{"id":27474,"date":"2022-10-20T15:13:33","date_gmt":"2022-10-20T15:13:33","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27474"},"modified":"2022-10-22T07:30:50","modified_gmt":"2022-10-22T07:30:50","slug":"venbig","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/venbig\/","title":{"rendered":"Venbig &#8211; Human immunoglobulin uses, dose and side effects"},"content":{"rendered":"\n<p>50 IU\/ml powder and liquid for infusion, solution<br>Human immunoglobulin against&nbsp;hepatitis&nbsp;B for&nbsp;intravenous&nbsp;use<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Venbig is and what it is used for<\/h2>\n\n\n\n<p>Venbig belongs to a group of medicines called immune sera and immunoglobulins.\u00a0Venbig is a solution of human immunoglobulin against\u00a0hepatitis\u00a0B (\u00a0proteins\u00a0that act as\u00a0antibodies\u00a0) for\u00a0intravenous\u00a0administration, and it is used in the following cases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To prevent reinfection with\u00a0hepatitis\u00a0B\u00a0virus\u00a0in patients who have undergone liver transplantation for liver failure caused by\u00a0hepatitis\u00a0B, in combination with antiviral therapy.<\/li><li>Prevention to quickly get\u00a0antibodies\u00a0against\u00a0the hepatitis\u00a0B\u00a0virus\u00a0to prevent\u00a0hepatitis\u00a0B in the following cases:<ul><li>in non-vaccinated persons inadvertently exposed to\u00a0hepatitis\u00a0B\u00a0virus\u00a0(i.e. persons not vaccinated against hepatitis B\u00a0virus\u00a0including persons whose vaccination is incomplete or where information on vaccination is missing)<\/li><li>in hemodialysis patients (i.e. patients with severe renal impairment and requiring artificial blood purification), until the vaccination has had an effect<\/li><li>in newborn children of mothers who are carriers of the\u00a0hepatitis\u00a0B\u00a0virus<\/li><li>in people who did not show an\u00a0immune response\u00a0(i.e. people in whom the vaccination did not have an effect) after vaccination and for whom continued preventive treatment is necessary due to the continued risk of becoming infected with\u00a0hepatitis\u00a0B<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Venbig<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Venbig<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to human immunoglobulin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have\u00a0antibodies\u00a0against\u00a0IgA\u00a0immunoglobulins\u00a0in\u00a0your blood because\u00a0administration\u00a0of an\u00a0IgA\u00a0preparation can cause a severe\u00a0allergic reaction.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Venbig.\u00a0Clot formation in blood vessels (\u00a0thrombosis\u00a0) has been associated with the use of normal immunoglobulin given\u00a0intravenously.\u00a0The doctor will therefore be particularly careful when using this medicine if you have any risk factors for blood clots (\u00a0thrombosis\u00a0).<\/p>\n\n\n\n<p>The number of\u00a0antibodies\u00a0against\u00a0hepatitis\u00a0B in the blood will be checked regularly.<\/p>\n\n\n\n<p>Some\u00a0side effects\u00a0may occur more frequently:<br>&#8211; in case of a high infusion rate;<br>&#8211; if you have signs of uncontrolled\u00a0infection\u00a0(e.g. fever) or signs of\u00a0chronic\u00a0inflammation;<br>&#8211; if you receive human normal immunoglobulins for the first time;<br>&#8211; in rare cases where preparations with human normal immunoglobulins have been changed, or when there has been a long interval since the previous\u00a0infusion.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>In certain circumstances, immunoglobulins can increase the risk of heart attack, stroke,\u00a0pulmonary embolism,<\/strong>\u00a0or deep\u00a0vein thrombosis<strong>, because they increase the\u00a0viscosity\u00a0of the blood<\/strong><\/li><\/ul>\n\n\n\n<p>The doctor will therefore be particularly careful in the following circumstances;<br>&#8211; if you are overweight<br>&#8211; if you are older,<br>&#8211; you suffer from high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0),<br>&#8211; you have too little blood volume (\u00a0hypovolemia\u00a0),<br>&#8211; you have or have had problems with the blood vessels (\u00a0vascular\u00a0disease)<br>&#8211; you have an increased tendency for the blood to clot (hereditary or acquired thrombotic disease)<br>&#8211; you suffer from episodes of blood clots<br>&#8211; you have a disease that makes your blood thicker (have higher viscosity\u00a0)<br>&#8211; you have been bedridden for a long time,<br>&#8211; you have or have had kidney problems or if you are taking medicines that can damage the kidneys (nephrotoxic medicines) when cases of\u00a0acute\u00a0kidney failure\u00a0have been reported.\u00a0In case of kidney problems, the doctor will consider stopping the treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You can be allergic (hypersensitive) to&nbsp;immunoglobulins&nbsp;(&nbsp;antibodies&nbsp;) without knowing it.<\/strong><\/li><\/ul>\n\n\n\n<p>This can occur even if you have previously received human normal immunoglobulins and tolerated this well.&nbsp;It can happen, especially if you do not have immunoglobulins of the&nbsp;IgA&nbsp;type (&nbsp;IgA&nbsp;deficiency with anti-IgA antibodies).&nbsp;In these rare cases, allergic reactions (hypersensitivity) such as a sudden drop in blood pressure or&nbsp;shock may&nbsp;occur.<\/p>\n\n\n\n<p>Whoever gives you this medicine will carefully follow the infusion rate recommended in section 3 &#8220;How to use Venbig&#8221;.\u00a0This is necessary because some\u00a0side effects\u00a0can be linked to the infusion rate.\u00a0In addition, you will be carefully observed and monitored throughout the\u00a0infusion, so that any symptoms of\u00a0side effects\u00a0can be detected.<\/p>\n\n\n\n<p>If any\u00a0side effect occurs, your doctor may decide to either lower the infusion rate or stop the\u00a0infusion.\u00a0In addition, your doctor will decide what treatment is required depending on the signs of the disease and the severity of the\u00a0side effect.<\/p>\n\n\n\n<p>Venbig contains a small amount of\u00a0IgA.\u00a0If you are deficient in\u00a0IgA, there is a risk that you can develop anti-IgA\u00a0antibodies\u00a0and you can have anaphylactic reactions after\u00a0the administration\u00a0of blood components that contain\u00a0IgA.\u00a0The physician must weigh the benefit of treatment with Venbig against the potential risk of\u00a0hypersensitivity reaction.<\/p>\n\n\n\n<p>Human\u00a0hepatitis\u00a0B immunoglobulin can rarely induce a drop in blood pressure with an\u00a0anaphylactic reaction, even if you have previously tolerated treatment with immunoglobulin.<\/p>\n\n\n\n<p>If you suffer from impaired kidney function, your doctor must consider stopping treatment with IVIg.\u00a0Reports of renal dysfunction and\u00a0acute\u00a0renal failure\u00a0have been associated with the use of many of the registered IVIg products containing various excipients such as sucrose,\u00a0glucose,\u00a0and maltose.\u00a0Those containing sucrose as a stabilizer accounted for a disproportionately large share of the total.\u00a0In patients at risk of\u00a0acute\u00a0renal failure\u00a0or thromboembolic\u00a0side effects, IVIg products should be administered at the lowest possible infusion rate and\u00a0dose.<\/p>\n\n\n\n<p>During treatment with immunoglobulin, you may suffer lung damage associated with the treatment, called transfusion-related lung injury (TRALI).\u00a0If you experience shortness of breath and feel that you are breathing rapidly during or within several hours of the\u00a0infusion, tell your doctor or nurse immediately as these symptoms may require immediate treatment.<\/p>\n\n\n\n<p>Suspicion of allergic or anaphylactic reactions requires immediate\u00a0discontinuation\u00a0of\u00a0injection.\u00a0In the event of\u00a0shock, standard medical treatment for\u00a0shock\u00a0must be instituted.<\/p>\n\n\n\n<p>Tell your doctor if at least one of the above conditions applies to you, your doctor will be especially careful when prescribing and&nbsp;administering&nbsp;Venbig to you.<\/p>\n\n\n\n<p>IVIg products may contain blood group antibodies that, in rare cases, can cause the breakdown of\u00a0red blood cells\u00a0(\u00a0hemolysis\u00a0).\u00a0After IVIg treatment, some form of\u00a0anemia\u00a0(\u00a0anemia\u00a0) may develop due to abnormal breakdown of\u00a0red blood cells\u00a0(\u00a0hemolytic anemia\u00a0).\u00a0During treatment with IVIg, you will be monitored for signs and symptoms of\u00a0hemolysis.<\/p>\n\n\n\n<p><em><strong>Blood samples<\/strong><\/em><\/p>\n\n\n\n<p>Venbig may interfere with some blood tests due to the temporary increase of the passively transferred\u00a0antibodies\u00a0in the blood after\u00a0injection\u00a0of immunoglobulin;\u00a0The elevated\u00a0antibody\u00a0levels can lead to misleading results in serological tests.\u00a0Passive transfer of\u00a0antibodies\u00a0to erythrocyte antigens, e.g.\u00a0A, B, D (which determine blood type), can affect certain serological tests of\u00a0antibodies\u00a0to\u00a0red blood cells, e.g.\u00a0antiglobulin test (Coombs test).<\/p>\n\n\n\n<p><em>Virus security<\/em><\/p>\n\n\n\n<p>When medicines are prepared from human blood or\u00a0plasma, special measures are taken to prevent\u00a0infection\u00a0from being transmitted to patients.\u00a0These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a careful selection of blood and plasma donors to ensure that persons who may be carriers are excluded.<\/li><li>testing of blood or&nbsp;plasma&nbsp;to ensure that there are no infectious agents and\/or&nbsp;viruses<\/li><li>measures to remove or disable&nbsp;viruses&nbsp;during manufacturing<\/li><\/ul>\n\n\n\n<p>Despite these measures, the risk of transmission of\u00a0infection\u00a0cannot be completely excluded when medicines made from human blood or\u00a0plasma\u00a0are given.\u00a0This also applies to new, hitherto unknown\u00a0viruses\u00a0and other types of\u00a0infection.<\/p>\n\n\n\n<p>The measures taken are considered effective against enveloped\u00a0viruses\u00a0such as human immunodeficiency virus (\u00a0HIV\u00a0),\u00a0hepatitis\u00a0B\u00a0virus\u00a0(HBV),\u00a0hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0), and non-enveloped\u00a0hepatitis\u00a0A\u00a0virus\u00a0(HAV).<\/p>\n\n\n\n<p>The measures may be of limited value against non-enveloped&nbsp;viruses&nbsp;such as parvovirus B19.<\/p>\n\n\n\n<p>Immunoglobulins have not been able to be linked to\u00a0infection\u00a0by\u00a0hepatitis\u00a0A or parvovirus B19, probably because the\u00a0antibodies\u00a0in the medicine against these\u00a0infections\u00a0are protective.<\/p>\n\n\n\n<p>It is strongly recommended that the product name and batch number be recorded each time Venbig is administered to a patient so that a link between the patient and the product batch can be maintained.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>No special measures or monitoring are required.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Venedig<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Human immunoglobulin against&nbsp;hepatitis&nbsp;B for&nbsp;intravenous&nbsp;use must not be mixed with other medicines.<\/p>\n\n\n\n<p><em>Live attenuated&nbsp;virus&nbsp;vaccines<\/em><\/p>\n\n\n\n<p>Venbig can affect the development of the\u00a0immune response\u00a0to vaccines with live attenuated\u00a0viruses\u00a0such as rubella, mumps, measles, and chicken pox.\u00a0The use of immunoglobulin may affect the effectiveness of these vaccines for a period of up to 3 months.\u00a0After\u00a0administration\u00a0of Venbig, wait at least 3 months before vaccination with the live attenuated\u00a0virus\u00a0is performed.<\/p>\n\n\n\n<p>Human&nbsp;hepatitis&nbsp;B immunoglobulin should be given three to four weeks after vaccination with such a live attenuated vaccine.&nbsp;In cases where the use of human&nbsp;hepatitis&nbsp;B immunoglobulin is essential within three to four weeks after vaccination, vaccination should be carried out again three months after the use of human&nbsp;hepatitis&nbsp;B immunoglobulin.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0The doctor will decide whether Venbig can be used during pregnancy and breastfeeding.<\/li><li>No\u00a0clinical trials\u00a0have been conducted with Venbig in pregnant women.\u00a0IVIg preparations have been shown to cross the placenta, to an increasing extent during the last three months of pregnancy.\u00a0However, antibody-containing drugs have been used by pregnant women for many years and it has been shown that no harmful effects on the course of pregnancy, the fetus, or the newborn are to be expected.\u00a0If you breastfeed and receive Venbig, the\u00a0antibodies\u00a0in the medicine can pass into the breast milk.\u00a0The child can thereby be protected against certain\u00a0infections.<\/li><li>Clinical experience with immunoglobulins suggests that no adverse effects on\u00a0fertility\u00a0are expected.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Venbig has no or negligible effect on the ability to drive and use machines.&nbsp;If you experience&nbsp;side effects&nbsp;during the treatment, you must wait until these subside before driving or operating machinery.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Venbig contains sodium and sucrose<\/h2>\n\n\n\n<p>This medicine contains 39 mg and 175.5 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) per\u00a010 ml vial and\u00a045\u00a0ml\u00a0vial, respectively.\u00a0This corresponds to 1.9% and 8.7% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults, respectively.<\/p>\n\n\n\n<p>This medicine contains up to 92 mg of sucrose (91.9 mg\/ml) per ml.\u00a0This should be considered by patients at risk of\u00a0acute\u00a0renal failure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Venbig<\/h2>\n\n\n\n<p>Venbig is only given in hospitals or healthcare centers by doctors or healthcare professionals.<\/p>\n\n\n\n<p>The dosage\u00a0and treatment schedule depend on the indication.\u00a0The doctor will decide which\u00a0dose\u00a0is suitable for you.\u00a0<\/p>\n\n\n\n<p>At the beginning of&nbsp;infusion&nbsp;one, you receive Venbig at a low infusion rate.&nbsp;If you tolerate this well, your doctor may gradually increase the infusion rate.<\/p>\n\n\n\n<p>For further information see the section &#8220;The following information is intended for healthcare professionals only&#8221;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Venbig<\/h2>\n\n\n\n<p>The consequences of overdose are not known.<\/p>\n\n\n\n<p>If you take more IVIg than you should, you may get an excess of\u00a0protein\u00a0in your blood and it will therefore become too thick (hyper viscous);\u00a0it may particularly affect at-risk patients, especially elderly patients or patients with reduced heart or kidney function.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you experience any of these\u00a0side effects, contact your doctor immediately or the nearest hospital:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions (hypersensitivity).\u00a0This side effect can in some cases develop into acute allergic reactions (anaphylactic\u00a0shock\u00a0): e.g.\u00a0itching, skin reactions, swelling\u00a0of\u00a0the lips, face, and tongue, difficulty swallowing, difficulty breathing, fainting<\/li><li>Acute\u00a0kidney failure\u00a0(eg reduced or absent urine output, fluid retention, shortness of breath).<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;can generally occur after treatment with human immunoglobulins given intravenously:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>chills, headache, dizziness, fever, vomiting, allergic reactions, nausea, joint pain (\u00a0arthralgia\u00a0), low\u00a0blood pressure,\u00a0and moderate pain in the lower back may sometimes occur;<\/li><li>in rare cases transient reduction in the number of red blood cells (\u00a0reversible\u00a0hemolytic reactions \/ reversible\u00a0hemolysis\u00a0), especially in patients with blood group A, B, and AB, and in rare cases\u00a0hemolytic anemia\u00a0(\u00a0blood deficiency\u00a0) requiring\u00a0transfusion<\/li><li>in rare cases, a sudden drop in blood pressure (\u00a0hypotension\u00a0) has been reported and, in isolated cases, a\u00a0hypersensitivity reaction\u00a0(anaphylactic\u00a0shock\u00a0) may occur, even when the patient has not shown hypersensitivity during the previous\u00a0administration.<\/li><li>rare cases of transient skin reactions have been observed;<\/li><li>in very rare cases, thromboembolic reactions (formation of blood clots) which can cause heart attack,\u00a0stroke, obstruction of the pulmonary artery (blood clot in the lung), and deep\u00a0vein thrombosis\u00a0(blood clot in the leg) have been reported;<\/li><li>cases of transient non-infectious\u00a0meningitis\u00a0(\u00a0reversible\u00a0aseptic meningitis;\u00a0meningitis\u00a0)<\/li><li>cases of increased serum creatinine level and\/or occurrence of\u00a0acute\u00a0renal failure<\/li><li>cases of transfusion-related lung injury (TRALI)<\/li><\/ul>\n\n\n\n<p>The following\u00a0side effects\u00a0have been reported during the post-marketing\u00a0administration\u00a0of Venbig (the frequency cannot be estimated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Fast heartbeat (&nbsp;tachycardia&nbsp;)<\/li><li>Drop in blood pressure (&nbsp;hypotension&nbsp;)<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Skin reactions,&nbsp;redness&nbsp;(&nbsp;erythema&nbsp;),&nbsp;itching<\/li><li>Joint pain (&nbsp;arthralgia&nbsp;)<\/li><li>Fever<\/li><li>Feeling of illness<\/li><li>Overindulge<\/li><\/ul>\n\n\n\n<p>For information on&nbsp;virus&nbsp;security, see section 2&nbsp;<em>&#8220;What you need to know before using Venbig&#8221;<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Venbig should be stored<\/h2>\n\n\n\n<p>Store out of sight and reach of children.&nbsp;<\/p>\n\n\n\n<p>Use before the expiry date stated on the outer carton and the label after EXP and EXP.<\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25\u00b0C.<\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Venbig should be used immediately after&nbsp;mixing&nbsp;with the solvent.<\/p>\n\n\n\n<p>Do not use this product if the solution is cloudy or contains particles.&nbsp;(See also the appearance and packaging sizes of the medicine in section 6).<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is human immunoglobulin against\u00a0hepatitis\u00a0B<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Venbig 500 IU<\/strong><\/th><th scope=\"col\"><strong>Venbig 2500 IU<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Human&nbsp;protein<\/td><td>50 g\/l<\/td><td>50 g\/l<\/td><\/tr><tr><td>of which human\u00a0immunoglobulin\u00a0G to last<\/td><td>95%<\/td><td>95%<\/td><\/tr><tr><td>the antibody\u00a0is against HBs\u00a0antigen\u00a0(anti &#8211; HBs) not less than<\/td><td>500 IU \/ vial<\/td><td>2500 IU \/ vial<\/td><\/tr><tr><td>antibody&nbsp;ar against HBs&nbsp;antigen&nbsp;(anti &#8211; HBs) after&nbsp;mixing&nbsp;with the solvent no less than<\/td><td>50 IU\/ml<\/td><td>50 IU\/ml<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>IgG (type G immunoglobulins) subgroups have the following distribution:<\/p>\n\n\n\n<p>IgG&nbsp;<sub>1<\/sub>&nbsp;26.0 \u2013 40.0 mg\/ml<\/p>\n\n\n\n<p>IgG&nbsp;<sub>2<\/sub>&nbsp;13.0 \u2013 25.0 mg\/ml<\/p>\n\n\n\n<p>IgG&nbsp;<sub>3<\/sub>&nbsp;1.20 \u2013 2.50 mg\/ml<\/p>\n\n\n\n<p>IgG&nbsp;<sub>4<\/sub>&nbsp;0.15 \u2013 0.50 mg\/ml<\/p>\n\n\n\n<p>Maximum&nbsp;IgA&nbsp;content 0.05 mg\/ml<\/p>\n\n\n\n<p>Made\u00a0from human\u00a0plasma.<\/p>\n\n\n\n<p>Other ingredients are sucrose, sodium chloride, and water for injections.<\/p>\n\n\n\n<p>The vial with powder contains human immunoglobulin against\u00a0hepatitis\u00a0B, sucrose, and sodium chloride.<\/p>\n\n\n\n<p>The diluent&nbsp;vial&nbsp;contains sodium chloride and water for injections.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The pack of Venbig contains a\u00a0vial\u00a0of powder and a\u00a0vial\u00a0of\u00a0diluent\u00a0used to prepare the solution for\u00a0infusion.<\/p>\n\n\n\n<p>Venbig is white or pale yellow powder or a solid friable lump.<\/p>\n\n\n\n<p>After\u00a0preparation, the solution is clear or slightly opalescent, colorless, or slightly yellow.<\/p>\n\n\n\n<p>Prepared products should be visually inspected for particulate matter or discoloration before\u00a0administration.\u00a0Do not use a solution that is cloudy or contains particles.<\/p>\n\n\n\n<p>Venbig 50 IU\/ml powder and liquid for\u00a0infusion, solution:<\/p>\n\n\n\n<p>Vial&nbsp;with 500 IU powder +&nbsp;vial&nbsp;with 10 ml&nbsp;diluent&nbsp;+ infusion set (1&nbsp;syringe&nbsp;with needle + 1 needle for&nbsp;administration&nbsp;)<\/p>\n\n\n\n<p>Vial&nbsp;with 2500 IU powder +&nbsp;vial&nbsp;with 45 ml&nbsp;diluent&nbsp;+ infusion set<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Kedrion SpA &#8211; Loc.&nbsp;Ai Conti, 55051 Castelvecchio Pascoli, Barga (Lucca), Italy<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Kedrion SpA &#8211; SS 7 bis Km 19.5, S. Antimo (Naples), Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Venbig belongs to a group of medicines called immune sera and immunoglobulins.\u00a0Venbig is a solution of human immunoglobulin against\u00a0hepatitis\u00a0B (\u00a0proteins\u00a0that act as\u00a0antibodies\u00a0) for\u00a0intravenous\u00a0administration\u00a0, and it is used in the following cases:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27194,27187,27190,27189,27191,27192,27188,27186,27195,27193],"class_list":["post-27474","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-venbig","tag-human-immunoglobulin","tag-human-immunoglobulin-against-hepatitis-b","tag-human-immunoglobulin-side-effects","tag-venbig","tag-venbig-side-effects","tag-what-human-immunoglobulin-is-used-for","tag-what-is-human-immunoglobulin","tag-what-is-venbig","tag-what-venbig-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27474","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27474"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27474\/revisions"}],"predecessor-version":[{"id":27712,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27474\/revisions\/27712"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27474"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}