{"id":27469,"date":"2022-10-20T15:07:16","date_gmt":"2022-10-20T15:07:16","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27469"},"modified":"2022-10-22T07:31:08","modified_gmt":"2022-10-22T07:31:08","slug":"velbe","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/velbe\/","title":{"rendered":"Velbe &#8211; Vinblastine uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg&nbsp;powder for solution for&nbsp;injection&nbsp;Vinblastine<br>sulfate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Valve is and what it is used for<\/h2>\n\n\n\n<p>The active ingredient is vinblastine.&nbsp;Vinblastine is a&nbsp;cytostatic drug&nbsp;that disrupts the cells&#8217; internal metabolism and inhibits cell division.&nbsp;The effect is seen especially in cells that grow and divide quickly, such as e.g.&nbsp;in cancer cells.<\/p>\n\n\n\n<p>The vinblastine contained in Velbe may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Velbe<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Velbe<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vinblastine or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have a bacterial\u00a0infection\u00a0that needs to be treated first<\/li><li>if the number of\u00a0white blood cells\u00a0is very low unless this is due to the disease being treated that causes the lack of\u00a0white blood cells.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to a doctor or nurse before receiving Velbe if you have ischemic heart disease or impaired liver function<\/li><li>Tell your doctor immediately if you have a sore throat, fever, chills, or mouth sores.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Velbe<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The dose\u00a0of\u00a0phenytoin, which is used against\u00a0epilepsy, should possibly be controlled during treatment with vinblastine, as the simultaneous use of cancer drugs and\u00a0phenytoin\u00a0increases the risk of seizures.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.\u00a0Use of Velbe is not recommended during pregnancy, for women considering pregnancy, or during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Some\u00a0side effects\u00a0can affect the ability to react.\u00a0Do not drive or use machines until you know the effect of treatment with Velde.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Velbe contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0of sodium\u00a0per\u00a0vial, i.e.\u00a0is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Velbe<\/h2>\n\n\n\n<p>The doctor prescribes you an individual&nbsp;dose&nbsp;that is suitable for you.&nbsp;Velbe&nbsp;injection&nbsp;should only be given by healthcare professionals experienced with vinblastine.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Side effects\u00a0are dose-dependent.\u00a0Apart from hair loss, reduction of\u00a0white blood cells,\u00a0and neurological (affecting the nervous system)\u00a0side effects\u00a0usually do not last more than 24 hours.\u00a0Neurological\u00a0side effects\u00a0are rare, but they usually last more than a day.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed during treatment with vinblastine:<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decrease in\u00a0white blood cells\u00a0and\u00a0platelets<\/li><li>blood deficiency\u00a0(\u00a0anemia\u00a0)<\/li><li>constipation<\/li><li>loss of appetite<\/li><li>nausea, vomiting (can be treated with anti-nausea drugs)<\/li><li>abdominal pain<\/li><li>hair loss (often partial and in some cases, the hair grows during the maintenance treatment)<\/li><li>local reactions at the injection site<\/li><li>leg pain<\/li><li>weakness<\/li><li>pain at the tumor site<\/li><li>jaw pain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>disturbed secretion of&nbsp;antidiuretic hormone&nbsp;(SIADH) which can lead to sodium deficiency<\/li><li>high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>headache<\/li><li>oral blisters<\/li><li>inflammation&nbsp;of the throat<\/li><li>sensory disturbances<\/li><li>bowel obstruction.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hearing loss or dizziness, caused by damage to the auditory nerve, especially if the drug is used in combination with other cancer drugs that damage the auditory nerve (e.g. cisplatin)<\/li><li>cramps<\/li><li>bleeding in the gastrointestinal tract.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart attack, spasms in external blood vessels, especially in the fingers (\u00a0Raynaud&#8217;s disease\u00a0), and effects on the\u00a0central nervous system\u00a0which can give rise to a feeling of electric disturbances in the arms and\/or legs if Velbe is given at the same time as another cancer medicine, e.g.\u00a0cisplatin and bleomycin.<\/li><li>azoospermia\u00a0(semen lacking sperm) and\u00a0amenorrhoea\u00a0(absence of menstruation) may occur in adults and adolescents treated with several cancer medicines at the same time.<\/li><li>bronchospasm\u00a0and shortness of breath if Velbe is given in combination with another cancer medicine, e.g.\u00a0mitomycin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Velbe should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store in a refrigerator (2\u00b0C &#8211; 8\u00b0C)<\/p>\n\n\n\n<p>The prepared solution is stored for 24 hours in a refrigerator (2\u00b0C &#8211; 8\u00b0C).<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is vinblastine sulfate.<\/li><li>Other ingredients are sodium hydroxide and sulfuric acid (to adjust\u00a0pH\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Velbe is an almost white powder.<\/p>\n\n\n\n<p>Packaging: Powder for injection bag, solution 1 x 10 mg<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>STADA Nordic Apps<\/p>\n\n\n\n<p>Marielundvej 46 A<\/p>\n\n\n\n<p>2730 Herlev<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>STADApharm GmbH<\/p>\n\n\n\n<p>Stadastrasse 2-18<\/p>\n\n\n\n<p>61118 Bad Vilbel<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active ingredient is vinblastine.\u00a0Vinblastine is a\u00a0cytostatic drug\u00a0that disrupts the cells&#8217; internal metabolism and inhibits cell division.\u00a0The effect is seen especially in cells that grow and divide quickly, such as e.g.\u00a0in cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27223,27220,27218,27221,27222,27214,27219,27217,27215,27216],"class_list":["post-27469","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-velbe","tag-benefits-of-vinblastine","tag-velbe","tag-velbe-is-used-for","tag-velbe-side-effects","tag-vinblastine","tag-vinblastine-side-effects","tag-what-is-velbe","tag-what-is-vinblastine","tag-what-vinblastine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27469"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27469\/revisions"}],"predecessor-version":[{"id":27715,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27469\/revisions\/27715"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}