{"id":28589,"date":"2022-11-01T14:59:50","date_gmt":"2022-11-01T14:59:50","guid":{"rendered":"https:\/\/zeepedia.com\/?p=28589"},"modified":"2022-11-02T11:05:00","modified_gmt":"2022-11-02T11:05:00","slug":"vimovo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vimovo\/","title":{"rendered":"Vimovo &#8211; Naproxen\u00a0and esomeprazole uses, dose and side effects"},"content":{"rendered":"\n<p>500 mg\/20 mg&nbsp;tablets with modified&nbsp;release<br>naproxen&nbsp;and esomeprazole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vimovo is and what it is used for<\/h2>\n\n\n\n<p><strong>What Vimovo is<\/strong><\/p>\n\n\n\n<p>Vimovo contains two different medicines called&nbsp;naproxen&nbsp;and esomeprazole.&nbsp;Each of them works in different ways.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Naproxen\u00a0belongs to a group of medicines called non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0).\u00a0It relieves pain and\u00a0inflammation.<\/li><li>Esomeprazole belongs to a group of medicines called\u00a0proton pump inhibitors.\u00a0It reduces the amount of stomach acid in the stomach.<\/li><\/ul>\n\n\n\n<p>Patients who need to take&nbsp;NSAIDs&nbsp;can get&nbsp;ulcers&nbsp;and stomach problems, but esomeprazole helps reduce that risk.<\/p>\n\n\n\n<p><strong>What Vimovo is used for<\/strong><\/p>\n\n\n\n<p>Vimovo is used by adults to relieve the symptoms of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>arthritis<\/li><li>rheumatoid arthritis<\/li><li>Bechterew&#8217;s disease.<\/li><\/ul>\n\n\n\n<p>Vimovo helps reduce pain, swelling,\u00a0redness,\u00a0and heat (\u00a0inflammation\u00a0).<\/p>\n\n\n\n<p>You are given this medicine because your doctor thinks that a lower\u00a0dose\u00a0of\u00a0NSAID\u00a0is unlikely to relieve your pain and you are at risk of developing\u00a0stomach ulcers\u00a0or ulcers in the first part of the small intestine (\u00a0duodenum\u00a0) when you take\u00a0NSAIDs.<\/p>\n\n\n\n<p>The naproxen\u00a0and esomeprazole found in Vimovo may also be approved to treat other conditions not listed in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Vimovo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Vimovo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0naproxen<\/li><li>if you are allergic to esomeprazole or other proton pump inhibitor medicines<\/li><li>if you are allergic to any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are taking a medicine called atazanavir or nelfinavir (used against\u00a0HIV\u00a0)<\/li><li>if\u00a0aspirin,\u00a0naproxen,\u00a0or other\u00a0NSAID\u00a0medicines, such as\u00a0ibuprofen,\u00a0diclofenac,\u00a0or\u00a0COX-2\u00a0inhibitors (e.g. celecoxib, etoricoxib) have caused you to have\u00a0asthma\u00a0(wheezing) or an\u00a0allergic reaction, such as\u00a0itching\u00a0or rash (\u00a0urticaria,\u00a0hives\u00a0)<\/li><li>if you are 7-9 months pregnant<\/li><li>if you have\u00a0severe\u00a0liver, kidney, or heart problems<\/li><li>if you have a stomach or intestinal ulcer<\/li><li>if you have a bleeding disorder or have severe and unexpected bleeding<\/li><\/ul>\n\n\n\n<p>Do not use Vimovo if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or pharmacist before taking Vimovo.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Vimovo.<\/p>\n\n\n\n<p>Vimovo can mask symptoms of other diseases.&nbsp;Therefore, you must not take Vimovo if any of the following happen to you before or while you are taking Vimovo, and you must contact your doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you lose a lot of weight for no reason at all and have difficulty swallowing.<\/li><li>you start vomiting food or blood.<\/li><li>the stool is black (with blood in it).<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or pharmacist before taking the medicine.<\/p>\n\n\n\n<p>Before taking this medicine, consult a doctor or pharmacist:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any\u00a0inflammation\u00a0of the intestine (\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis\u00a0)<\/li><li>if you have any other liver or kidney problems, or if you are elderly.<\/li><li>if you are taking certain medicines such as\u00a0oral corticosteroids,\u00a0warfarin, clopidogrel,\u00a0SSRIs\u00a0(selective serotonin reuptake inhibitors),\u00a0aspirin,\u00a0or\u00a0NSAIDs, including\u00a0COX-2\u00a0inhibitors (see section Other medicines and Vimovo)<\/li><li>if you have ever had a skin reaction after treatment with a medicine similar to esomeprazole (one of the components of Vimovo) which reduces stomach acid<\/li><li>if you are going to undergo a specific blood test (chromogranin A)<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or pharmacist before taking the medicine.<\/p>\n\n\n\n<p>If you have had&nbsp;stomach ulcers&nbsp;or bleeding in the stomach in the past, tell your doctor.&nbsp;Your doctor will ask you to report any unusual stomach symptoms (eg pain).<\/p>\n\n\n\n<p>Medicines such as Vimovo may be associated with a small increase in the risk of heart attack (myocardial infarction) or\u00a0stroke.\u00a0The possible risk is higher if you take a high\u00a0dose\u00a0and are treated for a long time.\u00a0Do not exceed the recommended\u00a0dose\u00a0or duration of treatment.<\/p>\n\n\n\n<p>Vimovo contains\u00a0naproxen\u00a0which is an\u00a0NSAID\u00a0medicine.\u00a0Like all\u00a0NSAIDs,\u00a0naproxen\u00a0should\u00a0be used in the lowest effective\u00a0dose\u00a0for the shortest possible time to reduce the risk of\u00a0side effects.\u00a0Your doctor will therefore periodically assess whether Vimovo is still suitable for you.<\/p>\n\n\n\n<p>Vimovo is not suitable for quick relief of&nbsp;acute&nbsp;pain, as it takes several hours for the pain-relieving substance&nbsp;naproxen&nbsp;to be absorbed into the blood.<\/p>\n\n\n\n<p>If you have any heart problems, have had a&nbsp;stroke&nbsp;in the past or if you think you are at risk of such diseases, you should also consult your doctor before taking the medicine.&nbsp;You may be at risk of getting such a disease:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have high&nbsp;blood pressure<\/li><li>if you have problems with blood circulation or blood clotting<\/li><li>if you have&nbsp;diabetes<\/li><li>if you have high cholesterol<\/li><li>if you smoke<\/li><\/ul>\n\n\n\n<p>Using\u00a0proton pump inhibitors\u00a0such as esomeprazole (which is an active substance in Vimovo) and especially if you use Vimovo for more than a year, may slightly increase the risk of having a hip, wrist, or vertebral fracture (broken bone).\u00a0Tell your doctor if you have osteoporosis\u00a0or\u00a0if you use medicines called\u00a0corticosteroids\u00a0because they can increase the risk of osteoporosis.<\/p>\n\n\n\n<p>If you develop a rash, especially in areas exposed to the sun, tell your doctor as soon as possible as you may need to stop treatment with Vimovo.\u00a0Also remember to mention any other\u00a0side effects, such as joint pain.<\/p>\n\n\n\n<p>Serious skin rashes have occurred in patients taking esomeprazole (see also section 4).\u00a0The rash can consist of sores in the mouth, throat, nose, genitals, and\u00a0conjunctivitis\u00a0(red and swollen eyes).\u00a0These severe skin rashes often come after\u00a0flu-like symptoms such\u00a0as fever, headache, and body aches.\u00a0The rash can cover large parts of the body with blisters and peeling skin.<\/p>\n\n\n\n<p>If at any time during treatment (even after several weeks) you develop a rash or any of these skin symptoms, stop taking this medicine and contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Vimovo is not recommended for use in children and adolescents who are 18 years of age or younger.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vimovo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This also includes over-the-counter medicines, including (traditional) herbal medicines and herbal medicines.\u00a0The reason for this is that Vimovo can affect the function of certain other medicines.\u00a0Some other medicines can also affect how Vimovo works.<\/p>\n\n\n\n<p>You should not take this medicine but instead tell your doctor or pharmacist if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a medicine called atazanavir or nelfinavir (used for&nbsp;HIV&nbsp;).<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>acetylsalicylic acid\u00a0(used as a pain reliever or as a blood clot prevention medicine).\u00a0If you are taking\u00a0low-dose\u00a0aspirin, you may still be able to take Vimovo<\/li><li>other\u00a0NSAIDs\u00a0(including\u00a0COX-2\u00a0inhibitors)<\/li><li>certain medicines such as\u00a0ketoconazole, itraconazole, posaconazole, or voriconazole (used to treat\u00a0infections\u00a0caused by a fungus)<\/li><li>erlotinib (or another cancer drug in the same class)<\/li><li>cholestyramine (used to lower cholesterol)<\/li><li>clarithromycin (used to treat\u00a0infection\u00a0)<\/li><li>quinolone antibiotics (against\u00a0infection\u00a0), such as\u00a0ciprofloxacin\u00a0or moxifloxacin.<\/li><li>diazepam\u00a0(used to treat anxiety, relax muscles, or in\u00a0epilepsy\u00a0)<\/li><li>hydantoins, e.g.\u00a0phenytoin\u00a0(used to treat\u00a0epilepsy\u00a0)<\/li><li>lithium (used to treat certain types of depression)<\/li><li>methotrexate (used to treat\u00a0rheumatoid arthritis,\u00a0psoriasis,\u00a0and cancer)<\/li><li>probenecid (for\u00a0gout\u00a0)<\/li><li>SSRIs\u00a0(selective serotonin reuptake inhibitors) (used to treat\u00a0endogenous\u00a0depression and anxiety disorders)<\/li><li>ciclosporin or tacrolimus (medicines used to suppress the body&#8217;s immune system).<\/li><li>digoxin\u00a0(used to treat heart disease)<\/li><li>sulfonamides, e.g.\u00a0glimepiride (medicine taken by mouth to regulate blood sugar in\u00a0diabetes\u00a0)<\/li><li>medicines used to treat high blood pressure:\u00a0diuretics\u00a0(eg\u00a0furosemide\u00a0or\u00a0hydrochlorothiazide,\u00a0ACE inhibitors\u00a0(eg\u00a0enalapril\u00a0),\u00a0angiotensin\u00a0II receptor antagonists (eg\u00a0losartan\u00a0), and beta-blockers\u00a0(eg propranolol)<\/li><li>corticosteroid drugs, e.g.\u00a0hydrocortisone\u00a0or\u00a0prednisolone\u00a0(used as anti-inflammatory\u00a0drugs)<\/li><li>medicines that prevent the blood from clotting (coagulating), e.g.\u00a0warfarin, dicoumarol,\u00a0heparin,\u00a0or clopidogrel<\/li><li>rifampicin (used to treat\u00a0tuberculosis\u00a0)<\/li><li>St. John&#8217;s wort\u00a0(Hypericum perforatum) (used to treat mild depression)<\/li><li>cilostazol (used for leg pain due to poor blood flow)<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or pharmacist before taking Vimovo.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vimovo with food and drink<\/h2>\n\n\n\n<p>Do not take Vimovo with food, as this may reduce and\/or delay the effect of Vimovo.&nbsp;Take the tablets at least 30 minutes before eating.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not take Vimovo during the last three months of pregnancy.<\/li><li>Consult your doctor before taking the medicine if you are 1-6 months pregnant.\u00a0Your doctor will decide if you can take Vimovo.<\/li><li>You must not breastfeed if you are taking Vimovo because small amounts of the medicine can pass into breast milk.\u00a0If you plan to breastfeed, you should not take Vimovo.<\/li><\/ul>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0Vimovo can make it harder to get pregnant.\u00a0You should tell your doctor if you are planning to become pregnant or if you have problems becoming pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You may feel dizzy or have blurred vision while taking Vimovo.&nbsp;In this case, you should not drive a car or use tools or machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vimovo contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216)<\/h2>\n\n\n\n<p>These ingredients can cause allergic reactions.&nbsp;Reactions may not occur immediately.<\/p>\n\n\n\n<p>Vimovo contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Vimovo<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Take the medicine like this<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablets whole with water.\u00a0The tablets must not be chewed, split, or crushed.\u00a0For the medicine to work as intended, you must take the tablets whole.<\/li><li>Take the tablets at least 30 minutes before eating.\u00a0Food can reduce Vimovo&#8217;s protective effect on the stomach and intestines.\u00a0Food can also significantly delay the relief of pain and\u00a0inflammation.<\/li><li>If you take the medicine for a long time, your doctor will want to check you regularly (especially if you take it for more than a year).<\/li><\/ul>\n\n\n\n<p><strong>This is how much you should take<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take one tablet twice a day for as long as your doctor says you need.<\/li><li>Vimovo is only available in the 500 mg\/20 mg strength.&nbsp;If your doctor thinks that&nbsp;dose&nbsp;one is not suitable for you, he\/she may prescribe another medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vimovo<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>The symptoms of overdose can include\u00a0lethargy, lack of energy, difficulty concentrating (\u00a0lethargy\u00a0), dizziness, drowsiness, pain and\/or discomfort in the upper abdomen, heartburn, indigestion, nausea, liver problems (shown with a blood test), kidney problems that can be serious, higher acidity of the blood than common, confusion, vomiting, bleeding in the stomach or intestines, high\u00a0blood pressure, difficulty breathing,\u00a0coma, sudden allergic reactions (which may include shortness of breath, rash, swelling of the face and\/or throat, and\/or collapse) and uncontrolled body movements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vimovo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have forgotten to take a\u00a0dose, take it as soon as you remember.\u00a0However, if it is almost time for the next\u00a0dose, skip the forgotten\u00a0dose.<\/li><li>Do not take a double\u00a0dose\u00a0(two\u00a0doses\u00a0at the same time) to compensate for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine.<\/p>\n\n\n\n<p><strong>Stop taking Vimovo and see a doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden onset of wheezing, swelling of the lips, tongue, and throat or body, rash, fainting, or difficulty swallowing (severe\u00a0allergic reaction\u00a0).<\/li><li>Sudden, severe skin rashes or skin redness with blisters and peeling skin may occur even after several weeks of treatment.\u00a0There may also be severe blistering and bleeding in the lips, eyes, mouth, nose, and genitals.\u00a0The skin rash can develop into serious widespread skin damage (skin peeling of the epidermis and superficial mucous membranes) with life-threatening consequences.\u00a0This could be &#8220;erythema multiforme&#8221;, &#8220;Stevens-Johnson syndrome&#8221;, &#8220;toxic\u00a0epidermal\u00a0necrolysis&#8221; or &#8220;drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms&#8221;.\u00a0These\u00a0side effects\u00a0are very rare and may occur in up to 1 in 10,000 users.<\/li><li>Yellowing of the skin or the whites of the eyes, dark urine, and tiredness, can be symptoms of liver disease.<\/li><li>Medicines such as Vimovo may be associated with a small increase in the risk of heart attack (myocardial infarction) or\u00a0stroke.\u00a0Signs include chest pain radiating up the neck and shoulders and out into the left arm;\u00a0confusion or muscle weakness or numbness, which may only be felt on one side of the body.<\/li><li>Sticky, black stools or bloody diarrhea.<\/li><li>Vomiting with blood or dark particles that look like coffee grounds.<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor as soon as possible if you notice any of the following:<\/strong><\/p>\n\n\n\n<p>In rare cases, Vimovo can affect the white\u00a0blood cells, leading to immunodeficiency.<\/p>\n\n\n\n<p>If you get an\u00a0infection\u00a0with symptoms such as fever and greatly worsened general condition.\u00a0or fever with symptoms of local\u00a0infection, such as pain in the neck, throat, or mouth, or difficulty urinating, you must see a doctor as soon as possible, so that a blood test can be taken to rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0You must inform us about which medicines you are currently taking.<\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>fatigue<\/li><li>thirst<\/li><li>Depression<\/li><li>shortness of breath<\/li><li>increased sweating<\/li><li>itching\u00a0and rash<\/li><li>vertigo (a feeling that everything is spinning)<\/li><li>red or purple marks, spots, or dots on the skin<\/li><li>nausea or vomiting<\/li><li>palpitation\u00a0_\u00a0_<\/li><li>sleep disorders or insomnia (insomnia)<\/li><li>hearing problems or\u00a0tinnitus\u00a0(ringing in the ears)<\/li><li>dizziness, drowsiness, or lightheadedness when standing up<\/li><li>swelling of the hands, feet, and ankles (\u00a0edema\u00a0)<\/li><li>inflammation\u00a0of the mouth<\/li><li>vision problems<\/li><li>diarrhea, stomach ache, heartburn, indigestion, constipation, belching,\u00a0or\u00a0flatulence<\/li><li>peptic ulcer\u00a0or ulcer in the first part of the small intestine (\u00a0duodenum\u00a0)<\/li><li>inflammation\u00a0of the lining of the stomach (\u00a0gastritis\u00a0)<\/li><li>benign\u00a0polyps\u00a0in the stomach<\/li><\/ul>\n\n\n\n<p><strong>Uncommon, rare, or very rare (may affect up to 1 in 100 users or less)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sore mouth or mouth sores<\/li><li>vision problems, such as blurred vision, eye inflammation (\u00a0conjunctivitis\u00a0), or eye pain<\/li><li>strange dreams<\/li><li>somnolence<\/li><li>the increased amount of sugar (\u00a0glucose\u00a0) in the blood.\u00a0Symptoms may include thirst and increased urine output<\/li><li>low levels of sugar (\u00a0glucose\u00a0) in the blood.\u00a0Symptoms may include feeling hungry or weak, sweating, and a fast heartbeat<\/li><li>coma<\/li><li>inflammation\u00a0of the blood vessels<\/li><li>hole in the stomach or intestine<\/li><li>systemic lupus erythematosus (\u00a0SLE\u00a0), is a disease in which the body&#8217;s immune system attacks the body, causing joint pain, rash, and fever<\/li><li>enlarged\u00a0lymph nodes<\/li><li>fracture\u00a0of the hip, wrist, or vertebrae (if Vimovo is used in high\u00a0doses\u00a0and for a long time)<\/li><li>fever<\/li><li>fainting<\/li><li>dry mouth<\/li><li>aggressiveness<\/li><li>hearing loss<\/li><li>asthma attacks<\/li><li>convulsions or convulsions<\/li><li>menstrual disorders<\/li><li>weight changes<\/li><li>hair loss (\u00a0alopecia\u00a0)<\/li><li>raised, bumpy rash (\u00a0hives\u00a0)<\/li><li>joint pain (\u00a0arthralgia\u00a0)<\/li><li>breast augmentation in men<\/li><li>tongue burning or a swollen tongue<\/li><li>muscle twitching or tremors<\/li><li>appetite disturbances or taste changes<\/li><li>muscle weakness or muscle pain (\u00a0myalgia\u00a0)<\/li><li>longer coagulation time for the blood<\/li><li>problems for women to get pregnant<\/li><li>fever,\u00a0redness,\u00a0or other signs of\u00a0infection<\/li><li>irregular, slow, or very fast heartbeat<\/li><li>tingling in the skin, as if a body part is &#8220;sleeping&#8221;<\/li><li>memory or concentration difficulties<\/li><li>worry, confusion, anxiety, or nervousness<\/li><li>general malaise, weakness, and lack of energy<\/li><li>swollen or sore body parts because you have accumulated fluid<\/li><li>high or low\u00a0blood pressure.\u00a0Fainting, dizziness<\/li><li>skin rash or blisters, or the skin becoming more sensitive to exposure to sunlight<\/li><li>that you see, feel, or hear things that are not there (hallucinations)<\/li><li>changed values \u200b\u200bof certain blood tests, for example, to check liver function.\u00a0Your doctor can explain more<\/li><li>an\u00a0infection\u00a0of the intestine with the fungus\u00a0Candida<\/li><li>blood in the urine or other kidney disease.\u00a0Possibly also back pain<\/li><li>breathing difficulties, which may slowly get worse.\u00a0This could be a sign of\u00a0pneumonia\u00a0or that your lungs are swelling<\/li><li>low levels of salt (\u00a0sodium\u00a0) in the blood.\u00a0This can cause weakness, vomiting, and convulsions<\/li><li>symptoms of\u00a0meningitis, e.g.\u00a0fever, nausea or vomiting, neck stiffness, headache, sensitivity to bright light, and confusion<\/li><li>problems with the pancreas.\u00a0Signs include severe abdominal pain that spreads to the back<\/li><li>pale stools which are a sign of serious liver problems (\u00a0hepatitis\u00a0).\u00a0Severe liver problems can lead to liver failure and brain disorders<\/li><li>colitis\u00a0or worsening of\u00a0inflammatory\u00a0bowel diseases, such as\u00a0Crohn&#8217;s disease\u00a0or\u00a0ulcerative colitis.\u00a0Signs include abdominal pain, diarrhea, vomiting, and weight loss<\/li><li>problems with the blood, e.g.\u00a0reduced a number of\u00a0red blood cells\u00a0(anemia;\u00a0anemia\u00a0),\u00a0white blood cells,\u00a0or\u00a0platelets.\u00a0This can cause weakness, bruising, fever, severe frostbite, sore throat, or increase the risk\u00a0of\u00a0infection<\/li><li>increased number of a certain type of\u00a0white blood cell\u00a0(\u00a0eosinophilia\u00a0).<\/li><li>lack of all types of\u00a0blood cells\u00a0(pancytopenia).<\/li><li>problems with how the heart pumps blood around the body or damage to blood vessels.\u00a0Signs may include fatigue, shortness of breath, feeling weak, chest pain, or general aches.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you use Vimovo for more than three months, magnesium levels in your blood may drop.\u00a0Low levels of\u00a0magnesium\u00a0can manifest as fatigue, involuntary muscle movements, confusion, seizures, dizziness, and a fast heart rate.\u00a0If you experience any of these symptoms, see a doctor immediately.\u00a0Low levels of\u00a0magnesium\u00a0can also lead to reduced levels of\u00a0potassium\u00a0or\u00a0calcium\u00a0in the blood.\u00a0The doctor may measure the magnesium level in the blood using regular blood tests.<\/li><li>skin rash, possibly with pain in the joints<\/li><\/ul>\n\n\n\n<p><strong>Don&#8217;t be alarmed by this list of possible\u00a0side effects.\u00a0<\/strong>You don&#8217;t have to get any of them.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vimovo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton, can or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>Bottle: Store in the original packaging in a tightly closed jar.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Blister: Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are\u00a0naproxen\u00a0500 mg and esomeprazole 20 mg.<\/li><li>Other ingredients (excipients) in the tablet core are croscarmellose sodium, magnesium stearate, povidone K90,\u00a0colloidal\u00a0silicon dioxide, and in the film coating carnauba wax, glycerol monostearate 40\u201155, hypromellose type 2910 (3 mPas, 6 mPas, and 50 mPas), iron oxide (E172, yellow, black), macrogol 8000, methacrylic acid-ethyl acrylate copolymer, (1:1)\u00a0dispersion\u00a030%, methyl parahydroxybenzoate (E218), polydextrose, polysorbate 80, propylene glycol, propyl parahydroxybenzoate (E216), sodium lauryl sulfate, titanium dioxide (E171), triethyl citrate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>18 x 9.5 mm oval yellow tablets marked 500\/20 with black print<\/p>\n\n\n\n<p>Can:<\/p>\n\n\n\n<p>Pack sizes \u2013 6, 10, 20, 30, 60, 100, 180, or 500 modified-release\u00a0tablets.<\/p>\n\n\n\n<p>The cans contain desiccant in the form of silica gel (to keep the tablets dry).&nbsp;Do not eat the desiccant sachet.<\/p>\n\n\n\n<p>The jars contain a desiccant in the form of silica gel in the screw cap (to keep the tablets dry).<\/p>\n\n\n\n<p>Aluminum blister pack:<\/p>\n\n\n\n<p>Pack sizes \u2013 10, 20, 30, 60, or 100 modified-release\u00a0tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder<\/p>\n\n\n\n<p>Gr\u00fcnenthal GmbH, Zieglerstra\u00dfe 6, 52078 Aachen, Germany<\/p>\n\n\n\n<p><br>Manufacturer<\/p>\n\n\n\n<p>AstraZeneca AB, 151 85 S\u00f6dert\u00e4lje, Sweden<\/p>\n\n\n\n<p>Gr\u00fcnenthal GmbH, Zieglerstra\u00dfe 6, 52078 Aachen, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vimovo contains two different medicines called\u00a0naproxen\u00a0and esomeprazole.\u00a0Each of them works in different ways.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[],"class_list":["post-28589","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=28589"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28589\/revisions"}],"predecessor-version":[{"id":28979,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28589\/revisions\/28979"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=28589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=28589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=28589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}