{"id":28075,"date":"2022-10-25T10:42:11","date_gmt":"2022-10-25T10:42:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=28075"},"modified":"2022-10-28T11:23:53","modified_gmt":"2022-10-28T11:23:53","slug":"vepesid","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vepesid\/","title":{"rendered":"Vepesid &#8211; Etoposide uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg&nbsp;soft capsules<br>etoposide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vepesid is and what it is used for<\/h2>\n\n\n\n<p>The name of this medicine is Vepesid.\u00a0Each capsule contains the active substance etoposide 50 mg.<br><br>Etoposide belongs to a group of medicines called\u00a0cytostatics, which are used to treat cancer.<br><br>Vepesid is used in the treatment of certain types of cancer in adults:<br><br>&#8211; testicular cancer<br>&#8211;\u00a0small cell lung cancer<br>&#8211; cancer of the blood (\u00a0acute myeloid leukemia\u00a0)<br>&#8211;\u00a0tumor\u00a0of the\u00a0lymphatic system\u00a0(\u00a0Hodgkin&#8217;s lymphoma,\u00a0non-Hodgkin&#8217;s lymphoma\u00a0)<br>&#8211; ovarian cancer<br><br>The exact reason why you have been prescribed Vepesid capsules is best discussed with your doctor.<br><br>Etoposide contained in Vepesid may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Vepesid<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Vepesid:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to etoposide, sodium ethyl parahydroxybenzoate (E215), sodium propyl parahydroxybenzoate (E217), or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have recently been vaccinated with a live vaccine, including the yellow fever vaccine.<\/li><li>If you are breastfeeding or plan to breastfeed<br>If any of the above applies to you, or if you are not sure if it applies to you, consult your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Vepesid<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any\u00a0<strong>infection\u00a0you<\/strong>.<\/li><li>if you have received\u00a0<strong>radiotherapy or\u00a0chemotherapy<\/strong>\u00a0recently.<\/li><li>if you have low levels of a\u00a0protein\u00a0called\u00a0<strong>albumin<\/strong>\u00a0in your blood.<\/li><li>if you have liver or kidney problems.<\/li><\/ul>\n\n\n\n<p>Effective treatment against cancer can rapidly destroy cancer cells on a large scale.\u00a0In very rare cases, this can cause harmful amounts of substances from these cancer cells to be released into the blood.\u00a0If this occurs, it can cause liver, kidney, heart, or blood problems and lead to death if left untreated.<br><br>To prevent this, your doctor needs to take regular blood tests to monitor the level of these substances during treatment with this medicine.<br><br>This medicine can cause a decrease in certain\u00a0blood cells\u00a0which can lead to you getting\u00a0an infection or it could mean that your blood doesn&#8217;t clot as well if you were to cut yourself.\u00a0Blood samples will be taken at the start of your treatment and before each\u00a0dose\u00a0you take to check that this does not happen.<br><br>If you have impaired liver or kidney function, your doctor may also want to take regular blood tests to monitor your liver and kidney function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Safety and efficacy in children have not been established.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vepesid<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This is particularly important<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking ciclosporin (a medicine used to reduce the activity of the immune system).<\/li><li>if you are being treated with cisplatin (a medicine used to treat cancer).<\/li><li>if you are taking\u00a0phenytoin\u00a0or other medicines used to treat\u00a0epilepsy.<\/li><li>if you are taking\u00a0warfarin\u00a0(a medicine that prevents blood clots from forming).<\/li><li>if you have recently been vaccinated with any live vaccines.<\/li><li>if you are taking phenylbutazone, sodium salicylate, or\u00a0acetylsalicylic acid.<\/li><li>if you are taking any\u00a0anthracyclines\u00a0(a group of medicines used to treat cancer).<\/li><li>if you are taking any medicines that have a similar mechanism of action to Vepesid.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<br><br>Vepesid must not be used during pregnancy unless your doctor considers it necessary.<br><br>You must not breastfeed while taking Vepesid.<br><br>Both male patients and female patients of childbearing potential must use effective contraception (eg, a\u00a0barrier method\u00a0or condom) during treatment and up to 6 months after stopping treatment with Vepesid.<br><br>Men treated with Vepesid are advised not to make a woman pregnant during treatment and for up to 6 months after treatment.\u00a0Men are also advised to obtain information about the possibility of conserving sperm before the treatment.<br><br>Both male and female patients who are considering having children after treatment with Vepesid should discuss this with a doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Effects on the ability to drive or use machines have not been studied.\u00a0If you feel tired, unwell, dizzy, or faint, do not drive or use machines until you have discussed this with your doctor.<br><br>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vepesid contains<\/h2>\n\n\n\n<p>Vepesid contains sodium ethyl parahydroxybenzoate and sodium propyl parahydroxybenzoate.&nbsp;These substances can cause allergic reactions (possibly delayed).<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per soft capsule, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Vepesid<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.\u00a0Ask your doctor or pharmacist if you are unsure.<br><br>The dose\u00a0you receive will be tailored to you and calculated by your doctor.\u00a0The usual\u00a0dose\u00a0is 100 to 200 mg\/\u00a0<sup>m2<\/sup>\u00a0of body surface area, daily for 5 consecutive days or 200 mg\/\u00a0<sup>m2<\/sup>\u00a0of body surface area on days 1, 3, and 5. The daily\u00a0dose of\u00a0one can sometimes be divided to be taken in the morning and the evening.\u00a0This course of treatment can then be repeated depending on the results of the blood tests, but this will not happen until at least 21 days after the first course of treatment.<br><br>An alternative\u00a0dosage\u00a0of 50 mg\/m\u00a02 body surface area taken daily for 2 to 3 weeks is sometimes used.\u00a0This course of treatment can then be repeated depending on the results of the blood tests, but this will not happen until at least 7 days after the first course of treatment.<br><br>The doctor can sometimes prescribe a different\u00a0dose, especially if you have kidney problems.<br><br>The capsules should be taken with a glass of water on an empty stomach.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vepesid<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.\u00a0Take the packaging and any remaining capsules with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vepesid<\/h2>\n\n\n\n<p>If you miss or forget to take a\u00a0dose\u00a0of this medicine, DON&#8217;T WORRY &#8211; just take the next\u00a0dose\u00a0when it is due.\u00a0DO NOT take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<br><br>If you have any further questions about this medicine, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<br><br>Stop taking the medicine and contact your doctor immediately if you experience any of the following symptoms: swollen tongue or throat, difficulty breathing, fast heart rate, flushing, or rash.\u00a0These can be signs of a serious\u00a0allergic reaction<strong>.<\/strong><br><br>Serious\u00a0<strong>liver, kidney, or heart damage from\u00a0<\/strong><strong>a<\/strong>\u00a0condition called tumor lysis syndrome, which is caused by harmful amounts of substances from the cancer cells entering the bloodstream, has sometimes been seen when Vepesid is taken with other medicines to treat cancer.<br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that can be experienced with Vepesid<\/strong>&nbsp;are;<\/p>\n\n\n\n<p><strong>Very common\u00a0side effects\u00a0(<\/strong>\u00a0affects more than 1 in 10 users)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>blood effects (this is why you will have blood samples taken between treatment courses)temporary hair loss nausea and vomiting abdominal pain<\/td><td>loss of appetite change in skin color (\u00a0pigmentation\u00a0)constipationweakness (\u00a0asthenia\u00a0)general malaiseliver damage (hepatotoxicity)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Common\u00a0side effects\u00a0(<\/strong>\u00a0affects up to 1 in 10 users)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>acute&nbsp;leukemiairregular heart rhythm (&nbsp;arrhythmia&nbsp;) or a heart attack (myocardial infarction)dizziness<\/td><td>diarrhea high\u00a0blood pressure sore lips, sores in the mouth, or throat skin problems such as\u00a0itching\u00a0or rashes<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Uncommon\u00a0side effects\u00a0(<\/strong>\u00a0affects up to 1 in 100 users)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>tingling or loss of feeling in the hands and feet<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Rare\u00a0side effects\u00a0(<\/strong>\u00a0affects up to 1 in 1,000 users)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>acid refluxrednessdifficulty swallowing change in how things taste severe allergic reactionsconvulsionsfeversleepiness or tirednessbreathing problems<\/td><td>temporary blindnessserious skin and\/or mucous membrane reactions which may include painful blisters and fever, including widespread skin shedding (Steven-Johnson syndrome and\u00a0toxic epidermal necrolysis\u00a0)a rash that resembles a sunburn and that can appear on the skin where you have previously received radiation treatment (&#8220;radiation recall&#8221;\u00a0dermatitis\u00a0), this can be serious<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Has been reported<\/strong>\u00a0(occurring in an unknown number of users)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>tumor lysis syndrome (complications of substances released from cancer cells entering the bloodstream)infection swelling of the face and tongueinfertilityallergic reactions (possibly delayed; caused by parabens)<\/td><td>bleeding breathing difficulties elevated liver enzymes elevated\u00a0bilirubin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How Vepesid should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><br>Use before the expiry date stated on the carton and blister card after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<br><br>Store at a maximum of 25 \u00b0C.&nbsp;Store in the original packaging.<\/p>\n\n\n\n<p>Do not open any blister card where there is evidence of capsule leakage.<br><br>As with all medicines used to treat cancer, care must be taken when handling Vepesid capsules.\u00a0You should avoid touching the capsules by wearing gloves and washing your hands with soap and water after handling the medicine.<br><br>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is etoposide.<\/li><li>Other ingredients are anhydrous citric acid (E330),\u00a0glycerol\u00a0(85%) (E422), macrogol 400 (E1521), and purified water.\u00a0The capsule shell contains gelatin (E441),\u00a0glycerol\u00a0(85%) (E422), red iron oxide (E172), sodium ethyl parahydroxybenzoate (E215), sodium propyl parahydroxybenzoate (E217) and titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Capsules with Vepesid are pale pink, soft gelatin capsules.<br><br>Vepesid capsules are supplied in blister cards in an outer carton.&nbsp;Package size: 20 tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>CHEPLAPHARM Arzneimittel GmbH<\/p>\n\n\n\n<p>Ziegelhof 24<\/p>\n\n\n\n<p>17489 Greifswald<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Corden Pharma Latina SpA<\/p>\n\n\n\n<p>Via del Murillo No.&nbsp;7<\/p>\n\n\n\n<p>04013 Sermoneta<\/p>\n\n\n\n<p>Latina, Italy<\/p>\n\n\n\n<p>CHEPLAPHARM Arzneimittel GmbH<\/p>\n\n\n\n<p>Ziegelhof 23-24<\/p>\n\n\n\n<p>17489 Greifswald<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>This medicine is approved in the European Economic Area under the names:<\/p>\n\n\n\n<p>50mg:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Finland<\/td><td>VEPESID<\/td><\/tr><tr><td>Germany<\/td><td>VEPESID K<\/td><\/tr><tr><td>Ireland<\/td><td>VEPESID<\/td><\/tr><tr><td>Italy<\/td><td>VEPESID<\/td><\/tr><tr><td>Netherlands<\/td><td>VEPESID<\/td><\/tr><tr><td>Norway<\/td><td>VEPESID<\/td><\/tr><tr><td>Romania<\/td><td>VEPESID<\/td><\/tr><tr><td>Spain<\/td><td>VEPESID<\/td><\/tr><tr><td>Sweden<\/td><td>VEPESID<\/td><\/tr><tr><td>UK<\/td><td>VEPESID<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The name of this medicine is Vepesid.\u00a0Each capsule contains the active substance etoposide 50 mg.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3510,27306,3513,27308,27312,27310,27307,3974,27309,27311],"class_list":["post-28075","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-etoposide","tag-etoposide-capsule","tag-etoposide-side-effects","tag-vepesid","tag-vepesid-capsule","tag-vepesid-side-effects","tag-what-etoposide-is-used-for","tag-what-is-etoposide","tag-what-is-vepesid","tag-what-vepesid-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=28075"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28075\/revisions"}],"predecessor-version":[{"id":28474,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/28075\/revisions\/28474"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=28075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=28075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=28075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}