{"id":29212,"date":"2022-11-02T16:15:05","date_gmt":"2022-11-02T16:15:05","guid":{"rendered":"https:\/\/zeepedia.com\/?p=29212"},"modified":"2022-11-03T10:09:12","modified_gmt":"2022-11-03T10:09:12","slug":"viread","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/viread\/","title":{"rendered":"Viread &#8211; Tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>123 mg&nbsp;film-coated tablets<br>tenofovir disoproxil<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Viread is and what it is used for<\/h2>\n\n\n\n<p>Viread contains the active substance\u00a0<em>tenofovir disoproxil<\/em>.\u00a0This active substance is an\u00a0antiretroviral\u00a0or antiviral medicine used to treat\u00a0HIV\u00a0infection\u00a0or\u00a0hepatitis\u00a0B\u00a0virus\u00a0( HBV)\u00a0infection\u00a0or\u00a0both.\u00a0Tenofovir is a nucleotide-type\u00a0reverse transcriptase inhibitor, commonly called an NRTI, and works by affecting the normal function of an\u00a0enzyme\u00a0(in\u00a0HIV\u00a0reverse transcriptase,\u00a0in\u00a0hepatitis\u00a0B\u00a0DNA polymerase\u00a0) that\u00a0viruses\u00a0need for their reproduction (propagation).\u00a0In the case of\u00a0HIV, Viread must always be taken in combination with other medicines against\u00a0HIV.<\/p>\n\n\n\n<p><strong>Viread 123 mg tablets are a treatment for\u00a0HIV<\/strong>\u00a0(human immunodeficiency virus)\u00a0infection.<\/p>\n\n\n\n<p>Viread 123 mg tablets are for use in children.&nbsp;They are only suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>children aged 6 to younger than 12 years<\/strong><\/li><li><strong>weighing from 17 kg to less than 22 kg<\/strong><\/li><li><strong>who has already been treated<\/strong>\u00a0with other\u00a0HIV\u00a0drugs that no longer have a satisfactory effect due to the development of resistance or have caused\u00a0side effects?<\/li><\/ul>\n\n\n\n<p><strong>Viread 123 mg tablets are also used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;B, an&nbsp;infection&nbsp;with HBV<\/strong>&nbsp;(&nbsp;hepatitis&nbsp;B&nbsp;virus&nbsp;).<\/p>\n\n\n\n<p>Viread 123 mg tablets are intended for children.&nbsp;They are only suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>children aged 6 to younger than 12 years<\/strong><\/li><li><strong>weighing from 17 kg to less than 22 kg.<\/strong><\/li><\/ul>\n\n\n\n<p>Your child does not need to have&nbsp;HIV&nbsp;to be treated with Viread against HBV.<\/p>\n\n\n\n<p>This medicine does not\u00a0cure\u00a0HIV\u00a0infection.\u00a0While your child is taking Viread, your child may still develop HIV\u00a0infection\u00a0or\u00a0other illnesses associated with\u00a0HIV\u00a0infection.\u00a0Your child can also pass\u00a0HIV\u00a0or HBV on to others, so it is important to take precautions to avoid infecting other people.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before your child takes Viread<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not give Viread<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If your child is allergic<\/strong>&nbsp;to tenofovir, tenofovir disoproxil, or any of the other ingredients of this medicine listed in section 6.<br><strong>\u2192<\/strong>&nbsp;If this applies to your child,&nbsp;<strong>tell your child&#8217;s doctor immediately and stop giving Viread.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>In the case of\u00a0HIV, Viread 123 mg tablets are only suitable\u00a0for children who have already been treated\u00a0with other\u00a0HIV\u00a0medicines that no longer have the full effect due to the development of resistance or have caused\u00a0side effects.<\/li><li><strong>Check your child&#8217;s age and weight<\/strong>\u00a0to see if Viread 123 mg tablets are suitable, see\u00a0<em>Children and adolescents.<\/em><\/li><\/ul>\n\n\n\n<p>Talk to your doctor or pharmacist before giving your child Viread.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be careful not to infect other people.\u00a0<\/strong>Your child can still transmit\u00a0HIV\u00a0when taking this medicine, although the risk is reduced with effective\u00a0antiviral\u00a0treatment.\u00a0Viread does not reduce the risk of transmitting HBV to others through sexual contact or blood infection.\u00a0Discuss with your child&#8217;s doctor the necessary measures to avoid infecting others.<\/li><li><strong>Talk to your child&#8217;s doctor or pharmacist if your child has a history of kidney disease or if tests have shown that your child has kidney problems<\/strong>.\u00a0Viread should not be given to children with kidney problems.\u00a0Viread can affect your child&#8217;s kidneys during treatment.\u00a0Before your child starts the treatment, your child&#8217;s doctor may\u00a0order\u00a0some blood tests to assess that your child&#8217;s kidneys are working normally.\u00a0Your child&#8217;s doctor may also\u00a0order\u00a0blood tests during treatment to check how your child&#8217;s kidneys are working.<br>Viread is not usually taken together with other medicines that can damage your child&#8217;s kidneys (see\u00a0Other medicines and Viread\u00a0).\u00a0If this cannot be avoided, your child&#8217;s doctor will check your child&#8217;s kidney function once a week.<\/li><li>Skeletal problems.\u00a0Some adult patients with\u00a0HIV\u00a0receiving\u00a0combination\u00a0antiretroviral\u00a0therapy may develop a bone disease called\u00a0osteonecrosis\u00a0(bone tissue dies due to loss of blood supply to the bone).\u00a0Some of the many risk factors for developing the disease are long-term\u00a0combination\u00a0antiretroviral\u00a0therapy, use of\u00a0corticosteroids, alcohol consumption, severe impairment of the immune system, and higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are joint stiffness and pain (especially in the hip, knee, and shoulders) and difficulty moving.\u00a0Tell your child&#8217;s doctor if your child experiences any of these symptoms. Bone problems (manifesting as persistent or worsening bone pain and sometimes leading to\u00a0fractures\u00a0) may also occur due to damage to renal tubule cells (see section 4,\u00a0Possible\u00a0side effects\u00a0).\u00a0Tell your child&#8217;s doctor if your child has bone pain or\u00a0a fracture.<br>Tenofovir disoproxil can also cause loss of bone mass.\u00a0The most pronounced loss of bone mass was seen in\u00a0clinical trials\u00a0when patients were treated with tenofovir disoproxil in combination with a boosted\u00a0protease inhibitor.<br>Overall, the effects of tenofovir disoproxil on long-term bone health and future fracture risk in adults and children are uncertain. Tell your child&#8217;s doctor if your child has osteoporosis.\u00a0Patients with osteoporosis are at higher risk of\u00a0fracture.<\/li><li>Inform your child&#8217;s doctor if your child already has or has had liver disease, including\u00a0hepatitis.\u00a0Patients with liver disease, including\u00a0chronic\u00a0hepatitis\u00a0B or C, who are treated with antiretroviral agents are at increased risk of severe and potentially fatal liver complications.\u00a0If your child has\u00a0hepatitis\u00a0B, your child&#8217;s doctor will carefully choose the best treatment for your child.\u00a0If your child has or has had liver disease or\u00a0chronic\u00a0hepatitis\u00a0B, your child&#8217;s doctor may take blood tests to check liver function.<\/li><li>Be observant\u00a0about\u00a0infection.\u00a0If your child has\u00a0advanced-stage\u00a0HIV\u00a0infection (\u00a0AIDS\u00a0) and has an\u00a0infection, your child may develop symptoms of\u00a0infection\u00a0and\u00a0inflammation\u00a0or worsening of symptoms of an existing\u00a0infection when\u00a0treatment\u00a0with Viread is started.\u00a0These symptoms may indicate that your child&#8217;s body&#8217;s improved immune system is fighting\u00a0infection.\u00a0Watch for signs of\u00a0inflammation\u00a0or\u00a0infection\u00a0during the first period after your child starts taking Viread.\u00a0If you detect signs of\u00a0inflammation or\u00a0infection,\u00a0you should inform your child&#8217;s doctor immediately.<br>In addition to opportunistic\u00a0infections, autoimmune disorders (conditions where the immune system attacks healthy body tissue) can also occur after your child starts taking medicines to treat\u00a0their\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders may occur several months after starting treatment.\u00a0If you notice that your child has any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the trunk, palpitations, tremors, or hyperactivity, inform your child&#8217;s doctor immediately to get the necessary treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Viread 123 mg tablets are&nbsp;<strong>only suitable<\/strong>&nbsp;for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>HIV\u00a0-1-infected children aged 6 to less than 12 years\u00a0<\/strong><strong>who weigh from 17 kg to less than 22 kg\u00a0<\/strong><strong>and who have already been treated<\/strong>\u00a0with other HIV drugs that are no longer fully effective due to the development of resistance or have caused\u00a0side\u00a0effects<\/li><li><strong>HBV-infected children aged 6 to less than 12 years weighing from 17 kg to less than 22 kg<\/strong>.<\/li><\/ul>\n\n\n\n<p>Viread 123 mg tablets are&nbsp;<strong>not<\/strong>&nbsp;suitable for the following groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Not for<\/strong>\u00a0children weighing under 17 kg or 22 kg and over.\u00a0Contact your child&#8217;s doctor if your child is outside the approved weight<strong>.<\/strong><\/li><li><strong>Not for<\/strong>\u00a0children and young people under 6 years or 12 years and over.<\/li><li><strong>Not for HBV (\u00a0hepatitis\u00a0B\u00a0virus\u00a0)-infected<\/strong>\u00a0children and adolescents of all ages.<\/li><\/ul>\n\n\n\n<p>For\u00a0dosage, see section 3,\u00a0<em>How your child takes Viread.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Viread<\/h2>\n\n\n\n<p>Tell your child&#8217;s doctor or pharmacist if your child is taking, has recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not stop taking\u00a0HIV\u00a0medicines previously prescribed by the doctor<\/strong>\u00a0when the child starts taking Viread if the child has both HBV and\u00a0HIV.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not give Viread<\/strong>\u00a0if your child is already taking other medicines containing tenofovir disoproxil or tenofovir alafenamide.\u00a0Do not give Viread together with medicines containing adefovir dipivoxil (a medicine used to treat\u00a0chronic\u00a0hepatitis\u00a0B).<\/li><li><strong>You must tell<\/strong> your child&#8217;s doctor if your child is taking other medicines that may harm your child&#8217;s kidneys. Such drugs are:<ul><li>aminoglycosides, pentamidine, or vancomycin (against a bacterial\u00a0infection\u00a0),<\/li><li>amphotericin B (for fungal infection),<\/li><li>foscarnet, ganciclovir, or cidofovir (for viral infection),<\/li><li>interleukin-2\u00a0(for the treatment of cancer),<\/li><li>adefovir dipivoxil (for HBV),<\/li><li>tacrolimus (for\u00a0suppressing\u00a0the immune system),<\/li><li>non-steroidal anti-inflammatory agents (\u00a0NSAID\u00a0preparations, to relieve bone or muscle pain).<\/li><\/ul><\/li><li>Other medicines containing didanosine (for\u00a0HIV\u00a0infection\u00a0): If your child takes\u00a0Viread\u00a0together with other antiviral medicines containing didanosine, the blood levels of didanosine may increase and the CD4 cell count may decrease.\u00a0Rare cases of pancreatitis and lactic acidosis (excess\u00a0lactic acid\u00a0in the blood), in some cases with a fatal outcome, have been reported during concomitant treatment with medicines containing tenofovir disoproxil and didanosine.\u00a0Your child&#8217;s doctor will carefully consider whether your child can be treated with a combination of tenofovir and didanosine.<\/li><li>It is also important that you tell your doctor\u00a0if your child is taking ledipasvir\/sofosbuvir, sofosbuvir\/velpatasvir, or sofosbuvir\/velpatasvir\/voxilaprevir to treat\u00a0hepatitis\u00a0C\u00a0infection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Viread with food and drink<\/h2>\n\n\n\n<p><strong>Give Viread food<\/strong>\u00a0(eg a meal or a snack).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If your child is pregnant or breastfeeding or thinks she may be pregnant, consult a doctor or pharmacist before your child uses this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If your child has taken Viread<\/strong>\u00a0during pregnancy, the doctor may ask your child to have regular blood tests and other diagnostic tests to check the baby&#8217;s development.\u00a0For children with a\u00a0mother\u00a0who took drugs such as Viread (NRTIs) during pregnancy, the benefit of protection against the\u00a0virus\u00a0is greater than the risk of\u00a0side effects.<\/li><li>If your baby has HBV and her baby has received treatment to prevent transmission of\u00a0hepatitis\u00a0B at birth, your baby may be able to breastfeed, but talk to your baby&#8217;s doctor first for more information.<\/li><li>If your child has\u00a0HIV, she should not breastfeed her infant to avoid transmission of the\u00a0virus\u00a0et to the baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Viread can cause dizziness.&nbsp;Your child must&nbsp;<strong>not drive or cycle<\/strong>&nbsp;and must not use tools or machines if he\/she feels dizzy when taking Viread.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Viread contains lactose<\/h2>\n\n\n\n<p><strong>Talk to your child&#8217;s doctor before giving Viread<\/strong><strong>.\u00a0<\/strong>If your child has an intolerance to certain sugars, you should contact the child&#8217;s doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Viread contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How your child takes Viread<\/h2>\n\n\n\n<p><strong>Your child should always take this medicine as directed by the doctor or pharmacist<\/strong>.\u00a0Consult your child&#8217;s doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Children aged 6 to under 12 years weighing from 17 kg to less than 22 kg:<\/strong>1 tablet a day with food (e.g. a meal or a snack).<\/li><\/ul>\n\n\n\n<p>Your child&#8217;s doctor will monitor your child&#8217;s weight.<\/p>\n\n\n\n<p><strong>Your child must always take the&nbsp;dose&nbsp;prescribed by the doctor<\/strong>&nbsp;to ensure that the medicine is effective and to reduce the development of&nbsp;resistance&nbsp;to the treatment.&nbsp;Do not change the&nbsp;dose&nbsp;unless your child&#8217;s doctor tells you to.<\/p>\n\n\n\n<p>For\u00a0HIV, your child&#8217;s doctor will prescribe Viread together with other antiretroviral medicines.<\/p>\n\n\n\n<p>Read the package leaflets of the other antiretroviral medicines for information on how to take these medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If your child has taken too much Viread<\/h2>\n\n\n\n<p><strong>\u2192<\/strong>\u00a0If your child accidentally takes too many Viread tablets, your child may be at risk of possible\u00a0side effects\u00a0from this medicine (see section 4,\u00a0<em>Possible\u00a0side effects\u00a0)<\/em>.\u00a0Contact your child&#8217;s doctor or nearest emergency department for advice.\u00a0Save the jar of tablets so you can easily describe what your child has taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If your child forgets to take Viread<\/h2>\n\n\n\n<p>Your child mustn&#8217;t miss a\u00a0dose\u00a0of Viread.\u00a0If your child misses a\u00a0dose, count when he\/she should have taken it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If it has been less than 12 hours<\/strong>\u00a0since the time it is usually taken, your child should take it as soon as possible, and then take the next\u00a0dose\u00a0at its regular time.<\/li><li><strong>If it has been more than 12 hours<\/strong>\u00a0since your child should have taken it, do not take the missed\u00a0dose.\u00a0Wait and give the next\u00a0dose\u00a0at its regular time.\u00a0Do not give a double\u00a0dose\u00a0to make up for a forgotten tablet.<\/li><\/ul>\n\n\n\n<p><strong>If your child vomits within less than 1 hour after a\u00a0dose\u00a0of Viread<\/strong>, give your child another tablet.\u00a0Your child does not need to take another tablet if your child vomits more than 1 hour after taking Viread.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If your child stops taking Viread<\/h2>\n\n\n\n<p>Your child must not stop taking Viread without consulting your child&#8217;s doctor.&nbsp;Discontinuing treatment with Viread may result in a reduced effect of the treatment recommended by your child&#8217;s doctor.<\/p>\n\n\n\n<p><strong>If your child has\u00a0<\/strong><strong>hepatitis\u00a0B or\u00a0\u00a0<\/strong><strong>HIV\u00a0infection\u00a0and\u00a0hepatitis\u00a0B\u00a0infection\u00a0at the same time,\u00a0your child mustn&#8217;t<\/strong> stop Viread treatment without first talking to your child&#8217;s doctor.\u00a0Some patients&#8217; blood tests or symptoms have shown that their\u00a0hepatitis\u00a0has worsened after stopping treatment with Viread.\u00a0Your child may need to provide blood samples for several months after finishing treatment.\u00a0In patients with advanced liver disease or\u00a0cirrhosis, stopping treatment is not recommended as this may lead to a worsening of your child&#8217;s\u00a0hepatitis.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your child&#8217;s doctor before your child stops taking Viread for any reason, especially if your child experiences any\u00a0side effects\u00a0or has another illness.<\/li><li>Tell your child&#8217;s doctor immediately about any new and unexpected symptoms that appear after stopping treatment, especially symptoms that you usually associate with your child&#8217;s\u00a0hepatitis\u00a0B\u00a0infection.<\/li><li>Contact your child&#8217;s doctor before your child starts taking Viread tablets again.<\/li><\/ul>\n\n\n\n<p>If you have any further questions about this medicine, ask your child&#8217;s doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During\u00a0HIV\u00a0treatment, weight gain and increased levels of\u00a0lipids\u00a0and\u00a0glucose\u00a0in the blood may occur.\u00a0This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with HIV\u00a0drugs.\u00a0Your child&#8217;s doctor will do tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Any serious side effects: inform your child&#8217;s doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Lactic acidosis<\/strong>\u00a0(excess\u00a0lactic acid\u00a0in the blood) is a\u00a0<strong>rare<\/strong>\u00a0(may affect up to 1 in 1,000 patients) but has serious\u00a0side effects\u00a0that can be fatal.\u00a0The following\u00a0side effects\u00a0can be signs of lactic acidosis:<ul><li>deep, rapid breathing<\/li><li>drowsiness<\/li><li>nausea, vomiting, and abdominal pain<br><strong>\u2192<\/strong>\u00a0If you think your child may have\u00a0<strong>lactic acidosis, contact your child&#8217;s doctor immediately.<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Other possible serious\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(they may affect up to 1 in 100 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>pain in the stomach<\/strong>&nbsp;(abdomen) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>damage to the kidney (renal tubule cells)<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(these may occur in up to 1 in 1,000 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney inflammation, that your child&nbsp;<strong>urinates a lot and feels thirsty<\/strong><\/li><li><strong>changes in urine<\/strong>&nbsp;and&nbsp;<strong>back pain<\/strong>&nbsp;caused by kidney problems, including&nbsp;kidney failure<\/li><li>decreased bone hardness (which causes&nbsp;<strong>bone pain<\/strong>&nbsp;and sometimes leads to&nbsp;fractures&nbsp;), which can occur due to damage to kidney tubule cells.<\/li><li><strong>fatty liver<\/strong><\/li><\/ul>\n\n\n\n<p><strong>\u2192\u00a0<\/strong><strong>If you think your child may have any of these serious\u00a0side effects, talk to your child&#8217;s doctor.<\/strong><\/p>\n\n\n\n<p><strong>The most common&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>very common<\/strong>&nbsp;(&nbsp;side effects&nbsp;occurring in more than 10 out of 100 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea, vomiting, nausea, dizziness, skin rash, feeling weak<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering the phosphate level in the blood<\/li><\/ul>\n\n\n\n<p><strong>Other possible\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>common<\/strong>&nbsp;(&nbsp;side effects&nbsp;occurring in up to 10 out of 100 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>gas formation<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver problems<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(&nbsp;side effects&nbsp;occurring in up to 1 in 100 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle breakdown, muscle pain, or muscle weakness<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowered potassium levels in the blood<\/li><li>increased creatinine level in the blood<\/li><li>pancreatic disorders<\/li><\/ul>\n\n\n\n<p>The breakdown of muscles decreased bone hardness (which causes bone pain and sometimes leads to\u00a0fractures\u00a0), muscle pain, muscle weakness, and lowered\u00a0potassium\u00a0or phosphate levels in the blood can occur due to damage to kidney tubule cells.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(&nbsp;side effects&nbsp;occurring in up to 1 in 1,000 patients):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain in the stomach (abdomen) caused by\u00a0inflammation\u00a0of the liver<\/li><li>swelling of the face, lips, tongue, or throat<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Viread should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after {EXP}.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>&#8211;\u00a0<strong>The active substance is<\/strong>\u00a0tenofovir.\u00a0Each Viread tablet contains 123 mg of tenofovir disoproxil (as fumarate).<\/p>\n\n\n\n<p>&#8211;\u00a0<strong>Other ingredients are<\/strong>\u00a0microcrystalline cellulose (E460), pregelatinized\u00a0starch, croscarmellose sodium,\u00a0lactose monohydrate\u00a0and magnesium stearate (E572) which make up the tablet core, and\u00a0lactose monohydrate, hypromellose (E464), titanium dioxide (E171) and glycerol triacetate (E1518) which make up the tablet coating.\u00a0See section 2 &#8220;Viread contains lactose&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Viread 123 mg film-coated tablets are white, triangular, film-coated tablets, 8.5 mm in diameter, debossed on one side with \u201cGSI\u201d and on the other side with \u201c150\u201d.&nbsp;Viread 123 mg film-coated tablets are supplied in bottles containing 30 tablets.&nbsp;Each jar contains desiccant (silica gel) which must be in the jar to protect the tablets.&nbsp;The desiccant (silica gel) is in a separate&nbsp;sachet&nbsp;or container and should not be swallowed.<\/p>\n\n\n\n<p>The following pack sizes are available: Outer cartons containing 1 bottle of 30 film-coated tablets or 3 bottles of 30 film-coated tablets.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Gilead Sciences Belgium BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><td><strong>Lithuania<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Gilead Sciences International LtdTel.: + 44 (0) 20 7136 8820<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Gilead Sciences Belgium BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Gilead Sciences s.r.oPhone: + 420 910 871 986<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Denmark<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><td><strong>Malta<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Gilead Sciences GmbHPhone: + 49 (0) 89 899890-0<\/td><td><strong>The Netherlands<\/strong>Gilead Sciences Netherlands BVPhone: + 31 (0) 20 718 3698<\/td><\/tr><tr><td><strong>Estonia<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><td><strong>Norway<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Greece<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><td><strong>Austria<\/strong>Gilead Sciences GesmbHPhone: + 43 1 260 830<\/td><\/tr><tr><td><strong>Spain<\/strong>Gilead Sciences, SLPhone: + 34 91 378 98 30<\/td><td><strong>Polish<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><\/tr><tr><td><strong>France<\/strong>Gilead SciencesTel: + 33 (0) 1 46 09 41 00<\/td><td><strong>Portugal<\/strong>Gilead Sciences, Lda.Phone: + 351 21 7928790<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><td><strong>Romania<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Ireland<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><td><strong>Slovenija<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Iceland<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><td><strong>Slovenian Republic<\/strong>Gilead Sciences International LtdPhone: + 421 232 121 210<\/td><\/tr><tr><td><strong>Italy<\/strong>Gilead Sciences SrlPhone: + 39 02 439201<\/td><td><strong>Finland\/Finland<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Gilead Sciences \u0395\u03bb\u03bb\u03ac\u03c2 \u039c.\u0395\u03a0\u0395.Tel: + 30 210 8930 100<\/td><td><strong>Sweden<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Latvia<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><td><strong>United Kingdom<\/strong>(Northern Ireland)Gilead SciencesIreland UCTel: + 44 (0) 8000 113 700<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>123 mg\u00a0film-coated tablets<br \/>\ntenofovir disoproxil<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3389,4331,4332,27507,27510,27511,4330,27508,13322,27509],"class_list":["post-29212","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tablet","tag-viread","tag-viread-side-effects","tag-viread-tablet","tag-what-is-tenofovir-disoproxil","tag-what-is-viread","tag-what-tenofovir-disoproxil-is-used-for","tag-what-viread-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=29212"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29212\/revisions"}],"predecessor-version":[{"id":29638,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29212\/revisions\/29638"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=29212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=29212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=29212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}