{"id":29210,"date":"2022-11-02T16:13:16","date_gmt":"2022-11-02T16:13:16","guid":{"rendered":"https:\/\/zeepedia.com\/?p=29210"},"modified":"2022-11-03T10:09:21","modified_gmt":"2022-11-03T10:09:21","slug":"viramune","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/viramune\/","title":{"rendered":"Viramune &#8211; Nevirapine uses, dose and side effects"},"content":{"rendered":"\n<p>400 mg&nbsp;prolonged-release tablet&nbsp;er<br>nevirapine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Viramune is and what it is used for<\/h2>\n\n\n\n<p>Viramune belongs to the drug group antiretroviral agents, which are used in the treatment of&nbsp;infection&nbsp;with the Human Immunodeficiency&nbsp;Virus&nbsp;(&nbsp;HIV&nbsp;&#8211; 1).<\/p>\n\n\n\n<p>The active substance in your medicine is called nevirapine.\u00a0Nevirapine belongs to a class of antiretroviral drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).\u00a0Reverse transcriptase is an\u00a0enzyme\u00a0that\u00a0HIV\u00a0needs to reproduce.\u00a0Nevirapine prevents reverse transcriptase from working.\u00a0By preventing reverse transcriptase from working, Viramune helps control\u00a0HIV\u00a0-1\u00a0infection.<\/p>\n\n\n\n<p>Viramune is intended for the treatment of\u00a0HIV\u00a0-infected adults, adolescents, and children over three years of age who can swallow tablets.\u00a0You must use Viramune together with other antiretroviral medicines.\u00a0Your doctor will recommend the medications that are best for you.<\/p>\n\n\n\n<p>Viramune\u00a0prolonged-release tablets\u00a0should only be used after a two-week treatment with another type of Viramune (immediate-release\u00a0or\u00a0suspension\u00a0tablets ) unless you are currently taking Viramune and switching to\u00a0prolonged-release tablets.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Viramune<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Viramune<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to nevirapine or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have used Viramune before and have to stop because of:<ul><li>severe skin rashes<\/li><li>skin rash with other symptoms such as:<ul><li>fever<\/li><li>blistering<\/li><li>mouth ulcers<\/li><li>eye inflammation<\/li><li>facial swelling<\/li><li>general swelling<\/li><li>shortness of breath<\/li><li>muscle or joint pain<\/li><li>general malaise<\/li><li>abdominal pain<\/li><\/ul><\/li><li>hypersensitivity reaction&nbsp;(allergic reactions)<\/li><li>inflammation of the liver (&nbsp;hepatitis&nbsp;)<\/li><\/ul><\/li><li>if you have severe liver disease<\/li><li>if you had to stop treatment with Viramune on a previous occasion due to changes in liver function<\/li><li>if you take products containing the plant St. John&#8217;s&nbsp;wort&nbsp;<em>(Hypericum perforatum).&nbsp;<\/em>This (traditional) herbal medicine may cause Viramune not to work as intended.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before using Viramune.<\/strong><\/p>\n\n\n\n<p><strong>During the first 18 weeks of treatment with Viramune, you and your doctor must watch for signs of liver or skin reactions.\u00a0These can become severe and even life-threatening.\u00a0There is the greatest risk of such reactions during the first 6 weeks of treatment.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>If you get severe skin rashes or hypersensitivity (allergic reactions that can appear in the form of skin rashes) along with other\u00a0side effects\u00a0such as fever<\/strong>\u00a0, blisters, mouth ulcers, eye inflammation, facial swelling, general swelling, shortness of breath, muscle or joint pain, general malaise, or abdominal pain should YOU STOP USING VIRAMUNE AND CONTACT YOUR DOCTOR IMMEDIATELY because such reactions can be potentially life-threatening or lead to death.\u00a0If you ever get symptoms of a mild rash without any other reactions, tell your doctor immediately, for advice on whether to stop using Viramune.<br>If you get symptoms that indicate liver damage, such as loss of appetite, nausea, vomiting, yellow skin (jaundice), abdominal pain should stop using Viramune and contact your doctor immediately.<br>If you develop a serious liver, skin,<strong> or\u00a0hypersensitivity reaction\u00a0while using Viramune, you should NEVER USE VIRAMUNE again without first talking to your doctor.<br>You must use Viramune at the\u00a0dosage\u00a0prescribed by your doctor.\u00a0This is especially important during the first 14 days of treatment (for more information, see\u00a0<em>How to take Viramune)<\/em><\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The following patients are at higher risk of developing liver problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>women<\/li><li>hepatitis\u00a0B or C infected<\/li><li>elevated values \u200b\u200bof liver function tests<\/li><li>previously untreated patients with high CD4 values \u200b\u200bwhen starting Viramune treatment (women more than 250 cells\/mm\u00a0<sup>3<\/sup>, men more than 400 cells\/mm\u00a03\u00a0)<\/li><li>previously treated patients with measurable\u00a0HIV\u00a0-1 viral load in\u00a0plasma\u00a0and high CD4 values \u200b\u200bwhen starting Viramune treatment (women more than 250 cells\/mm\u00a03, men more than 400 cells\/mm\u00a0<sup>3<\/sup>\u00a0).<\/li><\/ul>\n\n\n\n<p>In some patients with advanced\u00a0HIV\u00a0infection\u00a0(AIDS) who previously had an opportunistic\u00a0infection\u00a0(which can be attributed to\u00a0AIDS\u00a0disease), signs and symptoms of\u00a0inflammation\u00a0from the previous\u00a0infection\u00a0may\u00a0occur shortly after starting anti-HIV\u00a0treatment.\u00a0These symptoms are probably due to an improvement in the body&#8217;s\u00a0immune response, which enables the body to fight\u00a0infections\u00a0that may have existed before, but did not cause any symptoms.\u00a0Inform your doctor immediately if you notice any symptoms of\u00a0infection.<\/p>\n\n\n\n<p>In addition to opportunistic\u00a0infections, autoimmune disorders (conditions where the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders may occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the trunk, palpitations, tremors, or hyperactivity, inform your doctor immediately to get the necessary treatment.<\/p>\n\n\n\n<p>Changes in fat distribution may occur in patients receiving combined&nbsp;antiretroviral&nbsp;therapy.&nbsp;Contact your doctor if you notice changes in body fat (see section 4 \u201c&nbsp;<em>Possible&nbsp;side effects&nbsp;\u201d<\/em>&nbsp;).<\/p>\n\n\n\n<p>Some patients receiving combination\u00a0antiretroviral\u00a0therapy may develop a bone disease called\u00a0osteonecrosis\u00a0(tissue death of the bone tissue caused by the restricted blood supply to the bone).\u00a0Some of the many risk factors for developing the disease are: long-term combination\u00a0antiretroviral\u00a0therapy, use of\u00a0corticosteroids, alcohol consumption, weakened immune system, and higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are joint stiffness and pain (especially in the hip, knee, and shoulders) and difficulty moving.\u00a0Tell your doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>If you are taking nevirapine and zidovudine at the same time, inform your doctor as he\/she may need to check your\u00a0white blood cells.<\/p>\n\n\n\n<p>Do not take Viramune after being exposed to the\u00a0HIV\u00a0unless\u00a0you have been diagnosed with\u00a0HIV\u00a0and instructed by your doctor to take Viramune.<\/p>\n\n\n\n<p>Prednisone should not be used to treat rashes due to Viramune.<\/p>\n\n\n\n<p>If you take oral contraceptives (for example, the pill\u00a0) or other hormonal contraceptives during treatment with Viramune, you should also use a\u00a0barrier method\u00a0(for example, a condom) to prevent pregnancy.<\/p>\n\n\n\n<p>If you are receiving hormone replacement for menopause symptoms, consult your doctor before taking this medicine.<\/p>\n\n\n\n<p>If you are taking or have been prescribed rifampicin to treat\u00a0tuberculosis, inform your doctor before taking the medicine together with Viramune.<\/p>\n\n\n\n<p>Viramune\u00a0prolonged-release tablets, or parts of tablets, can sometimes pass through the body and be seen in the stool.\u00a0They may look like whole tablets but have not been seen to affect the effect of nevirapine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Viramune 400 mg&nbsp;prolonged-release tablets&nbsp;can be used by children if they:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>are \u2265 8 years old and weigh 43.8 kg or more<\/li><li>are older than 3 years and younger than 8 years and weigh 25 kg or more<\/li><li>have a body surface area of \u200b\u200b1.17 m&nbsp;<sup>2<\/sup>&nbsp;or more<\/li><\/ul>\n\n\n\n<p>For smaller children,&nbsp;oral&nbsp;suspension&nbsp;in liquid form is available.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Viramune<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Tell your doctor about all other medicines you are taking before you start taking Viramune tablets.\u00a0The reason is that the doctor may need to decide whether your other medicines are still working and whether the\u00a0dose\u00a0needs to be changed.\u00a0Carefully read the package leaflets of all the other\u00a0HIV\u00a0medicines that you will use together with Viramune.<\/p>\n\n\n\n<p>You must tell your doctor if you are using or have recently used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>St. John&#8217;s wort&nbsp;(Hypericum perforatum, (traditional) herbal remedies for mild depression)<\/li><li>rifampicin (&nbsp;tuberculosis&nbsp;drug)<\/li><li>rifabutin (&nbsp;tuberculosis&nbsp;drug)<\/li><li>macrolides&nbsp;e.g. clarithromycin (&nbsp;antibiotics&nbsp;)<\/li><li>fluconazole&nbsp;(for fungal infections)<\/li><li>ketoconazole&nbsp;(for fungal infections)<\/li><li>itraconazole (for fungal infections)<\/li><li>methadone&nbsp;(for opiate withdrawal)<\/li><li>warfarin&nbsp;(blood thinner)<\/li><li>hormonal contraceptives (e.g.&nbsp;birth control pills&nbsp;)<\/li><li>atazanavir (&nbsp;HIV&nbsp;medicine)<\/li><li>lopinavir\/ritonavir (&nbsp;HIV&nbsp;medicine)<\/li><li>fosamprenavir (&nbsp;HIV&nbsp;medicine)<\/li><li>efavirenz (&nbsp;HIV&nbsp;medicine)<\/li><li>etravirine (&nbsp;HIV&nbsp;medicine)<\/li><li>rilpivirine (&nbsp;HIV&nbsp;medicine)<\/li><li>zidovudine (&nbsp;HIV&nbsp;medicine)<\/li><li>elvitegravir\/cobicistat (&nbsp;HIV&nbsp;medicine)<\/li><\/ul>\n\n\n\n<p>Your doctor will closely monitor the effect of Viramune and these medicines if you use them together.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Viramune with food and drink<\/h2>\n\n\n\n<p>There are no obstacles to taking Viramune with food and drink.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Breastfeeding&nbsp;<strong><em>is not recommended<\/em><\/strong>&nbsp;for women&nbsp;<strong>living with&nbsp;HIV<\/strong>&nbsp;because&nbsp;HIV&nbsp;infection&nbsp;can be transmitted to&nbsp;the baby through breast milk.<\/p>\n\n\n\n<p>If you are breastfeeding or thinking about starting to breastfeed, you should discuss this with\u00a0your doctor\u00a0as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You may feel tired while using Viramune.&nbsp;Be careful when doing activities such as driving or using machinery.&nbsp;If you feel tired, avoid tasks that may be risky, such as driving or using tools or machinery.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Viramune contains lactose<\/h2>\n\n\n\n<p>Viramune&nbsp;prolonged-release tablets&nbsp;contain&nbsp;lactose&nbsp;(milk sugar).&nbsp;If you have an intolerance to some sugars, consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Viramune<\/h2>\n\n\n\n<p>You should not use Viramune alone.&nbsp;You must use it with at least two other antiretroviral medicines.&nbsp;Your doctor will recommend the best medicines for you.<\/p>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><em>Dosage:<\/em><\/p>\n\n\n\n<p>Adults:<\/p>\n\n\n\n<p>During the first 14 days (introduction period), the\u00a0dose\u00a0is one Viramune tablet 200 mg once a day.\u00a0A separate starter pack of\u00a0Viramune\u00a0tablets 200 mg is available for this insertion period.\u00a0After 14 days, the usual\u00a0dose\u00a0is one 400 mg\u00a0prolonged-release tablet\u00a0once a day.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>It is very important that you only take one Viramune tablet per day during the first 14 days (the break-in period).\u00a0If you get any skin rashes during this period, do not start Viramune\u00a0prolonged-release tablets, contact your doctor instead.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>This 14-day insertion period has been shown to result in a lower risk of skin rashes.<\/p>\n\n\n\n<p>Patients who are already being treated with immediate-release\u00a0tablets or\u00a0oral\u00a0suspension\u00a0can switch to\u00a0prolonged-release tablets\u00a0without a break-in period.<\/p>\n\n\n\n<p>As Viramune will always be given together with other drugs that inhibit the\u00a0HIV,\u00a0you must follow the instructions for these drugs carefully.\u00a0These can be found in the package leaflets for these medicines.<\/p>\n\n\n\n<p>Viramune is also available as an\u00a0oral\u00a0suspension\u00a0(for all ages, weights, and BSA groups).<\/p>\n\n\n\n<p>You should continue to use Viramune for as long as your doctor recommends.<\/p>\n\n\n\n<p>In the\u00a0<em>&#8220;Warnings and precautions&#8221;<\/em>\u00a0section above, it is stated that your doctor will monitor liver tests and be aware of unwanted effects, such as skin rashes.\u00a0Depending on the development, the doctor may decide to interrupt or end treatment with Viramune.\u00a0The doctor may then decide to resume the treatment with a lower\u00a0dose.<\/p>\n\n\n\n<p>If you have impaired kidney or liver function, use only Viramune 200 mg tablets or Viramune 50 mg\/5 ml\u00a0oral\u00a0suspension.<\/p>\n\n\n\n<p>Viramune&nbsp;prolonged-release tablets&nbsp;should only be taken by mouth.&nbsp;Do not chew the tablets.&nbsp;Viramune can be taken with or without food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Viramune<\/h2>\n\n\n\n<p>Do not use more Viramune than your doctor has prescribed and as described in this leaflet.&nbsp;There is currently limited information on the effects of Viramune in overdose.&nbsp;Contact a doctor if you have taken too much Viramune.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Viramune<\/h2>\n\n\n\n<p>Try not to miss a\u00a0dose.\u00a0If you notice a missed\u00a0dose\u00a0within 12 hours of the scheduled time, take the missed\u00a0dose\u00a0as soon as possible.\u00a0If it has been more than 12 hours after the scheduled time, just take the next\u00a0dose\u00a0at the regular time instead.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Viramune<\/h2>\n\n\n\n<p>Taking all your&nbsp;doses&nbsp;of&nbsp;HIV&nbsp;medicine at the right time<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>leads to a large increase in the effectiveness of your combination of antiretroviral drugs<\/li><li>and reduces the risk of your\u00a0HIV\u00a0infection\u00a0becoming\u00a0resistant\u00a0to\u00a0your antiretroviral drugs.<\/li><\/ul>\n\n\n\n<p>It is important to continue using Viramune correctly as directed above unless your doctor instructs you to stop.<\/p>\n\n\n\n<p>If you stop treatment with Viramune\u00a0prolonged-release tablets\u00a0for more than 7 days, your doctor will suggest that you start the 14-day loading period with Viramune tablets (see above) again before returning to once-daily treatment with Viramune\u00a0prolonged-release tablets.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of blood fats and blood sugar may occur.&nbsp;This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with the&nbsp;HIV&nbsp;drugs themselves.&nbsp;The doctor will do tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>In the section\u00a0<em>&#8220;Warnings and precautions&#8221;<\/em><\/strong>, above, it is stated that the most important\u00a0side effects\u00a0of Viramune tablets are severe and life-threatening skin reactions and serious liver damage.\u00a0These reactions mainly occur during the first 18 weeks of treatment with Viramune.\u00a0This period, therefore,<strong> requires careful follow-up by your doctor.<\/strong><\/p>\n\n\n\n<p>If you ever observe any skin rash, inform your doctor immediately.<\/p>\n\n\n\n<p>When skin rashes occur, they are normally mild to moderate in severity.\u00a0However, in some patients, the rash, which appears as blistering of the skin, can be severe or life-threatening (\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0) and death has been reported.\u00a0Most cases of rash, both severe and mild to moderate, appear in the first 6 weeks.<\/p>\n\n\n\n<p>If skin rash and nausea occur at the same time, you must stop the treatment and see your doctor immediately.<\/p>\n\n\n\n<p>Hypersensitivity reactions&nbsp;(allergic reactions) may occur.&nbsp;Such reactions can occur in the form of&nbsp;anaphylaxis&nbsp;(a severe form of&nbsp;allergic reaction&nbsp;) with symptoms such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>facial swelling<\/li><li>breathing difficulties (spasms in the airways)<\/li><li>anaphylactic\u00a0shock<\/li><\/ul>\n\n\n\n<p>Hypersensitivity reaction&nbsp;can also appear as a skin rash along with other&nbsp;side effects&nbsp;such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>blisters on the skin<\/li><li>mouth ulcers<\/li><li>eye inflammation<\/li><li>facial swelling.<\/li><li>general swelling<\/li><li>shortness of breath<\/li><li>muscle or joint pain<\/li><li>a decrease in the number of&nbsp;white blood cells&nbsp;(&nbsp;granulocytopenia&nbsp;)<\/li><li>general malaise<\/li><li>severe liver or kidney problems (liver or&nbsp;kidney failure&nbsp;)<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get a rash and any of the other&nbsp;side effects&nbsp;associated with a&nbsp;hypersensitivity reaction&nbsp;(&nbsp;allergic reaction&nbsp;).&nbsp;Such reactions can be life-threatening.<\/p>\n\n\n\n<p>Abnormal liver function has been reported with treatment with Viramune.&nbsp;This includes some cases of&nbsp;inflammation&nbsp;of the liver (&nbsp;hepatitis&nbsp;) which can be sudden and intense (&nbsp;fulminant&nbsp;hepatitis&nbsp;) and liver failure, both of which can lead to death.<\/p>\n\n\n\n<p>Inform your doctor if you experience any of the following clinical symptoms of liver damage:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite<\/li><li>nausea<\/li><li>vomiting<\/li><li>yellow skin (jaundice)<\/li><li>abdominal pain<\/li><\/ul>\n\n\n\n<p>The side effects&nbsp;listed below have been reported from patients using Viramune 200 mg tablets during the 14-day loading period:<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>fever<\/li><li>headache<\/li><li>abdominal pain<\/li><li>nausea<\/li><li>loose stools (diarrhea)<\/li><li>fatigue<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction\u00a0(hypersensitivity)<\/li><li>allergic reaction\u00a0such as skin rash, facial swelling, difficulty breathing (\u00a0bronchospasm\u00a0), or anaphylactic\u00a0shock<\/li><li>drug-induced reaction with general symptoms (drug-induced reaction with\u00a0eosinophilia\u00a0(increased number of\u00a0white blood cells\u00a0of a certain type) combined with general symptoms)<\/li><li>sudden and intense\u00a0inflammation\u00a0of the liver (\u00a0fulminant\u00a0hepatitis\u00a0)<\/li><li>severe and life-threatening skin rashes (Stevens-Johnson syndrome\/toxic\u00a0epidermal\u00a0necrolysis\u00a0)<\/li><li>yellow skin (jaundice)<\/li><li>hives\u00a0(\u00a0urticaria\u00a0)<\/li><li>fluid accumulation under the skin (\u00a0angioedema\u00a0)<\/li><li>vomiting<\/li><li>muscle pain (\u00a0myalgia\u00a0)<\/li><li>joint pain (\u00a0arthralgia\u00a0)<\/li><li>reduced number of\u00a0white blood cells\u00a0(\u00a0granulocytopenia\u00a0)<\/li><li>abnormal liver function tests<\/li><li>decreased blood phosphorus<\/li><li>increased\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>reduced number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><\/ul>\n\n\n\n<p>The side effects&nbsp;listed below have been reported from patients using Viramune&nbsp;prolonged-release tablets&nbsp;once daily as maintenance therapy.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>headache<\/li><li>abdominal pain<\/li><li>nausea<\/li><li>inflammation of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>fatigue<\/li><li>abnormal liver function tests<\/li><li>fever<\/li><li>vomiting<\/li><li>loose stools (diarrhea)<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction\u00a0(hypersensitivity)<\/li><li>allergic reaction\u00a0such as skin rash, facial swelling, difficulty breathing (\u00a0bronchospasm\u00a0), or anaphylactic\u00a0shock<\/li><li>drug-induced reaction with general symptoms (drug-induced reaction with\u00a0eosinophilia\u00a0(increased number of\u00a0white blood cells\u00a0of a certain type) combined with general symptoms)<\/li><li>sudden and intense\u00a0inflammation\u00a0of the liver (\u00a0fulminant\u00a0hepatitis\u00a0)<\/li><li>severe and life-threatening skin rashes (Stevens-Johnson syndrome\/toxic\u00a0epidermal\u00a0necrolysis\u00a0)<\/li><li>reduced number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0)<\/li><li>reduced number of\u00a0white blood cells\u00a0(\u00a0granulocytopenia\u00a0)<\/li><li>yellow skin (jaundice)<\/li><li>hives\u00a0(\u00a0urticaria\u00a0)<\/li><li>fluid accumulation under the skin (\u00a0angioedema\u00a0)<\/li><li>muscle pain (\u00a0myalgia\u00a0)<\/li><li>joint pain (\u00a0arthralgia\u00a0)<\/li><li>decreased blood phosphorus<\/li><li>increased\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p>When Viramune has been used together with other&nbsp;HIV&nbsp;medicines, the following&nbsp;side effects&nbsp;have also been reported:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;red blood cells&nbsp;or&nbsp;platelets<\/li><li>inflammation&nbsp;of the pancreas<\/li><li>decreased or abnormal sensation in the skin<\/li><\/ul>\n\n\n\n<p>These&nbsp;side effects&nbsp;often occur during treatment with other&nbsp;HIV&nbsp;drugs and can be expected when Viramune is used in combination with other drugs.&nbsp;However, it is unlikely that these&nbsp;side effects&nbsp;are caused by the treatment with Viramune.<\/p>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;in children and adolescents<\/strong><\/p>\n\n\n\n<p>A decrease in\u00a0white blood cells\u00a0(\u00a0granulocytopenia\u00a0) may occur, which is more common in children.\u00a0A decrease in\u00a0red blood cells\u00a0(\u00a0anemia\u00a0), which may be related to the nevirapine treatment, is also observed more often in children.\u00a0As with skin rashes, please inform your doctor of any\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Viramune<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and blister card after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Viramune should be used within 2 months of opening.<\/p>\n\n\n\n<p>This medicine does not require any special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is nevirapine.\u00a0Each\u00a0prolonged-release tablet\u00a0contains 400 mg of nevirapine.<\/li><li>Other ingredients are\u00a0lactose\u00a0(as monohydrate), hypromellose, yellow iron oxide, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Yellow, oval, and biconvex\u00a0prolonged-release tablets.\u00a0The prolonged-release tablets\u00a0are approx. 9.3 mm x 19.1 mm and are embossed with V04 on one side and the company&#8217;s logo on the other side.\u00a0Viramune\u00a0prolonged-release tablet\u00a0er 400 mg is supplied in blisters with 30 or 90\u00a0prolonged-release tablets\u00a0er per carton.\u00a0Alternatively, there are 30\u00a0prolonged-release tablets\u00a0of 400 mg in a jar.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>Viramune is also available as an\u00a0oral\u00a0suspension\u00a0or as tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim International GmbH<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Boehringer Ingelheim France<\/p>\n\n\n\n<p>100-104 avenue de France<\/p>\n\n\n\n<p>75013 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Boehringer Ingelheim SComm T\u00e9l\/Tel: +32 2 773 33 11<\/td><td><strong>Lithuania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG Lietuvos filialasPhone: +370 5 2595942<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>B\u00f6ringer Ingelheim \u0420\u0426\u0412 \u0413\u043c\u0431\u0425 \u0438 \u041a\u043e \u041a\u0413 &#8211; branch \u0411\u044a\u043b\u0433\u0430\u0440\u0441\u043a\u0438Phone: +359 2 958 79 98<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Boehringer Ingelheim SCommT\u00e9l\/Tel: +32 2 773 33 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Boehringer Ingelheim coil.\u00a0s iPhone: +420 234 655 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGMagyarorsz\u00e1gi Fi\u00f3ktelepeTel.: +36 1 299 8900<\/td><\/tr><tr><td><strong>Denmark<\/strong>Boehringer Ingelheim Danmark A\/SPhone: +45 39 15 88 88<\/td><td><strong>Malta<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +35 31 295 9620<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KGPhone: +49 (0) 800 77 90 900<\/td><td><strong>The Netherlands<\/strong>Boehringer Ingelheim bvPhone: +31 (0) 800 22 55 889<\/td><\/tr><tr><td><strong>Estonia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG Eesti branchPhone: +372 612 8000<\/td><td><strong>Norway<\/strong>Boehringer Ingelheim Norway KSPhone: +47 66 76 13 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Boehringer Ingelheim \u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Austria<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPhone: +43 1 80 105 7870<\/td><\/tr><tr><td><strong>Spain<\/strong>Boehringer Ingelheim Espa\u00f1a, SAPhone: +34 93 404 51 00<\/td><td><strong>Polish<\/strong>Boehringer Ingelheim Sp.&nbsp;z o. oTel.: +48 22 699 0 699<\/td><\/tr><tr><td><strong>France<\/strong>Boehringer Ingelheim France SASTel: +33 3 26 50 45 33<\/td><td><strong>Portugal<\/strong>Boehringer Ingelheim Portugal, Lda.Phone: +351 21 313 53 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Boehringer Ingelheim Zagreb dooPhone: +385 1 2444 600<\/td><td><strong>Romania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG Viena &#8211; Sucursala BucurestiPhone: +40 21 302 2800<\/td><\/tr><tr><td><strong>Ireland<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><td><strong>Slovenija<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPodru\u017enica LjubljanaPhone: +386 1 586 40 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGorganiza\u010dn\u00e1 zlo\u017ekaPhone: +421 2 5810 1211<\/td><\/tr><tr><td><strong>Italy<\/strong>Boehringer Ingelheim Italia SpAPhone: +39 02 5355 1<\/td><td><strong>Finland\/Finland<\/strong>Boehringer Ingelheim Finland KyPhone\/Tel: +358 10 3102 800<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Boehringer Ingelheim \u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Sweden<\/strong>Boehringer Ingelheim ABPhone: +46 8 721 21 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLatvijas branchPhone: +371 67 240 011<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Viramune belongs to the drug group antiretroviral agents, which are used in the treatment of\u00a0infection\u00a0with the Human Immunodeficiency\u00a0Virus\u00a0(\u00a0HIV\u00a0&#8211; 1).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27512,27516,27515,27517,27521,27520,27514,27518,27513,27519],"class_list":["post-29210","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-nevirapine","tag-nevirapine-side-effects","tag-nevirapine-tablet","tag-viramune","tag-viramune-side-effects","tag-viramune-tablet","tag-what-is-nevirapine","tag-what-is-viramune","tag-what-nevirapine-is-used-for","tag-what-viramune-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=29210"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29210\/revisions"}],"predecessor-version":[{"id":29640,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29210\/revisions\/29640"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=29210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=29210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=29210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}