{"id":28525,"date":"2022-10-29T13:01:10","date_gmt":"2022-10-29T13:01:10","guid":{"rendered":"https:\/\/zeepedia.com\/?p=28525"},"modified":"2022-11-01T10:28:37","modified_gmt":"2022-11-01T10:28:37","slug":"vfend","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vfend\/","title":{"rendered":"VFEND &#8211; Voriconazole uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg and 200 mg&nbsp;film-coated tablets<br>voriconazole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What VFEND is and what it is used for<\/h2>\n\n\n\n<p>VFEND contains the active substance voriconazole.\u00a0VFEND is a medicine against fungal\u00a0infections.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection.<\/p>\n\n\n\n<p>VFEND is used to treat patients (adults and children from 2 years of age) with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>invasive&nbsp;aspergillosis&nbsp;(a type of fungal infection caused by&nbsp;<em>Aspergillus sp<\/em>&nbsp;)<\/li><li>candidemia&nbsp;(another type of fungal infection caused by&nbsp;<em>Candida&nbsp;sp<\/em>&nbsp;) in non-&nbsp;neutropenic&nbsp;patients (patients without abnormally low&nbsp;white blood cell counts&nbsp;)<\/li><li>severe invasive&nbsp;<em>Candida&nbsp;sp<\/em>&nbsp;.&nbsp;infection&nbsp;when the fungus is resistant to&nbsp;fluconazole&nbsp;(another antifungal medicine)<\/li><li>severe fungal infections caused by&nbsp;<em>Scedosporium sp<\/em>&nbsp;.&nbsp;or&nbsp;<em>Fusarium sp<\/em>&nbsp;.&nbsp;(two different mushroom species).<\/li><\/ul>\n\n\n\n<p>VFEND is intended for patients with worsening and potentially life-threatening fungal infections.<\/p>\n\n\n\n<p>Preventive treatment in stem cell transplant patients who are at high risk of developing fungal infection.<\/p>\n\n\n\n<p>This product should only be used under medical supervision.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use VFEND<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use VFEND<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to voriconazole or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>It is very important that you tell your doctor or pharmacist if you are taking or have taken any other medicines, even those without a prescription, or herbal remedies.<\/p>\n\n\n\n<p>The following medicines must not be taken during your treatment with VFEND:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>terfenadine (used for&nbsp;allergy&nbsp;)<\/li><li>astemizole (used for&nbsp;allergy&nbsp;)<\/li><li>cisapride (used for stomach upset)<\/li><li>pimozide (used to treat mental illness)<\/li><li>quinidine&nbsp;(used for irregular heartbeat)<\/li><li>ivabradine&nbsp;(used for symptoms of&nbsp;chronic&nbsp;heart failure&nbsp;)<\/li><li>rifampicin (used in the treatment of&nbsp;tuberculosis&nbsp;)<\/li><li>efavirenz (used in the treatment of&nbsp;HIV&nbsp;) at a&nbsp;dose&nbsp;of 400 mg or more once daily<\/li><li>carbamazepine (used to treat seizures)<\/li><li>phenobarbital (used for severe sleep disorders and convulsions)<\/li><li>ergot alkaloids (eg,&nbsp;ergotamine&nbsp;, dihydroergotamine; used for&nbsp;migraine&nbsp;)<\/li><li>sirolimus (used in transplant patients)<\/li><li>ritonavir (used in the treatment of&nbsp;HIV&nbsp;) at a&nbsp;dose&nbsp;of 400 mg or more twice daily<\/li><li>St. John&#8217;s wort&nbsp;(natural medicine)<\/li><li>naloxegol (used to treat constipation specifically caused by painkillers called&nbsp;opioids&nbsp;(eg morphine, oxycodone,&nbsp;fentanyl&nbsp;, tramadol,&nbsp;codeine&nbsp;))<\/li><li>tolvaptan (used to treat&nbsp;hyponatremia&nbsp;(low levels of&nbsp;sodium&nbsp;in the blood) or to slow the deterioration of kidney function in patients with polycystic kidney disease)<\/li><li>lurasidone (used to treat depression)<\/li><li>venetoclax (used in the treatment of patients with&nbsp;chronic lymphocytic leukemia&nbsp;&#8211;&nbsp;CLL&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before using VFEND if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have previously had an&nbsp;allergic reaction&nbsp;to other azoles<\/li><li>you have or have previously had liver disease.&nbsp;If you have liver disease, your doctor may prescribe a lower&nbsp;dose&nbsp;of VFEND.&nbsp;The doctor must also use blood tests to check your liver function while you are being treated with VFEND<\/li><li>you have a known disease of the heart muscle, irregular heartbeats, slow heartbeats or an&nbsp;ECG&nbsp;change called &#8220;long QTc syndrome&#8221;.<\/li><\/ul>\n\n\n\n<p>Avoid all sunlight and sun exposure while you are being treated with VFEND.&nbsp;It is important to cover exposed areas of the skin and to use sunscreen with a high sun protection factor (SPF), as the skin can become more sensitive to the sun&#8217;s UV rays.&nbsp;These precautions also apply to children.<\/p>\n\n\n\n<p>While you are being treated with VFEND, tell your doctor immediately if you receive<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sun damage<\/li><li>skin rash or blisters<\/li><li>bone pain<\/li><\/ul>\n\n\n\n<p>If you develop the above skin problems, your doctor may refer you to a dermatologist who, after a consultation, may decide that it is important for you to be examined regularly.&nbsp;There is a small risk of developing skin cancer during long-term use with VFEND.<\/p>\n\n\n\n<p>Tell your doctor if you develop signs of &#8216;adrenal insufficiency&#8217;.&nbsp;This means that the adrenal glands do not produce enough of certain steroid hormones such as&nbsp;cortisol&nbsp;, which can lead to symptoms such as&nbsp;chronic&nbsp;or prolonged fatigue, muscle weakness, loss of appetite, weight loss, abdominal pain.<\/p>\n\n\n\n<p>Talk to your doctor if you develop signs of Cushing&#8217;s syndrome.&nbsp;This means that the body produces too much of the&nbsp;hormone cortisol&nbsp;,&nbsp;which&nbsp;can lead to symptoms such as weight gain, lumps of fat between the shoulder blades, a round face, darker skin on the stomach, thighs, breasts and arms, thin skin, bruising more easily, high blood sugar, excessive hair growth, excessive sweating.<\/p>\n\n\n\n<p>Your doctor checks liver and kidney function by taking certain blood samples.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>VFEND should not be given to children under 2 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and VFEND<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p>Some medicines can affect or be affected by the simultaneous use of VFEND.<\/p>\n\n\n\n<p>Tell your doctor if you are taking the following medicines as VFEND should not be taken at the same time if it can be avoided:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ritonavir (for the treatment of&nbsp;HIV&nbsp;) in a&nbsp;dose&nbsp;of 100 mg twice daily.<\/li><li>Glasdegib (for cancer treatment) \u2013 if you need to be treated with both medicines, your doctor will do frequent checks on your heart rhythm.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines as co-treatment with VFEND should be avoided if possible, and dose adjustment of voriconazole may be necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifabutin (for the treatment of&nbsp;tuberculosis&nbsp;).&nbsp;If you are already being treated with rifabutin, your blood values \u200b\u200band&nbsp;side effects&nbsp;must be monitored .<\/li><li>Phenytoin&nbsp;(for the treatment of&nbsp;epilepsy&nbsp;).&nbsp;If you are already being treated with&nbsp;phenytoin&nbsp;, the concentration of&nbsp;phenytoin&nbsp;in the blood must be monitored during treatment with VFEND and the&nbsp;dose&nbsp;may need to be adjusted.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines as a dose adjustment or check may be needed to make sure these medicines and\/or VFEND are still having the desired effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>warfarin&nbsp;and other&nbsp;anticoagulants&nbsp;(eg phenprocoumon, acenocoumarol) (used to&nbsp;inhibit&nbsp;the blood&#8217;s ability to clot)<\/li><li>ciclosporin (used in transplant patients)<\/li><li>tacrolimus (used in transplant patients)<\/li><li>sulfonylureas (eg tolbutamide, glipizide and glyburide) (used for&nbsp;diabetes&nbsp;)<\/li><li>statins (eg atorvastatin,&nbsp;simvastatin&nbsp;) (cholesterol-lowering drugs)<\/li><li>benzodiazepines (eg midazolam, triazolam) (used for severe sleep disorders and stress)<\/li><li>omeprazole (used in the treatment of&nbsp;stomach ulcers&nbsp;)<\/li><li>Birth control pills&nbsp;(if you take VFEND while using&nbsp;birth control pills&nbsp;, you may experience&nbsp;side effects&nbsp;such as nausea and menstrual disturbances)<\/li><li>vinca alkaloids (eg vincristine and vinblastine) (used in the treatment of cancer)<\/li><li>tyrosine kinase inhibitors (eg axitinib, bosutinib, cabozantinib, ceritinib, cobimetinib, dabrafenib, dasatinib, nilotinib, sunitinib, ibrutinib, ribociclib) (used to treat cancer)<\/li><li>tretinoin (used in the treatment of&nbsp;leukemia&nbsp;)<\/li><li>indinavir and other&nbsp;HIV&nbsp;protease&nbsp;inhibitors&nbsp;(used in the treatment of&nbsp;HIV&nbsp;)<\/li><li>non-nucleoside reverse transcriptase inhibitors (eg, efavirenz, delavirdine, nevirapine) (used in the treatment of&nbsp;HIV&nbsp;) (certain&nbsp;doses&nbsp;of efavirenz must NOT be used concurrently with VFEND)<\/li><li>methadone&nbsp;(used to treat heroin addiction)<\/li><li>alfentanil and&nbsp;fentanyl&nbsp;and other short-acting opiates such as sufentanil (painkillers used in surgery)<\/li><li>oxycodone and other long-acting opiates such as hydrocodone (used for moderate to severe pain)<\/li><li>non-steroidal anti-inflammatory drugs (eg&nbsp;ibuprofen&nbsp;,&nbsp;diclofenac&nbsp;) (used to treat pain and&nbsp;inflammation&nbsp;)<\/li><li>fluconazole&nbsp;(used for fungal infections)<\/li><li>everolimus (used in the treatment of advanced kidney cancer and in transplant patients).<\/li><li>letermovir (used to prevent cytomegalovirus (&nbsp;CMV&nbsp;) disease after bone marrow transplantation)<\/li><li>ivacaftor (used in the treatment of&nbsp;cystic fibrosis&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>VFEND must not be taken during pregnancy, unless prescribed by a doctor.&nbsp;Effective contraception must be used by women of&nbsp;childbearing&nbsp;age.&nbsp;Contact your doctor immediately if you become pregnant while taking VFEND.<\/p>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>VFEND may cause blurred vision or unpleasant sensitivity to light.&nbsp;While you are experiencing something like this, do not drive, use tools or machines.&nbsp;Contact a doctor if you experience this.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">VFEND contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, you should contact your doctor before taking VFEND.<\/p>\n\n\n\n<p><strong>VFEND contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per 50 mg tablet, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per 200 mg tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use VFEND<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will decide your&nbsp;dose&nbsp;depending on your weight and the type of&nbsp;infection&nbsp;you have.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults (including elderly patients) is as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td><\/td><td><strong>Tablets<\/strong><\/td><\/tr><\/thead><tbody><tr><td>&nbsp;<\/td><td><em>Patients 40 kg or more<\/em><\/td><td><em>Patients under 40 kg<\/em><\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong>(Load dosage)<\/td><td>400 mg every 12 hoursin the first 24 hours<\/td><td>200 mg every 12 hoursin the first 24 hours<\/td><\/tr><tr><td><strong>Dose&nbsp;after the first 24 hours<\/strong>(Maintenance dose)<\/td><td>200 mg twice daily<\/td><td>100 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may&nbsp;prescribe&nbsp;an increase in the&nbsp;dose&nbsp;from one to 300 mg twice daily.<\/p>\n\n\n\n<p>The doctor may&nbsp;prescribe&nbsp;a reduction in&nbsp;dose&nbsp;if you have mild to moderate liver dysfunction.<\/p>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for children and adolescents is:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Tablets<\/strong><\/th><\/tr><\/thead><tbody><tr><td>&nbsp;<\/td><td>Children from 2 years and up to 12 years and young people aged 12-14 who weigh less than 50 kg<\/td><td>Youth 12 -14 years of age weighing more than 50 kg;&nbsp;and young people older than 14 years<\/td><\/tr><tr><td><strong>Dose&nbsp;one for the first 24 hours<\/strong>(Load dosage)<\/td><td>Treatment will be started as an&nbsp;infusion<\/td><td>400 mg every 12 hoursin the first 24 hours<\/td><\/tr><tr><td><strong>Dose&nbsp;after the first 24 hours<\/strong>(Maintenance dose)<\/td><td>9 mg\/kg twice daily(maximum&nbsp;dose&nbsp;is 350 mg twice daily)<\/td><td>200 mg twice daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Depending on how the treatment works, the doctor may increase or decrease the daily&nbsp;dose&nbsp;.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tablets may only be given to children who can swallow tablets.<\/li><\/ul>\n\n\n\n<p>Take your tablet at least one hour before, or one hour after, a meal.&nbsp;Swallow the tablet whole with water.<\/p>\n\n\n\n<p>If you or your child are taking VFEND to prevent fungal infections, the doctor may stop giving VFEND if you or your child develop&nbsp;side effects&nbsp;caused by the treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much VFEND&nbsp;<\/h2>\n\n\n\n<p>If you take more VFEND than prescribed (or if someone else takes your tablets), you must consult a doctor or go immediately to the emergency department of the nearest hospital.&nbsp;Bring your pack of VFEND tablets.&nbsp;You may notice an abnormal sensitivity to light if you take too much VFEND.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take VFEND<\/h2>\n\n\n\n<p>It is important that you take your VFEND tablets regularly at the same time each day.&nbsp;If you forget to take a&nbsp;dose&nbsp;, take the next&nbsp;dose&nbsp;as planned.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed&nbsp;dose&nbsp;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking VFEND<\/h2>\n\n\n\n<p>It has been shown that the effect of your medicine can be significantly increased if all&nbsp;doses&nbsp;are taken at the right time.&nbsp;Therefore, unless your doctor tells you to stop treatment, it is important to continue taking VFEND as described above.<\/p>\n\n\n\n<p>Keep taking VFEND until your doctor tells you to stop.&nbsp;Do not stop treatment prematurely as your&nbsp;infection&nbsp;may not clear up.&nbsp;Patients with a weakened immune system or patients with severe&nbsp;infections&nbsp;may need long-term treatment to prevent the&nbsp;infection&nbsp;from recurring.<\/p>\n\n\n\n<p>When treatment with VFEND is stopped by your doctor, you should not notice any effect.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>If any&nbsp;side effects&nbsp;occur, most are likely to be minor or temporary.&nbsp;However, some can be serious and require medical attention.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;&#8211; Stop taking VFEND and see a doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>jaundice;&nbsp;changes in blood tests that test liver function<\/li><li>inflammation&nbsp;of the pancreas<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>visual impairment (visual changes, including blurred vision, altered color vision, abnormal hypersensitivity to light, color blindness, eye disorders, experience of halo phenomenon,&nbsp;night blindness&nbsp;, oscillating visual experience, flashes in the&nbsp;visual field&nbsp;, visual&nbsp;aura&nbsp;, decreased&nbsp;visual acuity&nbsp;, enhanced visual experience of light, loss of parts of the normal field of&nbsp;vision&nbsp;et, spots in front of the eyes (fly vision))<\/li><li>fever<\/li><li>rash<\/li><li>nausea, vomiting, diarrhoea<\/li><li>headache<\/li><li>swollen arms and legs<\/li><li>stomach pains<\/li><li>breathing difficulties<\/li><li>elevated liver enzyme levels.<\/li><\/ul>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sinusitis,&nbsp;inflammation&nbsp;of the gums, chills, weakness<\/li><li>reduced number, even severe, of certain types of red (sometimes immune-related) and\/or&nbsp;white blood cells&nbsp;(sometimes with fever), reduced number of&nbsp;thrombocytes&nbsp;(&nbsp;platelets&nbsp;) &#8211; cells that help with blood clotting<\/li><li>low blood sugar, low level of&nbsp;potassium&nbsp;in the blood, low level of&nbsp;sodium&nbsp;in the blood<\/li><li>anxiety, depression, confusion, restlessness, difficulty sleeping, hallucinations<\/li><li>seizures, tremors or uncontrolled muscle movements, tingling or abnormal skin sensations, increased muscle tension, sleepiness, dizziness<\/li><li>bleeding in the eye<\/li><li>heart rhythm disorders, including very fast heartbeats, very slow heartbeats, fainting<\/li><li>low&nbsp;blood pressure&nbsp;,&nbsp;inflammation&nbsp;of a blood vessel (which can cause blood clots)<\/li><li>acute breathing problems, chest pain, swelling of the face (mouth, lips and around the eyes), water in the lungs<\/li><li>constipation, indigestion,&nbsp;inflammation&nbsp;of the lips<\/li><li>jaundice,&nbsp;inflammation&nbsp;of the liver and liver damage<\/li><li>skin rash that can lead to severe blistering and scaling of the skin characterized by a flat, red area of \u200b\u200bskin covered in small confluent bumps, redness of the skin<\/li><li>itching<\/li><li>hair loss<\/li><li>back pain<\/li><li>kidney failure&nbsp;, blood in the urine, altered kidney function values.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>flu-like symptoms&nbsp;, irritation and&nbsp;inflammation&nbsp;of the gastrointestinal tract, inflammation of the gastrointestinal tract causing antibiotic-associated diarrhea,&nbsp;inflammation&nbsp;of the lymphatic vessels<\/li><li>inflammation&nbsp;of the thin membrane that covers the inside of the abdominal wall and the abdominal organs<\/li><li>enlarged&nbsp;lymph nodes&nbsp;(sometimes painful), bone marrow failure ,&nbsp;increased levels of&nbsp;eosinophils<\/li><li>impaired adrenal function, underactive&nbsp;thyroid gland<\/li><li>abnormal brain function, Parkinson-like symptoms, nerve damage that causes numbness, pain, tingling or burning in the hands or feet<\/li><li>impaired balance and coordination<\/li><li>brain swelling<\/li><li>double vision, serious eye conditions including: pain and&nbsp;inflammation&nbsp;of the eye and eyelid, abnormal eye movements, damage to the&nbsp;optic nerve&nbsp;leading to visual impairment, swelling of the optic nerve papilla<\/li><li>impaired sense of touch<\/li><li>altered sense of taste<\/li><li>hearing difficulties, ringing in the ears,&nbsp;vertigo<\/li><li>inflammation&nbsp;of certain internal organs \u2013 the pancreas and&nbsp;duodenum&nbsp;, swelling of and&nbsp;inflammation&nbsp;of the tongue<\/li><li>liver enlargement, liver failure, gallstones,&nbsp;gallstones<\/li><li>joint inflammation,&nbsp;inflammation&nbsp;of veins under the skin (which may be associated with blood clot formation)<\/li><li>nephritis, protein in the urine, kidney damage<\/li><li>very fast&nbsp;pulse&nbsp;or skipped heartbeats, sometimes with irregular electrical impulses<\/li><li>abnormal&nbsp;EKG<\/li><li>increased level of&nbsp;cholesterol&nbsp;in the blood, increased level of&nbsp;urea&nbsp;in the blood<\/li><li>allergic skin reactions (sometimes serious), including life-threatening skin diseases that cause painful blisters and sores on the skin and mucous membranes, especially in the mouth,&nbsp;inflammation&nbsp;of the skin,&nbsp;hives&nbsp;, sunburn or severe skin reactions after exposure to light or sun, skin redness and skin irritation, red or purple discoloration of the skin which may be due to a reduced number of&nbsp;platelets&nbsp;,&nbsp;eczema<\/li><li>infusion site reaction.<\/li><li>allergic reactions or excessive&nbsp;immune response<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>overactive&nbsp;thyroid<\/li><li>impaired brain function which is a serious complication of liver disease<\/li><li>loss of most of the fibers in&nbsp;optic nerve&nbsp;one, clouding of the cornea, involuntary eye movements<\/li><li>bullous&nbsp;photosensitivity<\/li><li>a disorder in which the body&#8217;s immune system attacks parts of the&nbsp;peripheral nervous system<\/li><li>disturbances of the heart rhythm or conduction in the heart (sometimes life-threatening)<\/li><li>life-threatening&nbsp;allergic reaction<\/li><li>changes in the blood&#8217;s ability to clot<\/li><li>allergic skin reactions (sometimes severe) including rapid swelling (&nbsp;oedema&nbsp;) of the &#8220;leather skin&#8221; (&nbsp;dermis&nbsp;),&nbsp;subcutaneous&nbsp;tissue&nbsp;, mucous membranes and sub-mucosal&nbsp;tissue&nbsp;, itchy or sore patches of thick, red skin with silvery scales, irritation of the skin and mucous membranes, life-threatening skin disease which causes large parts of the skin&#8217;s outermost layer (&nbsp;epidermis&nbsp;) to detach from the underlying skin layer<\/li><li>small patches of dry and scaly skin, sometimes thickened with corns.<\/li><\/ul>\n\n\n\n<p>Adverse effects&nbsp;with no known frequency:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>freckles and pigment spots.<\/li><\/ul>\n\n\n\n<p>Other important&nbsp;side effects&nbsp;are whose frequency is not known but which should be reported to the doctor immediately<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin cancer<\/li><li>inflammation&nbsp;of the&nbsp;tissue&nbsp;surrounding the bone<\/li><li>red, scaly patches or ring-shaped skin changes which may be symptoms of an&nbsp;autoimmune&nbsp;disease called&nbsp;cutaneous&nbsp;lupus erythematosus.<\/li><\/ul>\n\n\n\n<p>Because VFEND can affect the liver and kidneys, your doctor should check your liver and kidney function by doing blood tests.&nbsp;Tell your doctor if you have a stomach ache or if your stool has a different consistency.<\/p>\n\n\n\n<p>Skin cancer has been reported in patients treated with VFEND during long-term treatment.<\/p>\n\n\n\n<p>Sun damage or severe skin reaction after exposure to light or sun was more common in children.&nbsp;If you or your child develop skin changes, the doctor may refer you or your child to a&nbsp;dermatologist&nbsp;who, after consultation, may decide that it is important for you or your child to have regular check-ups.<\/p>\n\n\n\n<p>Elevated liver enzyme levels were also seen more often in children.<\/p>\n\n\n\n<p>If any of these&nbsp;side effects&nbsp;do not go away or are bothersome, tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store VFEND<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is voriconazole.&nbsp;Each tablet contains 50 mg voriconazole (for VFEND 50 mg film-coated tablets) or 200 mg voriconazole (for VFEND 200 mg film-coated tablets).<\/li><li>Other ingredients are&nbsp;lactose monohydrate&nbsp;, pregelatinized&nbsp;starch&nbsp;, croscarmellose sodium, povidone and magnesium stearate which make up the tablet core and hypromellose, titanium dioxide (E171),&nbsp;lactose monohydrate&nbsp;and glycerol triacetate which make up the film coating (see section 2, VFEND 50 mg film-coated tablets or VFEND 200 mg film-coated tablets contain&nbsp;lactose&nbsp;and&nbsp;sodium&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>VFEND 50 mg film-coated tablets are supplied as white to off-white round film-coated tablets marked Pfizer on one side and VOR50 on the other.<\/p>\n\n\n\n<p>VFEND 200 mg film-coated tablets are supplied as white to off-white capsule-shaped tablets marked Pfizer on one side and VOR200 on the other.<\/p>\n\n\n\n<p>VFEND 50 mg film-coated tablets and 200 mg film-coated tablets are available in pack sizes of 2, 10, 14, 20, 28, 30, 50, 56 and 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Pfizer Europe MA EEIG, Boulevard de la Plaine 17, 1050 Bruxelles, Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>R-Pharm Germany GmbH<\/p>\n\n\n\n<p>Heinrich-Mack-Str.&nbsp;35, 89257 Illertissen,<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Pfizer Italia Srl<\/p>\n\n\n\n<p>Localit\u00e0 Marino del Tronto<\/p>\n\n\n\n<p>63100 Ascoli Piceno (AP)<\/p>\n\n\n\n<p>Italy<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb \/Belgique\/Belgien\/ Luxembourg\/Luxemburg<\/strong>Pfizer NV\/SA T\u00e9l\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARLfililas LietuvojeTel.&nbsp;+3705 2514000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044ftel.: +3592 970 43 33<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Pfizer SATel: +32 (0)2 554 62 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.&nbsp;sroPhone: +420-283-004-111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.&nbsp;+ 36 1 488 37 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>Malta<\/strong>VJ Salomone Pharma Ltd.Phone: +356 21 22 01 74<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbH Tel: +49 (0)30 550055-51000<\/td><td><strong>The Netherlands<\/strong>Pfizer bvPhone: +31 (0)800 63 34 636<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branchPhone: +372 6 66 7500<\/td><td><strong>Norway<\/strong>Pfizer ASPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer \u0395\u039b\u039b\u0391\u03a3 AETel.: +30 210 6785 800<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. o.Tel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0)1 58 07 34 40<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: + 351 214 235 500<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Romania<\/strong>Pfizer Rom\u00e2nia SRLPhone: +40 (0)21 207 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0)1304 616161<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, branch of marketing, LjubljanaPhone: + 386(0)152 11 400<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.,Telephone: + 354 540 8000<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaPhone: +421\u20132\u20133355 5500<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358(0)9 43 00 40<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.&nbsp;(Cyprus Branch)Phone: +357 22 817690<\/td><td><strong>Sweden<\/strong>Pfizer ABPhone: +46 (0)8 5505 2000<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARLBranch in LatviaPhone: +371 670 35 775<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0)1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>VFEND contains the active substance voriconazole.\u00a0VFEND is a medicine against fungal\u00a0infections\u00a0.\u00a0It works by killing or stopping the growth of the fungi that cause the\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27443,27447,27448,27439,27441,27442,27445,27444,27446,27440],"class_list":["post-28525","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-vfend","tag-vfend-side-effects","tag-vfend-tablet","tag-voriconazole","tag-voriconazole-side-effects","tag-voriconazole-tablet","tag-what-is-vfend","tag-what-is-voriconazole","tag-what-vfend-is-used-for","tag-what-voriconazole-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=28525"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28525\/revisions"}],"predecessor-version":[{"id":28576,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28525\/revisions\/28576"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=28525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=28525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=28525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}