50 mg, 100 mg, and 150 mg\u00a0film-coated tablets
abemaciclib<\/p>\n\n\n\n
Verzenios is a cancer medicine that contains the active substance abemaciclib.<\/p>\n\n\n\n
Abemaciclib blocks the action of the\u00a0proteins\u00a0called cyclin-dependent\u00a0kinase\u00a04 and 6. These\u00a0proteins\u00a0are abnormally active in some cancer cells and can cause the cancer cells to grow uncontrollably.\u00a0By blocking these\u00a0proteins, you can slow the growth of cancer cells, shrink the size of the tumor and delay the development of cancer.<\/p>\n\n\n\n
Verzenios is used to treat certain types of hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative ( HER2- ) breast cancer, where the breast cancer;<\/p>\n\n\n\n
<\/a><\/p>\n\n\n\n Verzenios can:<\/p>\n\n\n\n See section 4 \u201cPossible side effects\u201d and talk to your doctor if you get any symptoms.<\/p>\n\n\n\n Checks are done before and during treatment<\/strong><\/p>\n\n\n\n Before and during treatment, blood samples are taken at regular intervals to see if Verzenios affects your blood (white and\u00a0red blood cells\u00a0and\u00a0platelets\u00a0) and to check the number of liver enzymes in the blood.<\/p>\n\n\n\n Children and young people<\/strong><\/p>\n\n\n\n Verzenios should not be used in children and adolescents under 18 years of age.<\/a><\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n It is especially important that, before taking Verzenios, you tell your doctor or pharmacist if you are taking the following:<\/p>\n\n\n\n Avoid grapefruit and grapefruit juice while taking this medicine because they can increase the concentration of Verzenios in the blood.<\/a><\/p>\n\n\n\n Discuss birth control with the doctor if there is a possibility that you could become pregnant.\u00a0If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n Pregnancy<\/p>\n\n\n\n You should not use Verzenios if you are pregnant.<\/p>\n\n\n\n You should avoid becoming pregnant while taking Verzenios.<\/p>\n\n\n\n If you can become pregnant, you must use suitable contraception (eg double barrier in the form of condoms and pessaries ) during treatment and for at least 3 weeks after the end of treatment.<\/p>\n\n\n\n If you become pregnant, you must tell the doctor.<\/p>\n\n\n\n Breast-feeding<\/p>\n\n\n\n You should not breastfeed while taking Verzenios.\u00a0It is not known whether Verzenios passes into breast milk.<\/p>\n\n\n\n Fertility<\/p>\n\n\n\n Verzenios may reduce fertility in men.<\/a><\/p>\n\n\n\n Fatigue and dizziness are very common\u00a0side effects.\u00a0If you feel unusually tired or dizzy, take extra care when driving a vehicle or using machinery.<\/p>\n\n\n\n Verzenios contains lactose<\/strong><\/p>\n\n\n\n If you have an intolerance to some sugars, you should contact your doctor before taking this medicine.<\/p>\n\n\n\n Verzenios contains sodium<\/strong><\/p>\n\n\n\n This medicine contains less than 1 mmol sodium (23 mg) per tablet, i.e. is almost “sodium-free”. Always take this medicine as directed by your doctor or pharmacist. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n When Verzenios is given in combination with hormonal therapy for breast cancer, the recommended dose is one Verzenios 150 mg by mouth twice daily.<\/p>\n\n\n\n If you experience certain\u00a0side effects\u00a0from Verzenios, the doctor may lower the\u00a0dose\u00a0or interrupts the treatment temporarily or permanently.<\/p>\n\n\n\n Take Verzenios twice daily, at about the same time each day. Preferably take it morning and evening so that you have sufficient amounts of medication in your body throughout the day.<\/p>\n\n\n\n You can take the tablets with or without food, but be sure to avoid grapefruit and grapefruit juice (see section 2 \u201cVerzenios with food and drink\u201d).<\/p>\n\n\n\n Swallow the tablet whole with a glass of water.\u00a0The tablets must not be chewed, crushed, or split before swallowing.<\/p>\n\n\n\n How long to take Verzenios<\/strong><\/p>\n\n\n\n Take Verzenios as long as your doctor tells you to.\u00a0If you take Verzenios as\u00a0an adjuvant\u00a0treatment, you must take it for up to 2 years.<\/p>\n\n\n\n If you take too many tablets, or if another person takes your tablets, contact a doctor or hospital for advice. Show the Verzenios package and this leaflet. Medical treatment may be necessary.<\/a><\/p>\n\n\n\n If you vomit after taking a\u00a0dose\u00a0or forget to take a\u00a0dose, take the next\u00a0dose\u00a0at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for the forgotten or vomited\u00a0dose.<\/p>\n\n\n\n Do not stop taking Verzenios unless your doctor tells you to.<\/p>\n\n\n\nBEFORE USING VERZENIOS<\/h2>\n\n\n\n
Do not take Verzenios:<\/h2>\n\n\n\n
Warnings and precautions<\/h2>\n\n\n\n
Use of other medicines<\/h2>\n\n\n\n
Verzenios with food and drink<\/h2>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
Driving ability and use of machinery<\/h2>\n\n\n\n
Important information about any ingredient(s) in Verzenios<\/h2>\n\n\n\n
<\/a><\/p>\n\n\n\nHOW TO USE VERZENIOS<\/h2>\n\n\n\n
Recommended dose<\/h2>\n\n\n\n
When and how to take Verzenios<\/h2>\n\n\n\n
If you use too much Verzenios <\/h2>\n\n\n\n
If you forget to take Verzenios<\/h2>\n\n\n\n
If you stop using Verzenios<\/h2>\n\n\n\n