nbsp;Typhi Ty21a<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vivotif is and what it is used for<\/h2>\n\n\n\n<p>Vivotif is a vaccine to be swallowed.\u00a0It stimulates a reaction of the immune system against a type of bacteria called\u00a0<em>Salmonella<\/em>\u00a0Typhi, which causes\u00a0typhoid fever.\u00a0The vaccine is used to protect against\u00a0typhoid fever\u00a0in adults and children 5 years of age and older.<\/p>\n\n\n\n<p><strong>How Vivotif works<\/strong><\/p>\n\n\n\n<p>The vaccine bacteria in Vivotif have been altered so that they cannot cause\u00a0typhoid fever\u00a0but can still stimulate the body&#8217;s natural defense system (the immune system) to fight bacteria that cause\u00a0typhoid fever.<\/p>\n\n\n\n<p><strong>Other types of&nbsp;<em>Salmonella&nbsp;&#8211;<\/em>&nbsp;disease<\/strong><\/p>\n\n\n\n<p>There are many other types of\u00a0<em>Salmonella<\/em>\u00a0bacteria.\u00a0Most of these cause diarrheal diseases that are quite different from\u00a0typhoid fever.\u00a0They are also less serious.\u00a0Vivotif cannot protect you against\u00a0infection\u00a0caused by these other types of\u00a0<em>Salmonella<\/em>\u00a0bacteria.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Vivotif<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vivotif<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to\u00a0<em>Salmonella\u00a0<\/em>Typhi Ty21a or any of the other ingredients of this vaccine (listed in section 6).<\/li><li>if you have had allergic reactions when you have previously taken Vivotif.<\/li><li>if for some reason you have a weakened immune system if you e.g.\u00a0have had reduced immunity to\u00a0infection\u00a0since birth.\u00a0You may also have reduced immunity due to certain\u00a0infections\u00a0or treatments that inhibit the immune system, e.g.\u00a0high\u00a0doses\u00a0of\u00a0corticosteroids, cancer drugs, or radiation.<\/li><li>if you have a high fever (above 38.5\u00baC) or an illness affecting the bowels (such as diarrhea) at the moment;\u00a0in that case, wait to take Vivotif until you have recovered.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Not everyone who takes a full treatment with Vivotif will be completely protected against\u00a0typhoid fever.\u00a0It is important to continue to follow hygiene advice and to be careful when consuming food and water in areas affected by\u00a0typhoid fever.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this vaccine to children younger than 5 years, as the capsule is not suitable for this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vivotif<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines or vaccines.\u00a0This also applies to over-the-counter medicines including (traditional) herbal medicines.\u00a0This is because Vivotif can affect the way other medicines and vaccines work.<\/p>\n\n\n\n<p>You must tell your doctor, pharmacist, or nurse if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Antibiotics\u00a0\u2013 Vivotif may not work if you take it at the same time as\u00a0antibiotics.\u00a0Do not take Vivotif earlier than 3 days after the last\u00a0dose of\u00a0an\u00a0antibiotic.<\/li><li>Medicines to prevent\u00a0malaria\u00a0&#8211; do not start these until 3 days after the last\u00a0dose\u00a0of Vivotif, unless your doctor, pharmacist, or nurse has told you otherwise.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, talk to your doctor, pharmacist, or nurse before taking Vivotif.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vivotif with food and drink<\/h2>\n\n\n\n<p>Vivotif should be taken on an empty stomach and at least one hour before the next meal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Vivotif is not expected to affect the ability to drive or use machines.&nbsp;However, do not drive or use machinery if you feel unwell.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vivotif contains lactose and sucrose<\/h2>\n\n\n\n<p>If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vivotif<\/h2>\n\n\n\n<p>Always take this vaccine exactly as your doctor, pharmacist, or nurse has told you.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.<\/p>\n\n\n\n<p>Check the blister pack containing the vaccine capsules to ensure that the foil seal and capsules are intact.<\/p>\n\n\n\n<p><strong>How much and when to take Vivotif<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is three capsules.&nbsp;Take one capsule every other day.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the first capsule on a selected day.&nbsp;This is day 1.<\/li><li>Take the second capsule on day 3.<\/li><li>Take the third capsule on day 5.<\/li><\/ul>\n\n\n\n<p><strong>How to take the capsules<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the capsules on an empty stomach and at least one hour before the next meal.<\/li><li>Do not crush or chew the capsules.<\/li><li>Swallow the capsules with cold or lukewarm water (temperature no more than 37 \u00b0C).<\/li><li>Swallow the capsules as quickly as possible after placing them in your mouth.<\/li><\/ul>\n\n\n\n<p>Protection against\u00a0typhoid fever\u00a0starts about seven to ten days after you take the three-capsule treatment.\u00a0Your doctor, pharmacist, or nurse will advise you on how close to the trip you should take Vivotif.<\/p>\n\n\n\n<p>After three years, you may need to take Vivotif again, if you continue to visit areas where\u00a0typhoid fever\u00a0occurs.\u00a0In this case, contact a doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vivotif<\/h2>\n\n\n\n<p>If you accidentally take all three\u00a0doses\u00a0at the same time or if e.g.\u00a0a child accidentally ingested the vaccine, contact a doctor or hospital for an assessment of the risk and advice.\u00a0You probably won&#8217;t get sick, but you might not get good protection against\u00a0typhoid fever.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vivotif<\/h2>\n\n\n\n<p>If you forget a\u00a0dose, take it as soon as you remember.\u00a0Then take the next\u00a0dose\u00a0about 48 hours later.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all vaccines, this vaccine can cause\u00a0side effects, but not all users will get them.<\/p>\n\n\n\n<p>Contact your doctor immediately if you experience any of the following serious side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe&nbsp;allergic reaction&nbsp;causing swelling of the face or throat and shortness of breath and\/or drop in blood pressure and fainting.<\/li><\/ul>\n\n\n\n<p>Other side effects:<\/p>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stomach pain<\/li><li>nausea or vomiting<\/li><li>diarrhea<\/li><li>fever<\/li><li>headache<\/li><li>skin redness<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;(frequency cannot be estimated from available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin irritation, rash, red or bumpy raised rash, and\u00a0itching<\/li><li>weakness<\/li><li>general malaise<\/li><li>overindulge<\/li><li>fatigue<\/li><li>tingling and numbness<\/li><li>dizziness<\/li><li>pain in joints or muscles<\/li><li>back pain<\/li><li>decreased appetite, flatulence, distended abdomen<\/li><li>flu-like illness<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vivotif<\/h2>\n\n\n\n<p>Keep this vaccine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C &#8211; 8 \u00b0C).<\/p>\n\n\n\n<p>Store the blister pack in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Do not use this vaccine if you notice that the blister pack or capsules are not whole.<\/p>\n\n\n\n<p>Medicines should not be thrown down the drain.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment contents of the packaging and other information<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Each capsule contains at least 2 x 10\u00a0<sup>9<\/sup>\u00a0live cells of\u00a0<em>Salmonella<\/em>\u00a0Typhi Ty21a.<\/li><li>Other ingredients are anhydrous\u00a0lactose, sucrose, casein hydrolyzate,\u00a0ascorbic acid\u00a0(E300), magnesium stearate (E470), and non-viable cells of\u00a0Salmonella\u00a0Typhi Ty21a.Capsule shell: gelatin, titanium dioxide (E171), erythrosine (E127), yellow iron oxide (E172), and red iron oxide (E172).\u00a0Capsule coating: hypromellose phthalate, ethylene glycol, and diethyl phthalate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The package contains a blister pack with three enteric-coated capsules.\u00a0The capsules are two-colored;\u00a0white and salmon-colored.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Emergent Netherlands BV<\/p>\n\n\n\n<p>Stravinskylaan 411<\/p>\n\n\n\n<p>1077XX Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>IL-CSM GmbH<\/p>\n\n\n\n<p>Marie-Curie-Strasse 8<\/p>\n\n\n\n<p>D-79539 L\u00f6rrach<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Emergent BioSolutions UK Ltd.<\/p>\n\n\n\n<p>Building 3, Chiswick Park<\/p>\n\n\n\n<p>566 Chiswick High Road<\/p>\n\n\n\n<p>London, W4 5YA<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p><strong>This medicine is authorized in the European Economic Area and the United Kingdom (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<p>Austria, Belgium, Czech Republic, Denmark, Finland, France, Italy, Luxembourg, Netherlands, Norway, Portugal, Slovakia, Spain, United Kingdom (Northern Ireland): Vivotif<\/p>\n\n\n\n<p>Germany: Typhoral L<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vivotif is a vaccine to be swallowed.\u00a0It stimulates a reaction of the immune system against a type of bacteria called\u00a0Salmonella\u00a0Typhi, which causes\u00a0typhoid fever\u00a0.\u00a0The vaccine is used to protect against\u00a0typhoid fever\u00a0in adults and children 5 years of age and older.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27657,27662,27660,27663,27666,27665,27658,27661,27659,27664],"class_list":["post-30843","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-salmonella-typhi-ty21a","tag-salmonella-typhi-ty21a-capsule","tag-salmonella-typhi-ty21a-side-effects","tag-vivotif","tag-vivotif-capsule","tag-vivotif-side-effects","tag-what-is-salmonella-typhi-ty21a","tag-what-is-vivotif","tag-what-salmonella-typhi-ty21a-is-used-for","tag-what-vivotif-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=30843"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30843\/revisions"}],"predecessor-version":[{"id":30976,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/30843\/revisions\/30976"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=30843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=30843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=30843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}