{"id":27473,"date":"2022-10-20T15:11:14","date_gmt":"2022-10-20T15:11:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27473"},"modified":"2022-10-22T07:30:55","modified_gmt":"2022-10-22T07:30:55","slug":"vemlidy","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vemlidy\/","title":{"rendered":"Vemlidy &#8211; Tenofovir alafenamide uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg&nbsp;film-coated tablets<br>tenofovir alafenamide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vemlidy is and what it is used for<\/h2>\n\n\n\n<p>Vemlidy contains the active substance&nbsp;<em>tenofovir alafenamide<\/em>&nbsp;.&nbsp;This is a drug against viral infection&nbsp;<em>(&nbsp;<\/em><em>antiviral drug)<\/em>&nbsp;also called&nbsp;<em>nucleotide reverse transcriptase inhibitor<\/em>&nbsp;(NtRTI).<\/p>\n\n\n\n<p>Vemlidy is used to&nbsp;<strong>treat&nbsp;chronic&nbsp;(long-term)&nbsp;hepatitis&nbsp;B<\/strong>&nbsp;in adults and adolescents aged 12 and over who weigh at least 35 kg.&nbsp;Hepatitis&nbsp;B is an&nbsp;infection&nbsp;that affects the liver and is caused by the&nbsp;hepatitis&nbsp;B&nbsp;virus&nbsp;et.&nbsp;In patients with&nbsp;hepatitis&nbsp;B, this medicine controls the&nbsp;infection&nbsp;by preventing the&nbsp;virus&nbsp;from multiplying.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Vemlidy<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Vemlidy<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to tenofovir alafenamide or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong>\u2192\u00a0<\/strong>\u00a0If this applies to you, do not take Vemlidy and tell your doctor immediately.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be careful not to spread your\u00a0hepatitis<\/strong>\u00a0<strong>\u00a0B to others.\u00a0<\/strong>While you are taking this medicine, you can still infect other people.\u00a0This medicine does not reduce the risk of transmitting\u00a0hepatitis\u00a0B to others through sexual contact or blood infection.\u00a0You must continue to take precautions to avoid this.\u00a0Discuss with the doctor what precautions are necessary to avoid infecting others.<\/li><li><strong>Tell your doctor if you have liver disease.\u00a0<\/strong>Patients with liver disease who are treated for hepatitis B with anti-viral drugs (antiviral drugs) are at higher risk of severe and potentially life-threatening liver complications.\u00a0Your doctor may need to carry out blood tests to check liver function.<\/li><li><strong>Talk to your doctor or pharmacist if you have kidney disease or if tests have shown that you have problems with your kidneys, before or during treatment.\u00a0<\/strong>\u00a0Before starting treatment and during treatment with Vemlidy, doctors may order blood or urine samples to check how your kidneys are working.<\/li><li><strong>Talk to your doctor if you also have\u00a0hepatitis\u00a0C or D.<\/strong>\u00a0This medicine has not been tested in patients who have both\u00a0hepatitis\u00a0C or D and\u00a0hepatitis\u00a0B.<\/li><li><strong>Talk to your doctor if you also have\u00a0HIV<\/strong>.\u00a0If you are not sure whether you have\u00a0HIV, your doctor should offer you an\u00a0HIV\u00a0test before you start taking this medicine for hepatitis B.<\/li><\/ul>\n\n\n\n<p><strong>\u2192<\/strong>&nbsp;If any of these apply to you,&nbsp;<strong>talk to your doctor before taking Vemlidy.<\/strong><\/p>\n\n\n\n<p>There is a risk of kidney problems when you take Vemlidy for a long time (see&nbsp;<em>Warnings and precautions<\/em>&nbsp;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children under 12 years of age and weighing less than 35 kg.&nbsp;<\/strong>It has not been tested on children younger than 12 years and weighing less than 35 kg.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vemlidy<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking, have recently taken, <\/strong><strong>or might\u00a0<\/strong><strong>take any other medicines.\u00a0<\/strong>Vemlidy can affect and is affected by other medicines.\u00a0This can result in the amount of Vemlidy or other medicines in the blood changing.\u00a0This can make your medicines not work properly or make possible\u00a0side effects\u00a0worse.<\/p>\n\n\n\n<p><strong>Medicines used to treat&nbsp;hepatitis&nbsp;B&nbsp;infection<\/strong><\/p>\n\n\n\n<p>You should not take this medicine with other medicines that contain:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>tenofovir alafenamide<\/strong><\/li><li><strong>tenofovir disoproxil<\/strong><\/li><li><strong>adefovir dipivoxil<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Other types of medicines<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>antibiotics\u00a0<\/strong>used to treat bacterial infections, including\u00a0tuberculosis, containing:- rifabutin, rifampicin, or rifapentine<\/li><li>anti-viral medicines\u00a0used to treat\u00a0HIV, such as- ritonavir or cobicistat-boosted darunavir, lopinavir, or atazanavir<\/li><li>anticonvulsant\u00a0drugs\u00a0used to treat\u00a0epilepsy,\u00a0such\u00a0as- carbamazepine, oxcarbazepine, phenobarbital, or\u00a0phenytoin<\/li><li><strong>herbal medicines<\/strong>\u00a0used for mild depression and mild anxiety, containing:<ul><li>St. John&#8217;s wort\u00a0<em>Hypericum perforatum<\/em>\u00a0)<\/li><\/ul><\/li><li><strong>antifungal medicines<\/strong>\u00a0used to treat fungal infections, which contain:-\u00a0ketoconazole\u00a0or itraconazole<\/li><\/ul>\n\n\n\n<p><strong>\u2192&nbsp;<\/strong><strong>Tell your doctor if you are taking these or any other medicines.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you become pregnant.<\/li><li><strong>Do not breastfeed<\/strong> during treatment with Vemlidy.\u00a0The recommendation is not to breastfeed to avoid transferring tenofovir alafenamide or tenofovir to the child through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Vemlidy can cause dizziness.&nbsp;If you feel dizzy while taking Vemlidy, you should not drive or use tools or machines<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vemlidy contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Vemlidy contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Vemlidy<\/h2>\n\n\n\n<p><strong>Always take\u00a0<\/strong><strong>this medicine\u00a0<\/strong><strong>as directed by\u00a0<\/strong><strong>your doctor<\/strong><strong>.\u00a0<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is\u00a0<strong>one tablet once daily with food.\u00a0<\/strong>It is best to take Vemlidy with food to get the right level of active substance in your body.\u00a0The treatment should continue for as long as the doctor tells you.\u00a0Usually, this is at least 6-12 months and can be several years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vemlidy<\/h2>\n\n\n\n<p>If you accidentally take more than the recommended\u00a0dose\u00a0of Vemlidy, you may run an increased risk of possible\u00a0side effects\u00a0of the medicine (see section 4,\u00a0<em>Possible\u00a0side effects\u00a0)<\/em>.<\/p>\n\n\n\n<p>Immediately contact a doctor or the nearest emergency department for advice.&nbsp;Take the jar of tablets with you so that you can easily describe what you have taken.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vemlidy<\/h2>\n\n\n\n<p>You mustn&#8217;t miss a\u00a0dose.\u00a0If you miss a\u00a0dose, calculate how long it has been since you\u00a0last took a\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If it\u00a0<\/strong><strong>has been\u00a0<\/strong><strong>less than 18 hours<\/strong>\u00a0since the time you usually take Vemlidy, take one\u00a0dose\u00a0as soon as possible and then take the next\u00a0dose\u00a0at the usual time.<\/li><li><strong>If it\u00a0<\/strong><strong>has been\u00a0<\/strong><strong>more than 18 hours<\/strong>\u00a0since the time you usually take Vemlidy, do not take the missed\u00a0dose.\u00a0Wait and then take the next\u00a0dose\u00a0at the usual time.\u00a0<strong>Do not take a double\u00a0dose<\/strong>\u00a0to make up for a missed tablet.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit within less than 1 hour after taking Vemlidy<\/strong>, take another tablet.\u00a0You do not need to take another tablet if you vomit more than 1 hour after taking Vemlidy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Vemlidy<\/h2>\n\n\n\n<p><strong>Do not stop taking Vemlidy without consulting a doctor.\u00a0<\/strong>If you stop taking Vemlidy, your\u00a0hepatitis\u00a0B may get worse.\u00a0In some patients with advanced liver disease or cirrhosis (\u00a0cirrhosis\u00a0), this can be life-threatening.\u00a0If you stop taking this medicine, you will need to have regular health checks and blood tests for several months to check for\u00a0hepatitis\u00a0B\u00a0infection.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor<\/strong>\u00a0before you stop taking this medicine for any reason, especially if you experience\u00a0side effects\u00a0or have another illness.<\/li><li><strong>Tell your doctor immediately if<\/strong>\u00a0new or unusual symptoms develop after you stop treatment, especially symptoms that you associate with hepatitis B\u00a0infection.<\/li><li><strong>Talk to your doctor<\/strong>\u00a0before you start taking Vemlidy tablets again.<\/li><\/ul>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common<\/strong><\/p>\n\n\n\n<p><em>(may affect more than 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><\/ul>\n\n\n\n<p><strong>Usual<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Vomiting<\/li><li>Nausea<\/li><li>Dizziness<\/li><li>Stomach pain<\/li><li>Joint pain&nbsp;<em>(&nbsp;arthralgia&nbsp;)<\/em><\/li><li>Rash<\/li><li>Itching<\/li><li>Feeling of bloating<\/li><li>Gas&nbsp;<em>(&nbsp;flatulence&nbsp;)<\/em><\/li><li>Feeling of fatigue&nbsp;<\/li><\/ul>\n\n\n\n<p><strong>Less common<\/strong><\/p>\n\n\n\n<p><em>(&nbsp;<\/em><em>may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, lips, tongue, or throat (\u00a0<em>angioedema<\/em>\u00a0)<\/li><li>Hives (\u00a0<em>urticaria<\/em>\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Blood tests may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An elevated level of a liver enzyme (\u00a0ALT\u00a0) in the blood<\/li><\/ul>\n\n\n\n<p><strong>\u2192&nbsp;<\/strong><strong>Tell your doctor if any of these&nbsp;side effects&nbsp;become serious.<\/strong><\/p>\n\n\n\n<p>During HBV treatment, body weight may increase as well as fasting levels of lipids&nbsp;and&nbsp;\/or&nbsp;glucose&nbsp;in the blood.&nbsp;The doctor will do tests to check for such possible changes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Vemlidy should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.&nbsp;Close the jar well.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substance is&nbsp;<\/strong>&nbsp;<em>tenofovir alafenamide<\/em>&nbsp;.&nbsp;Each Vemlidy film-coated tablet contains tenofovir alafenamide fumarate equivalent to 25 mg of tenofovir alafenamide.<\/p>\n\n\n\n<p><strong>Other ingredients are<\/strong><\/p>\n\n\n\n<p><em>Tablet core:<\/em><\/p>\n\n\n\n<p>Lactose monohydrate, microcrystalline cellulose (E460(i)), croscarmellose sodium (E468), magnesium stearate (E470b).<\/p>\n\n\n\n<p><em>Film coating:<\/em><\/p>\n\n\n\n<p>Polyvinyl alcohol (E1203), titanium dioxide (E171), macrogol (E1521), talc (E553b), and yellow iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vemlidy film-coated tablets are yellow, round, printed (or marked) with \u201cGSI\u201d on one side of the tablet and \u201c25\u201d on the other side of the tablet.&nbsp;It is supplied in tins of 30 tablets (with silica gel desiccant which must remain in the tin to protect the tablets).&nbsp;The silica gel desiccant is stored in a separate bag or container and must not be swallowed.<\/p>\n\n\n\n<p>The following pack sizes are available: outer cartons containing 1 bottle of 30 film-coated tablets and outer cartons containing 90 (3 bottles of 30) film-coated tablets.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>Country Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vemlidy contains the active substance\u00a0tenofovir alafenamide\u00a0.\u00a0This is a drug against viral infection\u00a0(\u00a0antiviral drug)\u00a0also called\u00a0nucleotide reverse transcriptase inhibitor\u00a0(NtRTI).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[25072,27198,27199,27197,27203,27202,25073,27200,27196,27201],"class_list":["post-27473","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-tenofovir-alafenamide","tag-tenofovir-alafenamide-side-effects","tag-tenofovir-alafenamide-tablet","tag-vemlidy","tag-vemlidy-side-effects","tag-vemlidy-tablet","tag-what-is-tenofovir-alafenamide","tag-what-is-vemlidy","tag-what-tenofovir-alafenamide-is-used-for","tag-what-vemlidy-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27473"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27473\/revisions"}],"predecessor-version":[{"id":27713,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27473\/revisions\/27713"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}