{"id":29201,"date":"2022-11-02T16:05:31","date_gmt":"2022-11-02T16:05:31","guid":{"rendered":"https:\/\/zeepedia.com\/?p=29201"},"modified":"2022-11-03T10:09:48","modified_gmt":"2022-11-03T10:09:48","slug":"vinorelbine-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vinorelbine-accord\/","title":{"rendered":"Vinorelbine Accord &#8211; Vinorelbine uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg\/ml&nbsp;concentrate for&nbsp;infusion&nbsp;liquid , solution<br>vinorelbine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vinorelbine Accord is and what it is used for<\/h2>\n\n\n\n<p>Vinorelbine Accord is a concentrate for\u00a0infusion solution.\u00a0The active substance vinorelbine belongs to the group\u00a0cytostatics\u00a0(cell-inhibiting agents).\u00a0These agents interfere with the growth of malignant (malignant) cells.<\/p>\n\n\n\n<p>Vinorelbine Accord is intended for adults for the treatment of cancer, specifically nonnon-smallll lung cancer\u00a0and breast cancer.<\/p>\n\n\n\n<p>Vinorelbine contained in Vinorelbine Accord may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Vinorelbine Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vinorelbine Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vinorelbine or to any medicine in the group called vinca alkaloids<\/li><li>if you are allergic to any other ingredient in Vinorelbine Accord (see section 6)<\/li><li>if you are pregnant or think you may be pregnant<\/li><li>if you are breastfeeding<\/li><li>if you have a low number of&nbsp;white blood cells&nbsp;(&nbsp;neutrophils&nbsp;) or have had (within the last 2 weeks) a serious&nbsp;infection<\/li><li>if you have a low&nbsp;platelet count<\/li><li>if you plan to be vaccinated (or have recently been vaccinated) against yellow fever<\/li><li>this medicine is for&nbsp;intravenous&nbsp;use only and should not be injected into the spine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Vinorelbine Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously had heart attacks or severe chest pain<\/li><li>if you have received radiation therapy and the treatment area included the liver<\/li><li>if you have symptoms of\u00a0infection\u00a0(such as fever, chills, cough)<\/li><li>if you plan to get vaccinated<\/li><li>if your liver is not working normally<\/li><li>Vinorelbine Accord must not come into contact with the eyes as there is a risk of severe irritation and even corneal ulceration.\u00a0If this occurs, immediately flush the eyes with physiological saline and consult an ophthalmologist.<\/li><li>Men and women treated with Vinorelbine Accord must use an effective method of contraception during treatment and after treatment.\u00a0See the section on pregnancy and brebreastfeedingOTH men and women should read the pregnancy and breastfeeding information below.<\/li><\/ul>\n\n\n\n<p>Before each administration of the Vinorelbine Accord, a blood sample is taken for analysis of the constituents of the blood.\u00a0If the results of this analysis are not satisfactory, your treatment may be delayed and additional samples were taken until these values \u200b\u200breturn to normal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vinorelbine Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The doctor must be especially careful if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to thin the blood (&nbsp;anticoagulants&nbsp;)<\/li><li>a medicine for&nbsp;epilepsy&nbsp;called&nbsp;phenytoin<\/li><li>an antifungal medicine called itraconazole<\/li><li>a cancer medicine called mitomycin C<\/li><li>medicines that affect the immune system, such as ciclosporin and tacrolimus<\/li><li>simultaneous use with lapatinib (cancer medicine)<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;)<\/li><li>antibiotics&nbsp;such as rifampicin, erythromycin, clarithromycin, telithromycin<\/li><li>antiviral drugs for&nbsp;AIDS&nbsp;(&nbsp;HIV&nbsp;) such as ritonavir (&nbsp;HIV&nbsp;protease&nbsp;inhibitor&nbsp;)<\/li><li>verapamil,&nbsp;quinidine&nbsp;(used for heart problems)<\/li><\/ul>\n\n\n\n<p>Vaccines (eg chickenpox, mumps, measles) and yellow fever vaccines are not recommended during treatment with Vinorelbine Accord as they may increase the risk of fatal systemic disease.<\/p>\n\n\n\n<p>Concomitant use of Vinorelbine Accord and other drugs are known to be toxic to the bone marrow (affects white and\u00a0red blood cells\u00a0and\u00a0platelets\u00a0) may worsen some of the\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vinorelbine Accord with food and drink<\/h2>\n\n\n\n<p>There are no special restrictions on food and drink during treatment with Vinorelbine Accord.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Safety and efficacy for children and adolescents have not been established.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not take Vinorelbine Accord if you are pregnant or think you may be pregnant.<\/li><li>If you have to start treatment with Vinorelbine Accord and are pregnant or if you become pregnant during treatment with Vinorelbine Accord, you must immediately contact your doctor for advice.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not take Vinorelbine Accord if you are brebreastfeedingreast-feeding must be discontinued if treatment with Vinorelbine Accord is necessary.<\/li><\/ul>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Men treated with Vinorelbine Accord should be advised not to impregnate their partner during and up to 6 months after the end of treatment and to seek advice on sperm storage before treatment.\u00a0Vinorelbine Accord may alter male\u00a0fertility.<\/p>\n\n\n\n<p>Women of childbearing potential must be advised to use an effective method of contraception during treatment and 3 months after the end of treatment and must inform the doctor if they become pregnant.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>No studies have been performed on the effect of Vinorelbine Accord on the ability to drive or use machines.&nbsp;Do not drive if your doctor has advised you not to or if you feel unwell.<\/p>\n\n\n\n<p>You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects&nbsp;.&nbsp;Description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Discuss with your doctor or pharmacist if you are unsure.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vinorelbine Accord<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Vinorelbine Accord can only be prepared and administered by trained healthcare professionals specialized in&nbsp;oncology&nbsp;.&nbsp;Before each&nbsp;administration&nbsp;, a blood sample will be taken to analyze the components of the blood to confirm that you have enough&nbsp;blood cells&nbsp;to receive Vinorelbine Accord.&nbsp;If the results of this analysis are not satisfactory, your treatment may be delayed and additional samples taken until these values \u200b\u200breturn to normal.&nbsp;The usual&nbsp;dose&nbsp;for adults is 25 to 30 mg\/m\u00b2.<\/p>\n\n\n\n<p><strong>Treatment frequency<\/strong><\/p>\n\n\n\n<p>Treatment with Vinorelbine Accord is scheduled for once a week.&nbsp;How often you should receive treatment is determined by the doctor.<\/p>\n\n\n\n<p>Always follow your doctor&#8217;s instructions.<\/p>\n\n\n\n<p>Dose adjustment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In case of severely impaired liver function, the doctor must adjust the&nbsp;dose&nbsp;.&nbsp;You must follow the doctor&#8217;s instructions.<\/li><li>In case of impaired renal function, dose adjustment is not necessary.&nbsp;You must follow the doctor&#8217;s instructions.<\/li><\/ul>\n\n\n\n<p><strong>Method and method of administration<\/strong><\/p>\n\n\n\n<p>Vinorelbine Accord must be diluted before it is given.<\/p>\n\n\n\n<p>Vinorelbine Accord may only be given as an&nbsp;infusion&nbsp;into a vein.<\/p>\n\n\n\n<p>It takes between 6 and 10 minutes.<\/p>\n\n\n\n<p>After&nbsp;administration&nbsp;, the vein will be thoroughly flushed with a&nbsp;sterile&nbsp;solution.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vinorelbine Accord<\/h2>\n\n\n\n<p>The doctor must always ensure that you receive the\u00a0dose\u00a0that is appropriate for your situation.\u00a0However, if you suspect or have symptoms of a possible overdose, such as fever, signs of\u00a0infection\u00a0or constipation, contact a doctor, emergency department or pharmacist.\u00a0If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>If you have further questions, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;&#8211; if any of the following&nbsp;side effects&nbsp;occur, contact a doctor immediately:<\/strong><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<p>Serious&nbsp;infection&nbsp;with failure of various organs or blood poisoning.&nbsp;Shortness of breath and narrow airways (&nbsp;bronchospasm&nbsp;).<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users)<\/em><\/p>\n\n\n\n<p>Chest pain, which may spread to the back of the neck and arm, due to lack of blood supply to the heart (&nbsp;angina pectoris&nbsp;).&nbsp;Heart attack (myocardial infection).<\/p>\n\n\n\n<p><em>Has been reported (may occur in an unknown number of users)<\/em><\/p>\n\n\n\n<p>Extensive and very severe allergic reactions.&nbsp;Symptoms may include sudden wheezing, swelling of the lips, tongue and throat or body, difficulty swallowing, rash, feeling unsteady, fainting (anaphylaxis\/anaphylactic shock\/anaphylactoid reaction).<\/p>\n\n\n\n<p>These&nbsp;side effects&nbsp;are very serious.&nbsp;You may need immediate medical attention.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;&#8211; if any of the following&nbsp;side effects&nbsp;occur, contact a doctor as soon as possible:<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users)<\/em><\/p>\n\n\n\n<p>Low number of&nbsp;white blood cells&nbsp;, which can increase the risk of&nbsp;infection&nbsp;.&nbsp;Low&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;), which can make you feel tired.&nbsp;Loss of deep tendon reflexes.&nbsp;Weakness in legs (lower&nbsp;extremity&nbsp;).&nbsp;Inflammation&nbsp;in the mouth or esophagus.&nbsp;Nausea and vomiting.&nbsp;Constipation.&nbsp;Abnormal liver function tests.&nbsp;Hair loss.&nbsp;Redness&nbsp;(&nbsp;erythema&nbsp;), burning pain, vein discoloration and\/or&nbsp;inflammation&nbsp;of the veins (local&nbsp;phlebitis&nbsp;) at the injection site.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<p>Infections&nbsp;(&nbsp;bacterial&nbsp;,&nbsp;viral&nbsp;or fungal infections) in the body (respiratory, urinary, gastrointestinal system and possibly others) with symptoms such as fever, pain and chills.&nbsp;Low&nbsp;platelet count&nbsp;(risk of bleeding).&nbsp;Diarrhea.&nbsp;Pain in muscles and joints, including jaw pain.&nbsp;Altered kidney function (increased creatinine values).&nbsp;Weakness, fatigue, fever, pain in various places.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<p>Severe numbness (&nbsp;paresthesia&nbsp;).&nbsp;Low&nbsp;blood pressure&nbsp;, high&nbsp;blood pressure&nbsp;, redness&nbsp;and&nbsp;cold hands and feet.<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users)<\/em><\/p>\n\n\n\n<p>Low levels of&nbsp;sodium&nbsp;in the blood (which can cause symptoms of tiredness, confusion, muscle twitching and&nbsp;coma&nbsp;).&nbsp;Changes in the activity of the heart (&nbsp;ECG&nbsp;changes).&nbsp;Severely low&nbsp;blood pressure&nbsp;or collapse.&nbsp;Lung disease (interstitial pneumopathy).&nbsp;Inflammation&nbsp;of the pancreas.&nbsp;Intestinal ulceration (&nbsp;ileus&nbsp;).&nbsp;Skin reactions such as rash,&nbsp;itching&nbsp;and&nbsp;hives&nbsp;.&nbsp;Necrosis&nbsp;at the injection site.<\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<p>Blood poisoning which can be life-threatening.&nbsp;Strong heartbeats, fast heartbeats, heart rhythm disturbances.<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<p>A general&nbsp;infection&nbsp;combined with a reduced number of&nbsp;white blood cells&nbsp;(&nbsp;neutropenic&nbsp;sepsis&nbsp;).&nbsp;Decreased number of&nbsp;white blood cells&nbsp;with fever (febrile&nbsp;neutropenia&nbsp;).&nbsp;Reduced number of white and&nbsp;red blood cells&nbsp;and&nbsp;platelets&nbsp;.&nbsp;Low sodium levels due to overproduction of a&nbsp;hormone&nbsp;that leads to fluid retention and weakness, tiredness or confusion (SIADH syndrome).&nbsp;Decreased appetite (&nbsp;anorexia&nbsp;).&nbsp;Redness&nbsp;(&nbsp;erythema&nbsp;) on the hands and feet.<\/p>\n\n\n\n<p>Like other vinca alkaloids, vinorelbine may lead to moderate blistering.<\/p>\n\n\n\n<p>As changes in the blood may occur, the doctor may order blood tests to check this (low&nbsp;white blood cell count&nbsp;,&nbsp;anemia&nbsp;and\/or low&nbsp;platelet count&nbsp;, effects on liver or kidney function and the body&#8217;s electrolyte balance).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vinorelbine Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the vial and outer carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C to 8 \u00b0C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p><em>Shelf life after dilution<\/em><\/p>\n\n\n\n<p>Chemical and physical stability of the ready-to-use solution has been demonstrated for 24 hours at 25 \u00b0C.&nbsp;From a&nbsp;microbiological&nbsp;point of view, unless the method of opening\/dilution excludes the risk of&nbsp;microbial&nbsp;contamination, the product should be used immediately after dilution.&nbsp;If not used immediately, in-use storage times and conditions are the responsibility of the user.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is vinorelbine (in the form of tartrate).&nbsp;1 ml of solution contains 10 mg of vinorelbine (as vinorelbine tartrate).<\/p>\n\n\n\n<p>Other ingredients are water for injections.<\/p>\n\n\n\n<p>Each 1 ml&nbsp;vial&nbsp;contains a total of 10 mg of vinorelbine (as tartrate).<\/p>\n\n\n\n<p>Each 5 ml&nbsp;vial&nbsp;contains a total of 50 mg of vinorelbine (as tartrate).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Clear, colorless to pale yellow solution.&nbsp;Vinorelbine Accord is packaged in clear type 1 glass vials with bromobutyl rubber stoppers and a blue aluminum flip-top seal.<\/p>\n\n\n\n<p>Vinorelbine Accord is available in:<\/p>\n\n\n\n<p>Vial of&nbsp;1 ml<\/p>\n\n\n\n<p>Vial&nbsp;of 5 ml<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Holland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road<\/p>\n\n\n\n<p>North Harrow, Middlesex, HA1 4HF<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomirska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vinorelbine Accord is a concentrate for\u00a0infusion solution\u00a0.\u00a0The active substance vinorelbine belongs to the group\u00a0cytostatics\u00a0(cell-inhibiting agents).\u00a0These agents interfere with the growth of malignant (malignant) cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[18617,27543,27547,27548,27544,18620,18618,27545,27546,18619],"class_list":["post-29201","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-vinorelbine","tag-vinorelbine-accord","tag-vinorelbine-accord-liquid","tag-vinorelbine-accord-side-effects","tag-vinorelbine-liquid","tag-vinorelbine-side-effects","tag-what-is-vinorelbine","tag-what-is-vinorelbine-accord","tag-what-vinorelbine-accord-is-used-for","tag-what-vinorelbine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=29201"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29201\/revisions"}],"predecessor-version":[{"id":29644,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/29201\/revisions\/29644"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=29201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=29201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=29201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}